Drug and alcohol dependence最新文献

{"title":"Intermittent theta burst to the left dorsolateral prefrontal cortex promoted decreased alcohol consumption and improved outcomes in those with alcohol use disorder: A randomized, double-blind, placebo-controlled clinical trial","authors":"Timothy C. Durazzo ,&nbsp;Eric P. Kraybill ,&nbsp;Lauren H. Stephens ,&nbsp;Daniel M. McCalley ,&nbsp;Keith Humphreys ,&nbsp;April C. May ,&nbsp;Claudia B. Padula","doi":"10.1016/j.drugalcdep.2025.112641","DOIUrl":"10.1016/j.drugalcdep.2025.112641","url":null,"abstract":"<div><h3>Background</h3><div>Over 60 % of individuals with alcohol use disorder (AUD) resume hazardous drinking within 6 months post-treatment, necessitating the development of more efficacious interventions. Accumulating evidence suggests transcranial magnetic stimulation (TMS) is a promising intervention for AUD. This randomized, double-blind, placebo-controlled trial assessed the efficacy of intermittent theta burst (iTBS), a form of TMS, as an adjunct treatment for AUD.</div></div><div><h3>Methods</h3><div>Forty-nine Veterans with AUD (48 males, 1 female) were recruited from residential AUD and substance use disorder treatment. Participants were randomized to 20 sessions of Active (n = 25) or Sham (n = 24) iTBS (1200 pulses/session), targeting the left dorsolateral prefrontal cortex (DLPFC) administered over 14 days or less. Five participants were withdrawn unrelated to iTBS procedure adverse events. Participant alcohol/substance use was monitored for 6-months following final iTBS session.</div></div><div><h3>Results</h3><div>Relative to participants who received Sham iTBS, those who received Active iTBS showed a significantly greater reduction in percent heavy drinking days and a trend for higher rate of continuous abstinence over 6-months. Among participants who resumed alcohol consumption, those in the Active group demonstrated significantly lower quantity and duration of alcohol consumption than Sham. Pre-study alcohol consumption variables were not related to post-iTBS treatment outcomes.</div></div><div><h3>Conclusions</h3><div>Findings indicated that Active left DLPFC iTBS, delivered over approximately 2-weeks, was a safe and efficient intervention for AUD that promoted significantly reduced heavy drinking and improved clinical outcomes compared to Sham over 6-months post-iTBS. This study provides novel data to inform and power future larger-scale, multi-site clinical trials employing iTBS for AUD.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"270 ","pages":"Article 112641"},"PeriodicalIF":3.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing inequities in buprenorphine treatment across the care cascade","authors":"Alyssa S. Tilhou ,&nbsp;Sarah Gasman ,&nbsp;Jiayi Wang ,&nbsp;Katherine Standish ,&nbsp;Laura F. White ,&nbsp;Ally Cogan ,&nbsp;Morgan Devlin ,&nbsp;Marc Larochelle ,&nbsp;William G. Adams","doi":"10.1016/j.drugalcdep.2025.112636","DOIUrl":"10.1016/j.drugalcdep.2025.112636","url":null,"abstract":"<div><h3>Objective</h3><div>Describe buprenorphine treatment gaps across the care cascade by race, ethnicity, age, sex and key clinical characteristics.</div></div><div><h3>Design</h3><div>Observational cohort study of new opioid use disorder (OUD) treatment episodes, 1/1/15–12/31/21</div></div><div><h3>Participants</h3><div>Individuals 16–89 years at Boston Medical Center and affiliated Boston-area clinics with OUD or buprenorphine prescription following 90-day washout</div></div><div><h3>Main outcomes and measures</h3><div>Buprenorphine initiation (by 14d), engagement (second prescription by 34d), and retention (continuous buprenorphine through 180d without &gt;14d gap). Covariates: sex, race and ethnicity, age, past 12-month buprenorphine, past 12-month overdose, co-occurring substance use disorder (SUD) and psychiatric diagnosis.</div></div><div><h3>Results</h3><div>24,165 episodes (14,182 individuals) included the following characteristics: female (34.1 %); Black (21.5 %), Latino (16.2 %), White (59.2 %); 16–25 years (4.1 %), 65–89 years (4.9 %). Initiation, engagement and retention were low: 39.3 %, 19.3 %, and 12.4 %. In adjusted models, compared with males, females’ lower probability of overall retention reflected lower engagement conditional on initiation (41 % vs. 53 %; OR:0.61, 95 %CI:0.56–0.67, p &lt; 0.001). Black individuals’ lower probability of retention overall reflected lower initiation than White individuals (28 % vs 44 %; OR:0.50, 95 %CI:0.46–0.55, p &lt; 0.001). The retention disadvantage for younger and older groups reflected cascade-wide gaps. Lower overall retention associated with co-occurring SUDs reflected lower initiation (OUD only:46 %; OUD plus: alcohol:19 % OR:0.27, 95 %CI:0.21–0.34, p &lt; 0.001; sedatives:21 %, OR:0.31, 95 %CI:0.20–0.49, p &lt; 0.001; stimulants:25 %, OR:0.40, 95 %CI:0.33–0.48, p &lt; 0.001; ≥3 SUDs:25 %, OR:0.40, 95 %CI:0.37–0.43, p &lt; 0.001).</div></div><div><h3>Conclusions and relevance</h3><div>Inequities in buprenorphine use emerged across the care cascade with unique patterns by sociodemographic and clinical subgroup. Health systems aiming to reduce buprenorphine inequities should identify the optimal cascade step based on the population of interest.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"270 ","pages":"Article 112636"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-fatal opioid overdose and unmet need for medications for opioid use disorder among recently incarcerated people who inject drugs","authors":"Valerie Madera-Garcia ,&nbsp;Dita Broz ,&nbsp;Amy R. Baugher ,&nbsp;Rebecca B. Hershow ,&nbsp;Sharoda Dasgupta ,&nbsp;Alice Asher ,&nbsp;Rose Hefferon ,&nbsp;Nancy Worthington ,&nbsp;Susan Cha ,&nbsp;for the NHBS Study Group","doi":"10.1016/j.drugalcdep.2025.112634","DOIUrl":"10.1016/j.drugalcdep.2025.112634","url":null,"abstract":"<div><h3>Background</h3><div>Medications for opioid use disorder (MOUD) are key to preventing opioid overdose. Despite the high risk of opioid overdose among recently incarcerated people who use drugs, missed opportunities for engagement in MOUD treatment persist in this population. We examined the association between unmet need for MOUD and non-fatal opioid overdose among recently incarcerated people who inject drugs (PWID) and assessed prevalence of non-fatal opioid overdose by selected characteristics.</div></div><div><h3>Methods</h3><div>We analyzed 2022 data from the National HIV Behavioral Surveillance (NHBS) system among PWID from 20 large U.S. cities. Adjusted prevalence ratios (aPR) and 95 % confidence intervals (95 % CI) were calculated to examine the association between unmet need for MOUD and non-fatal opioid overdose.</div></div><div><h3>Results</h3><div>Among 1648 recently incarcerated PWID, 28 % reported an unmet need for MOUD and 39 % reported a non-fatal opioid-involved overdose in the past 12 months. Experiencing homelessness in the last 12 months (aPR=1.43, 95 % CI=1.27–1.61) and living in the Midwest region of the U.S. (aPR=1.18, 95 % CI=1.01–1.38) were significantly associated with reporting a non-fatal opioid overdose. Recently incarcerated PWID with an unmet need for MOUD were 1.4 times as likely to report a non-fatal opioid overdose in the past 12 months (50 %; aPR=1.42, 95 % CI=1.29–1.56) compared with recently incarcerated PWID without an unmet need for MOUD (35 %).</div></div><div><h3>Conclusions</h3><div>Unmet need for MOUD was significantly associated with non-fatal opioid overdose among PWID who were incarcerated in the past 12 months, suggesting the need to investigate specific strategies to improve to MOUD treatment among recently incarcerated PWID.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"270 ","pages":"Article 112634"},"PeriodicalIF":3.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental enrichment attenuates reinstatement of heroin seeking and reverses heroin-induced upregulation of mesolimbic ghrelin receptors","authors":"Apoorva Vashisht ,&nbsp;George Adamson ,&nbsp;Zuzu Gacso ,&nbsp;Joseph Slama ,&nbsp;Matthew Freund ,&nbsp;Sneha Vinod ,&nbsp;Natalie Sandoval ,&nbsp;Ziv Nachshon ,&nbsp;Sami Gubin ,&nbsp;Elizabeth Corso ,&nbsp;Zhi-Bing You ,&nbsp;Robert Ranaldi ,&nbsp;Ewa Galaj","doi":"10.1016/j.drugalcdep.2025.112635","DOIUrl":"10.1016/j.drugalcdep.2025.112635","url":null,"abstract":"<div><div>We have shown that environmental enrichment (EE) can effectively reduce reinstatement and facilitate true abstinence in animal models of drug use. Here, we investigated whether EE is effective against reinstatement of heroin seeking in long access (LA) model, which has been argued to capture the compulsive features of human drug addiction. We also explored the neurobiology by which EE produces its anti-drug addiction effects. In particular, we focused here on the ghrelin system, which is known for its involvement in reward-motivated behaviors and upregulation following intravenous drug self-administration. Following LA to heroin, rats were housed in either non-EE or EE conditions. During extinction and cue-induced reinstatement test, EE rats showed a significant reduction in active lever responding compared to non-EE rats, suggesting that EE facilitates extinction of drug seeking and reduces the capacity of drug-associated stimuli to elicit and maintain drug seeking. Using Western Blotting, we found that rats with LA to heroin IVSA showed a significant increase in ghrelin receptor (GHS-R1a) expression in the ventral tegmental area and nucleus accumbens, the brain regions implicated in resumption of drug use . Exposure to EE attenuated heroin-induced upregulation of GHS-R1a receptor in these regions but produced no significant changes other brain regions. Our findings suggest that EE can be an effective behavioral approach to diminish drug seeking even following LA to heroin. Compulsive drug taking and seeking seem to be correlated with an upregulation of GHS-R1a expression in the limbic regions, and EE can reverse these neuroadaptations, potentially contributing to a reduction in drug seeking.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"270 ","pages":"Article 112635"},"PeriodicalIF":3.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adapting and applying tobacco dependence indicators to cannabis dependence","authors":"Robert J. Wellman ,&nbsp;David R. Strong ,&nbsp;Erin K. O'Loughlin ,&nbsp;Marie-Pierre Sylvestre ,&nbsp;Jennifer L. O’Loughlin","doi":"10.1016/j.drugalcdep.2025.112613","DOIUrl":"10.1016/j.drugalcdep.2025.112613","url":null,"abstract":"<div><h3>Objectives</h3><div>Dependence on addictive substances is indicated by impaired control, strong desires/craving, withdrawal symptoms with abstinence, challenges with quitting, etc. Most measures of dependence are substance-specific, which inhibits comparisons across substances. In light of increasing prevalence of cannabis and tobacco co-use, we aimed to adapt indicators of tobacco dependence to assess cannabis dependence (CD).</div></div><div><h3>Methods</h3><div>In 2024, past-year cannabis consumers (<em>n</em> = 320; <em>M</em>age = 35) from an ongoing 24-year longitudinal study completed self-report questionnaires. We examined the factor structure and measurement invariance across sex of the adapted 15-item scale, assessed the likelihood of endorsing and discriminative power of each item in participants with different degrees of CD, and explored the internal consistency, and construct and criterion-related validity of the scale.</div></div><div><h3>Results</h3><div>Items loaded strongly on a single factor, and strict measurement invariance across sex was confirmed. Items demonstrated strong discriminative power among individuals with varying degrees of CD. The scale demonstrated high internal consistency (ω_cat=0.94), excellent convergent reliability (<em>r</em> = 0.76 with the Cannabis Abuse Screening Test), and a small though statistically significant inverse correlation with age at first use (<em>ρ</em>=−0.20). There was a dose-response relationship with frequency of cannabis use (<em>ρ</em>=0.81).</div></div><div><h3>Conclusions</h3><div>The adapted scale has excellent psychometric properties and is invariant across sex. Additional research is needed to determine whether these properties hold with larger and more diverse samples and across types of cannabis products (e.g., leaf, edibles, hashish). The scale may permit direct comparison of dependence across tobacco vs. cannabis consumers.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"270 ","pages":"Article 112613"},"PeriodicalIF":3.9,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive interventions for alcohol misuse and violent behaviors among adolescents and emerging adults in the emergency department: Outcomes from a sequential multiple assignment randomized controlled trial","authors":"Maureen A. Walton ,&nbsp;Laura Seewald ,&nbsp;Patrick M. Carter ,&nbsp;Quyen Ngo ,&nbsp;Frederic C. Blow ,&nbsp;Carrie Bourque ,&nbsp;Claire Pearson ,&nbsp;Katherine A. Battisti ,&nbsp;Larry An ,&nbsp;Mari Wank ,&nbsp;Yanruyu Zhu ,&nbsp;Kelley M. Kidwell","doi":"10.1016/j.drugalcdep.2025.112615","DOIUrl":"10.1016/j.drugalcdep.2025.112615","url":null,"abstract":"<div><h3>Introduction</h3><div>Harnessing technology for delivery of behavioral health interventions to reduce alcohol use and aggression may reduce morbidity among youth. This paper describes the outcomes from a sequential, multiple assignment, randomized trial (SMART) testing interventions for youth (ages 14–20) in the emergency department (ED).</div></div><div><h3>Methods</h3><div>Youth (n = 400) in the ED screening positive for binge drinking and aggression received the SafERteens brief intervention (BI) and were randomly assigned to boosters: Text Messages (TM) or Health Coach (HC) (1st stage; weeks 1–4). Participants completed 8 weekly surveys, with outcomes assessed at 4- and 8-months. After the 1st stage, response/non-response was determined (e.g., binge drinking or aggression). Responders were re-randomized to continued or minimized condition; non-responders were re-randomized to continued or intensified condition (2nd stage; weeks 5–8). Analyses examined outcomes from the initial randomization; and comparisons between responders and non-responders on primary (alcohol consumption, aggression), secondary (alcohol consequences, violence consequences) and exploratory (alcohol misuse, victimization, drug use, drug consequences) outcomes.</div></div><div><h3>Results</h3><div>There were no significant differences in outcomes between 1st stage boosters or 2nd stage boosters for non-responder or responder groups. However, significant changes over time were observed across all participants, with the odds of abstaining from alcohol increased at 4 (OR 3.97, 95 % CI 2.46–6.41) and 8-months (OR 4.36, 95 % CI 2.11–9.02), while the odds of aggression (OR 0.39, 95 % CI 0.16–0.94) decreased at 8-months; significant decreases were also observed for other outcomes.</div></div><div><h3>Conclusions</h3><div>Findings support the promise of digital health interventions for youth with binge drinking and aggression.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"270 ","pages":"Article 112615"},"PeriodicalIF":3.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient–navigator working alliance and hepatitis C treatment cascade outcomes among persons who inject drugs: The HERO study","authors":"Snehal S. Lopes ,&nbsp;J. Edward Dotherow ,&nbsp;Irene Pericot-Valverde ,&nbsp;Paula J. Lum ,&nbsp;Lynn E. Taylor ,&nbsp;Shruti H. Mehta ,&nbsp;Judith I. Tsui ,&nbsp;Judith Feinberg ,&nbsp;Arthur Y. Kim ,&nbsp;Brianna L. Norton ,&nbsp;Kimberly Page ,&nbsp;Cristina Murray-Krezan ,&nbsp;Jessica Anderson ,&nbsp;Alison Karasz ,&nbsp;Julia Arnsten ,&nbsp;Phillip Moschella ,&nbsp;Moonseong Heo ,&nbsp;Alain H. Litwin ,&nbsp;the HERO study group","doi":"10.1016/j.drugalcdep.2025.112617","DOIUrl":"10.1016/j.drugalcdep.2025.112617","url":null,"abstract":"<div><h3>Introduction</h3><div>Integrating patient navigation (PN) interventions in hepatitis C virus (HCV) elimination efforts enhances HCV treatment cascade outcomes from screening to cure. Nonetheless, little is known about how the patient–navigator working alliance influences the effectiveness of PN interventions. This study among persons who inject drugs (PWID) living with HCV aimed to assess the association between patient–navigator working alliance and HCV treatment cascade outcomes.</div></div><div><h3>Methods</h3><div>This study utilized the Hepatitis C Real Options (HERO) study data for a subset of participants from the PN arm who responded to the patient–navigator working alliance survey at the end-of-treatment timepoint (N = 227). Working alliance was measured using the 16-item Brief Alliance Inventory (BAI). The average BAI overall and subscales (‘bonds’ and ‘tasks/goals’) scores were calculated. Outcomes included sustained virologic response (SVR), HCV treatment adherence, duration, completion and HCV reinfection. Linear and logistic regression models were used for continuous and binary outcomes, respectively.</div></div><div><h3>Results</h3><div>Stronger overall working alliance was associated with a higher likelihood of achieving SVR [aOR (95 % CI) = 6.31 (1.68, 23.77); p = .007]. Similarly, the likelihood of SVR was higher for stronger ‘bonds’ [7.65 (1.79, 32.76); p = .006] and 'tasks/goals’ [4.50 (1.35, 15.02); p = .014] working alliance. However, working alliance was not significantly associated with the other outcomes.</div></div><div><h3>Discussion</h3><div>A stronger patient–navigator working alliance is associated with achieving HCV cure but not treatment adherence or completion. More studies are needed to understand the factors that enhance patient–navigator working alliance so that future PN interventions may further incorporate those features to improve HCV outcomes among PWID.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"270 ","pages":"Article 112617"},"PeriodicalIF":3.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Affective reinforcement of simultaneous versus single use of alcohol and cannabis","authors":"Andrea M. Wycoff ,&nbsp;Timothy J. Trull","doi":"10.1016/j.drugalcdep.2025.112612","DOIUrl":"10.1016/j.drugalcdep.2025.112612","url":null,"abstract":"<div><h3>Background</h3><div>Simultaneous alcohol and cannabis use is prevalent among adults who drink alcohol and is associated with more negative consequences than use of either substance alone. Understanding reinforcement processes that maintain simultaneous versus single-substance use will highlight intervention targets specific to this pattern of use. In individuals’ daily lives, we tested whether simultaneous use moments are associated with more affectively reinforcing outcomes compared to single use moments.</div></div><div><h3>Methods</h3><div>We used ecological momentary assessment with 6 +  daily reports for 14 days. Participants were 88 adults ages 18–44 who reported simultaneous use at least twice per week. Mean age was 25.22 years and participants were 60.2 % female. At each momentary survey, participants reported alcohol and cannabis use, affect, momentary coping and enhancement motives, and subjective appraisals of use.</div></div><div><h3>Results</h3><div>Simultaneously using cannabis during alcohol-use moments attenuated the <em>increase</em> in negative affect that accompanied coping-motivated drinking (anxious mood <em>b</em> = −0.11, <em>95 % CI</em> = [-0.19, −0.02], <em>p</em> = .016; depressed mood <em>b</em> = −0.14, <em>95 % CI</em> = [-0.23, −0.05], <em>p</em> = .003). Simultaneously using cannabis during alcohol-use moments attenuated the positive association between enhancement drinking motives and subjective drinking-contingent pleasure (<em>b</em> = −0.34, <em>95 % CI</em> = [-0.50, −0.18], <em>p</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>Simultaneously using cannabis during alcohol-use moments altered the subjective effects of alcohol, whereas simultaneously consuming alcohol during cannabis-use moments did not alter the subjective effects of cannabis. Individuals may perceive that simultaneous cannabis use mitigates undesirable effects of coping-motivated drinking, thereby driving simultaneous use of cannabis alongside alcohol.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"270 ","pages":"Article 112612"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are you feeling what I’m feeling? Momentary interactions between personal and perceived peer subjective response predict craving and continued drinking in young adults","authors":"Scott E. King ,&nbsp;Jack T. Waddell ,&nbsp;Abigail E. McDonald ,&nbsp;William R. Corbin","doi":"10.1016/j.drugalcdep.2025.112601","DOIUrl":"10.1016/j.drugalcdep.2025.112601","url":null,"abstract":"<div><h3>Background</h3><div>Subjective response to alcohol is a robust predictor of alcohol outcomes. It is possible that the perceived subjective response of others may influence concurrent experiences of one’s own subjective response. However, no studies have examined how the perceived subjective response of others might interact with personal subjective response and how such interactions may influence levels of craving and subsequent drinking.</div></div><div><h3>Method</h3><div>Emerging adults (ages 18–25, N = 131, 53.4 % female) completed 21 days of ecological momentary assessments. During drinking events (N = 1335) both personal and perceived peer subjective response (four domains encompassing high- and low-arousal positive &amp; negative effects) were assessed at drink initiation and two subsequent surveys 60 and 120<!--> <!-->min later. Current craving and drinking quantity since last report were also collected. Three-level multilevel structural equation models with Bayesian estimation tested indirect relations between subjective response and drinking continuation via craving and whether perceived subjective response moderated such relations.</div></div><div><h3>Results</h3><div>Levels of both personal (<em>b</em>=0.029,95 %BCI:[0.012,0.053]) and perceived (<em>b</em>=0.027,95 %BCI:[0.012,0.051]) experiences of alcohol’s rewarding, stimulating effects indirectly predicted drinking continuation via increased craving, and relations were potentiated when perceptions of peer reward were highest (<em>b</em>=0.015,95 %BCI:[0.008,0.020]). Personal experiences of alcohol’s relaxing, calming effects indirectly predicted a lower likelihood of drinking continuation via decreased craving (<em>b</em>=-0.017,95 %BCI:[-0.036,-0.003]) whereas perceived effects directly predicted lower likelihoods of drinking (<em>b</em>=-0.133,95 %CI:[-0.239, −0.031]).</div></div><div><h3>Conclusion</h3><div>Results suggest both personal and perceived peer subjective response independently influence drinking behavior even when controlling for one another. Targeted interventions focused on altering interpretations of peer subjective effects may be effective at reducing momentary risk.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"270 ","pages":"Article 112601"},"PeriodicalIF":3.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143478771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventions targeting adolescent substance use and misuse in South Asian Countries: A systematic review","authors":"Rabia Hanif ,&nbsp;Wendy Kliewer ,&nbsp;John W. Cyrus","doi":"10.1016/j.drugalcdep.2025.112614","DOIUrl":"10.1016/j.drugalcdep.2025.112614","url":null,"abstract":"<div><h3>Background</h3><div>This systematic review synthesizes evidence from 10 intervention studies focused on substance use interventions for adolescents across eight South Asian countries.</div></div><div><h3>Methods</h3><div>A literature search was conducted across MEDLINE (Ovid), Embase (Ovid), PsycINFO (EBSCO), Global Index Medicus, Web of Science (Clarivate), and Global Health (CAB Direct), covering studies from database October 1, 2016 to May 28, 2024. Only randomized control trials and quasi-experimental designs were included. The search strategy was pre-registered on the Open Science Framework.</div></div><div><h3>Results</h3><div>Out of 6356 studies identified, 4494 were screened, 193 were assessed for eligibility, and 10 studies were included in the review after consensus by two independent reviewers. Across these studies, which included 16,241 participants aged 9–18, seven were universal interventions, while three were targeted toward adolescents who were already using substances. Interventions primarily were conducted in school settings (<em>n</em> = 8) with a focus on tobacco, alcohol, inhalants, and supari use. Most studies demonstrated low selection and reporting bias, though performance and detection bias were unclear due to blinding limitations. Intervention duration ranged from 2 to 24 weeks and included between 2 and 119 sessions. Effectiveness was noted in four studies, three had mixed outcomes, two reported no significant effects, and one showed effects opposite of predicted outcomes.</div></div><div><h3>Conclusion</h3><div>This review reveals varied intervention outcomes on adolescent substance use in South Asia, with positive effects in a subset of studies. These findings highlight the need for additional interventions with strong methodological rigor to reduce adolescent substance use and misuse in this region.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"269 ","pages":"Article 112614"},"PeriodicalIF":3.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}