Optimized intranasal delivery of segesterone acetate progestin to the brain using nanoemulsions and microemulsions.

IF 5.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Drug Delivery and Translational Research Pub Date : 2025-06-18 DOI:10.1007/s13346-025-01897-7

Carina Peres, Sara Meirinho, Samille Ferreira da Silva, Izamara Maocha, Anabela Chiangalala, Susana Alves Ferreira, Márcio Rodrigues, Shimin Zhang, Narender Kumar, Regine Sitruk-Ware, Rui Caetano Oliveira, Carlos Gaspar, Ana Palmeira-de-Oliveira, Rita Palmeira-de-Oliveira, Gilberto Alves, Graça Baltazar, Adriana O Santos

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使用纳米乳液和微乳液优化醋酸孕酮黄体酮经鼻给药到大脑。

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来源期刊

Drug Delivery and Translational Research MEDICINE, RESEARCH & EXPERIMENTALPHARMACOL-PHARMACOLOGY & PHARMACY

CiteScore

11.70

自引率

1.90%

发文量

160

期刊介绍： The journal provides a unique forum for scientific publication of high-quality research that is exclusively focused on translational aspects of drug delivery. Rationally developed, effective delivery systems can potentially affect clinical outcome in different disease conditions. Research focused on the following areas of translational drug delivery research will be considered for publication in the journal. Designing and developing novel drug delivery systems, with a focus on their application to disease conditions; Preclinical and clinical data related to drug delivery systems; Drug distribution, pharmacokinetics, clearance, with drug delivery systems as compared to traditional dosing to demonstrate beneficial outcomes Short-term and long-term biocompatibility of drug delivery systems, host response; Biomaterials with growth factors for stem-cell differentiation in regenerative medicine and tissue engineering; Image-guided drug therapy, Nanomedicine; Devices for drug delivery and drug/device combination products. In addition to original full-length papers, communications, and reviews, the journal includes editorials, reports of future meetings, research highlights, and announcements pertaining to the activities of the Controlled Release Society.