Drug and alcohol dependence最新文献

{"title":"The association between benzodiazepine proliferation in the unregulated drug supply and experiences of violence: A gender-based analysis","authors":"Anmol Swaich ,&nbsp;Kali Rufus-Sedgemore ,&nbsp;JinCheol Choi ,&nbsp;Kora DeBeck ,&nbsp;Jade Boyd ,&nbsp;M-J Milloy ,&nbsp;Thomas Kerr ,&nbsp;Kanna Hayashi","doi":"10.1016/j.drugalcdep.2025.113009","DOIUrl":"10.1016/j.drugalcdep.2025.113009","url":null,"abstract":"<div><h3>Background</h3><div>Rising contamination of illicitly-manufactured benzodiazepines in unregulated opioids in Canada poses concern as their strong sedative effects may increase vulnerability to violence for people who use drugs (PWUD), particularly women. The current study longitudinally examined the relationship between suspected exposure to benzodiazepines (SEB) and violent victimization, assessing for gender differences.</div></div><div><h3>Methods</h3><div>Data were drawn from 1049 participants (40.9 % women) from three harmonized prospective cohorts of community-recruited PWUD in Vancouver, Canada between 2021 and 2023. We conducted gender-stratified analyses, with a three-level exposure variable 1) primary SEB: through using unregulated benzodiazepines, 2) secondary SEB: only through using other unregulated drugs, and 3) no exposure (reference category). Patterns of unregulated opioid and stimulant use were examined as effect modifiers.</div></div><div><h3>Findings</h3><div>At baseline, 249 (58.0 %) women and 349 (56.3 %) men reported any SEB; 84 (19.6 %) women and 126 (20.3 %) men reported experiencing violence. For all participants, secondary SEB was significantly related to higher odds of violence (adjusted odds ratio [AOR]=1.48; 95 % confidence interval [CI]:1.14–1.92), however this association did not persist for primary SEB (AOR=1.26; 94 % CI:0.73–2.18). In gender-stratified analyses, the association between secondary SEB and violence was only significant for women (AOR=1.62; 95 % CI:1.10–2.38). Secondary SEB was also associated with higher odds of violence when participants reported daily stimulant and no daily opioid use (AOR=2.76; 95 % CI:1.58–4.82).</div></div><div><h3>Conclusions</h3><div>Our findings suggest lack of agency over exposure to benzodiazepines, as created by drug supply unpredictability, may exacerbate risk of violence among women who use drugs and PWUD who do not frequently use opioids.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"278 ","pages":"Article 113009"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reciprocal relationships among youth social media use, internalizing symptoms, and substance use","authors":"Xia Zheng ,&nbsp;Meng Yang ,&nbsp;Ruobing Li ,&nbsp;Wenbo Li ,&nbsp;Nicole Lis ,&nbsp;Hsien-Chang Lin","doi":"10.1016/j.drugalcdep.2025.113018","DOIUrl":"10.1016/j.drugalcdep.2025.113018","url":null,"abstract":"<div><h3>Objective</h3><div>Mental health, substance use, and social media are three important, inter-related factors influencing youth development. This study examines the dynamic, reciprocal relationships among social media use, internalizing mental health symptoms, and substance use (e-cigarette, alcohol, cigarette, and marijuana) among U.S. adolescents.</div></div><div><h3>Methods</h3><div>Data were from restricted Population Assessment of Tobacco and Health (PATH) Study, Waves 4, 4.5, and 5 (2016–2019). The sample included 7759U.S. adolescents (weighted N = 15,032,305) who completed all three waves. Weighted generalized structural equation models with lagged dependent variables were performed to examine the reciprocal relationships between youth’s social media use frequency, internalizing symptoms, and use of substances. Each variable has a dual role as both a predictor and outcome across waves, with earlier waves predicting subsequent ones, to assess bidirectional influences over time.</div></div><div><h3>Results</h3><div>Higher social media use and internalizing symptoms were associated with higher odds of subsequent e-cigarette, alcohol, and marijuana use. Higher social media use predicted higher odds of e-cigarette use (AOR=1.33, <em>p</em> &lt; 0.001) and alcohol use (AOR=1.19, <em>p</em> &lt; 0.001). Internalizing symptoms predicted higher odds of cigarette use (AOR=1.71, 95 % CI=1.15–2.53). Social media use also predicted greater odds of experiencing internalizing symptoms (AORs=1.05, all <em>p</em>s &lt; 0.01). We found both similarities and differences in the patterns of the reciprocal pathways overtime across the four substances.</div></div><div><h3>Conclusions</h3><div>Our study reveals a complex and dynamic relationship among social media use, mental health, and substance use among youth. The findings support the need for integrative interventions that simultaneously address mental health, social media behaviors, and substance use risk.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"278 ","pages":"Article 113018"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145880252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drinking on empty: Daily associations between food and alcohol disturbance, subjective alcohol intoxication, and negative consequences","authors":"Luke Herchenroeder ,&nbsp;Ellen W. Yeung","doi":"10.1016/j.drugalcdep.2025.112994","DOIUrl":"10.1016/j.drugalcdep.2025.112994","url":null,"abstract":"<div><h3>Background</h3><div>Food and alcohol disturbance (FAD) refers to restricting caloric intake prior to, or during a drinking episode to increase/quicken alcohol’s effects (FAD-intoxication) or to offset calories consumed from alcohol (FAD-calories). FAD is common among college students and is associated with alcohol-related harms cross-sectionally. However, to date there is limited research examining FAD’s association with negative alcohol-related consequences, as well as mechanisms linking FAD and negative consequences, at the event level.</div></div><div><h3>Basic procedure</h3><div>The present study utilized a within-person, day-level design to assess whether individuals reported higher levels of subjective alcohol intoxication on days when they engaged in FAD compared to drinking days absent of FAD. In turn, we examined whether increased subjective alcohol intoxication positively associated with same-day negative consequences. The sample included 72 college students (73.8 % female; 51.4 % White non-Hispanic; M_age=19.64) who completed up to two surveys daily (Wednesday-Sunday) for five weeks.</div></div><div><h3>Main findings</h3><div>For FAD-intoxication analyses, we found a significant mediation effect such that on days when students engaged in FAD-intoxication they reported higher subjective alcohol intoxication than on days when they consumed alcohol absent of FAD-intoxication. In turn, on days when students reported higher subjective alcohol intoxication they also reported more negative alcohol-related consequences. In contrast, the mediation effect for the FAD-calories model was not significant.</div></div><div><h3>Conclusions</h3><div>These findings further highlight the risk associated with engaging in FAD-intoxication and provides preliminary evidence that FAD-intoxication should be considered in interventions aiming to reduce event-level alcohol-related harms among college students.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"278 ","pages":"Article 112994"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher levels of naloxone protection are associated with lower risk-taking: A longitudinal analysis of New York City residents using unprescribed opioids","authors":"Luther Elliott ,&nbsp;Adrian Harris ,&nbsp;Dev Crasta ,&nbsp;Melody S. Goodman ,&nbsp;Yuyu Chen ,&nbsp;Saba Rouhani ,&nbsp;David Frank ,&nbsp;Jemar R. Bather ,&nbsp;Alex S. Bennett","doi":"10.1016/j.drugalcdep.2025.112989","DOIUrl":"10.1016/j.drugalcdep.2025.112989","url":null,"abstract":"<div><h3>Objective</h3><div>To apply risk compensation theory to naloxone peer access and evaluate whether reported naloxone <em>protection</em>—having naloxone and someone to administer it present when using unprescribed opioids—correlated with greater opioid overdose risk behaviors.</div></div><div><h3>Methods</h3><div>Longitudinal cohort of 422 NYC residents using unprescribed opioids who completed at least three monthly surveys over 24 months. Mixed-effects models estimated unadjusted and adjusted associations between naloxone protection and both opioid risk and overdose events and were used to test whether race/ethnicity and gender modified the relationship between naloxone protection and risk behaviors.</div></div><div><h3>Results</h3><div>Being protected 75 % of the time or more was identified as a meaningful cutoff in the sample and was associated with fewer opioid risk behaviors and overdose events. Race/ethnicity, but not gender, was found to be a significant effect modifier of naloxone protection.</div></div><div><h3>Conclusions</h3><div>Findings indicate no support for the risk compensation-derived hypothesis that people who use opioids while protected by naloxone pursue more overdose-associated risk behaviors than those unprotected.</div></div><div><h3>Policy implications</h3><div>Concerns about how naloxone may disinhibit people who use opioids, leading to greater risk-taking, appear unfounded, reaffirming the importance of universal naloxone access.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"278 ","pages":"Article 112989"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145692346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality and duration following the use and co-use of alcohol and cannabis in the daily life of community adults","authors":"Melissa Nance ,&nbsp;Mary Beth Miller ,&nbsp;Jarrod M. Ellingson ,&nbsp;Ryan W. Carpenter","doi":"10.1016/j.drugalcdep.2025.112946","DOIUrl":"10.1016/j.drugalcdep.2025.112946","url":null,"abstract":"<div><h3>Background</h3><div>Sleep-promotion is one of the most common reasons people use cannabis. Previous studies, primarily among young adults, suggest that cannabis use has negligible day-level effects on sleep but may attenuate alcohol’s negative effects when both substances are used. Studies among middle-aged/older adults are needed to determine the generalizability of these day-level associations.</div></div><div><h3>Methods</h3><div>This preregistered secondary data analysis examined daily-life associations between alcohol and cannabis use with next-day sleep quality and duration in a community sample of 48 adults (50 % female; age <em>M</em>=36.42, <em>SD</em>=10.96) reporting weekly alcohol and/or cannabis use. Participants completed ecological momentary assessments over 60 days. Multilevel models examined whether alcohol use, cannabis use, or alcohol-cannabis co-use (vs. no use) that day were associated with sleep quality and duration that night. Next, sleep quality and duration were examined as predictors of next-day craving and alcohol/cannabis use.</div></div><div><h3>Results</h3><div>Cannabis use was associated with longer sleep duration than days of alcohol use, co-use, or no use, which were not different from one another. Sleep quality did not differ following alcohol/cannabis use. Sleep quality and duration were not associated with next-day craving for alcohol or cannabis. Longer sleep duration was associated with higher likelihood of next-day cannabis use.</div></div><div><h3>Conclusions</h3><div>Community adults report sleeping ~15<!--> <!-->min longer on days of cannabis use, unless they also drank alcohol that day. This finding underscores the importance of examining co-use in daily life. Cannabis use demonstrated limited benefits for sleep, which should be evaluated in context with risk for increasing cannabis use over time.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112946"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Back on track: Feasibility and efficacy randomized trial of a two-week online self-guided intervention for cannabis use reduction","authors":"E. Kroon ,&nbsp;J.W.B. Elsey ,&nbsp;L.N. Kuhns ,&nbsp;P. Rietveld ,&nbsp;O. De Vries ,&nbsp;H. Larsen ,&nbsp;R.W.H.J. Wiers ,&nbsp;J. Cousijn","doi":"10.1016/j.drugalcdep.2025.112943","DOIUrl":"10.1016/j.drugalcdep.2025.112943","url":null,"abstract":"<div><h3>Background and aims</h3><div>Many individuals aiming to reduce or quit cannabis use prefer self-guided interventions over formal treatment. In this pilot and feasibility randomized trial, we tested a two-week self-guided online intervention combining multiple evidence-based behavior change approaches.</div></div><div><h3>Participants</h3><div>A total of 168 adults who used cannabis weekly, experienced severe cannabis use disorder on average, and reported being motivated to reduce or quit use participated in the baseline assessment and two-week follow-up of this international online intervention study. An additional three-month follow-up was included.</div></div><div><h3>Interventions</h3><div>Participants were randomized into three conditions: SMART goals alone (minimal intervention control), SMART +  mental contrasting with implementation intentions (MCII), or SMART +  MCII +  Cue-control.</div></div><div><h3>Measurements</h3><div>Participants set personal reduction or quit goals. We measured subjective goal achievement, objective goal achievement, and cannabis use reduction in grams per week.</div></div><div><h3>Findings</h3><div>Both intervention conditions outperformed the (minimal intervention) control condition in achieving subjective and objective reduction goals, with 69 % (MCII) and 60 % (MCII + Cue-control) meeting their objective targets compared to 49 % in the control condition. Adding Cue-control to MCII did not enhance outcomes compared to MCII alone. All conditions, including the control, reported similar reductions in cannabis use (grams per week) and these reductions were largely maintained at three-month follow-up. Two-week retention was high in the active intervention groups, especially in the MCII condition, highlighting the accessibility and appeal of the intervention.</div></div><div><h3>Conclusions</h3><div>This pilot and feasibility randomized trial showed promise of this intervention as an accessible and effective self-guided online cannabis reduction program.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112943"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific alterations in brain network topology in methamphetamine use disorder: A graph theory-based fMRI study","authors":"Cheng Xu ,&nbsp;Gangliang Zhong ,&nbsp;Xiyuan Zhang,&nbsp;Yicheng Wei,&nbsp;Xiaotong Li,&nbsp;Zhaoyang Xie,&nbsp;Hang Su,&nbsp;Jiang Du","doi":"10.1016/j.drugalcdep.2025.112952","DOIUrl":"10.1016/j.drugalcdep.2025.112952","url":null,"abstract":"<div><h3>Background</h3><div>Methamphetamine use disorder (MUD) imposes severe neurological and societal challenges, yet the sex-specific alterations in brain network topology remain poorly understood.</div></div><div><h3>Methods</h3><div>Resting-state fMRI data were acquired from 78 patients with MUD (49 male, 29 female) and 65 demographically matched healthy controls (HCs). Functional connectivity matrices were constructed using RESTplus V1.30, and graph metrics (global efficiency, nodal centrality) were computed using GRETNA V2.0.0. Group comparisons (MUD vs. HCs; male vs. female) and correlation analyses with Barratt Impulsiveness Scale scores were conducted, applying false discovery rate correction.</div></div><div><h3>Results</h3><div>Compared to HCs, patients with MUD exhibited disrupted nodal metrics across multiple brain regions, including bilateral anterior-inferior triangular regions, right gyrus rectus, left cuneus, bilateral supplementary motor areas, bilateral parietal regions, and occipital lobes, without significant alterations in global network metrics. Furthermore, significant sex-related main effects were observed in widespread brain areas, involving key nodal metrics such as degree centrality, local efficiency, clustering coefficient, and nodal efficiency. Female patients with MUD demonstrated higher global network measures and showed more extensive nodal metric differences compared to males. These findings highlight distinct sex-dependent network alterations in MUD and emphasize the need for sex-stratified therapeutic approaches targeting specific network vulnerabilities.</div></div><div><h3>Conclusion</h3><div>This study provides evidence of sexually dimorphic network pathology in MUD, revealing that females exhibit widespread front-parietal-occipital disruptions, whereas males demonstrate relative network preservation. These findings underscore the importance of sex-stratified therapeutic strategies targeting network-specific vulnerabilities in MUD.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112952"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversal of fentanyl-induced laryngospasm with ketanserin and naloxone: A prospective randomized blinded study in rats","authors":"Nora Digranes ,&nbsp;Emma Pettersson ,&nbsp;Andreas Lervik ,&nbsp;Inger Lise Bogen ,&nbsp;Jannike Mørch Andersen ,&nbsp;Janicke Nordgreen ,&nbsp;Henning Andreas Haga","doi":"10.1016/j.drugalcdep.2025.112969","DOIUrl":"10.1016/j.drugalcdep.2025.112969","url":null,"abstract":"<div><h3>Background</h3><div>Fentanyl can induce laryngospasm in humans and rats, a lethal effect if unresolved. The aim was to compare the effect of ketanserin, alone and combined with naloxone, to resolve fentanyl-induced laryngospasm in a rat model.</div></div><div><h3>Material</h3><div>Male Sprague-Dawley rats (n = 75) were instrumented with a venous catheter under isoflurane anesthesia before converting to IV α-chloralose (50–60<!--> <!-->mg<!--> <!-->kg⁻¹). Each rat was administered 25<!--> <!-->µg<!--> <!-->kg⁻¹ IV fentanyl or saline (Control) and further allocated to receive either 2<!--> <!-->mg<!--> <!-->kg⁻¹ ketanserin and 2<!--> <!-->mg<!--> <!-->kg⁻¹ naloxone (Fentanyl-Ketanserin-Naloxone), saline and 2<!--> <!-->mg<!--> <!-->kg⁻¹ naloxone (Fentanyl-Naloxone), 2<!--> <!-->mg<!--> <!-->kg⁻¹ ketanserin and saline (Fentanyl-Ketanserin), or two injections of saline (Fentanyl-Saline). Videos of the larynx were recorded by an endoscope positioned orally. The glottic diameter was measured retrospectively by a blinded observer. The effect of treatment on the change in glottic diameter from baseline after antagonist or saline injections was analyzed using a Wilcoxon Rank-Sum Test and a Bonferroni-corrected alpha of 0.01.</div></div><div><h3>Results</h3><div>Fentanyl reduced glottic opening to median −100 %. Median (IQR) changes in glottic opening were 51 % (10, 96), −13 % (-40, 10), −97 % (-100, −47) and −100 % (-100, −72) for Fentanyl-Ketanserin-Naloxone, Fentanyl-Naloxone, Fentanyl-Ketanserin and Fentanyl-Saline respectively. Fentanyl-Ketanserin-Naloxone was significantly different from Fentanyl-Naloxone, Fentanyl-Ketanserin and Fentanyl-Saline (p &lt; 0.001). Fentanyl-Naloxone was significantly different from Fentanyl-Saline (p &lt; 0.0001), no significant difference was found between Fentanyl-Ketanserin and Fentanyl-Saline.</div></div><div><h3>Conclusion</h3><div>Co-administration of ketanserin and naloxone resolved fentanyl-induced laryngospasm with an enhanced glottic opening compared to baseline. Findings suggest that both opioid and serotonergic mechanisms can be involved in fentanyl-induced laryngospasm.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112969"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145576582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of a method to compile a national list of cannabis dispensaries","authors":"Jennifer L. Pearson ,&nbsp;Luciana Borges ,&nbsp;Lyndsey A. Darrow ,&nbsp;Grant Nippler ,&nbsp;Abigail S. Friedman","doi":"10.1016/j.drugalcdep.2025.112964","DOIUrl":"10.1016/j.drugalcdep.2025.112964","url":null,"abstract":"<div><h3>Introduction</h3><div>Understanding how retail availability impacts cannabis attitudes and use requires data on the geographic distribution of cannabis dispensaries. However, with no single comprehensive source for dispensary locations, accurately mapping dispensaries presents unique challenges. This study’s purpose was to: 1) describe a systematic process for identifying dispensaries that can be applied nationwide using two unexplored resources—RefUSA and Google Maps; 2) compare the accuracy of these resources with three commonly used sources of location data – state regulatory lists, Weedmaps, and Potguide; and 3) examine whether accuracy varies by urbanicity.</div></div><div><h3>Methods</h3><div>We obtained dispensary lists from Google Maps, Weedmaps, Potguide, RefUSA, and state regulatory data in three zip codes in every state that had legal recreational cannabis marketplaces, calling the dispensaries to confirm that they were operational. We present sensitivity and positive predictive value (PPV) by list and by Rural-Urban Commuting Area Codes (RUCAs), using the call-verified dispensary list as the gold standard.</div></div><div><h3>Results</h3><div>Google Maps identified the greatest number of dispensaries (n = 264), had the best sensitivity of all lists (96.0 %; 95 % CI: 92.6, 99.2), and yielded the highest proportion of potentially unlicensed dispensaries (29 %). There were no clear trends in sensitivity or PPV by RUCA. Removing listings that Google Maps marked as closed or that lacked phone numbers increased PPV from 82.2 % (95 % CI: 77.0, 86.6) to 96.4 % (95 % CI: 93.1, 98.5) without decreasing sensitivity.</div></div><div><h3>Conclusions</h3><div>Google Maps currently offers the most accurate source of dispensary data for cross sectional analyses and performs equally well in urban and rural areas.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112964"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between cannabis use and romantic relationship satisfaction: The role of intensity, concordance, and sex differences","authors":"Aviya Ashwal-Malka ,&nbsp;Yoram Braw ,&nbsp;Hadar Nataf ,&nbsp;Daniel Feingold","doi":"10.1016/j.drugalcdep.2025.112956","DOIUrl":"10.1016/j.drugalcdep.2025.112956","url":null,"abstract":"<div><h3>Introduction</h3><div>The effect of cannabis use on romantic relationship satisfaction remains unclear, partly due to methodological shortcomings in earlier studies, such as the reliance on a single index of cannabis exposure.</div></div><div><h3>Methods</h3><div>In this study, we explored the association between an integrated frequency-by-quantity measure of cannabis use exposure and quality of romantic relationships, while addressing possible sex differences. 110 couples completed validated questionnaires assessing cannabis use patterns, general satisfaction with relationship quality, satisfaction with the quality of sex, and perceived partner responsiveness. The effects of between-partner concordance in cannabis use intensity on relationship quality were tested using multilevel linear regression analyses. Within-partner and between-partner effects of cannabis use intensity on relationship quality, as well as possible sex differences, were tested using the Actor-Partner Interdependence Model.</div></div><div><h3>Results</h3><div>Regression analyses indicated that a discrepancy in cannabis use intensity was negatively associated with general relationship satisfaction (β = −.19, <em>p</em> = .008) and with the quality of sex (β = −.16, <em>p</em> = .02). Dyadic analyses revealed significant Actor and Partner intensity ×  sex interactions related to the quality of romantic relationship. These interactions indicated that women who used cannabis at high intensity reported greater relationship satisfaction and perceived both their own and their partner's responsiveness as higher, whereas men reported the opposite.</div></div><div><h3>Conclusions</h3><div>Cannabis use intensity may have different effects on romantic relationship satisfaction for men and women. Further research is needed to uncover the nature of these differences.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112956"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145526319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}