Dielectrophoresis in Carcinoma Diagnosis: Recent Developments and Applications.

IF 3 3区生物学 Q2 BIOCHEMICAL RESEARCH METHODS

ELECTROPHORESIS Pub Date : 2025-03-18 DOI:10.1002/elps.8127

Alaleh Vaghef-Koodehi, Blanca H Lapizco-Encinas

引用次数: 0

Abstract

Accurate cancer cell analysis is critical across a wide range of medical fields, including clinical diagnostics, personalized medicine, drug development, and cancer research. The ability to rapidly analyze and characterize cancer cells is key to understanding tumor characteristics, developing targeted therapies, and improving patient outcomes. Microscale electrokinetic (EK) techniques have demonstrated their effectiveness and reliability as powerful tools for cell analysis, including cancerous cells. The applications of dielectrophoresis (DEP), an EK technique, in cancer cell analysis are discussed here with a focus on carcinomas, cancer that develops in epithelial tissue. In this review article, the working mechanism of DEP is first introduced, followed by an in-depth review of recent studies published between 2015 and 2024. The concluding remarks section provides a summary of the key points discussed in this review and offers insights into potential future advancements in DEP-based systems for analyzing cancerous cells.

查看原文本刊更多论文

双电泳在癌症诊断中的最新进展和应用。

准确的癌细胞分析在广泛的医学领域至关重要，包括临床诊断、个性化医疗、药物开发和癌症研究。快速分析和表征癌细胞的能力是了解肿瘤特征、开发靶向治疗和改善患者预后的关键。微尺度电动力学（EK）技术已经证明了其作为细胞分析（包括癌细胞）的强大工具的有效性和可靠性。本文讨论了介电电泳（DEP）技术在癌细胞分析中的应用，重点是在上皮组织中发展的癌症。在这篇综述文章中，首先介绍了DEP的工作机制，然后深入回顾了2015年至2024年间发表的最新研究。结束语部分对本文讨论的要点进行了总结，并对基于dep的癌细胞分析系统的潜在未来进展进行了展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ELECTROPHORESIS 生物-分析化学

CiteScore

6.30

自引率

13.80%

发文量

244

审稿时长

1.9 months

期刊介绍： ELECTROPHORESIS is an international journal that publishes original manuscripts on all aspects of electrophoresis, and liquid phase separations (e.g., HPLC, micro- and nano-LC, UHPLC, micro- and nano-fluidics, liquid-phase micro-extractions, etc.). Topics include new or improved analytical and preparative methods, sample preparation, development of theory, and innovative applications of electrophoretic and liquid phase separations methods in the study of nucleic acids, proteins, carbohydrates natural products, pharmaceuticals, food analysis, environmental species and other compounds of importance to the life sciences. Papers in the areas of microfluidics and proteomics, which are not limited to electrophoresis-based methods, will also be accepted for publication. Contributions focused on hyphenated and omics techniques are also of interest. Proteomics is within the scope, if related to its fundamentals and new technical approaches. Proteomics applications are only considered in particular cases. Papers describing the application of standard electrophoretic methods will not be considered. Papers on nanoanalysis intended for publication in ELECTROPHORESIS should focus on one or more of the following topics: • Nanoscale electrokinetics and phenomena related to electric double layer and/or confinement in nano-sized geometry • Single cell and subcellular analysis • Nanosensors and ultrasensitive detection aspects (e.g., involving quantum dots, "nanoelectrodes" or nanospray MS) • Nanoscale/nanopore DNA sequencing (next generation sequencing) • Micro- and nanoscale sample preparation • Nanoparticles and cells analyses by dielectrophoresis • Separation-based analysis using nanoparticles, nanotubes and nanowires.