Drug Delivery and Translational Research最新文献

{"title":"Bioavailability enhancement and neuropharmacological effects of Dauricine under intranasal administration to improve cognitive impairment via PI3K/AKT/mTOR pathway.","authors":"Ruiye Xie, Zhen Liu, Jingjing Zheng, Qiwen Tan, Haitao Wu, Yong Liang","doi":"10.1007/s13346-025-01975-w","DOIUrl":"10.1007/s13346-025-01975-w","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a neurodegenerative disorder strongly associated with aging, and Dauricine (DAU) has demonstrated significant neuropharmacological properties for AD treatment. However, its bioavailability is significantly limited when administered orally, leaving the mechanisms underlying its effects on AD largely unexplored. In this study, a DAU-loaded thermosensitive gel was formulated for delivery via the nasal-nerve route, and its potential to enhance the bioavailability of DAU in rat plasma and cerebrospinal fluid (CSF) was assessed through a pharmacokinetic study. The anti-Alzheimer's disease (AD) mechanism of DAU was investigated using network pharmacology approaches, molecular docking, and dynamics simulations, complemented by in vivo experimental validation. DAU can be effectively incorporated into a thermosensitive gel and administered to the brain within 30 min via intranasal delivery. Following nasal administration, the pharmacokinetic parameters of DAU in cerebrospinal fluid and plasma were significantly elevated compared to oral administration (^**P < 0.01), indicating a substantial improvement in bioavailability at equivalent doses. Behavioral studies demonstrated that DAU (dose of 1 mg/kg and 2 mg/kg in gel) enhanced cognitive function in intracerebroventricular-streptozotocin (ICV-STZ) rats and decelerated aging processes by reversing oxidative stress and mitigating neuronal apoptosis. Additionally, DAU contributed to lowering blood glucose levels, increasing insulin-like growth factor 1 (IGF-1) content, and reducing insulin resistance. Network pharmacological analysis, molecular docking, molecular dynamics simulations, and in vivo experiments collectively suggested that DAU exerted significant therapeutic effects on Alzheimer's disease by inhibiting the PI3K/AKT/mTOR pathway. Our study demonstrates a significant enhancement in the bioavailability of DAU in the brain via nasal-nerve delivery route and also this research is the first to report that DAU ameliorates cognitive impairment in ICV-STZ rats through the PI3K/AKT/mTOR pathway. Our findings contribute to the scientific understanding of DAU's potential in Alzheimer's disease treatment and offer a novel experimental foundation for the development of anti-Alzheimer's drugs.</p>","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"1607-1628"},"PeriodicalIF":5.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial 3D printed implants for periprosthetic joint infections.","authors":"Iván Yuste, Francis C Luciano, Carmina Rodríguez, Bianca I Ramirez, Chrysi Rapti, Brayan J Anaya, Aikaterini Lalatsa, Almudena Ribed-Sánchez, Pablo Sanz-Ruiz, Elena González-Burgos, Dolores R Serrano","doi":"10.1007/s13346-025-01934-5","DOIUrl":"10.1007/s13346-025-01934-5","url":null,"abstract":"<p><p>Periprosthetic joint infections (PJIs) remain a serious complication following hip and knee arthroplasty, affecting 1-5% of patients in developed countries and posing significant challenges to patients, clinicians, and healthcare systems. Conventional prophylactic strategies, such as antibiotic-loaded bone cement, suffer from limited post-implantation drug release and potential compromise of mechanical integrity. To overcome these limitations, we developed a personalized, 3D-printed implant designed to integrate with the acetabular component of joint prostheses. These implants deliver either monotherapy or a combination of amphotericin B (AmB) and vancomycin (VAN), targeting both fungal and bacterial pathogens. Fabricated via fused deposition modeling using a biocompatible polyvinyl alcohol-polyethylene glycol (PVA-PEG) matrix, the implants enable passive drug loading and rapid adhesion to prosthetic surfaces within 60 s, minimizing operative time. In vitro testing confirmed broad-spectrum antimicrobial activity against Candida spp. (C. albicans, C. parapsilosis, C. glabrata, C. krusei) and Staphylococcus spp. (S. aureus, S. epidermidis). VAN was released rapidly, while AmB exhibited sustained release for up to 10 h, with both maintaining saturation solubility for 48 h. Notably, AmB-loaded implants showed five-fold lower hemolytic toxicity compared to free drug. These results highlight the potential of 3D-printed, drug-eluting implants as a clinically viable solution for the prevention and early treatment of PJIs.</p>","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"1333-1348"},"PeriodicalIF":5.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid dissolving microneedle patch integrated with benidipine-loaded nanotransfersomes for transdermal drug delivery: optimization, characterizations, and preclinical bioavailability assessment.","authors":"Khater Al-Japairai, Samah Hamed Almurisi, Fawaz Alheibshy, Nadiya Abdul-Halim, Syed Mahmood","doi":"10.1007/s13346-025-01976-9","DOIUrl":"10.1007/s13346-025-01976-9","url":null,"abstract":"<p><p>Benidipine hydrochloride (BEN) is widely prescribed for managing hypertension; however, its clinical efficacy is limited by poor oral bioavailability. This study introduces an innovative delivery approach, incorporating BEN-loaded nanotransfersomes (BEN-TF) into a rapid dissolving microneedles (DMNs) patch for transdermal administration. The nanotransfersomal formulation was optimised via a Box-Behnken design following preparation using a thin-film hydration method. The optimised formulation exhibited favourable characteristics, including a vesicle size of 124.9 ± 1.49 nm, high entrapment efficiency (98.12 ± 0.18%), and transdermal flux of 9.74 ± 0.53 μg/cm²/hr. DSC, ATR-FTIR, and XRD analyses confirmed the amorphous state of BEN. Imaging via FESEM and HRTEM demonstrated spherical, uniform nanosized vesicles. Confocal microscopy revealed deep skin penetration. The integration of BEN-TF into DMNs (BEN-TF-DMNs) resulted in efficient skin insertion, rapid dissolution, and good mechanical strength. Ex-vivo results indicated superior permeation compared to BEN-TF or BEN-DMNs alone, while the in-vivo study confirmed improved bioavailability versus both oral tablets and BEN-DMNs. This hybrid delivery platform offers a promising strategy for improving the systemic delivery of BEN.</p>","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"1629-1649"},"PeriodicalIF":5.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phyto-assisted synthesized CuO NPs embedded in crosslinked zein/alginate composite films for hastening wound healing and tissue regeneration in rats bio-template.","authors":"Sarah A El-Lakany, Nazik A Elgindy, Elbadawy A Kamoun, Perusi M Masanga, Shahira H El-Moslamy, Marwa Abu-Serie, Rania G Aly, Noha Khalifa Abo Aasy","doi":"10.1007/s13346-025-01948-z","DOIUrl":"10.1007/s13346-025-01948-z","url":null,"abstract":"<p><p>Biopolymer-based composite films were primed by incorporating alginate and zein natural polymers using a solution-casting method and superbly assisted by eco-friendly prepared copper oxide nanoparticles (CuO NPs). The influence of the addition method of CaCl₂ as a crosslinker and CuO NPs loading content (0.1, 0.2, and 0.4 wt%) on the microstructural, physical, and mechanical properties of the films, were appraised. The formation of composite films and incorporation of CuO NPs were verified by FT-IR and XRD studies. The results unearthed that double crosslinking (Dipping method) succeeded in forming a firm, homogenous film that maintains its integrity in water for up to 24 h in comparison to the single (Blending) method. Inclusion of zein in the film and further loading with CuO NPs are manifested in a significant decrease in water vapor permeability, swelling and degradation percentage about (58.57, 52.26, and 25.80%); respectively. In addition to 1.26-folds increase in the tensile strength and 1.19-folds decrease in elongation to break, endorsing the excellent barrier property and durability of the formed films. Nevertheless, CuO loaded composite film proposes high biocompatibility against HBF4 cells with the highest IC50 and EC100 values, compared to alginate film and free-CuO NPs. The composite film exhibited the most effective antimicrobial activity against extremely drug-resistant human pathogens of both Gram-ve and Gram + ve bacteria strains, as well as fungal cells. The healed diabetic wound demonstrated an intact fully thickened keratinized epidermal epithelialization, and a complete absence of any inflammatory infiltrate after 13 days of treatment, emphasizing its suitability as a promising dressing candidate for skin tissue bioengineering.</p>","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"1388-1405"},"PeriodicalIF":5.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucocorticoid receptor-targeted liposomal delivery of wnt/β-catenin pathway inhibitor selectively induces efficient colorectal tumor regression.","authors":"Pritam Das, Tithi Bhattacharyya, Aasia Ansari, Anjaneyulu Eanti, Yogesh Chandra, Rajkumar Banerjee","doi":"10.1007/s13346-025-01952-3","DOIUrl":"10.1007/s13346-025-01952-3","url":null,"abstract":"<p><p>Wnt/β-catenin signaling pathway is a highly conserved developmental pathway. This pathway is also involved in colorectal cancer and thus its selective targeting to cancer cells, albeit the risk involved, can serve as a promising therapeutic approach. Glucocorticoid receptor (GR) is a nuclear hormone receptor present in both cancer and non-cancer cells. Previously, we showed that cancer cell-associated GR, without eliciting any effect in normal cells, could be targeted for selective drug-sensitization in cancer cells. Based on this unique feature, we intended to sensitize the wnt/β-catenin pathway by co-formulating a GR-targeted cationic liposomal formulation carrying dexamethasone, a synthetic GR-ligand, and a wnt/β-catenin pathway inhibitor, FH535, to form D1XFH formulation. The nanometric and positively charged D1XFH formulation selectively kills colorectal cancer cells at much lower FH535 concentration than free drug or drug-associated GR-non-targeted liposome, while exhibiting unique nuclear uptake, increased ROS generation, apoptosis and G2-M phase cell cycle arrest in cancer cells. Further, in vivo data shows enhanced tumor-specific localization of this formulation, significant tumor growth inhibition and increased mice survivability, signifying its efficacy and biocompatibility in mouse colon subcutaneous and orthotopic tumor models. Protein expression analysis reveals enhanced reversal of epithelial-to-mesenchymal transition (EMT) and inhibition of various downstream proteins of wnt/β-catenin pathway. Additionally, analysis of tumor lysate from D1XFH-treated group shows an increased Th1/Th2 ratio, indicating favorable, anti-tumor immune response. The formulation exhibits no sub-chronic toxicity against healthy mice. In overall, our data strongly suggest that the GR-targeted FH535 liposomal delivery can safely target the highly sensitive wnt/β-catenin pathway for effective treatment of colorectal tumor.</p>","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"1435-1460"},"PeriodicalIF":5.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mannosylated fisetin/carveol lipid nanocapsules: brain-targeted dual therapy for modulation of epileptogenesis and cognitive deficits.","authors":"Julie R Youssef, Nabila A Boraie, Fatma A Ismail, Basant A Bakr, Eman A Allam, Mahmoud A Agami, Riham M El-Moslemany","doi":"10.1007/s13346-025-01937-2","DOIUrl":"10.1007/s13346-025-01937-2","url":null,"abstract":"<p><p>Pharmacological treatment of epilepsy is challenged by several barriers with the blood brain barrier (BBB) imposing the utmost restrictions to brain drug delivery. Antiepileptic drugs aim to reduce seizures frequency and severity while exerting minimal toxic effects. Herein, the merits of phytomedicine and brain targeted nanocarriers were combined for the control of seizures in a chronic epilepsy model. Fisetin (FS); a polyphenol and carveol (CAR); a limonene monoterpenoid were selected for their neuroprotective roles and co-loaded into lipid nanocapsules (FS/CAR@LNC). This was further decorated with mannose by post insertion targeting glucose transporter (GLUT-1) overexpressed on BBB (MAN-FS/CAR@LNC). The optimized MAN-FS/CAR@LNC revealed good colloidal properties with particle size (53.17 ± 4.06 nm), and low polydispersity index (0.11) and 26.9 ± 1.05 mV zeta potential. A high entrapment efficiency exceeding 99% and sustained drug release profile over 72 h were observed for both FS and CAR. In the in vivo imaging system (IVIS), MAN-FS/CAR@LNC attained 1.3-fold increase in fluorescence intensity at 5 h interval compared to FS/CAR@LNC. Following intraperitoneal administration in PTZ- induced chronic epilepsy mouse model, MAN-FS/CAR@LNC achieved maximal control of epileptic seizures accompanied with rehabilitation of locomotion, depressive and anxiety like-behaviors compared to FS/CAR and FS/CAR@LNC. Similarly, analysis of biomarkers reflecting depression and anxiety actions (brain-derived neurotrophic factor; BDNF, serotonin and glutamate) together with inflammatory markers (IL-6 and IL-1ꞵ) and histopathological assessment affirmed MAN-FS/CAR@LNC excelling in enhancing LNC brain targetability and hence seizures control. In conclusion, FS/CAR co-therapy aided with mannosylated LNC could present a compelling podium for the effective management of CNS disorders.</p>","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"1349-1371"},"PeriodicalIF":5.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research trends on nanomaterials in triple negative breast cancer (TNBC): a bibliometric analysis from 2010 to 2024.","authors":"Hongyi Liang, Guoliang Yin, Dandan Feng, Hanhan Chen, Xiaofei Liu, Jingwei Li","doi":"10.1007/s13346-024-01704-9","DOIUrl":"10.1007/s13346-024-01704-9","url":null,"abstract":"<p><p>Breast cancer (BC) is an important cause of cancer-related death in the world. As a subtype of BC with the worst prognosis, triple-negative breast cancer (TNBC) is a serious threat to human life and health. In recent years, there has been an increasing amount of research aimed at designing and developing nanomaterials for the diagnosis and treatment of TNBC. The purpose of this study was to comprehensively evaluate the current status and trend of the application of nanomaterials in TNBC through bibliometric analysis. Studies focusing on nanomaterials and cancer were searched from the Web of Science core collection (WOSCC) database, and relevant literature meeting the inclusion criteria was selected for inclusion in the study. VOSviewer and CiteSpace were used to perform bibliometric and visual analysis of the included publications. A total of 2338 studies were included. Annual publications have increased from 2010 to 2024. China, the United States and India were the leading countries in the field, accounting for 66.1%, 11.5% and 7.2% of publications, respectively. The Chinese Academy of Sciences and Li Yaping were the most influential institutions and authors, respectively. Journal of Controlled Release was considered the most productive journal. Cancer Research was considered to be the most co-cited journal. Drug delivery and anti-cancer mechanisms related to nanomaterials were considered to be the most widely studied aspects, and green synthesis and anti-cancer mechanisms were also recent research hotspots. In this study, the characteristics of publications were summarized, and the most influential countries, institutions, authors, journals, hot spots and trends in the application of nanomaterials in cancer were identified. These findings provide valuable insights into the current state and future direction of this dynamic field.</p>","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"1650-1665"},"PeriodicalIF":5.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle-targeting LNP vaccines enable potent immune responses against varicella zoster virus.","authors":"Honglei Zhang, Jingxuan Ma, Lijie Jin, Yuqing Ma, Kai Dong, Jing Li, Fei Yu, Gengshen Song","doi":"10.1007/s13346-025-01961-2","DOIUrl":"10.1007/s13346-025-01961-2","url":null,"abstract":"<p><p>Messenger RNA (mRNA) therapeutics have shown considerable promise across a wide range of medical applications with lipid nanoparticles (LNPs) emerging as the most clinically advanced mRNA delivery vehicles. However, the risk of off-target tissue delivery remains a concern, underscoring the need for diverse ionizable lipids to optimize LNP-based delivery systems. In this study, we designed and synthesized a library of 21 novel ionizable lipids and evaluated their potential for mRNA delivery. The resulting LNPs displayed favorable physicochemical properties and low cytotoxicity. In vitro transfection assay identified 3 high efficiency LNPs: YK-305, YK-310 and YK-319. In a mouse model, intramuscular injection of firefly luciferase (Fluc) mRNA-LNPs resulted in high transfection efficiency in muscle tissue, with significantly reduced gene expression in the liver. After encapsulating varicella zoster virus (VZV) glycoprotein E (gE)-encoding mRNA, the three LNP formulations induced robust humoral and cellular immune responses specific to the gE antigen, demonstrated improved selectivity and immunogenicity compared to SM-102, the ionizable lipid used in Moderna's Spikevax. The safety of the gE-mRNA LNP formulations were subsequently demonstrated in a mouse model. Collectively, these findings provide a foundation for the optimization of tissue-targeting ionizable lipids and highlight their potential to advance mRNA-based vaccines in clinical applications.</p>","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"1517-1529"},"PeriodicalIF":5.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of cancer cell membrane-coated Gambogic acid-loaded pH-sensitive liposomes to enhance targeted anti-hepatocellular carcinoma effect.","authors":"Yi-Feng Zhang, Kun Chen, Yu-Qing Zhu, Lin Liu, Xiang-Tao Kong, Yan Dai, Xiu-Juan Fu, Ya-Ling Li, Ming-Hua Liu, Dan Zhang","doi":"10.1007/s13346-025-01949-y","DOIUrl":"10.1007/s13346-025-01949-y","url":null,"abstract":"<p><p>Hepatocellular carcinoma has an insidious onset, and therefore, most patients are already in the middle or advanced stage once diagnosed, which seriously affects the prognosis of the patients. For a long time, it has been difficult to achieve the expected effect of the treatment that can effectively deal with the middle-or-late -stage liver cancer. Gambogic acid (GA), a dry resin secreted by the Garcinia hanbaryi Hook.f., is a natural active ingredient with various biological activities, especially the strong anti-hepatocellular carcinoma activity. However, the drawbacks such as high toxicity to the liver and kidney and low solubility have greatly limited its application. Therefore, it is necessary to develop suitable Gambogic acid formulations to overcome these disadvantages. In this study, injectable HepG2 cell membrane-modified pH-responsive liposomes (PEOz/GA@HepG2m) were prepared for active targeted delivery of Gambogic acid for the treatment of hepatocellular carcinoma. The physicochemical properties of PEOz/GA@HepG2m were evaluated in terms of the drug loading efficiency, particle size, morphology and drug release. The inhibitory effect of PEOz/GA@HepG2m on the proliferation of hepatocellular carcinoma cells was assessed by CCK8 assay and calcein-AM/PI assay in vitro. The effect of unloaded liposome PEOz@HepG2m on cellular internalization was assessed in different cell lines and it's in vivo biodistribution was analyzed by near-infrared (NIR) fluorescence imaging. The antitumor effect of PEOz/GA@HepG2m in vivo was evaluated in HepG2 tumor-bearing nude mice. The PEOz@HepG2m liposomes exhibit excellent targeting ability toward HepG2 cells. PEOz/GA@HepG2m possesses high delivery efficiency and a remarkably therapeutic effect both in vitro and vivo. The coating HepG2 cell membrane could significantly enhance the tumor-targeting effect of the liposomes and improve the antitumor effect of the loaded drug GA in vivo, indicating that the active-targeting biomimetic liposome, PEOz/GA@HepG2m, is a promising nanoplatform for delivery of drugs to hepatocellular carcinoma.</p>","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"1406-1422"},"PeriodicalIF":5.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photothermal and pH-stimuli-responsive mesoporous silica nanoparticles drug delivery system for targeting the tumor cells.","authors":"Qi Chen, Zhengxi Wu, Yingying Ji, Xiaoying Zheng, Chunyan Liu, Chenyu Zhou, Xiaoqian Shan, Jiying Sheng, Qiang Ren, Kuijie Wei","doi":"10.1007/s13346-025-01972-z","DOIUrl":"10.1007/s13346-025-01972-z","url":null,"abstract":"<p><p>To improve the precision of cancer therapy, multi-stimuli responsiveness and targeted, controllable drug release are essential components. In this study, we designed an intelligent drug delivery system that integrates chemotherapy and photothermal therapy with pH- and photothermal-sensitive controlled drug release capabilities. This system encapsulates CuS nanoparticles and a model drug Metformin (Met) within Mesoporous Silica Nanoparticles (MSN), which are subsequently coated with a thin layer of Polydopamine (PDA) to enhance multiple photothermal conversion functions. Met, widely recognized for its role in treating type 2 diabetes, has been shown to possess anti-tumor properties. Consequently, it was chosen as the model drug encapsulated within the mesoporous silica nanoparticles. Our investigation about the drug release behavior demonstrated that the PDA coating on MSN not only mitigates the initial burst release of metformin but also facilitates sustained, pH- and thermally-responsive release at pH 6.5, achieving a cumulative release of 67.1% by the tenth day. Furthermore, the PDA modification significantly improves the photothermal conversion performance and stability of CuS@MSN. The photothermal conversion efficiency (PCE) of CuS@MSN and CuS@MSN@PDA (CMP) were measured at 42.7% and 59.9%, respectively. Additionally, on the 28th day post-tumor resection, the met@CMP group exhibited an 80% lower tumor recurrence rate compared to the met group alone. This research highlights the substantial potential of intelligent CMP nanoparticles for multi-stimuli responsive, precise chemo-photothermal synergistic therapy in cancer treatment.</p>","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"1561-1580"},"PeriodicalIF":5.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}