Current Microbiology最新文献_第9页

Furfurilactobacillus entadae sp. nov., Isolated from Bark of Entada phaseoloides. 从齿状芽胞杆菌树皮中分离的齿状芽胞杆菌。

IF 2.6 3区生物学

Current Microbiology Pub Date : 2025-08-29 DOI: 10.1007/s00284-025-04450-4

Shunya Suzuki, Karin Okano, Mizuna Tamaki, Yoshimasa Tsujii, Akihito Endo, Akinobu Kajikawa

{"title":"Furfurilactobacillus entadae sp. nov., Isolated from Bark of Entada phaseoloides.","authors":"Shunya Suzuki, Karin Okano, Mizuna Tamaki, Yoshimasa Tsujii, Akihito Endo, Akinobu Kajikawa","doi":"10.1007/s00284-025-04450-4","DOIUrl":"10.1007/s00284-025-04450-4","url":null,"abstract":"A novel lactic acid bacterium, OKN36T, was isolated from the bark of Entada phaseoloides on Amami Island in Japan. Strain OKN36T is characterized as a Gram-stain-positive, non-motile, catalase-negative, heterofermentative, and rod-shaped bacterium. The strain grew at temperatures ranging from 10 to 37 °C, in a pH range of 4.0-8.0, and in the presence of 0-6.5% (w/v) NaCl. Phylogenetic analysis using the 16S rRNA gene analysis revealed that strain OKN36T belongs to the Furfurilactobacillus group. The average nucleotide identity (ANI) and the digital DNA-DNA hybridization (dDDH) values between strain OKN36T and type strains of validly published Furfurilactobacillus species were 71.83-73.85% and 19.7-20.6%, respectively. These values are below the cutoff of species differentiation, which is 95-96% for ANI and 70% for dDDH. Based on these data, we propose a novel species, named Furfurilactobacillus entadae sp. nov., with the type strain OKN36T (= JCM 37107T = DSM 118293T).","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 10","pages":"480"},"PeriodicalIF":2.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Codon Usage Pattern of Papillomavirus E6, E7, and L1 Genes Across Hosts. 乳头瘤病毒E6、E7和L1基因在宿主中的密码子使用模式

IF 2.6 3区生物学

Current Microbiology Pub Date : 2025-08-29 DOI: 10.1007/s00284-025-04468-8

Xudong Liu, Kexin Li, Xiaojing Chen, Yaqian Li, Tianshu Sun, Roujie Huang, Yanan Shi, Zilong He, Lei Li

引用次数: 0

Halophiles and Halotolerants: From Industry to Astrobiology. 嗜盐菌和耐盐菌：从工业到天体生物学。

IF 2.6 3区生物学

Current Microbiology Pub Date : 2025-08-29 DOI: 10.1007/s00284-025-04462-0

Camila de Souza Vieira, Marcos Rogério Tótola

{"title":"Halophiles and Halotolerants: From Industry to Astrobiology.","authors":"Camila de Souza Vieira, Marcos Rogério Tótola","doi":"10.1007/s00284-025-04462-0","DOIUrl":"10.1007/s00284-025-04462-0","url":null,"abstract":"Halophilic and halotolerant microorganisms, as members of the extremophile group, hold significant potential for both industrial applications and astrobiological research. Conventional microorganisms used in wastewater treatment and bioremediation often cannot withstand the high salinity present in industrial effluents and certain contaminated environments. Similarly, planetary environments such as those on Mars, Europa, and Enceladus are often considered inhospitable due to extreme salinity, temperatures, and radiation levels. However, halophiles possess adaptive mechanisms that allow them to thrive under such harsh conditions, including high salt concentrations, extreme pH, temperature, and ultraviolet radiation. This review explores the primary industrial applications of halophilic and halotolerant microorganisms-particularly their roles and the use of their enzymes in saline wastewater treatment and bioremediation. It also examines the habitability of other planetary bodies and highlights how the unique adaptations of halophiles make them valuable model organisms for astrobiological studies. A deeper understanding of these mechanisms is essential not only for expanding their industrial use but also for shedding light on their evolutionary trajectories on Earth and their potential to survive and evolve beyond our planet. Importantly, this review emphasizes the need for an integrated approach that avoids dissociating biotechnology and astrobiology, recognizing the mutual benefits that arise from collaboration between these fields.","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 10","pages":"482"},"PeriodicalIF":2.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-bacterial Properties of Propolis: A Comprehensive Review. 蜂胶的抗菌性能综述。

IF 2.6 3区生物学

Current Microbiology Pub Date : 2025-08-26 DOI: 10.1007/s00284-025-04456-y

Anita Rana, Arjun Malik, Ranbir Chander Sobti

{"title":"Anti-bacterial Properties of Propolis: A Comprehensive Review.","authors":"Anita Rana, Arjun Malik, Ranbir Chander Sobti","doi":"10.1007/s00284-025-04456-y","DOIUrl":"10.1007/s00284-025-04456-y","url":null,"abstract":"Propolis, a resinous substance collected by bees from plant sources, possesses a complex chemical composition rich in flavonoids (galangin, chrysin, quercetin), phenolic acids (caffeic, ferulic, cinnamic acid derivatives), and other bioactive compounds like artepillin C and coumaric acid. These constituents confer broad-spectrum antimicrobial activity against bacteria, viruses, fungi, and parasites. Mechanistically, propolis exerts antibacterial effects through multiple pathways: inhibiting bacterial cell wall synthesis, disrupting membrane integrity (causing ion leakage and ATP depletion), and blocking nucleic acid synthesis by targeting DNA gyrase and topoisomerase II. It also inhibits biofilm formation. Flavonoids interfere with bacterial enzymes and DNA synthesis, while artepillin C modulates inflammatory pathways, such as NF-κB, reducing prostaglandin and nitric oxide production. Propolis demonstrates synergistic effects with conventional antibiotics, enhancing their efficacy against drug-resistant strains by increasing membrane permeability and inhibiting resistance enzymes. This suggests potential for reduced antibiotic dosages and side effects, though clinical validation is still required to optimize such combinations. However, the therapeutic application of propolis faces key challenges. Its chemical composition varies by geographic origin, botanical source, and bee species complicating standardization. Extraction methods also affect the yield and potency of active compounds. Clinical data are limited, especially regarding long-term safety in immunocompromised individuals and risks of allergic reactions. Furthermore, the pharmacokinetics and molecular targets of propolis remain incompletely understood, underscoring the need for rigorous research to standardize formulations and define effective and safe therapeutic protocols.","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 10","pages":"479"},"PeriodicalIF":2.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deinococcus lichenicola sp. nov., A Bacterium Isolated from a Lichen Sample. 地衣球菌，一种从地衣样品中分离出来的细菌。

IF 2.6 3区生物学

Current Microbiology Pub Date : 2025-08-26 DOI: 10.1007/s00284-025-04453-1

Guo-Hua Chen, Lian-Shuang Xiong, Rui Yang, Shu-Ya Zuo, Qing Yuan, Li-Song Wang, Cheng-Lin Jiang, Xin-Yu Wang, Yi Jiang

{"title":"Deinococcus lichenicola sp. nov., A Bacterium Isolated from a Lichen Sample.","authors":"Guo-Hua Chen, Lian-Shuang Xiong, Rui Yang, Shu-Ya Zuo, Qing Yuan, Li-Song Wang, Cheng-Lin Jiang, Xin-Yu Wang, Yi Jiang","doi":"10.1007/s00284-025-04453-1","DOIUrl":"10.1007/s00284-025-04453-1","url":null,"abstract":"A Gram-stain-positive bacterium, designated as YIM 134068T, was isolated from a lichen. Strain YIM 134068T was non-motile, non-spore forming, coccus shaped, oxidase, and catalase positive. Cells could grow at 10-40 °C (optimum 28 °C) and pH 7.0-8.0 (optimum pH 7.0), and they could proliferate in the salinity range of 0-3.0% (w/v) NaCl. Strain YIM 134068T possessed MK-8 as the major respiratory quinone, and its predominant cellular fatty acids (> 10%) were summed feature 3 (C16:1ω7c and/or C16:1ω6c), C16:0N alcohol, and C16:0. Polar lipids comprised of phosphatidyl ethanolamine, two unidentified phospholipids, and seven unindentified phosphoglycolipids. Phylogenetic analysis using 16S rRNA gene sequence indicated that strain YIM 134068T shared the highest sequence similarities with Deinococcus aetherius ST0316T (93.2%) and Deinococcus aestuarii SYSU M49105T (92.1%). The DNA G + C content of YIM 134068T was 69.1% and the average nucleotide identity and digital DNA-DNA hybridization values between strain YIM 134068T and the reference strains were 82.6-83.0% and 26.3-26.7%, respectively. Based on the phylogenetic and phenotypic analyses, strain YIM 134068T is considered to represent a novel species within the genus Deinococcus, for which the name Deinococcus lichenicola sp. nov. is proposed. The type strain is YIM 134068T = CGMCC 1.61729T = MCCC 1K08693T = NBRC 117087 T.","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 10","pages":"478"},"PeriodicalIF":2.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole Genome Sequencing-Based Taxonomic Identification of Dulcitol-Positive Cronobacter dublinensis subsp. beijingensis subsp. nov. and Cronobacter dublinensis subsp. infanticibi subsp. nov. from Infant Cereals in China. dulcitol阳性都柏林克罗诺杆菌亚种的全基因组分类鉴定。beijingensis无性系种群。11 .和都柏林克罗诺杆菌亚种。infanticibi无性系种群。11月来自中国的婴儿谷物。

IF 2.6 3区生物学

Current Microbiology Pub Date : 2025-08-26 DOI: 10.1007/s00284-025-04447-z

Xin Gan, Menghan Li, Fengqin Li, Jianyun Zhao, Hui Li, Séamus Fanning, Yinping Dong, Li Bai

{"title":"Whole Genome Sequencing-Based Taxonomic Identification of Dulcitol-Positive Cronobacter dublinensis subsp. beijingensis subsp. nov. and Cronobacter dublinensis subsp. infanticibi subsp. nov. from Infant Cereals in China.","authors":"Xin Gan, Menghan Li, Fengqin Li, Jianyun Zhao, Hui Li, Séamus Fanning, Yinping Dong, Li Bai","doi":"10.1007/s00284-025-04447-z","DOIUrl":"10.1007/s00284-025-04447-z","url":null,"abstract":"Cronobacter, a Gram-negative opportunistic pathogen, poses a significant risk to neonates. The taxonomic position of strains CFSA2021A14T and CFSA2021A84T, isolated from cereal-based infant noodles in China, was investigated. Phenotypic and genotypic analyses identified both strains as novel subspecies of Cronobacter dublinensis, with dulcitol utilization attributed to the presence of the gatYZABCD gene cluster. Based on ANI analysis, the strains are proposed as Cronobacter dublinensis subsp. beijingensis subsp. nov. and Cronobacter dublinensis subsp. infanticibi subsp. nov. The type strain C. dublinensis subsp. beijingensis CFSA2021A14T (= CGMCC 1.61450T, = JCM 35886T) grew aerobically at 25-41 °C, with negative myo-inositol and amygdalin utilization. Strain CFSA2021A14T genome size was 4.71 Mbp with a G + C content of 57.2%. The type strain C. dublinensis subsp. infanticibi CFSA2021A84T (= CGMCC 1.61451T, = JCM 35887T) exhibited similar growth conditions to C. dublinensis subsp. beijingensis CFSA2021A14T, but showed positive myo-inositol and amygdalin utilization. Strain CFSA2021A84T genome size was 4.73 Mbp with a G + C content of 57.4%.","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 10","pages":"477"},"PeriodicalIF":2.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lentibacillus songyuanensis sp. nov., A Drought- and Salt- Tolerant Bacterium with Ability to Degrade Aniline Blue Isolated from Saline-Alkali Soil. 从盐碱地中分离的具有降解苯胺蓝能力的耐干旱耐盐细菌松原慢芽孢杆菌

IF 2.6 3区生物学

Current Microbiology Pub Date : 2025-08-25 DOI: 10.1007/s00284-025-04445-1

Enyi Wang, Leyao Chen, Leyun Dong, Jian He, Zongzhuan Shen, Jiandong Jiang, Qirong Shen

{"title":"Lentibacillus songyuanensis sp. nov., A Drought- and Salt- Tolerant Bacterium with Ability to Degrade Aniline Blue Isolated from Saline-Alkali Soil.","authors":"Enyi Wang, Leyao Chen, Leyun Dong, Jian He, Zongzhuan Shen, Jiandong Jiang, Qirong Shen","doi":"10.1007/s00284-025-04445-1","DOIUrl":"10.1007/s00284-025-04445-1","url":null,"abstract":"A Gram-stain-positive, aerobic and drought- and salt-resistant bacterium, designated as N15T, was isolated from a saline-alkali soil in Songyuan city, Jilin Province, China. The strain grew in the presence of 0-12% (w/v) NaCl, at pH 6.0-8.0 and 15-42 °C; optimum growth was observed with 6.0% (w/v) NaCl, at pH 7.0 and 30 °C. Strain N15T tolerated up to 45% PEG6000 and 12% NaCl, and could efficiently degrade aniline blue. Phylogenetic analysis based on 16S rRNA genes placed strain N15T within genus Lentibacillus, forming a subclade with Lentibacillus daqui ZS110521T (97.5% similarity) and L. garicola SL-MJ1T (95.9% similarity). The major cellular fatty acids (≥ 5%) were anteiso-C15:0, ananteiso-C17:0 and iso-C17:0. The respiratory quinone was MK-7 and peptidoglycan contained meso-DAP. The polar lipid profile consisted of phosphatidylethanolamine, diphosphatidylglycerol, phosphatidylglycerol and an unidentified phospholipid. The genome size of strain N15T was 4.5 Mb, and the DNA G + C content was 40.1%. The nucleotide identity (ANI) and digital DNA-DNA hybridization (dDDH) values between strain N15T and L. daqui ZS110521T were 77.8% and 22.6%, respectively, which were significantly below the recommended thresholds (ANI < 95-96% and dDDH < 70%) for species delineation. Based on the phenotypic, phylogenetic, chemotaxonomic, and genomic results from this study, strain N15T represents a novel species in genus Lentibacillus, for which the name Lentibacillus songyuanensis sp. nov. is proposed, the type strain is N15T (= MCCC 1K09143T = KCTC 43718T).","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 10","pages":"475"},"PeriodicalIF":2.6,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibiotic Susceptibility Evaluation in Bacterial Infections from Orthopedic Inpatients with Leg Trauma. 骨科住院患者腿部外伤细菌感染的抗生素敏感性评价。

IF 2.6 3区生物学

Current Microbiology Pub Date : 2025-08-25 DOI: 10.1007/s00284-025-04458-w

Juanjuan Zhang, Fangfang Jiao, Yonghan Ge, Bei Cheng, Jingjing Guo

{"title":"Antibiotic Susceptibility Evaluation in Bacterial Infections from Orthopedic Inpatients with Leg Trauma.","authors":"Juanjuan Zhang, Fangfang Jiao, Yonghan Ge, Bei Cheng, Jingjing Guo","doi":"10.1007/s00284-025-04458-w","DOIUrl":"10.1007/s00284-025-04458-w","url":null,"abstract":"The COVID-19 pandemic has profoundly impacted healthcare delivery systems worldwide, but its impact on orthopedic infection patterns remains unclear. This retrospective comparative study analyzed 173 patients with leg trauma-related orthopedic infections from June 2018 to May 2025, divided into two periods based on China's pandemic control policy changes in December 2022: pre-policy adjustment (n = 86) and post-policy adjustment (n = 87). Our study revealed four major pandemic-driven changes: First, patients were significantly younger (50.6 ± 15.0 vs 52.6 ± 16.1 years, p < 0.001) with dramatically reduced hospital stays (16.9 ± 11.3 vs 28.0 ± 26.2 days, p < 0.001). Second, bacterial ecology shifted markedly, with S. aureus prevalence declining from 53.5% to 41.4% while E. faecium emerged exclusively in the post-policy period (4.6%). Third, antibiotic resistance patterns showed divergent trends: β-lactam resistance improved (40.1% to 30.2%), whereas resistance to fluoroquinolones (24.9% to 36.3%), macrolides (40.0% to 59.2%), and lincosamides (40.8% to 52.5%) increased significantly. Fourth, MRSA prevalence among S. aureus isolates rose from approximately 40% to 45%, although glycopeptides and lipopeptides maintained excellent efficacy (≤ 1.1% resistance). These findings highlight pandemic-driven changes in orthopedic infections, necessitating updated antibiotic protocols and strengthened antimicrobial stewardship.","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 10","pages":"476"},"PeriodicalIF":2.6,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacillus Strains as Increased Soil Fertility and Biomass Yield Tactics in a Reclaimed Tidal Flat, Saemangeum, Korea. 芽孢杆菌菌株在韩国新万金开垦潮滩提高土壤肥力和生物量产量策略。

IF 2.6 3区生物学

Current Microbiology Pub Date : 2025-08-25 DOI: 10.1007/s00284-025-04446-0

Jihwi Jang

{"title":"Bacillus Strains as Increased Soil Fertility and Biomass Yield Tactics in a Reclaimed Tidal Flat, Saemangeum, Korea.","authors":"Jihwi Jang","doi":"10.1007/s00284-025-04446-0","DOIUrl":"10.1007/s00284-025-04446-0","url":null,"abstract":"The demand for bioenergy resources continues to grow due to increased emerging economic value and emission trading systems. On top of that, energy crop (EC) resources are key to addressing the interconnected global challenges of sustainable development with the adoption of Renewable Portfolio Standard (RPS) and the post-Paris Agreement in Korea. Current research on interactions between EC and plant growth-promoting rhizobacteria (PGPR) emphasizes the energy potential regarding greatly enhanced ecological and economic effects that may increase in the future. However, less attention has been focused on soil fertility management after crop planting in reclaimed tidal land using bio-fertilizers such as rhizobacteria. This review paper documented and evaluated the potential of ECs by discussing the evidence for interactions between PGPR and crops where representative species have grown on Korean reclaimed land during the recent decade. The existing literature revealed several important generalizations that emerge from this synthesis of mechanisms and interaction. First, EC-PGPR interactions affect the increase of biomass yield on reclaimed land without a decrease in values of soil and crop quality. Second, PGPR Bacillus subtilis JS increased the T-N (total nitrogen), P (phosphorus), and chlorophyll contents owing to mineral nutrient solubilization and chlorophyll a/b binding protein, and B. licheniformis MH48 affected the increase of the T-N and P contents in soil because of N2 fixation. In this respect, this scoping review highlighted that short-rotation plantation management through PGPR in reclaimed tidal land may be more sustainable than chemical fertilizer treatment in the context of land-use change.","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 10","pages":"474"},"PeriodicalIF":2.6,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological Activities of Aspergillus niger MF6: Antimicrobial, Antioxidant, and Cytotoxic Potential of Marine-Derived Fungus Metabolites. 黑曲霉MF6的生物活性：海洋真菌代谢物的抗菌、抗氧化和细胞毒性潜力

IF 2.6 3区生物学

Current Microbiology Pub Date : 2025-08-25 DOI: 10.1007/s00284-025-04457-x

Moaz M Hamed, Mohamed A A Abdrabo, Lamis Sh Abdelfattah, Yasser A Geneid

{"title":"Biological Activities of Aspergillus niger MF6: Antimicrobial, Antioxidant, and Cytotoxic Potential of Marine-Derived Fungus Metabolites.","authors":"Moaz M Hamed, Mohamed A A Abdrabo, Lamis Sh Abdelfattah, Yasser A Geneid","doi":"10.1007/s00284-025-04457-x","DOIUrl":"10.1007/s00284-025-04457-x","url":null,"abstract":"Marine-derived fungi have emerged as a promising source of bioactive compounds with therapeutic potential. This study investigates the biological activities of Aspergillus niger MF6, a fungal isolate derived from coral reefs along the Hurghada coast in the Red Sea, Egypt. The isolate demonstrated significant antimicrobial activity, with broad-spectrum inhibition against pathogens, including E. coli, S. aureus, and C. albicans, achieving inhibition zones up to 20 mm. Ethyl acetate was identified as the most effective solvent for extracting bioactive compounds, facilitating the isolation of metabolites responsible for antimicrobial activity. Antioxidant assays revealed robust activity, with dose-dependent scavenging effects across multiple mechanisms. Furthermore, cytotoxicity assays against HepG-2 and MCF-7 cancer cell lines demonstrated moderate cytotoxic activity, with IC50 values of 177.25 ± 5.42 µg/ml and 256.97 ± 7.45 µg/ml, respectively. GC-MS analysis identified key bioactive compounds, including hexadecenoic acid and 9-octadecenoic acid, likely contributing to these effects. This study underscores the therapeutic promise of coral-associated fungi as a sustainable source of antimicrobial, antioxidant, and anticancer agents.","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 10","pages":"473"},"PeriodicalIF":2.6,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0