Advanced Materials最新文献_第3页

Bioinspired Smart Nanogels for Rapid Blue Laser-Activated Hemostasis in Gastrointestinal Bleeding 生物启发智能纳米凝胶用于快速蓝色激光激活止血胃肠道出血

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-06-04 DOI: 10.1002/adma.202506955

Ruijue Dan, Yu Huang, Shali Tan, Kaige Xu, Yuchen Zhang, Zhaohui Luan, Paipai Qi, Xingyue Zhang, Donghui Zhu, Wen Zhong, Chaoqiang Fan, Malcolm Xing, Shiming Yang

{"title":"Bioinspired Smart Nanogels for Rapid Blue Laser-Activated Hemostasis in Gastrointestinal Bleeding","authors":"Ruijue Dan, Yu Huang, Shali Tan, Kaige Xu, Yuchen Zhang, Zhaohui Luan, Paipai Qi, Xingyue Zhang, Donghui Zhu, Wen Zhong, Chaoqiang Fan, Malcolm Xing, Shiming Yang","doi":"10.1002/adma.202506955","DOIUrl":"https://doi.org/10.1002/adma.202506955","url":null,"abstract":"Gastrointestinal bleeding (GIB) is a critical condition that requires rapid and effective intervention. Although thrombin is a widely used hemostatic agent, its efficacy is limited in the harsh environment of the digestive tract, especially in patients with chronic liver disease or coagulation disorders. Current treatment techniques often fall short, particularly when faced with severe blood loss and coagulation challenges. Here, a novel solution: waxberry-inspired smart nanogels that offer a cost-effective, highly efficient, and mechanically stable approach for local hemostasis is presented. Drawing inspiration from the microfibrous structures of waxberry, a waxberry-like nano-silica with a radially fibrous structure is synthesized for effective thrombin loading and release upon emergency. This nano-silica, coated with GelMA, forms a stable nanogel network activated by blue laser during endoscopy. Within just 5 s, the nanogel effectively triggers coagulation, even in patients with coagulation disorders. The formed blood clots are stable enough to withstand the challenging conditions of the digestive tract, preventing secondary bleeding. Upon injection, thrombin rapidly converts fibrinogen to fibrin, creating a secondary network that reinforces clot stability. This dual-network system demonstrates strong adhesive properties and effective hemostasis in the blood of cirrhotic patients, as well as in gastrointestinal bleeding scenarios involving the esophagus, stomach, and duodenum of mini-pigs.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"62 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterocluster-Assembled Crystalline Hydrophobic Complexes with Delayed Fluorescence 具有延迟荧光的异簇组装晶体疏水配合物

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-06-04 DOI: 10.1002/adma.202505734

Jing He, Liang He, Minyi Zhang, Jian Zhang, Qipu Lin

{"title":"Heterocluster-Assembled Crystalline Hydrophobic Complexes with Delayed Fluorescence","authors":"Jing He, Liang He, Minyi Zhang, Jian Zhang, Qipu Lin","doi":"10.1002/adma.202505734","DOIUrl":"https://doi.org/10.1002/adma.202505734","url":null,"abstract":"Metal–organic frameworks (MOFs) with metal─sulfur bonds exhibit unique electrical, redox, and optical properties. However, their development has been hindered by rapid nucleation during crystallization. To address this challenge, amine-based modulators to retard nucleation through competitive coordination with ligands, enabling the synthesis of a series of Cu-S cluster-based MOFs with diverse network topologies: Cu-BDT-hcb (1), Cu-TBT-acs (2), Cu-TBT-pcu (3), Cu-TBT-sql (4), Cu-TBT-dia (5), and Cu-TBT-hcb (6), are utilized. Using donor-acceptor (D-A) ligands (o/p-mercaptobenzoic acid—o/pMBA), [Sn4]-based MOFs: Sn-oDTBA-cds (7) and Sn-pDTBA-pcu (8), are fabricated. During synthesis, sulfhydryl groups underwent reductive coupling to generate novel dicarboxylate ligands with disulfide (S–S) linkages. Notably, the first bimetallic heterocluster MOF, SnCu-mMBA-dia (9), incorporating both a metal-oxygen cluster [Sn4O2(carboxylate)4] and a metal-sulfur cluster [Cu8(thiolate)8] is developed. This framework, constructed using m-mercaptobenzoic acid (mMBA) as a D–A bifunctional ligand, exhibits spatially separated HOMO and LUMO, minimizing the singlet–triplet energy gap to promote thermally activated delayed fluorescence (TADF). Compound 9 also demonstrates exceptional hydrolytic stability due to steric shielding by hydrophobic organotin moieties. This work pioneers a modulator-assisted strategy for heterocluster MOF construction, offering a paradigm for designing stable luminescent materials with tailored optoelectronic functionalities.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"5 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hour-Level and Air-Stable Organic Long-Persistent Luminescence from Organic–Inorganic Hybrid Materials 有机-无机杂化材料的小时级和空气稳定有机长持久发光

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-06-04 DOI: 10.1002/adma.202419213

Linhao Guan, Qiuqin Huang, Rujun Yang, Suhua Jiang, Yixi Zhuang, Peiyuan Wang, Yong Gao, Rong-Jun Xie, Qidan Ling, Zhenghuan Lin

{"title":"Hour-Level and Air-Stable Organic Long-Persistent Luminescence from Organic–Inorganic Hybrid Materials","authors":"Linhao Guan, Qiuqin Huang, Rujun Yang, Suhua Jiang, Yixi Zhuang, Peiyuan Wang, Yong Gao, Rong-Jun Xie, Qidan Ling, Zhenghuan Lin","doi":"10.1002/adma.202419213","DOIUrl":"https://doi.org/10.1002/adma.202419213","url":null,"abstract":"Organic long-persistent luminescence (OLPL) materials show important application prospects in bioimaging due to their low biotoxicity and the ability to eliminate the interference of background fluorescence. However, OLPL materials suffer from poor environmental stability and short afterglow times. Herein, by introducing the phosphorescent guest 2, 3-naphthalimide (NAI) into the B2O3 (BO) matrix using a solvent-free method in an air atmosphere, an organic–inorganic hybrid material NAI/BO is obtained, exhibiting OLPL lasting for more than 20 h, visible to the naked eye for up to 180 min. Photoluminescence and thermoluminescence spectra reveal that the OLPL originates from pure phosphorescence of NAI, and is induced by inorganic defects generated by oxygen vacancies in BO. The NAI electrons in the excited state can be captured by the defect, then detrapped through the thermal activation process, and eventually returned to the triplet state of NAI, thereby achieving OLPL emission. NAI/BO is successfully applied in vivo imaging stimulated in vitro. In addition, the universality of this strategy is verified by changing the phosphorescent guest molecules, enabling the regulation of OLPL from green to orange–red light. These results provide an important foundation for the design and development of stable OLPL materials and the practical applications in biological imaging.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"15 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conjugation Pathway of Benzobisoxazoles in Polymer Donors Mediates the Charge Management and Enables Organic Solar Cells with Record Certified Efficiency 苯并双恶唑在聚合物供体中的偶联途径介导电荷管理并使有机太阳能电池具有创纪录的认证效率

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-06-04 DOI: 10.1002/adma.202503702

Miao Liu, Lunbi Wu, Yulong Hai, Yongmin Luo, Yao Li, Rouren Chen, Yue Ma, Tao Jia, Qingduan Li, Sha Liu, Ruijie Ma, Yue-Peng Cai, Jiaying Wu, Gang Li, Shengjian Liu

{"title":"Conjugation Pathway of Benzobisoxazoles in Polymer Donors Mediates the Charge Management and Enables Organic Solar Cells with Record Certified Efficiency","authors":"Miao Liu, Lunbi Wu, Yulong Hai, Yongmin Luo, Yao Li, Rouren Chen, Yue Ma, Tao Jia, Qingduan Li, Sha Liu, Ruijie Ma, Yue-Peng Cai, Jiaying Wu, Gang Li, Shengjian Liu","doi":"10.1002/adma.202503702","DOIUrl":"https://doi.org/10.1002/adma.202503702","url":null,"abstract":"Charge management plays a pivotal role in achieving high-performance bulk heterojunction (BHJ) organic solar cells (OSCs). In this study, two efficient polymer donors are designed, P[4,8]BBO and P[2,6]BBO, by regulating the conjugation pathways of benzobisoxazoles (BBO) through 4,8- and 2,6-linkages, respectively. Comparing to P[2,6]BBO, the isomer of conjugation pathway has been proved to enable P[4,8]BBO a shallower highest occupied molecular orbital (HOMO) energy level of −5.20 eV, significantly enhanced luminescence efficiency, and reduced aggregation property. These improvements lead to a dramatic increase in device efficiencies from 2.6% for P[2,6]BBO:eC9-2Cl to 19.0% for P[4,8]BBO:eC9-2Cl. The combined characterizations show that a better comprehensive charge management can be reached in P[4,8]BBO:eC9-2Cl-based OSCs, yielding a significantly higher short-circuit current density (JSC) and fill factor (FF) parameters compared to P[2,6]BBO:eC9-2Cl-based ones. Furthermore, P[4,8]BBO demonstrates good applicability and can achieve an impressive efficiency of 19.4% in all-polymer solar cells with a third-party certified efficiency of 19.1%. This work highlights the critical role of conjugation pathway isomerism in mediating polymeric properties and advancing the development of high-performance multifunctional photovoltaic materials.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"30 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Impurity-Induced Room-Temperature Phosphorescence 杂质诱导的室温磷光研究进展

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-06-04 DOI: 10.1002/adma.202506549

Zheng Yin, Zhu Wu, Bin Liu

{"title":"Recent Advances in Impurity-Induced Room-Temperature Phosphorescence","authors":"Zheng Yin, Zhu Wu, Bin Liu","doi":"10.1002/adma.202506549","DOIUrl":"https://doi.org/10.1002/adma.202506549","url":null,"abstract":"Organic room-temperature phosphorescence (RTP) materials with large Stokes shifts and prolonged afterglows are gaining increasing attention in a variety of applications, including displays, anti-counterfeiting, sensing, and bioimaging. However, achieving high-performance organic RTP remains challenging due to weak spin-orbit coupling, rapid non-radiative decay, and unstable triplet excitons. Early studies focused on crystal engineering, as ordered lattices restrict molecular motion and stabilize triplet excitons. Analyzing crystal structures and packing provides valuable insights into intermolecular interactions, while theoretical calculations have clarified electronic structures, laying the foundation for rational RTP material design. However, recent findings suggest RTP in many single-component systems may arise from trace impurities, significantly influencing RTP properties. This discovery has greatly advanced the understanding of impurity-induced phosphorescence. This review systematically examines the role of impurities in RTP, detailing their origins from starting materials, solvents, and side reactions. It also explores how these identified impurities can serve as essential building blocks for designing new RTP materials. Finally, essential methods for evaluating compound purity, emphasizing the critical importance of rigorous analysis and validation are presented. Material purity plays a pivotal role in RTP research, as impurities can distort experimental data, potentially leading to misinterpretations that can impede advancements in understanding the underlying mechanisms.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"11 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modular Molecular Editing of End-of-Life PBT for High-Performance Sustainable and 3D-Printable Platforms 用于高性能可持续和3d打印平台的寿命结束PBT的模块化分子编辑

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-06-04 DOI: 10.1002/adma.202503881

Huilin Xie, Guang Xiao, Geng Ren, Guodong Lu, Wu Chen, Huimei Zhang, Jialei Li, Wenjie Luo, Hongjie Zhang, Weipu Zhu, Qiuquan Cai

{"title":"Modular Molecular Editing of End-of-Life PBT for High-Performance Sustainable and 3D-Printable Platforms","authors":"Huilin Xie, Guang Xiao, Geng Ren, Guodong Lu, Wu Chen, Huimei Zhang, Jialei Li, Wenjie Luo, Hongjie Zhang, Weipu Zhu, Qiuquan Cai","doi":"10.1002/adma.202503881","DOIUrl":"https://doi.org/10.1002/adma.202503881","url":null,"abstract":"Engineering polyesters, particularly poly(butylene terephthalate) (PBT), are widely used but generate significant waste, with limited recycling options. Existing mechanical and chemical recycling strategies struggle to sustainably and efficiently reuse PBT, resulting in product performance degradation and making the recycling process more costly than the upstream synthesis routes for raw materials. Inspired by DNA editing technologies in molecular biology, a modular molecular editing strategy is proposed to sequentially modify the backbone and end groups of end-of-life PBT, transforming it into a high-performance, sustainable, and 3D-printable poly(butylene adipate-co-terephthalate) (PBAT) platform. Unlike traditional commercial PBATs that produce only single components, this platform surpasses them in tensile strength and toughness without requiring additional additives and features programmable properties for diverse applications, including injection-molded parts, 3D-printed components, films, packaging, fibers, and fabrics. The industrial scalability of this strategy is validated through successful 100-L pilot-scale production. The resulting PBAT allows closed-loop polymer-to-polymer recycling by reintroducing PBT or monomers, thereby enhancing its social sustainability. When recovery is no longer feasible, the materials remain ecologically sustainable through composting, avoiding harmful environmental accumulation. This work achieves a direct polymer-to-polymer conversion of end-of-life PBT into high-performance materials, with techno-economic analysis highlighting both environmental and economic advantages.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"15 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

De Novo Design of Efficient NIR-II-Activated Heavy-Atom-Free Type-I Photosensitizer for Anti-Tumor Photoimmunotherapy 用于抗肿瘤光免疫治疗的高效nir - ii激活重原子无i型光敏剂的从头设计

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-06-04 DOI: 10.1002/adma.202501919

Huan Chen, Yu Wang, Zhangxin He, Yingpeng Wan, Chen Cao, Ziwei Lu, Yijian Gao, Xiao Cui, Ka-Wai Lee, Ji-Hua Tan, Wenchang Xu, Yuliang Yang, Xiliang Li, Yali Wang, Jianquan Hou, Shengliang Li, Chun-Sing Lee

{"title":"De Novo Design of Efficient NIR-II-Activated Heavy-Atom-Free Type-I Photosensitizer for Anti-Tumor Photoimmunotherapy","authors":"Huan Chen, Yu Wang, Zhangxin He, Yingpeng Wan, Chen Cao, Ziwei Lu, Yijian Gao, Xiao Cui, Ka-Wai Lee, Ji-Hua Tan, Wenchang Xu, Yuliang Yang, Xiliang Li, Yali Wang, Jianquan Hou, Shengliang Li, Chun-Sing Lee","doi":"10.1002/adma.202501919","DOIUrl":"https://doi.org/10.1002/adma.202501919","url":null,"abstract":"Type-I photosensitizers (PSs) are considered to be efficient agents for overcoming the oxygen-dependent deficiency of traditional photodynamic therapy (PDT). However, it is still challenging to design type-I PSs that can be activated by the second near-infrared (NIR-II) irradiation. Herein, a series of organic heavy-atom-free molecules are designed (named as CTU1, CTU2, and CTU3) and exhibit strong absorption bands over the first near-infrared and NIR-II regions. Among them, water-dispersible CTU3 nanoparticles (NPs) show strong J-aggregate characteristics and a good NIR-II absorption band, resulting in highly efficient •O2− generation upon irradiation of 1064 nm light. In addition, the CTU3 NPs also exhibit a high photothermal conversion efficiency of 88.6%. In vitro and in vivo experiments show that CTU3 NPs have superior PDT and photothermal therapy (PTT) effects, which can further induce immunogenic cell death and activate immune cells in 4T1 tumor-bearing mice for combined PDT/PTT anti-tumor photoimmunotherapy against refractory tumors. This work presents a paradigm of de novo design of NIR-II light-activated type-I PS for combinational photoimmunotherapy of cancer.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"5 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topology in Biological Piezoelectric Materials 生物压电材料的拓扑学

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-06-04 DOI: 10.1002/adma.202500466

Chen Chen, Yanhu Zhang, Yi Zheng, Yi Zhang, Hongyi Liu, Jiang Wu, Liang Yang, Zhengbao Yang

引用次数: 0

A Metabolism-Oriented Strategy to Directly Generate Photosensitizer-Engineered Extracellular Vesicles from Cancer Cells 从癌细胞中直接产生光敏剂工程细胞外囊泡的代谢导向策略

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-06-04 DOI: 10.1002/adma.202505726

Dandan Wang, Xingang Liu, Xianming Zhang, Thach Tuan Pham, Jiahao Zhuang, Bowen Li, Kok Chan Chong, Can Liu, Yi Shan, Min Wu, Minh T. N. Le, Kai Li, Bin Liu

{"title":"A Metabolism-Oriented Strategy to Directly Generate Photosensitizer-Engineered Extracellular Vesicles from Cancer Cells","authors":"Dandan Wang, Xingang Liu, Xianming Zhang, Thach Tuan Pham, Jiahao Zhuang, Bowen Li, Kok Chan Chong, Can Liu, Yi Shan, Min Wu, Minh T. N. Le, Kai Li, Bin Liu","doi":"10.1002/adma.202505726","DOIUrl":"https://doi.org/10.1002/adma.202505726","url":null,"abstract":"Extracellular vesicles (EVs) hold great potential for delivering cancer therapy drugs. However, limited efficiency and sophisticated drug encapsulation procedures have hindered their effectiveness. Herein, β-D-glucose is modified with the synthesized photosensitizer (1-(4-carboxybutyl)-4-(7-(4-(diphenylamino)phenyl)benzo[c][1,2,5] thiadiazol-4-yl)pyridin-1-ium, named TB) via amide bond to form a glucose-conjugated photosensitizer, referred to as TBG, which is further utilized as a metabolic substrate for cancer cells. Through simple co-incubation with TBG, cancer cells directly generate TBG-engineered EVs in situ via a metabolism-driven process, in which glucose transporters play a critical role. Notably, a higher yield of engineered EVs is observed in TBG-treated cells compared to the TB-treated group. This enhancement could be attributed to increased glucose transporter activity and adenosine triphosphate (ATP) synthesis, highlighting the significance of glucose-modified chemicals. Remarkably, this metabolism-driven strategy has been successfully validated across three cell lines, highlighting its versatility and broad applicability. The extracted TBG-EVs maintain a strong targeting ability toward cancer cells and demonstrate enhanced efficacy in photodynamic therapy for tumor ablation. The study offers an alternative strategy to efficiently produce cargo-loading EVs via direct biological metabolism.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"36 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering Red Blood Cells for Amplified Tumor Dual-Gas Transfusion Therapy 工程红细胞用于放大肿瘤双气输注治疗

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-06-04 DOI: 10.1002/adma.202503206

Tao Li, Min Ouyang, Wei Wang, Sijin Chen, Chengxinqiao Wang, Jiahui Lai, Peixian Weng, Zhenhua Li, Yupeng Wang, Dongfang Zhou

{"title":"Engineering Red Blood Cells for Amplified Tumor Dual-Gas Transfusion Therapy","authors":"Tao Li, Min Ouyang, Wei Wang, Sijin Chen, Chengxinqiao Wang, Jiahui Lai, Peixian Weng, Zhenhua Li, Yupeng Wang, Dongfang Zhou","doi":"10.1002/adma.202503206","DOIUrl":"https://doi.org/10.1002/adma.202503206","url":null,"abstract":"Red blood cell (RBC) transfusion therapy constitutes a vital medical intervention primarily aimed at enhancing oxygen delivery. Furthermore, RBCs possess the ability to stably bind therapeutic gas molecules such as carbon monoxide (CO) and nitric oxide (NO). As natural gas carriers, RBCs have the potential to mitigate the non-specific gas release and biosafety issues associated with conventional gas donors, which currently hinder the clinical application of gas therapy. In this study, RBCs are innovatively engineered for amplified tumor dual-gas transfusion therapy. The RBCs delivering CO and NO are developed using advanced nano- and gas-engineering techniques. These engineered RBCs are activated by tumor cell-specific hydrogen peroxide (H2O2) to release gases, and it induces a cascade amplification of reactive oxygen species (ROS) and reactive nitrogen species (RNS) (ONOO−) production through the catalytic action of the ferrous hemoglobin (HbFe2+). This process disrupts glycometabolism and reshapes the tumor immunosuppressive microenvironment, thereby enhancing therapeutic efficacy. By integrating tumor cell membrane engineering, this approach enables targeted, personalized therapy and effectively suppresses metastatic tumors synergistically with αPD-L1. Comprehensive evaluation demonstrates that engineered RBC-based amplified tumor dual-gas transfusion therapy exhibits excellent biosafety, and holds significant potential as a highly translatable and promising cancer treatment modality.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"32 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0