{"title":"Piezoelectric-Augmented Thermoelectric Ionogels for Self-Powered Multimodal Medical Sensors (Adv. Mater. 6/2025)","authors":"Ya-Hsin Pai, Chen Xu, Renyang Zhu, Xinyi Ding, Shengqiang Bai, Ziqi Liang, Lidong Chen","doi":"10.1002/adma.202570043","DOIUrl":"https://doi.org/10.1002/adma.202570043","url":null,"abstract":"<p><b>Multimodal Sensing Ionogels</b></p><p>In article number 2414663, Chen Xu, Shengqiang Bai, Ziqi Liang, and coworkers demonstrat the multimodal sensing capabilities of a paradigm ionogel, [EMIM][TFSI]/PVDF–HFP. Under applied temperature and pressure fields, the iongel exhibits piezoelectric (PE) augmented ionic thermoelectric (iTE) properties, where ion transport is modulated by a PE-induced internal field. Such dual-stimuli sensitivity, coupled with iTE-based humidity responsiveness, holds great potential for clinical applications. It can effectively monitor vital signs such as blood pressure, cardiac function, and blood loss from wounds.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"37 6","pages":""},"PeriodicalIF":27.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adma.202570043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bing Wu, Haolan Yang, Longbin Li, Xiannong Tang, Yonggan Wu, Bingyu Huang, Dirk Lützenkirchen‐Hecht, Ming Qiu, Kai Yuan, Yiwang Chen
{"title":"Integrating PtCo Intermetallic with Highly Graphitized Carbon Toward Durable Oxygen Electroreduction in Proton Exchange Membrane Fuel Cells","authors":"Bing Wu, Haolan Yang, Longbin Li, Xiannong Tang, Yonggan Wu, Bingyu Huang, Dirk Lützenkirchen‐Hecht, Ming Qiu, Kai Yuan, Yiwang Chen","doi":"10.1002/adma.202500096","DOIUrl":"https://doi.org/10.1002/adma.202500096","url":null,"abstract":"Exploiting robust and high‐efficiency electrocatalysts for sluggish oxygen reduction reaction (ORR) is essential for proton exchange membrane fuel cells (PEMFCs) toward long‐term operation for practical applications, yet remains challenging. Herein, the ordered PtCo intermetallic is reported with a Pt‐rich shell loaded on a highly graphitized carbon carrier (O‐PtCo@GCoNC) prepared by an impregnation annealing strategy. Systematic X‐ray spectroscopic, operando electrochemical techniques and theoretical calculations reveal that thanks to the synergistic interaction of the core–shell PtCo intermetallic structure with a tailor‐made Pt electronic configuration and highly graphitized carbon, O‐PtCo@GCoNC exhibits significantly enhanced activity and stability toward ORR. Crucially, O‐PtCo@GCoNC delivers a much‐enhanced mass activity of 0.83 A mg<jats:sub>Pt</jats:sub><jats:sup>−1</jats:sup> at 0.9 V versus reversible hydrogen electrode (RHE) in 0.1 <jats:sc>m</jats:sc> HClO<jats:sub>4</jats:sub>, which only drops by 26.5% after 70 000 cycles (0.6–1.0 V vs RHE), and 10.8% after 10 000 cycles (1.0–1.5 V vs RHE), apparently overmatching Pt/C (0.19 A mg<jats:sub>Pt</jats:sub><jats:sup>−1</jats:sup>, 73.7%, and 63.1%). Moreover, O‐PtCo@GCoNC employed as the cathode catalyst in H<jats:sub>2</jats:sub>/air PEMFC achieves a superb peak power density (1.04 W cm<jats:sup>−2</jats:sup> at 2.06 A cm<jats:sup>−2</jats:sup>), outperforming that of Pt/C (0.86 W cm<jats:sup>−2</jats:sup> at 1.79 A cm<jats:sup>−2</jats:sup>). The cell voltage loss at 0.8 A cm<jats:sup>−2</jats:sup> is 28 mV after 30 000 cycles, outstripping the United States Department of Energy 2025 target.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"6 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kiup Kim, Youngsun Lee, Kwang Bo Jung, Yoojeong Kim, Eunyoung Jang, Mi-Ok Lee, Mi-Young Son, Hyunjoo J. Lee
{"title":"Highly Stretchable 3D Microelectrode Array for Noninvasive Functional Evaluation of Cardiac Spheroids and Midbrain Organoids (Adv. Mater. 6/2025)","authors":"Kiup Kim, Youngsun Lee, Kwang Bo Jung, Yoojeong Kim, Eunyoung Jang, Mi-Ok Lee, Mi-Young Son, Hyunjoo J. Lee","doi":"10.1002/adma.202570046","DOIUrl":"10.1002/adma.202570046","url":null,"abstract":"<p><b>Stretchable Microelectrode Array</b></p><p>In article number 2412953, Kiup Kim and co-workers introduce a highly stretchable 3D MEA with PEDOT:PSS protruding microelectrodes structurally designed to ensure a reliable and stable interface with organoids even under buoyant forces in media. This design achieves high SNR electrophysiological signals, enabling precise and non-invasive functional assessments of organoids. The system demonstrates significant potential for drug screening and disease modeling.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"37 6","pages":""},"PeriodicalIF":27.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adma.202570046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High-Throughput Single-Cell Analysis of Local Nascent Protein Deposition in 3D Microenvironments via Extracellular Protein Identification Cytometry (EPIC) (Adv. Mater. 6/2025)","authors":"Marieke Meteling, Castro Johnbosco, Alexis Wolfel, Francisco Conceição, Kannan Govindaraj, Liliana Moreira Teixeira, Jeroen Leijten","doi":"10.1002/adma.202570044","DOIUrl":"10.1002/adma.202570044","url":null,"abstract":"<p><b>Extracellular Protein Identification Cytometry</b></p><p>Knowledge of the extracellular matrix drives our understanding of cell behavior. However, current analysis methods are limited to either bulk or low-throughput single-cell analysis, thus masking the heterogeneity in matrix deposition. Extracellular protein identification cytometry (EPIC) combines the high-throughput single-cell analysis of flow cytometry with engineered microniche 3D cell culture, jointly enabling in situ matrix analysis of large cell populations. More details can be found in article number 2415981 by Jeroen Leijten and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"37 6","pages":""},"PeriodicalIF":27.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adma.202570044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tunable Electron Correlation in Epitaxial 1T-TaS2 Spirals (Adv. Mater. 6/2025)","authors":"Chung-Jen Chen, Chun-An Chen, Yu-Hsiang Cheng, Chia-Tzu Chung, Yu-Ting Lin, Yi-Cheng Chiang, Ting-Kuo Lee, Yi-Hsien Lee","doi":"10.1002/adma.202570047","DOIUrl":"10.1002/adma.202570047","url":null,"abstract":"<p><b>Epitaxial 1T-TaS<sub>2</sub> Spirals</b></p><p>In article number 2413926, Yi-Hsien Lee and his colleagues demonstrate scalable synthesis of epitaxial TaS<sub>2</sub> spirals. An intertwined charge density wave (CDW)-Mott appears with a commensurate CDW phase at room temperature. Modulated interlayer spacing effectively manipulates interlayer interactions, which opens a new avenue toward tunable collective properties in spiral 2D lattices.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"37 6","pages":""},"PeriodicalIF":27.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adma.202570047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liane IF Moura, Alessio Malfanti, Ana I Matos, Carina Peres, Ana Armiñán, Aroa Duro‐Castaño, Inmaculada Conejos‐Sánchez, María Medel, Snežana Đorđević, Paula Carrascosa, Bárbara Carreira, Rita C Acúrcio, Helena Xavier‐Ferreira, Alberto Hernández‐Barranco, Elena Castellano, Esther Roselló, José C. Machado, Héctor Peinado, María J. Vicent, Helena F. Florindo
{"title":"Off‐The‐Shelf Multivalent Nanoconjugate Cancer Vaccine Rescues Host Immune Response against Melanoma","authors":"Liane IF Moura, Alessio Malfanti, Ana I Matos, Carina Peres, Ana Armiñán, Aroa Duro‐Castaño, Inmaculada Conejos‐Sánchez, María Medel, Snežana Đorđević, Paula Carrascosa, Bárbara Carreira, Rita C Acúrcio, Helena Xavier‐Ferreira, Alberto Hernández‐Barranco, Elena Castellano, Esther Roselló, José C. Machado, Héctor Peinado, María J. Vicent, Helena F. Florindo","doi":"10.1002/adma.202417348","DOIUrl":"https://doi.org/10.1002/adma.202417348","url":null,"abstract":"Tumor‐associated antigen‐based cancer vaccines suffer from limited clinical success compared to alternative immunotherapies in melanoma, an aggressive skin cancer with an immunosuppressive tumor microenvironment. The anti‐tumor potential of a multivalent nanoconjugate cancer vaccine platform – a cross‐linked star‐shaped polyglutamate carrier (StCl) with marked lymphotropic character conjugated with melanoma‐associated peptide antigens is evaluated through redox‐responsive linkers. The co‐delivery of melanoma‐associated peptide antigens by the nanoconjugate platform induced significant effector immune responses in a mouse melanoma model. The nanoconjugate platform synergized with a PD‐1 inhibitor to revert the immunosuppressive melanoma tumor microenvironment by improving cytotoxic T‐cell infiltration, which prompted a superior anti‐tumor effect with prolonged overall survival without acute organ toxicity. The antigen‐specific anti‐tumor immune response induced by the nanoconjugate platform is also validated in a melanoma patient‐derived xenograft mouse model. A promising, versatile StCl‐based platform is reported for generating off‐the‐shelf multivalent nanoconjugate cancer vaccines for the safe and efficient immunotherapeutic treatment of melanoma.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"103 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Min Ge, Wanbo Zhu, Jiawei Mei, Tingting Hu, Chuang Yang, Han Lin, Jianlin Shi
{"title":"Piezoelectric-Enhanced Nanocatalysts Trigger Neutrophil N1 Polarization against Bacterial Biofilm by Disrupting Redox Homeostasis (Adv. Mater. 6/2025)","authors":"Min Ge, Wanbo Zhu, Jiawei Mei, Tingting Hu, Chuang Yang, Han Lin, Jianlin Shi","doi":"10.1002/adma.202570050","DOIUrl":"10.1002/adma.202570050","url":null,"abstract":"<p><b>Biofilm Eradication</b></p><p>In article number 2409633, Min Ge, Chuang Yang, Han Lin, Jianlin Shi, and co-workers developed a physical and chemical barrier breakthrough strategy for biofilms via redox homeostasis manipulation. The nanosystem can enhance the attack of ROS via exogenous stimulation while providing interference with endogenous H<sub>2</sub>S synthase to reduce the resistance of reducing species, which together lead to severe structural damage in biofilms. In addition, oxidative stress mediates N1 polarization of neutrophils, leading to immunobactericidal effects.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"37 6","pages":""},"PeriodicalIF":27.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adma.202570050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nebojša Ilić, Kui Tan, Felix Mayr, Shujin Hou, Benedikt M. Aumeier, Eder Moisés Cedeño Morales, Uwe Hübner, Jennifer Cookman, Andreas Schneemann, Alessio Gagliardi, Jörg E. Drewes, Roland A. Fischer, Soumya Mukherjee
{"title":"Trace Adsorptive Removal of PFAS from Water by Optimizing the UiO-66 MOF Interface (Adv. Mater. 6/2025)","authors":"Nebojša Ilić, Kui Tan, Felix Mayr, Shujin Hou, Benedikt M. Aumeier, Eder Moisés Cedeño Morales, Uwe Hübner, Jennifer Cookman, Andreas Schneemann, Alessio Gagliardi, Jörg E. Drewes, Roland A. Fischer, Soumya Mukherjee","doi":"10.1002/adma.202570048","DOIUrl":"10.1002/adma.202570048","url":null,"abstract":"<p><b>Trace Adsorptive Removal of PFAS</b></p><p>By tuning the interfacial chemistry of water-stable metal-organic frameworks (MOFs) and polymer-MOF hybrids, sorbent filters were developed for rapid, recyclable, and efficient PFAS removal, even at concentrations as low as two parts per billion. More details can be found in article number 2413120 by Jörg E. Drewes, Roland A. Fischer, Soumya Mukherjee, and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"37 6","pages":""},"PeriodicalIF":27.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adma.202570048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Near-Infrared Luminescent Imaging-Based 3D QR Cube Platform for Spatial Information Storage and Security (Adv. Mater. 6/2025)","authors":"Sohyung Kim, Jiheon Lim, Suyeon Kim, Joonseok Lee","doi":"10.1002/adma.202570049","DOIUrl":"10.1002/adma.202570049","url":null,"abstract":"<p><b>3D QR Cube Platform</b></p><p>In article number 2416121, Sohyung Kim, Jiheon Lim, and co-workers present a 3D quick response (QR) cube platform that utilizes near-infrared (NIR)-to-NIR upconversion nanoparticles for spatial information storage and security. By employing volumetric space and a convolutional neural network, the platform precisely reconstructs the 3D QR cube and achieves high prediction accuracy. Leveraging the cube's 3D spatial design, it offers advanced encryption capabilities far beyond traditional 2D codes, presenting new possibilities for secure and robust multi-level encryption in 3D space.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"37 6","pages":""},"PeriodicalIF":27.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adma.202570049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}