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Weak Near-Infrared Light Visualization Enabled by Smart Multifunctional Optoelectronics
IF 29.4 1区 材料科学
Advanced Materials Pub Date : 2025-02-09 DOI: 10.1002/adma.202416785
Pengqing Bi, Jianqiu Wang, Zhihao Chen, Zelong Li, Cheng Tan, Jiawei Qiao, Jiangbo Dai, Tao Zhang, Jiajia Gao, Wei Peng Goh, Chengkun Lyu, Changyun Jiang, Xiaotao Hao, Jianhui Hou, Le Yang
{"title":"Weak Near-Infrared Light Visualization Enabled by Smart Multifunctional Optoelectronics","authors":"Pengqing Bi, Jianqiu Wang, Zhihao Chen, Zelong Li, Cheng Tan, Jiawei Qiao, Jiangbo Dai, Tao Zhang, Jiajia Gao, Wei Peng Goh, Chengkun Lyu, Changyun Jiang, Xiaotao Hao, Jianhui Hou, Le Yang","doi":"10.1002/adma.202416785","DOIUrl":"https://doi.org/10.1002/adma.202416785","url":null,"abstract":"Visualizing weak NIR light is critical for sensing, imaging, and communication, but remains challenging due to inefficient detection and upconversion (UC) mechanisms. A smart NIR-to-visible photon-UC organic optoelectronic device is reported that integrates photodetection, light-emitting diode (LED), and photovoltaic capabilities to enable clear visualization of weak NIR light. The programmable device has continuous photodetection monitoring of the incident NIR intensity. When the incident intensity falls below a preset threshold, the LED function is automatically triggered to compensate for the UC emission, amplifying the visualization. The smart multifunctional device uses a carefully designed ternary bulk heterojunction sensitizer doped with rubrene:DBP as the emitter. It demonstrates high UC efficiency (&gt;1.5%) for upconversion from 808 to 608 nm, allowing NIR visualization without external power under strong illumination. It also shows excellent NIR photodetection with photoresponsivity of 0.35 A W<sup>−1</sup> at 800 nm and specific detectivity reaching 10¹<sup>2</sup>–10¹<sup>3</sup> Jones, enabling sensitive detection under low-light conditions. It also exhibits a low turn-on voltage (0.9 V) and luminance exceeding 1200 cd m<sup>−</sup><sup>2</sup> at 5 V, ensuring energy-efficient light compensation. Furthermore, it achieves &gt;10% power conversion efficiency, enabling sustainable self-powered operation. This multifunctional, high-performance system offers great potential in sensing, energy harvesting, and display technologies.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"132 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photoinduced Cleavage of Respiratory Syncytial Virus by Chiral Vanadium Trioxide Nanoparticles
IF 29.4 1区 材料科学
Advanced Materials Pub Date : 2025-02-09 DOI: 10.1002/adma.202420563
Baimei Shi, Xinxin Xu, Maozhong Sun, Yingcai Xiong, Jianjian Ji, Aihua Qu, Hua Kuang
{"title":"Photoinduced Cleavage of Respiratory Syncytial Virus by Chiral Vanadium Trioxide Nanoparticles","authors":"Baimei Shi, Xinxin Xu, Maozhong Sun, Yingcai Xiong, Jianjian Ji, Aihua Qu, Hua Kuang","doi":"10.1002/adma.202420563","DOIUrl":"https://doi.org/10.1002/adma.202420563","url":null,"abstract":"Respiratory syncytial virus (RSV) poses a significant threat to the health of infants, children, and the elderly, and as of now there is a lack of effective therapeutic drugs. To tackle this challenge, chiral vanadium trioxide nanoparticles (V<sub>2</sub>O<sub>3</sub> NPs) with a particle size of 2.56 ± 0.34 nm are successfully synthesized, exhibiting a <i>g</i>-factor value of 0.048 at 874 nm in terms of circular dichroism. Under 808 nm light irradiation, these chiral V<sub>2</sub>O<sub>3</sub> NPs demonstrated selective cleavage of the RSV pre-fusion protein (RSV protein), effectively blocking its conformational rearrangement and preventing RSV infection both in vitro and in vivo. Experimental analysis revealed that the chiral V<sub>2</sub>O<sub>3</sub> NPs specifically bind to the functional domain spanning from aspartate<sub>200</sub> (D<sub>200</sub>) to asparagine<sub>208</sub> (N<sub>208</sub>) in the primary sequence of the RSV protein. Notably, <i>L</i>-V<sub>2</sub>O<sub>3</sub> NPs exhibited a higher affinity, which is 4.06 times that of <i>D</i>-V<sub>2</sub>O<sub>3</sub> NPs and 13.55 times that of <i>DL</i>-V<sub>2</sub>O<sub>3</sub> NPs. The precise cutting site is located between amino acid residues leucine<sub>204</sub> (L<sub>204</sub>) and proline<sub>205</sub> (P<sub>205</sub>), attributed to the reactive oxygen species (ROS) generated by photoinduced nanoparticles. In addition, <i>L</i>-V<sub>2</sub>O<sub>3</sub> NPs inhibited RSV infection by 99.6% in nasal epithelial cells and 99.2% in Vero cells. In the RSV-infected mouse model, intranasal administration of <i>L</i>-V₂O₃ NPs effectively controlled the viral load in the lungs of mice, reducing it by 92.43%. The hematoxylin and eosin staining of mouse organs and serum biochemical indicators are similar to those of the wild-type group, indicating the biosafety of <i>L</i>-V₂O₃ NPs. The findings suggest that chiral nanoparticles hold great potential in controlling RSV and provide new directions and ideas for drug development against viruses.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"9 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anisotropic Electrical Transport in Mechanically Responsive Silver-Coated Microparticle-Gel Composites for Flowable Semiconducting Materials
IF 29.4 1区 材料科学
Advanced Materials Pub Date : 2025-02-09 DOI: 10.1002/adma.202415066
Matthew D. Brucks, Alina Arslanova, Nicholas F. Byrne, Janan Hui, Heather E. Kurtz, Mark C. Hersam, Jeffrey J. Richards
{"title":"Anisotropic Electrical Transport in Mechanically Responsive Silver-Coated Microparticle-Gel Composites for Flowable Semiconducting Materials","authors":"Matthew D. Brucks, Alina Arslanova, Nicholas F. Byrne, Janan Hui, Heather E. Kurtz, Mark C. Hersam, Jeffrey J. Richards","doi":"10.1002/adma.202415066","DOIUrl":"https://doi.org/10.1002/adma.202415066","url":null,"abstract":"Soft materials with reversible electrical and mechanical properties are critical for the development of advanced bioelectronics that can distinguish between different rates of applied strain and eliminate performance degradation over many cycles. However, the current paradigm in mechano-electronic devices involves measuring changes in electrical current based on the accumulation of strain within a conductive material that alters the geometry through which electrons flow. Attempts have been made to incorporate soft materials like liquid metals and concentrated solutions of conjugated polymers and salts to overcome materials degradation but are limited in their ability to detect changes in the rate of the applied strain. Herein, the anisotropic electrical performance of a soft semiconducting composite prepared with silver-coated microspheres dispersed within a swollen copolymer gel is demonstrated. This composite exhibits an electrical response proportional to the magnitude of the applied shear force to enable a rate-of-strain dependent conductivity. Furthermore, a 100-fold increase in the conductivity of the composite is observed when the electric field is oriented parallel to the flow direction. This improvement in the electrical response can be attributed to the enhanced alignment of microspheres in viscoelastic media and can be leveraged in the development of mechanically responsive electronic devices.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"62 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare-Earth Oxychlorides as Promoters of Ruthenium Toward High-Performance Hydrogen Evolution Electrocatalysts for Alkaline Electrolyzers
IF 29.4 1区 材料科学
Advanced Materials Pub Date : 2025-02-09 DOI: 10.1002/adma.202417621
Tongtong Liu, Yanan Chen, Xinyu Wang, Yajing Di, Klaus Müllen, Zhengping Zhang, Feng Wang
{"title":"Rare-Earth Oxychlorides as Promoters of Ruthenium Toward High-Performance Hydrogen Evolution Electrocatalysts for Alkaline Electrolyzers","authors":"Tongtong Liu, Yanan Chen, Xinyu Wang, Yajing Di, Klaus Müllen, Zhengping Zhang, Feng Wang","doi":"10.1002/adma.202417621","DOIUrl":"https://doi.org/10.1002/adma.202417621","url":null,"abstract":"Developing efficient electrocatalysts for hydrogen evolution reaction (HER) in alkaline environments is vital for hydrogen production, owing to the extra water dissociation and hydroxyl desorption steps. Here, rare-earth oxychlorides (REOCl) are proposed as innovative promoters for ruthenium as HER electrocatalyst in alkali. The lamellar structure of REOCl with weakly bond [Cl] layers can facilitate the formation of an internal electric field that enhances interphase charge transfer. Taking ruthenium/ neodymium oxychloride (Ru/NdOCl) composites as a case study, sub ≈4 nm Ru nanoparticles are successfully embedded into NdOCl crystals through a rapid self-exothermic process, and the highly-coupled Ru−Cl/O−Nd interfaces are observed as metallic Ru particles with the edge of the NdOCl lamellar layers, where the [Nd<sub>2</sub>O<sub>2</sub>] and [Cl] layers act as the negative and positive charge transfer channels, respectively. The enhanced charge transfer between REOCl and Ru makes the highly-coupled Ru/REOCl catalysts show better electrocatalytic activity than both the benchmark Pt and Ru catalysts in alkaline electrolyte. This work will encourage more novel promoters for electrocatalysis and other emerging technologies.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"55 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biopolymeric Gels: Advancements in Sustainable Multifunctional Materials
IF 29.4 1区 材料科学
Advanced Materials Pub Date : 2025-02-09 DOI: 10.1002/adma.202419906
Chuxin Lei, Qing Li, Wenshuai Chen, Guihua Yu
{"title":"Biopolymeric Gels: Advancements in Sustainable Multifunctional Materials","authors":"Chuxin Lei, Qing Li, Wenshuai Chen, Guihua Yu","doi":"10.1002/adma.202419906","DOIUrl":"https://doi.org/10.1002/adma.202419906","url":null,"abstract":"With the growing emphasis on building a global sustainable community, biopolymeric gels have emerged as a promising platform for environmentally friendly and sustainable applications, garnering significant research attention. Compared to conventional synthetic gels, biopolymeric gels offer numerous advantages, including abundant and renewable raw materials, energy-efficient and eco-friendly fabrication processes, tunable physicochemical properties, and superior biocompatibility and biodegradability. This review provides a comprehensive overview of recent advancements in multifunctional biopolymeric gels. It begins by introducing various biopolymeric building blocks and their intrinsic properties across multiple scales. Subsequently, the synthetic strategies for biopolymeric gels are thoroughly discussed, emphasizing versatile gelation strategies, multiple approaches for fabricating gels, diverse processing approaches to achieve tailorable gels with desired functionalities. The sustainable applications of biopolymeric gels are systematically explored, focusing on their roles in energy storage, environmental remediation of water management, thermal management, and bioelectronics. Finally, the review concludes with an outlook on the challenges and opportunities for advancing biopolymeric gels as key materials in the pursuit of sustainability.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"29 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modular Design of Lipopeptide-Based Organ-Specific Targeting (POST) Lipid Nanoparticles for Highly Efficient RNA Delivery
IF 29.4 1区 材料科学
Advanced Materials Pub Date : 2025-02-09 DOI: 10.1002/adma.202415643
Chuanmei Tang, Yexi Zhang, Bowen Li, Xiangwei Fan, Zixuan Wang, Rongxin Su, Wei Qi, Yuefei Wang
{"title":"Modular Design of Lipopeptide-Based Organ-Specific Targeting (POST) Lipid Nanoparticles for Highly Efficient RNA Delivery","authors":"Chuanmei Tang, Yexi Zhang, Bowen Li, Xiangwei Fan, Zixuan Wang, Rongxin Su, Wei Qi, Yuefei Wang","doi":"10.1002/adma.202415643","DOIUrl":"https://doi.org/10.1002/adma.202415643","url":null,"abstract":"Lipid nanoparticles (LNPs) with highly efficient and specific extrahepatic targeting abilities are promising in gene delivery, and the lipopeptides (LPs) with excellent designability and functionality are expected to empower the construction of functional LNPs. This study aims to develop highly efficient ionizable components that accurately match different targeting lipid systems through the modular design of LPs. Based on this, a lipopeptide-based organ-specific targeting (POST) LNP screening strategy is constructed, in which lysine-histidine-based lipopeptides (KH-LPs) are designed as highly efficient ionizable components. The optimal KH-LP LNP screened in vitro shows excellent siRNA/mRNA transfecting ability in various hard-to-transfect cell lines. Compared to the classic LNPs, the POST LNPs screened in vivo achieve even higher (or at least comparable) efficiency and specificity in delivering mRNA and siRNA to the lung, liver, and spleen, respectively. The structure-activity relationship (SAR) proves that the modular regulation of LP structures can accurately provide the optimal ionizable components for different targeting lipid systems, demonstrating the potential of this strategy in developing efficient and selective targeting systems, which is expected to open up more possibilities for gene therapy.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"64 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atomic Layer Deposition Stabilizes Nanocrystals, Enabling Reliably High-Performance Quantum Dot LEDs
IF 29.4 1区 材料科学
Advanced Materials Pub Date : 2025-02-09 DOI: 10.1002/adma.202418300
Haoyue Wan, Pan Xia, Euidae Jung, Muhammad Imran, Ruiqi Zhang, Yiqing Chen, Julian A. Steele, Sabah Gaznaghi, Yanjiang Liu, Ya-Kun Wang, Lianzhou Wang, Yu-Ho Won, Kwang-Hee Kim, Vladimir Bulović, Sjoerd Hoogland, Edward H. Sargent
{"title":"Atomic Layer Deposition Stabilizes Nanocrystals, Enabling Reliably High-Performance Quantum Dot LEDs","authors":"Haoyue Wan, Pan Xia, Euidae Jung, Muhammad Imran, Ruiqi Zhang, Yiqing Chen, Julian A. Steele, Sabah Gaznaghi, Yanjiang Liu, Ya-Kun Wang, Lianzhou Wang, Yu-Ho Won, Kwang-Hee Kim, Vladimir Bulović, Sjoerd Hoogland, Edward H. Sargent","doi":"10.1002/adma.202418300","DOIUrl":"https://doi.org/10.1002/adma.202418300","url":null,"abstract":"Quantum dot light-emitting diodes (QD-LEDs) with stable high efficiencies are crucial for next-generation displays. However, uncontrollable aging, where efficiency initially increases during storage (positive aging) but is entirely lost upon extended aging (negative aging), hinders further device development. It is uncovered that it is chemical changes to nanocrystal (NC)-based electron transport layer (ETL) that give rise to positive aging, their drift in structure and morphology leading to transiently improved charge injection balance. Using grazing-incidence small-angle X-ray scattering, it is found that ZnMgO NCs undergo size-focusing ripening during aging, improving size uniformity and creating a smoother energy landscape. Electron-only device measurements reveal a sevenfold reduction in trap states, indicating enhanced surface passivation of ZnMgO. These insights, combined with density functional theory calculations of ZnMgO surface binding, inspire an atomic layer deposition (ALD) strategy with Al₂O₃ to permanently suppress surface traps and inhibit NC growth, effectively eliminating aging-induced efficiency loss. This ALD-engineered ZnMgO ETL enables reproducible external quantum efficiencies (EQEs) of 17% across 30 batches of LEDs with a T<sub>60</sub> of 60 h at an initial luminance of 4500 cd m<sup>−2</sup>, representing a 1.6-fold increase in EQE and a tenfold improvement in operating stability compared to control devices.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"60 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing Amino Acid Modularity for Programmable Function in Covalent Peptide Assemblies
IF 29.4 1区 材料科学
Advanced Materials Pub Date : 2025-02-09 DOI: 10.1002/adma.202419941
Yun-Mi Hur, Kyoung-Ik Min
{"title":"Harnessing Amino Acid Modularity for Programmable Function in Covalent Peptide Assemblies","authors":"Yun-Mi Hur, Kyoung-Ik Min","doi":"10.1002/adma.202419941","DOIUrl":"https://doi.org/10.1002/adma.202419941","url":null,"abstract":"Covalent peptide assembly leverages robust covalent bonds and dynamic non-covalent interactions to provide enhanced stability and introduce diverse functionalities. Nevertheless, it remains significantly challenging to achieve modular control over the structural diversity and functional complexity while elucidating how specific amino acid sequences contribute to these processes. Here, the systematic encoding of peptide derivative characteristics is demonstrated through amino acid modularity to enable precise control over both the structural diversity and functional complexity in covalent peptide assemblies. By systematically screening single amino acid substitutions in pentapeptides using tyrosine crosslinking, a diverse library of peptide constructs is developed. Each construct is tailored to exhibit distinct properties, including charge repulsion, aggregation-induced quenching, disassembly behavior, and redox responsiveness. The strategic manipulation of sequence composition, both in individual assemblies and combinatorial systems, enables programmable control over the structural diversity and functional complexity. This approach yields various module-specific functions, including frustrated growth, hierarchical hollow architecture formation, affinity enrichment, stimuli-responsive behavior, and fluorescence signal amplification. This work establishes a framework for the design of modular peptide materials with programmable functionalities, advancing the development of next-generation multicomponent peptide assembly technologies characterized by unprecedented complexity and adaptability.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"29 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rolling Light-Driven Pneumatic Soft Actuator Based on Liquid–Gas Phase Change
IF 29.4 1区 材料科学
Advanced Materials Pub Date : 2025-02-09 DOI: 10.1002/adma.202418218
Wenfei Ai, Jiaxin Wu, Yue Long, Kai Song
{"title":"A Rolling Light-Driven Pneumatic Soft Actuator Based on Liquid–Gas Phase Change","authors":"Wenfei Ai, Jiaxin Wu, Yue Long, Kai Song","doi":"10.1002/adma.202418218","DOIUrl":"https://doi.org/10.1002/adma.202418218","url":null,"abstract":"Light-driven wireless actuators provide obvious advantages for remote control. However, traditional double-layer actuators are restricted to the thin film deformation mode when undertaking complex tasks. Here, an actuator is proposed that employs thermal strain and local photothermal effects induced by low boiling point liquids to generate asymmetry along the fiber axis, thereby causing elastic deformation of the fiber. Under continuous irradiation, the sustained elastic deformation results in dynamic frustration within the fiber, creating torque around its axis. Based on this principle, the fiber actuator fabricated in this study enables rolling translation, while the ring actuator achieves simultaneous rolling and lifting motion for object manipulation. Continuous rolling under light eliminates the need for complex light manipulation. This new movement method offers an insight for various application scenarios.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"62 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A DNA Nanopatch-Bacteriophage System Targeting Streptococcus Gallolyticus for Inflammatory Bowel Disease Treatment and Colorectal Cancer Prevention
IF 29.4 1区 材料科学
Advanced Materials Pub Date : 2025-02-09 DOI: 10.1002/adma.202417334
Yadan Zhao, Mengna Zhu, Yufan ling, Yingying Zhao, Xing Lu, Binbin Chu, Yao He, Houyu Wang
{"title":"A DNA Nanopatch-Bacteriophage System Targeting Streptococcus Gallolyticus for Inflammatory Bowel Disease Treatment and Colorectal Cancer Prevention","authors":"Yadan Zhao, Mengna Zhu, Yufan ling, Yingying Zhao, Xing Lu, Binbin Chu, Yao He, Houyu Wang","doi":"10.1002/adma.202417334","DOIUrl":"https://doi.org/10.1002/adma.202417334","url":null,"abstract":"Persistent inflammation in inflammatory bowel disease (IBD) increases <i>Streptococcus gallolyticus</i> (<i>Sg</i>) colonization, increasing the risk of colorectal cancer progression via the <i>Sg</i>-activated cyclooxygenase-2 (COX-2) pathway and β-catenin upregulation. This study presents <i>Sg</i>-specific bacteriophages modified with DNA nanopatches (DNPs@P) designed to treat IBD and prevent <i>Sg</i>-induced malignancy. The DNPs are composed of DNA origami nanosheets and phage capture strands. The DNPs scavenge reactive oxygen species, enhancing the therapeutic efficacy of the phages while targeting and lysing pathogenic bacteria. Coating with an enteric polymer, DNPs@P ensures effective delivery in the gastrointestinal tract. These findings demonstrate significant restoration of colonic length, reduced inflammation, and improved gut microbiota diversity compared with current clinical treatments. Additionally, DNPs@P effectively prevents colonic tumourigenesis in mouse models. This approach presents a promising strategy for treating gastrointestinal diseases by remodeling the gut microenvironment, addressing a critical gap in current therapies.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"13 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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