Advanced Materials最新文献_第3页

Advances and Outlooks for Carbon Nanotube-Based Thermoelectric Materials and Devices

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-02-16 DOI: 10.1002/adma.202500947

Shanshan Zhou, Xiao-Lei Shi, Lan Li, Qian Liu, Boxuan Hu, Wenyi Chen, Chenyang Zhang, Qingfeng Liu, Zhi-Gang Chen

{"title":"Advances and Outlooks for Carbon Nanotube-Based Thermoelectric Materials and Devices","authors":"Shanshan Zhou, Xiao-Lei Shi, Lan Li, Qian Liu, Boxuan Hu, Wenyi Chen, Chenyang Zhang, Qingfeng Liu, Zhi-Gang Chen","doi":"10.1002/adma.202500947","DOIUrl":"https://doi.org/10.1002/adma.202500947","url":null,"abstract":"The unique structure of carbon nanotubes (CNTs) endows them with exceptional electrical and mechanical properties, along with a high surface area, making them highly beneficial for use as flexible, high-performing thermoelectric materials. As a result, the application of CNTs in the thermoelectric field has become increasingly widespread. Considering the rapid advancements in this field, this review offers a timely overview of the most recent progress on CNT-based thermoelectric materials and devices over the past five years. This review begins by introducing the fundamental concepts and thermoelectric mechanisms of CNT-based thermoelectric materials. Then new strategies are explored to enhance their thermoelectric performance, focusing on doping and composites, while emphasizing the importance of CNT stability as a key research area. Additionally, the latest design concepts and expanded application scenarios for flexible and wearable CNTs-based thermoelectric devices are summarized. Finally, the current challenges are addressed and future directions for the development of CNT-based thermoelectric materials and devices are discussed.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"180 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryo-Shocked Tumor-Reprogrammed Sonosensitive Antigen-Presenting Cells Improving Sonoimmunotherapy via T Cells and NK Cells Immunity

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-02-16 DOI: 10.1002/adma.202413289

Xindi Qian, Wenzhe Yi, Wenlu Yan, Ying Cai, Shuangshuang Hu, Dan Yan, Zhiwen Zhao, Rongzhang Li, Liying Wang, Huixiong Xu, Yaping Li

{"title":"Cryo-Shocked Tumor-Reprogrammed Sonosensitive Antigen-Presenting Cells Improving Sonoimmunotherapy via T Cells and NK Cells Immunity","authors":"Xindi Qian, Wenzhe Yi, Wenlu Yan, Ying Cai, Shuangshuang Hu, Dan Yan, Zhiwen Zhao, Rongzhang Li, Liying Wang, Huixiong Xu, Yaping Li","doi":"10.1002/adma.202413289","DOIUrl":"https://doi.org/10.1002/adma.202413289","url":null,"abstract":"Ultrasound therapy has turned up as a noninvasive multifunctional tool for cancer immunotherapy. However, the insufficient co-stimulating molecules and loss of peptide-major histocompatibility complex I (MHC-I) expression on tumor cells lead to poor therapy of sonoimmunotherapies. Herein, this work develops a sonosensitive system to augment MHC-I unrestricted natural killer (NK) cell-mediated innate immunity and T cell-mediated adaptive immunity by leveraging antigen presentation cell (APC)-like tumor cells. Genetically engineered tumor cells featuring sufficient co-stimulating molecules are cryo-shocked and conjugated with a sonosensitizer, hematoporphyrin monomethyl ether, using click chemistry. These cells (DPNLs) exhibit characteristics of tumor and draining lymph node homing. Under ultrasound, NK cell-mediated innate immunity within the tumor microenvironment could be activated, and T cells in the tumor-draining lymph nodes (TDLNs) are stimulated through co-stimulatory molecules. In combination with programmed cell death ligand 1 (PD-L1) antibody, DPNLs extend the survival time and inhibited lung metastasis in triple-negative breast cancer (TNBC) models. This study provides an alternative approach for sonoimmunotherapy with precise sonosensitizer delivery and enhanced NK cell and T cell activation.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"64 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

All-Climate Energy-Dense Cascade Aqueous Zn-I2 Batteries Enabled by a Polycationic Hydrogel Electrolyte

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-02-16 DOI: 10.1002/adma.202415979

Yangyang Liu, Longhai Zhang, Ling Liu, Quanwei Ma, Rui Wang, Peng Xiong, Hongbao Li, Shilin Zhang, Junnan Hao, Chaofeng Zhang

{"title":"All-Climate Energy-Dense Cascade Aqueous Zn-I2 Batteries Enabled by a Polycationic Hydrogel Electrolyte","authors":"Yangyang Liu, Longhai Zhang, Ling Liu, Quanwei Ma, Rui Wang, Peng Xiong, Hongbao Li, Shilin Zhang, Junnan Hao, Chaofeng Zhang","doi":"10.1002/adma.202415979","DOIUrl":"https://doi.org/10.1002/adma.202415979","url":null,"abstract":"The practical development of aqueous zinc-iodine (Zn-I2) batteries is greatly hindered by the low energy density resulting from conventional I0/I− conversion and the limited temperature tolerance. Here, a temperature-insensitive polycationic hydrogel electrolyte borax-bacterial cellulose / p(AM-co-VBIMBr) (denoted as BAVBr) for achieving an energy-dense cascade aqueous Zn-I2 battery over a wide temperature range from −50 to 50 °C is designed. A comprehensive investigation, combining advanced spectroscopic investigation and DFT calculations, has revealed that the presence of Br species in the gel electrolyte facilitates the conversion reaction of Br0/Br−. Simultaneously, it activates the high voltage I+/I0 redox reaction through interhalogen formation. Consequently, sequential and highly reversible redox reactions involving I0/I−, I+/I0, and Br0/Br− are achieved with the assistance of −NR3+ units in BAVBr, effectively suppressing interhalogen hydrolysis in aqueous electrolyte. The cascade reactions lead to a high area capacity of 0.76 mAh cm−2 at a low I2 loading of 1 mg cm−2 or 760 mAh g−1 based on the mass of iodine, demonstrating exceptional long-term cycling stability over a wide temperature range from −50 to 50 °C. This study offers valuable insights into the rational design of electrolytes for high-energy aqueous batteries, specifically tailored for wide-temperature operation.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"11 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA-Capturing Manganese-Coordinated Chitosan Microparticles Potentiate Radiotherapy via Activating the cGAS-STING Pathway and Maintaining Tumor-Infiltrating CD8+ T-Cell Stemness DNA捕获锰配位壳聚糖微粒通过激活cGAS-STING通路和维持肿瘤浸润CD8+T细胞干性增强放疗效果

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-02-16 DOI: 10.1002/adma.202418583

Shuai Zhang, Chunjie Wang, Yujie Zhu, Juxin Gao, Yifan Yan, Minming Chen, Xiaoying Yan, Zhuang Liu, Liangzhu Feng

{"title":"DNA-Capturing Manganese-Coordinated Chitosan Microparticles Potentiate Radiotherapy via Activating the cGAS-STING Pathway and Maintaining Tumor-Infiltrating CD8+ T-Cell Stemness","authors":"Shuai Zhang, Chunjie Wang, Yujie Zhu, Juxin Gao, Yifan Yan, Minming Chen, Xiaoying Yan, Zhuang Liu, Liangzhu Feng","doi":"10.1002/adma.202418583","DOIUrl":"https://doi.org/10.1002/adma.202418583","url":null,"abstract":"The radiotherapy-induced release of DNA fragments can stimulate the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) pathway to prime antitumor immunity, but this pathway is expected to be less potent because of the inefficient cytosolic delivery of negatively charged DNA fragments. In this study, manganese-coordinated chitosan (CS-Mn) microparticles with selective DNA-capturing capacity are concisely prepared via a coordination-directed one-pot synthesis process to potentiate the immunogenicity of radiotherapy. The obtained CS-Mn microparticles that undergo rapid disassembly under physiological conditions can selectively bind with DNA to form positively charged DNA-CS assemblies because of the strong electrostatic interaction between linear chitosan and DNA molecules. They thus enable efficient cytosolic delivery of DNA in the presence of serum to cooperate with Mn2+ to activate the cGAS-STING pathway in dendritic cells. Upon intratumoral injection, the CS-Mn microparticles markedly enhance the efficacy of radiotherapy against both irradiated and distal tumors in different tumor models via collectively promoting tumor-infiltrating CD8+ T-cell stemness and the activation of innate immunity. The radiosensitization effect of CS-Mn microparticles can be further augmented by concurrently applying anti-programmed cell death protein 1 (anti-PD-1) immunotherapy. This work highlights an ingenious strategy to prepare Trojan horse-like DNA-capturing microparticles as cGAS-STING-activating radiosensitizers for effective radioimmunotherapy.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"48 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perturbing Organelle-Level K+/Ca2+ Homeostasis by Nanotherapeutics for Enhancing Ion-Mediated Cancer Immunotherapy 用纳米疗法扰乱细胞器水平的 K+/Ca2+ 平衡以增强离子介导的癌症免疫疗法

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-02-16 DOI: 10.1002/adma.202416574

Jun-Long Liang, Qian-Xiao Huang, Qi-Wen Chen, Xiao-Kang Jin, Zi-Yi Han, Ping Ji, Si-Xue Cheng, Wei-Hai Chen, Xian-Zheng Zhang

{"title":"Perturbing Organelle-Level K+/Ca2+ Homeostasis by Nanotherapeutics for Enhancing Ion-Mediated Cancer Immunotherapy","authors":"Jun-Long Liang, Qian-Xiao Huang, Qi-Wen Chen, Xiao-Kang Jin, Zi-Yi Han, Ping Ji, Si-Xue Cheng, Wei-Hai Chen, Xian-Zheng Zhang","doi":"10.1002/adma.202416574","DOIUrl":"https://doi.org/10.1002/adma.202416574","url":null,"abstract":"Intracellular ions are involved in numerous pivotal immune processes, but the precise regulation of these signaling ions to achieve innovative immune therapeutic strategies is still a huge challenge. Here, an ion-mediated immunotherapy agent (IMIA) is engineered to achieve precise spatiotemporal control of perturbing K+/Ca2+ homeostasis at the organelle-level, thereby amplifying antitumor immune responses to achieve high-performance cancer therapy. By taking in intracellular K+ and supplying exogenous Ca2+ within tumor cells, K+/Ca2+ homeostasis is perturbed by IMIA. In parallel, perturbing K+ homeostasis induced endoplasmic reticulum (ER) stress triggers the release of Ca2+ from ER and causes a decreased concentration of Ca2+ in ER, which further accelerates ER-mitochondria Ca2+ flux and the influx of extracellular Ca2+ (store-operated Ca2+ entry (SOCE)) via opening Ca2+ release-activated Ca2+ (CRAC) channels, thus creating a self-amplifying ion interference loop to perturb K+/Ca2+ homeostasis. In this process, the elevated immunogenicity of tumor cells would evoke robust antitumor immune responses by driving the excretion of damage-associated molecular patterns (DAMPs). Importantly, this ion-immunotherapy strategy reshapes the immunosuppressive tumor microenvironment (TME), and awakens the systemic immune response and long-term immune memory effect, thus effectively inhibiting the growth of primary/distant tumors, orthotopic tumors as well as metastatic tumors in different mice models.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"63 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultra-Fast Gallium Oxide Solar-Blind Photodetector with Novel Thermal Pulse Treatment 采用新型热脉冲处理技术的超快氧化镓太阳盲光电探测器

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-02-16 DOI: 10.1002/adma.202414130

Lili Luo, Hong Huang, Lu Yang, Rui Hao, Xiaoliang Hu, Yingtao Li, Xiaolong Zhao, Zemin Zhang, Shibing Long

{"title":"Ultra-Fast Gallium Oxide Solar-Blind Photodetector with Novel Thermal Pulse Treatment","authors":"Lili Luo, Hong Huang, Lu Yang, Rui Hao, Xiaoliang Hu, Yingtao Li, Xiaolong Zhao, Zemin Zhang, Shibing Long","doi":"10.1002/adma.202414130","DOIUrl":"https://doi.org/10.1002/adma.202414130","url":null,"abstract":"Gallium oxide (Ga2O3) emerges as a promising solar-blind photodetector (SBPD) material if the “Response Speed (RS) dilemma” can be resolved. Devices with spatially segregated carrier generation and transport channels offer a potential solution but remain less available. This work introduces a novel thermal pulse treatment (TPT) method to achieve a vertically stratified crystalline structure and oxygen vacancies (VO) throughout the Ga2O3 film, validated through extensive characterizations. Technology Computer-Aided Design (TCAD) simulations corroborated the critical role of VO stratification in enhancing the responsivity (Rλ) and response speed simultaneously. Consequently, the TPT-processed SBPD exhibited exceptional performance, boasting a maximum Rλ of 312.6 A W−1 and a faster decay time of 40 µs, respectively. Moreover, the corresponding SBPD chips show significant potential for applications in solar-blind imaging, light trajectory tracking, and solar-blind power meters. This work thus provides a viable strategy to address the “RS dilemma” common in most wide-bandgap materials, showcasing excellent application value.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"11 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-Inspired, Miniaturized Magnetic Heart Valve System for Superior Performance Cardiovascular Simulator

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-02-16 DOI: 10.1002/adma.202419504

Jeongmin Yoo, Gooyoon Chung, Yoonseok Park

{"title":"Bio-Inspired, Miniaturized Magnetic Heart Valve System for Superior Performance Cardiovascular Simulator","authors":"Jeongmin Yoo, Gooyoon Chung, Yoonseok Park","doi":"10.1002/adma.202419504","DOIUrl":"https://doi.org/10.1002/adma.202419504","url":null,"abstract":"The demand for accurate vascular simulators is increasing to facilitate effective clinical studies on cardiovascular diseases. The research presents the miniaturized design and precise programable regulation of an artificial magnetic heart valve inspired by the human aortic valve, demonstrating the diverse types of pulsating waves. The heart valve is constructed using an elastomeric silicone composite embedded with neodymium magnetic micro-particles. This valve system responds rapidly to changes in magnetic fields controlled by miniaturized electromagnets, enabling precise regulation of fluid pressure and flow rate. This allows for the generation of various pressure waveforms and accurately replicates diverse blood pressure changes with a compact design. The design, working mechanism, fabrication process, and optimization of the magnetically controlled biomimetic heart valve are discussed and its performance as a cardiovascular simulator for human and animal models is evaluated. This artificial valve system has the potential to be utilized in humanoid robots to generate heart-like pressure, thereby paving the way for replicating human physiological characteristics. This research promises significant advancements in cardiovascular clinical trials and biomedical research along with the development of humanoid robots and biomimetic mechanical systems.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"15 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leaf Vein-Inspired Programmable Superstructure Liquid Metal Photothermal Actuator for Soft Robots 用于软机器人的叶脉启发式可编程超结构液态金属光热致动器

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-02-16 DOI: 10.1002/adma.202416991

Xiaofei Li, Yiming Du, Xiaoshuan Pan, Chao Xiao, Xin Ding, Kang Zheng, Xianglan Liu, Lin Chen, Yi Gong, Meng Xue, Xingyou Tian, Xian Zhang

{"title":"Leaf Vein-Inspired Programmable Superstructure Liquid Metal Photothermal Actuator for Soft Robots","authors":"Xiaofei Li, Yiming Du, Xiaoshuan Pan, Chao Xiao, Xin Ding, Kang Zheng, Xianglan Liu, Lin Chen, Yi Gong, Meng Xue, Xingyou Tian, Xian Zhang","doi":"10.1002/adma.202416991","DOIUrl":"https://doi.org/10.1002/adma.202416991","url":null,"abstract":"Asymmetric-expansion photothermal actuators have attracted the attention of researchers owing to their simple structure, superior stability, rapid response, and precise controllability. However, their response speed, deformation capacity, and load-carrying capacity are mutually constrained by their thickness. Inspired by the veins and pulp in plant leaves, this study uses laser etching to apply a superstructure of ordered grooves to liquid metal (LM) photothermal actuators. The resulting LM@low-expansion polyimide (4.52 ppm K−1)/polydimethylsiloxane (LM@PI/PDMS) programmable photothermal actuators demonstrate exceptional performance, including a load-carrying capacity of 190 times their weight, a rapid oscillation frequency of 19 Hz, a response speed of 60.96 ± 3.08°/ s, and a bending angle of 159.05 ± 2.52°. Hence, the proposed design resolves the inherent conflict between the load-carrying capacity and response speed. Furthermore, incorporating LM microspheres into actuators increases their stability and allows them to endure more than 20 800 cycles without damage. The actuators are used to create versatile smart devices and robots, such as photothermally actuated robotic dogs that can function across various terrains. This study provides a novel strategy for the design and fabrication of programmable photothermal actuators and highlights their potential for applications in advanced robotics, which paves the way for their integration into complex environments.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"114 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glassy Thermal Transport Triggers Ultra-High Thermoelectric Performance in GeTe 玻璃热传输引发 GeTe 的超高热电性能

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-02-16 DOI: 10.1002/adma.202417561

Debattam Sarkar, Subarna Das, Vaishali Taneja, Manisha Samanta, Koushik Jagadish, Animesh Das, Monika Bhakar, Prasad V. D. Matukumilli, Suresh Perumal, Goutam Sheet, Dirtha Sanyal, Koushik Pal, N. Ravishankar, Umesh V. Waghmare, Kanishka Biswas

{"title":"Glassy Thermal Transport Triggers Ultra-High Thermoelectric Performance in GeTe","authors":"Debattam Sarkar, Subarna Das, Vaishali Taneja, Manisha Samanta, Koushik Jagadish, Animesh Das, Monika Bhakar, Prasad V. D. Matukumilli, Suresh Perumal, Goutam Sheet, Dirtha Sanyal, Koushik Pal, N. Ravishankar, Umesh V. Waghmare, Kanishka Biswas","doi":"10.1002/adma.202417561","DOIUrl":"https://doi.org/10.1002/adma.202417561","url":null,"abstract":"The consequences of broken long-range atomic arrangement in glasses or amorphous solids are reflected in the temperature dependence of lattice thermal conductivity (κlat). However, the appearance of glassy ultralow κlat in a crystalline solid with high electrical transport like metal is unusual but can have a remarkable impact on the thermoelectric performance of a material. Here, an ultra-high thermoelectric performance is demonstrated with a maximum figure of merit, zT ≈ 2.7 (≈2.92 with Dulong–Petit heat capacity) via achieving glassy thermal transport along with significant electrical conductivity in ball milled BiSe, Pb co-doped polycrystalline Ge1.03Te followed by spark plasma sintering. The glassy thermal transport results from the inhomogeneous ferroelectric instability developed due to local polar distortions near the dopant sites, which interacts with soft polar optical modes via strain fluctuations. Resulting structural degeneracy and associated soft vibrations sink heat effectively from acoustic phonons, which along with various nanoscale defects, confine the phonon mean free path (MFP) close to the interatomic distance, rendering the thermal transport glassy. However, the material still maintains a high electrical conductivity at ambient condition due to much longer MFP of the charge carriers. A promising output power density of ≈0.8 W cm−2 for ΔT ≈441 K in double-leg thermoelectric device demonstrate the potential of this material for mid-temperature thermoelectric applications.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"11 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A PD-L1 siRNA-Loaded Boron Nanoparticle for Targeted Cancer Radiotherapy and Immunotherapy 用于癌症放射治疗和免疫治疗的 PD-L1 siRNA 负载硼纳米粒子

IF 29.4 1区材料科学

Advanced Materials Pub Date : 2025-02-16 DOI: 10.1002/adma.202419418

Shaohui Deng, Lijun Hu, Guo Chen, Jujian Ye, Zecong Xiao, Tianwang Guan, Shuai Guo, Wei Xia, Du Cheng, Xiaochun Wan, Ke Cheng, Caiwen Ou

{"title":"A PD-L1 siRNA-Loaded Boron Nanoparticle for Targeted Cancer Radiotherapy and Immunotherapy","authors":"Shaohui Deng, Lijun Hu, Guo Chen, Jujian Ye, Zecong Xiao, Tianwang Guan, Shuai Guo, Wei Xia, Du Cheng, Xiaochun Wan, Ke Cheng, Caiwen Ou","doi":"10.1002/adma.202419418","DOIUrl":"https://doi.org/10.1002/adma.202419418","url":null,"abstract":"Although the combination of radiotherapy and immunotherapy is regarded as a promising clinical treatment strategy, numerous clinical trials have failed to demonstrate synergistic effects. One of the key reasons is that conventional radiotherapies inevitably damage intratumoral effector immune cells. Boron Neutron Capture Therapy (BNCT) is a precise radiotherapy that selectively kills tumor cells while sparing adjacent normal cells, by utilizing 10B agents and neutron irradiation. Therefore, combinational BNCT-immunotherapy holds promise for achieving more effective synergistic effects. Here it develops a 10B-containing polymer that self-assembled with PD-L1 siRNA to form 10B/siPD-L1 nanoparticles for combinational BNCT-immunotherapy. Unlike antibodies, PD-L1 siRNA can inhibit intracellular PD-L1 upregulated by BNCT, activating T-cell immunity while also suppressing DNA repair. This can enhance BNCT-induced DNA damage, promoting immunogenic cell death (ICD) and further amplifying the antitumor immune effect. The results demonstrated that BNCT using 10B/siPD-L1 nanoparticles precisely killed tumor cells while sparing adjacent T cells and induced a potent antitumor immune response, inhibiting distal and metastatic tumors.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"85 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0