Drug and alcohol dependence最新文献

{"title":"Retraction notice to \"Correlates of hazardous alcohol drinking among trans and non-binary people in Canada: A community-based cross-sectional study\" [Drug Alcohol Dependence 250 (2023) 110872]","authors":"Gioi Minh Tran , Nathan Lachowsky , Karen A. Urbanoski , Ayden I. Scheim , Greta R. Bauer","doi":"10.1016/j.drugalcdep.2025.112916","DOIUrl":"10.1016/j.drugalcdep.2025.112916","url":null,"abstract":"","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112916"},"PeriodicalIF":3.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An evaluation of paid social media advertising and traditional advertising for addiction research recruitment","authors":"Laura C. Chambers ,&nbsp;Tayla Giguere ,&nbsp;Ralph A. Welwean ,&nbsp;Alyssa M. Peachey ,&nbsp;Sarah E. Wiehe ,&nbsp;Matthew C. Aalsma ,&nbsp;Megan L. Ranney ,&nbsp;Francesca L. Beaudoin","doi":"10.1016/j.drugalcdep.2025.112923","DOIUrl":"10.1016/j.drugalcdep.2025.112923","url":null,"abstract":"<div><h3>Background</h3><div>Social media advertising may improve efficiency and reduce costs for research recruitment. However, few studies comparing social media-based and traditional recruitment methods aimed to recruit people with a history of substance use.</div></div><div><h3>Methods</h3><div>Between May 2022 and September 2024, we enrolled people in treatment and/or recovery from an opioid use disorder into a randomized trial of a mobile app-based peer recovery support program with six months of follow-up. We used multiple recruitment strategies including paid social media advertising (Facebook, Craigslist) and traditional methods (trial website, bus advertisements, flyers). We summarized cost per enrollment, enrollments per month, and the percentage of inquiries that were valid, valid inquiries that were from eligible people, and eligible people who enrolled by advertising modality.</div></div><div><h3>Results</h3><div>All measures of performance differed by modality (each P &lt; 0.01). Cost per enrollment was lowest for the trial website, flyers, and Craigslist ($0–$13.88) and highest for bus advertisements and Facebook ($101.30–$644.26). Recruitment rates were highest for Facebook and Craigslist (10.0–14.7 enrollments/month) and lowest for flyers, bus advertisements, and the trial website (2.9–6.2 enrollments/month). Craigslist was least likely to yield valid inquiries (59.0 % vs. 68.8 %–77.8 %). Valid inquiries from Facebook were least likely to be from eligible people (33.0 % vs. 53.8%–65.2 %), and eligible people identified through Facebook were least likely to enroll (55.2 % vs. 76.3%–91.1 %).</div></div><div><h3>Discussion</h3><div>Researchers recruiting a national sample of people with a history of substance use may maximize cost-effectiveness and efficiency by using a study website and paid Craigslist advertisements. Flyers may also be highly cost-effective for local recruitment.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112923"},"PeriodicalIF":3.6,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous alcohol and cannabis use is associated with daily consequences reflective of alcohol use disorder symptoms","authors":"Lindy K. Howe ,&nbsp;Olivia L. Bolts ,&nbsp;Jane Metrik ,&nbsp;Rachel L. Gunn","doi":"10.1016/j.drugalcdep.2025.112924","DOIUrl":"10.1016/j.drugalcdep.2025.112924","url":null,"abstract":"<div><div>Alcohol use is common in the U.S., with 10.9 % of adults meeting criteria for alcohol use disorder (AUD) in 2023. Co-use of alcohol and cannabis is also widespread and is associated with increased alcohol-related harms. Few studies have examined how different co-use patterns, such as simultaneous (same day use with overlapping effects) versus concurrent (same day use without overlapping effects) use affect alcohol-related consequences, particularly those reflecting AUD symptoms. This study compares the associations between daily simultaneous, concurrent, and alcohol-only use patterns with the likelihood of endorsing alcohol consequences categorized as AUD symptoms. Participants (<em>N</em> = 116, 56 % female at birth, M_age=23.2) completed a 28-day ecological momentary assessment study, reporting daily alcohol and cannabis use and alcohol-related negative consequences. Analyses were preregistered. Consequences were categorized into four AUD categories based on DSM-5 criteria: impaired control, social impairment, risky use, and pharmacological effects. Multilevel binomial logistic regressions assessed the relationship between daily substance use patterns and each AUD consequence subtype. Compared to simultaneous use, concurrent use (i.e. using in the same day but without overlapping effects) was associated with a lower likelihood of endorsing (all p &lt; 0.05): impaired control (OR=0.45), social impairment (OR=0.47), risky use (OR=0.41), and pharmacological effects (OR=0.36). No significant differences were found between simultaneous and alcohol-only days. Results underscore the relevance of the timing and pattern of alcohol and cannabis co-use in understanding alcohol-related problems. Further research is needed to explore the clinical implications of concurrent versus simultaneous use for AUD prevention and treatment.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112924"},"PeriodicalIF":3.6,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross sectional multi-sample study of nonfatal overdose in adolescents and young adults in the fentanyl era","authors":"Amy M. Yule ,&nbsp;Amy S.B. Bohnert ,&nbsp;Ty A. Ridenour ,&nbsp;Barrett Montgomery ,&nbsp;Timothy E. Wilens ,&nbsp;Maureen Walton ,&nbsp;Erin E. Bonar ,&nbsp;Lisa Saldana ,&nbsp;Lynn E. Fiellin ,&nbsp;Danica K. Knight ,&nbsp;Yang Yang ,&nbsp;Jason Williams ,&nbsp;Sazid Khan ,&nbsp;Liann Tucker ,&nbsp;Feker Wondimagegnehu ,&nbsp;Kym Ahrens","doi":"10.1016/j.drugalcdep.2025.112921","DOIUrl":"10.1016/j.drugalcdep.2025.112921","url":null,"abstract":"<div><h3>Introduction</h3><div>Overdose deaths disproportionately increased among adolescents and young adults (AYA) between 2019 and 2022, despite declining substance use. We examined the prevalence of nonfatal overdose and characteristics associated with overdose history in AYA.</div></div><div><h3>Methods</h3><div>AYA enrolled between 2020 and 2023 in five opioid use disorder prevention studies in child welfare, healthcare, and legal settings from six states were included in this analysis. Nonfatal overdose history, demographic, and clinical characteristics were assessed at baseline. Across studies, overdose history was assessed with slight variations in wording, but most other measures were standardized. Odds ratios (OR) of lifetime overdose were calculated with logistic regression for each risk factor with demographic control variables (age, sex, race) included as covariates, and reported separately by sample.</div></div><div><h3>Results</h3><div>Sample sizes ranged from 137 to 929 (total N = 1856). Characteristics across samples ranged from <em>M</em> = 16.2–26.4 years for age, and 11.7–91.9 % for female sex. For race, samples ranged from 35 % to 89.4 % White and 17.3–89.4 % Black. History of nonfatal overdose ranged from 6.6 % to 41.4 %. Statistically significant characteristics associated with overdose history in all samples included history of opioid misuse (ORs ranging from 1.98 to 6.73) and family members with a substance use problem (ORs range from 1.27 to 2.05). Frequent and early onset alcohol and cannabis use was also associated with overdose history in several samples.</div></div><div><h3>Conclusions</h3><div>Overdose prevention interventions for AYA should include a focus on AYA who misuse opioids and families with a history of substance use problems.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112921"},"PeriodicalIF":3.6,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing stigma and bias in perinatal substance use care: A training for obstetric and neonatal providers","authors":"Karli S. Swenson,&nbsp;Katie Breen","doi":"10.1016/j.drugalcdep.2025.112913","DOIUrl":"10.1016/j.drugalcdep.2025.112913","url":null,"abstract":"<div><h3>Background</h3><div>Accidental overdose is the second leading cause of death among pregnant and postpartum individuals in Colorado, with substance use disorders (SUD) contributing significantly to maternal morbidity. Stigma and bias from healthcare providers exacerbate these challenges, leading to suboptimal care and reduced access to essential resources. Few interventions aim to reduce such biases in healthcare settings. Here, we aim to evaluate the impact of a 90-minute live, virtual or in person training on reducing stigma and bias among healthcare providers caring for patients with perinatal SUD.</div></div><div><h3>Methods</h3><div>This modified pre-post intervention study enrolled obstetric and neonatal healthcare professionals who completed a training developed by the Colorado Perinatal Care Quality Collaborative (CPCQC) in partnership with experts with lived experience of perinatal SUD. The training focused on evidence-based education, stigma and bias reduction, and patient-centered strategies informed by lived experiences. Outcomes were assessed, a modified pre-post-training knowledge and comfortability survey using Likert scales and open response questions, and post-training qualitative feedback.</div></div><div><h3>Results</h3><div>Participants (n = 549) demonstrated statistically significant improvements in response scores (p &lt; 0.05), indicating reduced stigma and bias toward perinatal patients with SUD. Qualitative feedback highlighted the training’s relevance and impact, with participants emphasizing the value of integrating lived experiences into educational initiatives.</div></div><div><h3>Conclusions</h3><div>This study demonstrates potential effectiveness of a brief, virtual training in reducing stigma and bias among healthcare providers caring for patients with perinatal SUD based on self-report. The findings underscore the importance of incorporating lived-experience expertise into training programs to promote equitable and compassionate care.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112913"},"PeriodicalIF":3.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in quality of life during 52 weeks of extended-release naltrexone treatment, subsequent by a 1-year post-treatment period","authors":"Christina L. Redondo ,&nbsp;Bente Weimand ,&nbsp;Jūratė Šaltytė Benth ,&nbsp;John-Kåre Vederhus ,&nbsp;Jon Mordal ,&nbsp;Asle Enger ,&nbsp;Lars Tanum ,&nbsp;Kristin Klemmetsby Solli","doi":"10.1016/j.drugalcdep.2025.112917","DOIUrl":"10.1016/j.drugalcdep.2025.112917","url":null,"abstract":"<div><h3>Background</h3><div>This study investigates changes in quality of life (QoL) among individuals with opioid use disorder (OUD) undergoing extended-release naltrexone (XR-NTX) treatment for 52 weeks, subsequent by a 1-year post-treatment period.</div></div><div><h3>Methods</h3><div>Conducted as a naturalistic, multicenter, open-label clinical trial across five urban hospitals in southern Norway, this observational study enrolled 158 participants with severe OUD. Participants received XR-NTX treatment for up to 52 weeks, with QoL assessed using the WHOQOL-BREF instrument at five time points during treatment and twice during the post-treatment period. The Addiction Severity Index, European version (EuropASI) was used to measure covariates. A linear mixed model was employed to analyze trends in QoL, adjusting for mental distress severity and substance use severity.</div></div><div><h3>Results</h3><div>Significant improvements in QoL were observed in the physical, psychological, social and environmental domains during the XR-NTX treatment, with less pronounced changes in the environmental domain. Mental distress and substance use severity were negatively associated with QoL scores. The most substantial QoL improvements occurred within the first year of treatment, with overall perceived QoL remaining stable during the 1-year post-treatment period.</div></div><div><h3>Conclusions</h3><div>This study highlights XR-NTX as a beneficial treatment option for enhancing QoL in individuals with OUD. The findings support the integration of XR-NTX into OUD treatment plans and emphasize the need for further research to explore long-term outcomes and the impact of external factors on QoL.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112917"},"PeriodicalIF":3.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The socioeconomic, health, and family situation of adult siblings of patients with substance use diagnosis: A descriptive registry study","authors":"Torleif Halkjelsvik ,&nbsp;Solveig Glestad Christiansen ,&nbsp;Inger Synnøve Moan ,&nbsp;Øystein Kravdal","doi":"10.1016/j.drugalcdep.2025.112918","DOIUrl":"10.1016/j.drugalcdep.2025.112918","url":null,"abstract":"<div><h3>Background</h3><div>Few studies have considered the characteristics of adult siblings of individuals with substance use diagnosis. We report on their family situation, labour market attachment, education, and healthcare utilisation.</div></div><div><h3>Methods</h3><div>Using Norwegian register data, we identified 131,249 siblings of individuals with substance use diagnoses recorded between 2008 and 2018 (‘SUD-Siblings’). A subsample of 112,320 siblings with no substance use diagnosis themselves ('SUD Siblings_Excl') was matched by age and gender to a comparison group with no substance use diagnosis among either the individuals or their siblings (‘Comparison’). We compared proportions and means.</div></div><div><h3>Results</h3><div>SUD-Siblings_Excl were more often divorced (13.8 %) than the Comparison group (11.3 %), fewer had work as the main income source (75.3 % vs. 83.3 %), and a larger share received disability pension (13.8 % vs. 8.6 %) or had sickness absence (23.2 % vs. 19.2 %). A greater proportion had consulted a general practitioner (75.2 % vs. 71.6 %), especially relating to mental health (17.4 % vs. 12.6 %) and musculoskeletal issues (29.9 % vs. 26.7 %). Hospital admissions were more common (8.5 % vs. 7.1 %; p-values of all above comparisons &lt;.001).</div></div><div><h3>Conclusions</h3><div>Adult siblings of individuals with substance use diagnosis face substantial challenges compared to individuals without siblings with such diagnoses. They are more likely to be divorced, less likely to have work as their main income source, and show higher levels of health challenges, as indicated by higher sickness absence, disability pension rates, and healthcare use.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112918"},"PeriodicalIF":3.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unhealthy alcohol use detection in electronic health records: A comparative study using natural language processing","authors":"Xintong Ju ,&nbsp;Jake Solka ,&nbsp;Katherine Weber ,&nbsp;VG Vinod Vydiswaran ,&nbsp;Lewei Allison Lin ,&nbsp;Erin E. Bonar ,&nbsp;Anne C. Fernandez","doi":"10.1016/j.drugalcdep.2025.112920","DOIUrl":"10.1016/j.drugalcdep.2025.112920","url":null,"abstract":"<div><h3>Background</h3><div>Unhealthy alcohol use, including risky alcohol use and alcohol use disorder (AUD), are under-identified in primary care settings. Natural Language Processing (NLP) is a promising approach that could identify unhealthy alcohol use from clinical notes even when structured data (SD) indicators are lacking. This study prospectively evaluated the performance of SD and NLP in identifying unhealthy alcohol use in primary care patients.</div></div><div><h3>Methods</h3><div>We extracted electronic health record (EHR) data of primary care patients at a large Midwestern Health System (N = 133,144) and applied two identification approaches; an SD approach (i.e., diagnostic codes and alcohol screening scores) and an NLP-based approach. We then recruited N = 170 participants identified by SD (N = 85) or NLP (N = 85) to complete gold-standard self-report measures and compared the number of positive cases identified by each method.</div></div><div><h3>Results</h3><div>In the full EHR sample, SD identified 820 cases of unhealthy alcohol use, and NLP identified 48,262 cases with unhealthy alcohol use. Among participants identified by SD, 41.18 % reported AUD, and 28.82 % reported risky alcohol use. Among those identified by NLP, 20 % reported AUD and 27.06 % reported risky alcohol use. Participants identified by SD had more AUD symptoms and mental health difficulties.</div></div><div><h3>Conclusions</h3><div>NLP identified many primary care patients with indicators of unhealthy alcohol use that SD missed, indicating NLP could substantially expand identification of unhealthy alcohol use in primary care populations, particularly those with lower severity alcohol use disorder. NLP could complement traditional screening methods for comprehensive unhealthy alcohol use detection.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"277 ","pages":"Article 112920"},"PeriodicalIF":3.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation opportunities for optimizing retention on buprenorphine treatment for people with opioid use disorder in West Virginia","authors":"Roman Ivasiy ,&nbsp;Lynn M. Madden ,&nbsp;Judith Feinberg ,&nbsp;Matthew Q. Christiansen ,&nbsp;Jessica Haas ,&nbsp;Kimberly A. Johnson ,&nbsp;Eteri Machavariani ,&nbsp;Bernadine Kwan ,&nbsp;Robert Lane ,&nbsp;Natalie Kil ,&nbsp;Frederick L. Altice","doi":"10.1016/j.drugalcdep.2025.112914","DOIUrl":"10.1016/j.drugalcdep.2025.112914","url":null,"abstract":"<div><h3>Background</h3><div>West Virginia leads the U.S. in overdose-related deaths, which can be decreased through buprenorphine treatment of opioid use disorder. Expanding buprenorphine benefits requires retaining patients in treatment. We explored prescribing real-world practices that affect retention.</div></div><div><h3>Methods</h3><div>We analyzed data from the West Virginia Prescription Drug Monitoring Program for individuals newly initiating buprenorphine in 2022. The primary outcome was time to treatment discontinuation. Baseline covariates included age, sex, and payment method. Dosage and days supplied were assessed at baseline to evaluate treatment initiation practices and as time-dependent measures to examine longitudinal patterns. Proportional hazards models with gamma frailty were used to estimate adjusted hazard ratios (aHRs).</div></div><div><h3>Results</h3><div>The 6686 individuals who initiated buprenorphine were in their late thirties (mean 37.8 years) and mostly male (54.3 %). Relative to lower initial dosages (&lt;8<!--> <!-->mg) and a shorter initial supply (&lt;7 days), higher initial dosages of 8–15<!--> <!-->mg (aHR=0.75, 95 %CI:0.68–0.82) and ≥ 16<!--> <!-->mg (aHR=0.67, 95 %CI:0.61–0.74) and longer initial prescription of 7–13 days (aHR=0.75; 95 %CI:0.68–0.81), 14–27 days (aHR=0.43; 95 %CI:0.35–0.52) and, especially ≥ 28 days (aHR=0.31; 95 %CI:0.26–0.37), significantly reduced discontinuation risk (p &lt; 0.001). In the time-dependent models with dosages and days of medication supplied changing over time, the protective effect significantly increased for higher dosages (≥16<!--> <!-->mg: aHR=0.45; 95 %CI:0.40–0.50) and number of days supplied (≥28 days: aHR=0.10; 95 %CI:0.10–0.11), p &lt; 0.0001. Discontinuation was higher for younger persons, males, and those paying out-of-pocket; public insurance reduced the risk.</div></div><div><h3>Conclusion</h3><div>Higher buprenorphine doses and extended take-home dosing substantially improved retention, especially at initiation. To combat West Virginia’s opioid crisis, clinicians should adjust prescribing practices accordingly.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112914"},"PeriodicalIF":3.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis use disorder risks among Medicaid enrollees with comorbid psychiatric illnesses: 2012–2021","authors":"Jialin Hou ,&nbsp;Jeffery C. Talbert ,&nbsp;Jayani Jayawardhana","doi":"10.1016/j.drugalcdep.2025.112915","DOIUrl":"10.1016/j.drugalcdep.2025.112915","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine trends in prevalence of cannabis use disorder (CUD) among Medicaid enrollees with and without comorbid psychiatric illnesses - depression, anxiety, or insomnia - overall and by sex and age subgroups.</div></div><div><h3>Methods</h3><div>Medicaid enrollees aged 18–64 in the Merative Multi-state Claims and Encounters Database with diagnoses of CUD and comorbid psychiatric illnesses - depression, anxiety, or insomnia - from 2012 to 2021 were examined using a multi-variate logit regression adjusting for sex, age, and race. Additionally, CUD and comorbid chronic pain diagnosis for the same population were examined as a comparison. We estimated the changes in the prevalence of CUD among enrollees with and without depression, anxiety, or insomnia.</div></div><div><h3>Results</h3><div>From 2012–2021, the predicted prevalence of CUD among enrollees with depression, anxiety, and insomnia as a comorbidity increased by 1.04 (p &lt; 0.001), 1.36 (p &lt; 0.001), 1.64 (p &lt; 0.001) times compared to the enrollees without those comorbidities, respectively, while the predicted prevalence of CUD among enrollees with chronic pain reduced by 0.90 (p &lt; 0.001) times compared to those without chronic pain. Relative increases in the predicted prevalence of CUD were higher among females and those aged 35–64 with anxiety and depression, and among males and those aged 21–34 with insomnia.</div></div><div><h3>Conclusions</h3><div>Medicaid enrollees with depression, anxiety, or insomnia were increasingly more likely to experience CUD diagnoses for the past decade compared to those without the condition. Further research is needed to understand the mechanism between cannabis use and psychiatric illnesses and curb the rising CUD associated with comorbid psychiatric illnesses.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112915"},"PeriodicalIF":3.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145262374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}