Advanced Materials最新文献_第2页

Backbone Tailoring Enables High‐Performance and Stable n‐Type Organic Mixed Ionic‐Electronic Conductors for Synaptic Simulation and Biosensor 为突触模拟和生物传感器提供高性能和稳定的n型有机混合离子电子导体

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-10-04 DOI: 10.1002/adma.202512070

Wanli Yang, Suxiang Ma, Sergio Gámez‐Valenzuela, Sang Young Jeong, Jin‐Woo Lee, Haihui Cai, Rongjin Zhu, Bin Liu, Han Young Woo, Bumjoon J. Kim, Shu‐Jen Wang, Paddy Kwok Leung Chan, Xugang Guo, Kui Feng

{"title":"Backbone Tailoring Enables High‐Performance and Stable n‐Type Organic Mixed Ionic‐Electronic Conductors for Synaptic Simulation and Biosensor","authors":"Wanli Yang, Suxiang Ma, Sergio Gámez‐Valenzuela, Sang Young Jeong, Jin‐Woo Lee, Haihui Cai, Rongjin Zhu, Bin Liu, Han Young Woo, Bumjoon J. Kim, Shu‐Jen Wang, Paddy Kwok Leung Chan, Xugang Guo, Kui Feng","doi":"10.1002/adma.202512070","DOIUrl":"https://doi.org/10.1002/adma.202512070","url":null,"abstract":"High‐performance and stable n‐type organic mixed ionic‐electronic conductors (OMIECs) are crucial for advancing organic electrochemical transistors (OECTs)‐based low‐power complementary circuits and biosensors, yet their development remains a great challenge. Herein, the study presents a series of donor‐acceptor polymers incorporating bithiophene (BTI) and fused BTI derivatives with varying conjugation backbone lengths as acceptors. The mid‐size fused BTI dimer enables polymer PBTI2g‐DTCN with simultaneously improved ion‐uptake capability, film structural order, and ion/electron transport capability. Consequently, an impressive electron mobility of 0.84 cm2 V−1 s−1 and a record figure‐of‐merit (µC*) of 287.8 F cm−1 V−1 s−1 are achieved for PBTI2g‐DTCN‐based n‐type conventional OECT in accumulation mode, while the vertical OECTs (vOECTs) attain a state‐of‐the‐art area‐normalized transconductance (gm,A) of 71.8 µS µm−2 with remarkable operational stability. Through finely manipulating the channel components, the vOECTs demonstrate dual‐mode operation, switching between non‐volatile and volatile states. In non‐volatile mode, vOECT‐based artificial synapses with excellent ambient stability enable dynamic learning and are employed in convolutional neural networks for image recognition. In volatile mode, they excel in biosensing, monitoring electrocardiography and electromyography signals. These remarkable results demonstrate that backbone tailoring is a powerful strategy for developing high‐performance n‐type OMIECs for synaptic and sensor applications.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"78 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptide Amphiphiles Hitchhike on Endogenous Biomolecules for Enhanced Cancer Imaging and Therapy 肽两亲体搭便车内源性生物分子增强癌症成像和治疗

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-10-04 DOI: 10.1002/adma.202509359

Li Xiang, Morgan R. Stewart, Kailin Mooney, Mingchong Dai, Samuel Drennan, Samantha Holland, Arnaud Quentel, Sinan Sabuncu, Benjamin R. Kingston, Isabel J. Dengos, Karla Bonic, Florian Goncalves, Xin Yi, Michael I. Henderson, Srivathsan Ranganathan, Bruce P. Branchaud, Leslie L. Muldoon, Ramon F. Barajas Jr, Jared M. Fischer, Adem Yildirim

{"title":"Peptide Amphiphiles Hitchhike on Endogenous Biomolecules for Enhanced Cancer Imaging and Therapy","authors":"Li Xiang, Morgan R. Stewart, Kailin Mooney, Mingchong Dai, Samuel Drennan, Samantha Holland, Arnaud Quentel, Sinan Sabuncu, Benjamin R. Kingston, Isabel J. Dengos, Karla Bonic, Florian Goncalves, Xin Yi, Michael I. Henderson, Srivathsan Ranganathan, Bruce P. Branchaud, Leslie L. Muldoon, Ramon F. Barajas Jr, Jared M. Fischer, Adem Yildirim","doi":"10.1002/adma.202509359","DOIUrl":"https://doi.org/10.1002/adma.202509359","url":null,"abstract":"The interactions of nanomaterials with biomolecules in vivo determine their biological fate. Here, it is shown that self‐assembled peptide amphiphile (PA) nanostructures can dynamically interact with endogenous biomolecules and take advantage of naturally occurring processes to target a broad range of solid tumors. In circulation, self‐assembled PA nanostructures disassemble and reassemble mainly with lipoproteins, which prolongs blood circulation and dramatically improves tumor accumulation and retention. Mechanistic studies suggested that PAs internalize into cancer cells by assembling with their cell membranes and independently of specific receptors. By exploiting these interactions, a PA developed in this study (namely Self‐Assembly ‐ Glutamic acid, SA‐E) demonstrates specific accumulation in various xenograft, syngeneic, patient‐derived xenograft, or transgenic rodent models. In addition, SA‐E enabled the effective delivery of highly potent chemotherapy to different syngeneic and xenografted tumors with reduced side effects. With its simple and modular design and universal tumor accumulation mechanism, SA‐E represents a promising platform for broad applications in cancer imaging and therapy.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"17 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Sustained Cooling and Adaptive Moisture Regulation Enabled by Core–Shell Structured Textiles 核壳结构纺织品的协同持续冷却和自适应湿度调节

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-10-04 DOI: 10.1002/adma.202511542

Na Meng, Yufei Zhang, Yuen Hu, Chao Wang, Chengfeng Ding, Yanyan Lin, Zhaoling Li, Xianfeng Wang, Jianyong Yu, Bin Ding

{"title":"Synergistic Sustained Cooling and Adaptive Moisture Regulation Enabled by Core–Shell Structured Textiles","authors":"Na Meng, Yufei Zhang, Yuen Hu, Chao Wang, Chengfeng Ding, Yanyan Lin, Zhaoling Li, Xianfeng Wang, Jianyong Yu, Bin Ding","doi":"10.1002/adma.202511542","DOIUrl":"https://doi.org/10.1002/adma.202511542","url":null,"abstract":"Thermal and moisture balance in the body–textile microclimate is critical for human comfort, health management, and prolonged wearability. However, designing a textile system capable of simultaneously achieving sustained cooling and dynamic moisture regulation remains an unaddressed and significant challenge. Herein, a thermal and moisture regulating textile (TMRT) is developed via coaxial electrospinning, featuring a rationally designed core–shell micro/nanofiber structure with a moisture–regulating polymer sheath and a thermal–responsive polymer core. The resulting TMRT exhibits exceptional mid‐infrared (MIR) emissivity (99.82%) and low solar reflectivity (7.71%), an outstanding contact cooling coefficient (0.43 W cm−2), and ultralow thermal resistance (0.08 m2 K W−1), enabling ≈ 6.6 °C reduction in skin temperature at 40 °C. Remarkably, the TMRT demonstrates low moisture resistance (2.49 m2 K W−1) and a high water evaporation rate (0.59 g h−1). Furthermore, it possesses favorable moisture regulation performance and rapid humidity response, achieving a humidity–sensing resolution of 0.5% relative humidity (RH). The TMRT–based protective clothing displays a comfortable microenvironment for the human body. This work establishes a groundbreaking paradigm for advanced textiles with synergistic thermal and moisture management, addressing critical limitations in conventional protective gear, particularly in mitigating heat and humidity accumulation during prolonged use.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"10 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental Response Temporal Release Injectable Hydrogel for Controlled Growth Factor Release to Enhance Inflammatory Periodontal Bone Defect Regeneration 环境反应时间释放可注射水凝胶控制生长因子释放促进炎症性牙周骨缺损再生

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-10-04 DOI: 10.1002/adma.202512531

Piaopiao Qiu, Yongliang Ouyang, Shuai Liu, Jiaxiu Dai, Ruiling Wang, Wei Zhao, Chun Xu, Zhen Fan

{"title":"Environmental Response Temporal Release Injectable Hydrogel for Controlled Growth Factor Release to Enhance Inflammatory Periodontal Bone Defect Regeneration","authors":"Piaopiao Qiu, Yongliang Ouyang, Shuai Liu, Jiaxiu Dai, Ruiling Wang, Wei Zhao, Chun Xu, Zhen Fan","doi":"10.1002/adma.202512531","DOIUrl":"https://doi.org/10.1002/adma.202512531","url":null,"abstract":"Regeneration of periodontal bone defects in an inflammatory microenvironment remains challenging due to oxidative stress and excessive bone resorption. Although various biomaterials have been developed, current strategies often fail to address the combined obstacles of immune dysregulation, oxidative damage, and bone loss. An injectable multifunctional hydrogel (HTF@HA) with a dynamic borate ester cross‐linked network is designed to provide environmental responsiveness and temporal release of bioactive factors. Under acidic and oxidative conditions, the hydrogel degrades more rapidly and preferentially releases antioxidative and anti‐inflammatory components, facilitating macrophage polarization toward the M2 phenotype and alleviating inflammation. During the subsequent repair phase, calcium‐phosphate interactions mediate the sustained release of concentrated growth factors (CGF) and low‐dose bone morphogenetic protein‐2 (BMP‐2), supporting osteogenic differentiation and angiogenesis. In vitro, HTF@HA exhibits high biocompatibility, antioxidative capacity, anti‐inflammatory effects, and significant enhancement of periodontal ligament stem cell osteogenesis and endothelial cell angiogenesis under inflammatory conditions. Animal studies confirm that the hydrogel promoted new bone and vessel formation (p < 0.001), and at a BMP‐2 dose of 50 µg/L, it achieved bone regeneration comparable to high‐dose BMP‐2 (500 µg/L, p > 0.05). Overall, HTF@HA provides a promising injectable biomaterial with “anti‐inflammatory‐antioxidant‐regenerative” synergy for treating inflammation‐associated periodontal bone defects.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"18 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano‐Particulate Surface Pinning of CeO2 Enables Durable High‐Voltage Lithium‐Ion Batteries 纳米颗粒表面钉住CeO2使耐用高压锂离子电池成为可能

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-10-04 DOI: 10.1002/adma.202517074

Zezhou Lin, Zhihang Xu, Yiran Ying, Gao Chen, Xi Gong, Daqin Guan, Yanhao Ren, Honglei Zhang, Xiao Sun, Zhaowen Bai, Yang Ren, Ting‐Shan Chan, Yu‐Cheng Huang, Ye Zhu, Peiyu Hou, Zongping Shao, Haitao Huang

{"title":"Nano‐Particulate Surface Pinning of CeO2 Enables Durable High‐Voltage Lithium‐Ion Batteries","authors":"Zezhou Lin, Zhihang Xu, Yiran Ying, Gao Chen, Xi Gong, Daqin Guan, Yanhao Ren, Honglei Zhang, Xiao Sun, Zhaowen Bai, Yang Ren, Ting‐Shan Chan, Yu‐Cheng Huang, Ye Zhu, Peiyu Hou, Zongping Shao, Haitao Huang","doi":"10.1002/adma.202517074","DOIUrl":"https://doi.org/10.1002/adma.202517074","url":null,"abstract":"Elevating the cut‐off voltage of LiCoO2 (LCO) cathode in lithium‐ion batteries (LIBs) enhances capacity but increases structural instability. While surface coatings are used to mitigate structural degradation at high voltages, conventional full coverage coatings often fail to withstand the cyclic mechanical stress, resulting in crack formation and performance decay. Here, a multifunctional CeO2 nanoparticle (NP) pinning structure is designed as a surface coating on LCO (LCO@CeO2) to enable stable operation at a high cut‐off voltage of 4.6 V (vs Li/Li+). This surface pinning architecture balances structural integrity with minimal inactive material usage. The CeO2 NPs are strategically anchored to the LCO surface, creating a pinning structure that accommodates volume changes and suppresses fracture formation in the cathode. Moreover, the CeO2‐mediated fast Li+ transport pathways are established, improving high‐rate capability. The interspersed CeO2 NPs also act as oxygen reservoirs, stabilizing reversible (O2)3− species during high‐voltage oxygen anionic redox reactions. Consequently, the optimized LCO@CeO2 cathode achieves a capacity retention of 85.3% after 500 cycles at 1C and a high‐rate capacity of 124.8 mAh g−1 at 10C. This CeO2 NP pinning structure offers a novel practical strategy for designing durable high‐voltage layered cathodes.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"28 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revealing How Acid Sites Enhance the Electrocatalytic Glycerol Oxidation Performance on Pt Loaded Zeolite‐Carbon Composite Materials 揭示酸位如何增强Pt负载沸石-碳复合材料电催化甘油氧化性能

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-10-04 DOI: 10.1002/adma.202511220

Ju Ye Kim, Sunjae No, Jinwoo Hwang, Mi Yoo, Hakju Lee, Youngbi Kim, Youngmin Kim, Yong Tae Kim, Jeong‐Chul Kim, Jeong Woo Han, Kyoungsoo Kim, Hyung Ju Kim

{"title":"Revealing How Acid Sites Enhance the Electrocatalytic Glycerol Oxidation Performance on Pt Loaded Zeolite‐Carbon Composite Materials","authors":"Ju Ye Kim, Sunjae No, Jinwoo Hwang, Mi Yoo, Hakju Lee, Youngbi Kim, Youngmin Kim, Yong Tae Kim, Jeong‐Chul Kim, Jeong Woo Han, Kyoungsoo Kim, Hyung Ju Kim","doi":"10.1002/adma.202511220","DOIUrl":"https://doi.org/10.1002/adma.202511220","url":null,"abstract":"The catalytic role and function of acid sites in solid acid catalysts, such as zeolites, are well understood in the context of heterogeneous catalytic reactions. But although many studies have highlighted the importance of acid sites, their catalytic effects in electrocatalytic reactions have rarely been investigated. In this work, a novel catalyst synthesis strategy is developed, integrating metal sites with acid sites for application in the electrocatalytic glycerol oxidation reaction (EGOR). Specifically, an ordered microporous carbon support containing acidic aluminum sites (AlYTC) is prepared through a nanocasting approach using a sacrificial zeolite template. Platinum (Pt) nanoclusters are then deposited onto the AlYTC support, forming a structure that exposes both acid sites and Pt nanoclusters on a zeolite‐templated 3D carbon framework (PtAlYTC). The prepared PtAlYTC catalyst demonstrates a turnover frequency (TOF, s−1) 30 times higher and a reaction rate () 17 times greater than those of a Pt catalyst lacking acid sites (PtYTC) in the EGOR. First‐principles density functional theory (DFT) calculations indicate that the combination of Pt sites and acidic Al sites lowers the Gibbs free energy of key reaction steps, improves charge transfer, and strengthens hydrogen adsorption, thereby significantly enhancing the catalytic performance in EGOR.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"121 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anisotropic 3D‐Printed Carbon Fiber‐Reinforced Liquid Metal Elastomer for Synergistic Enhancement of Electrical Conductivity, Thermal Performance, and Leakage Resistance 各向异性3D打印碳纤维增强液态金属弹性体，协同增强电导率、热性能和防泄漏性能

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-10-04 DOI: 10.1002/adma.202511498

Xiaohui Shan, Sen Chen, Weichen Feng, Xiyu Zhu, Bo Wang, Xudong Zhang, Ruizhi Yuan, Jianye Gao, Ziliang Cui, Hanchi Xu, Xin Liao, Bingjie Wu, Jing Liu

{"title":"Anisotropic 3D‐Printed Carbon Fiber‐Reinforced Liquid Metal Elastomer for Synergistic Enhancement of Electrical Conductivity, Thermal Performance, and Leakage Resistance","authors":"Xiaohui Shan, Sen Chen, Weichen Feng, Xiyu Zhu, Bo Wang, Xudong Zhang, Ruizhi Yuan, Jianye Gao, Ziliang Cui, Hanchi Xu, Xin Liao, Bingjie Wu, Jing Liu","doi":"10.1002/adma.202511498","DOIUrl":"https://doi.org/10.1002/adma.202511498","url":null,"abstract":"Developing multifunctional composites with high electrical/thermal conductivity and excellent flexibility remains a critical challenge for flexible electronics and thermal management systems. While liquid metal elastomers offer intrinsic softness and conductivity, their real‐world application is hindered by the trade‐off between outstanding dual conductivity (electrical and thermal) and leakage resistance. To tackle this issue, high‐stability carbon fiber‐reinforced liquid metal elastomer (CFLME) is fabricated via an integrated method: Ni plating on carbon fiber to enhance reactive wetting with liquid metal, followed by composite formation with elastomer and 3D printing for directional fiber alignment, yielding anisotropic CFLME. Such anisotropic architecture enables efficient conductive pathways along fiber axes, reducing the electrical percolation threshold to 25%, achieving a high electrical conductivity of 3.44 × 10⁵ S/m, and a thermal conductivity of 7.26 W/(m∙K). The fiber network securely locks liquid metal, enabling zero leakage under 400% strain, 1000‐cycle stretching, or 833 kPa compression. For practical applications, CFLME exhibits exceptional electromagnetic shielding (93.74 dB), high‐sensitivity biosensing with an 82.62 dB signal‐to‐noise ratio, and efficient thermal management (16 °C reduction vs liquid metal elastomer). This work demonstrates a dual‐innovation strategy of structural design and interfacial regulation, providing a robust solution for flexible electronics and thermal management applications with balanced performance.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"121 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasensitive Pa‐Level Persistent Mechanoluminescent Material Toward All‐Optical Neural Synapses for Tactile‐Visual Information Recognition and Memory 面向触觉-视觉信息识别和记忆的全光学神经突触的超灵敏Pa级持久性机械发光材料

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-10-04 DOI: 10.1002/adma.202514909

Zhijie Ye, Shuangqiang Fang, Tiancheng Zhang, Haoliang Cheng, JiaQi Ou, Jiali Yu, Yixi Zhuang, Rongjun Xie, Le Wang

{"title":"Ultrasensitive Pa‐Level Persistent Mechanoluminescent Material Toward All‐Optical Neural Synapses for Tactile‐Visual Information Recognition and Memory","authors":"Zhijie Ye, Shuangqiang Fang, Tiancheng Zhang, Haoliang Cheng, JiaQi Ou, Jiali Yu, Yixi Zhuang, Rongjun Xie, Le Wang","doi":"10.1002/adma.202514909","DOIUrl":"https://doi.org/10.1002/adma.202514909","url":null,"abstract":"Mechanoluminescence (ML), a self‐recovering and passive luminescent modality, offers a promising path toward tactile‐visual all‐optical neuromorphic computing, potentially overcoming the inefficiency of von Neumann architecture. However, existing ML materials are hindered by high response thresholds and single‐mode luminescence, preventing sub‐kPa perception and multilevel neural transmission. Here, we employ Li+/Dy3+ co‐doping in Sr2SiO4:Eu2+ (LSSO) to implement a defect engineering strategy that synergistically optimizes oxygen vacancies and suppresses strontium vacancies, achieving dual breakthroughs in sensitivity and signal clarity. This approach yields a record‐low ML threshold of 72 Pa—the only Pa‐level system achieved without external electricity or elastomeric structural modifications. This material also responds to sunlight, force, and heat, emulating diverse synaptic functions like tactile/optic nerve perception, short‐term potentiation, and memory. It exhibits a 7‐s persistent ML with a signal‐to‐noise ratio of 20.57 which is 15.6 times higher than commercial SrAl2O4:Eu2+,Dy3+, a micron‐scale imaging resolution (≈200 µm), and a 36‐hour memory capacity. These properties enable thermal‐activated information awakening and visual imaging over 1000 cycles, with a memory accuracy 209% superior to the Ebbinghaus curve. This work not only advances the design of all‐optical synapses but also forges a pivotal connection between ML and neuromorphic engineering, propelling energy‐efficient, light‐driven artificial intelligence.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"4 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personalized Vaccination of Tumor‐Derived Antigens and STING Agonists for Specific Cancer Immunotherapy 肿瘤源性抗原和STING激动剂的个性化疫苗接种用于特异性癌症免疫治疗

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-10-04 DOI: 10.1002/adma.202420325

Ning Wang, Xiaohui Zhang, Zhiliang Gao, Xinyi Jiang, Jianhua Li, Jingcheng Hao, Jiwei Cui

{"title":"Personalized Vaccination of Tumor‐Derived Antigens and STING Agonists for Specific Cancer Immunotherapy","authors":"Ning Wang, Xiaohui Zhang, Zhiliang Gao, Xinyi Jiang, Jianhua Li, Jingcheng Hao, Jiwei Cui","doi":"10.1002/adma.202420325","DOIUrl":"https://doi.org/10.1002/adma.202420325","url":null,"abstract":"Personalized vaccines have shown their promise in cancer immunotherapy, while screening of personalized antigens remains challenging. Herein, a personalized immunotherapy strategy to treat tumors by its own mechanism is reported, which is achieved through the hydrogel‐integrated delivery of tumor‐derived antigens and STING signaling activation. Self‐assembled nanoparticles composed of gallic acid, manganese ions, and mitoxantrone are prepared to induce immunogenic cell death of tumor cells in vitro to release damage‐associated molecular patterns and autologous antigens. Sodium alginate integrated with the released antigens and STING agonists (i.e., MSA‐2) can be instantaneously cross‐linked with endogenous calcium ions in vivo to form hydrogels upon subcutaneous injection. The hydrogels allow for the controlled release of autologous tumor antigens and agonists to activate specific anti‐tumor immune responses via promotion of the maturation of dendritic cells and elicitation of tumor infiltration of cytotoxic T lymphocytes. As a result, the in‐situ formation of hydrogel‐based vaccines can prevent homologous tumor progression and inhibit metastatic tumor growth. This work outlines a straightforward and generalized strategy for personalized vaccination to enhance cancer immunotherapy.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"22 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Materials Design and Assessment of Redox‐Mediated Flow Cell Systems for Enhanced Energy Storage and Conversion 用于增强能量储存和转换的氧化还原介导的流动电池系统的材料设计和评估

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-10-04 DOI: 10.1002/adma.202509991

Zhiyu Wang, Yan Jing, Qing Wang

{"title":"Materials Design and Assessment of Redox‐Mediated Flow Cell Systems for Enhanced Energy Storage and Conversion","authors":"Zhiyu Wang, Yan Jing, Qing Wang","doi":"10.1002/adma.202509991","DOIUrl":"https://doi.org/10.1002/adma.202509991","url":null,"abstract":"The transition toward sustainable energy systems necessitates innovations that overcome the limitations of conventional electrochemical systems. Redox‐mediated flow cell systems emerge as a transformative paradigm by decoupling energy storage, conversion, and chemical processes from traditional electrode‐bound reactions. These systems employ soluble redox mediators to shuttle electrons between electrodes and spatially separated reactive phases (solid, liquid, or gas), thereby enabling unprecedented operational flexibility and scalability. This standpoint underscores the adaptability of redox‐mediated electrified systems across a range of applications, encompassing high‐energy‐density redox targeting‐based flow batteries, fuel cells, electrified CO2 capture, sustainable chemical synthesis, waste recycling, etc. The rational design of redox‐active materials is central to their success, with precise alignment of redox potentials, enhanced electron‐transfer kinetics, and robust stability underpinning performance. The challenges of new materials development, system durability, and cost‐effectiveness can be addressed through advances in experimental measurement, computational modeling, operando characterization, and interdisciplinary collaboration. Moving forward, the integration of redox‐mediated technologies with renewable energy systems and industrial processes is predicted to transform energy and chemical landscapes. The integration of laboratory innovations with real‐world deployment facilitates a pathway to decarbonization, resource efficiency, and the circular economy. This perspective emphasizes the pivotal functions of redox‐mediated architectures in fostering a robust, electrified future, where the convergence of energy storage, environmental stewardship, and sustainable chemical production is pivotal in addressing global challenges.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"13 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0