Drug and alcohol dependence最新文献

{"title":"Longitudinal association of exclusive and dual use of menthol cigarettes and flavored cigars with cigarette and cigar smoking cessation among U.S. adults – population assessment of tobacco and health study waves 1–5 (2013–2019)","authors":"James H. Buszkiewicz,&nbsp;Akash Patel,&nbsp;Steven Cook,&nbsp;Nancy L. Fleischer","doi":"10.1016/j.drugalcdep.2025.112906","DOIUrl":"10.1016/j.drugalcdep.2025.112906","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the relationship between menthol cigarette and flavored cigar use, alone or in combination, and short-term smoking cessation among U.S. adults.</div></div><div><h3>Methods</h3><div>We used restricted Waves 1–5 Population Assessment of Tobacco and Health Study data to estimate the risk of 30-day smoking cessation associated with menthol cigarette and flavored cigar use, alone or combined, and compared to unflavored tobacco product use. We fit multivariable discrete-time survival models to a nationally representative sample of U.S. adults with current established cigarette or cigar use, adjusting for age, sex, race, ethnicity, income, cigarette pack-years, tobacco dependency, cigarette and cigar smoking intensity, and blunt use.</div></div><div><h3>Results</h3><div>The majority of sample respondents (n = 8840) were male (53.5 %), non-Hispanic White (69.4 %), had a high school/General Educational Development (GED) education or less (53.9 %), and had an annual income of less than $50,000 (74.9 %). Most respondents used unflavored tobacco products (59.9 %), 33.8 % exclusively used menthol cigarettes, 2.4 % used both menthol cigarettes and flavored cigars, 1.8 % used both non-menthol cigarettes and flavored cigars, 1.3 % exclusively used flavored cigars, and 0.9 % used both menthol cigarettes and unflavored cigars. In fully adjusted models, we found no associations between menthol cigarette and flavored cigar use alone or in combination and 30-day cigarette and cigar smoking cessation relative to unflavored tobacco product use. These results were robust to sensitivity tests varying survey weights, sample inclusion criteria, and exposure definitions.</div></div><div><h3>Conclusion</h3><div>We found that menthol cigarette and flavored cigar use, alone or in combination, was not associated with short-term cigarette and cigar smoking cessation.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112906"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Punishment of ethanol choice in group-housed male cynomolgus monkeys","authors":"EA Cronin,&nbsp;PM Epperly,&nbsp;AP Floge,&nbsp;PW Czoty","doi":"10.1016/j.drugalcdep.2025.112903","DOIUrl":"10.1016/j.drugalcdep.2025.112903","url":null,"abstract":"<div><h3>Background</h3><div>A common characteristic of individuals with alcohol use disorder (AUD) is that they continue to consume alcohol despite adverse consequences. A better understanding of the factors that influence this relative insensitivity to punishment may help identify novel treatments for AUD. In animal models, this characteristic can be studied by adding the bitter-tasting alkaloid, quinine, to an ethanol solution. In the present study, punishment of ethanol drinking was assessed in socially housed male cynomolgus monkeys to determine whether sensitivity to punishment is influenced by a monkey’s position in the social hierarchy. <em>Methods:</em> Ten adult male cynomolgus monkeys with 4.5 years of experience drinking ethanol were given concurrent access to a 4 % ethanol solution and a 0.5 % Tang solution for 3<!--> <!-->h each day, 5 days per week. When ethanol choice was stable, a single quinine concentration (0.003–5.6<!--> <!-->g/L) was added to the ethanol solution for one day. This was repeated until a full quinine concentration-effect curve was created. <em>Results:</em> Addition of quinine produced a concentration-dependent decrease in ethanol choice and intake. The potency of quinine to decrease ethanol choice did not differ significantly between socially dominant and socially subordinate monkeys. However, only in dominant monkeys were significant positive relationships found between quinine EC₅₀ values and both the volume of ethanol consumed at baseline and baseline ethanol intake.</div></div><div><h3>Conclusions</h3><div>These results demonstrate the ability of quinine to produce robust punishment of ethanol choice and suggest that the chronic subordination stress experienced by the low-ranking monkeys alters sensitivity to punishment.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112903"},"PeriodicalIF":3.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substance use treatment completion does not mediate the relationship between family treatment court participation and reunification: Results from five courts in the Southwestern U.S.","authors":"Margaret Lloyd Sieger ,&nbsp;Jessica Becker ,&nbsp;Jon D. Phillips ,&nbsp;Cindy Nichols ,&nbsp;Elizabeth J. Goldsborough ,&nbsp;John Prindle","doi":"10.1016/j.drugalcdep.2025.112904","DOIUrl":"10.1016/j.drugalcdep.2025.112904","url":null,"abstract":"<div><h3>Background</h3><div>Family treatment courts (FTC) apply judicial theory and behavioral economics to increase parent substance use treatment completion and family reunification for families in foster care due to parental substance use disorder. Dozens of quasi-experiments and case studies suggest FTC programs outperform traditional child welfare courts. However, methodological limitations in earlier research limit causal inference.</div></div><div><h3>Study purpose</h3><div>The current study aimed to examine the relationship between FTC participation and family reunification, and to investigate whether substance use treatment completion mediates this relationship.</div></div><div><h3>Methods</h3><div>Foster care, substance use treatment, and FTC administrative records from 2018 to 2022 were probabilistically linked across six counties in a Southwestern U.S. state. The final sample included 200 FTC-involved and 1367 comparison child/caregiver dyads. To address selection bias, we applied inverse probability weighting based on propensity scores. The weights balanced the treatment and control groups based on fifteen covariates, including demographic characteristics, child welfare system involvement, and novel substance use treatment metrics such as caregivers’ Addiction Severity Index scores, level of care recommendation, and primary substance of choice.</div></div><div><h3>Results</h3><div>Applying the weight, our logistic regression model revealed that FTC-involved dyads’ odds of reunification were 66 % greater compared to dyads served in traditional settings (OR = 1.66, 95 % CI: 1.14–2.40). The mediation model revealed that the effect of FTC participation on reunification was independent of treatment completion.</div></div><div><h3>Conclusions</h3><div>FTC demonstrates its own treatment effect on family reunification, above and beyond substance use treatment experiences. These findings point to a “value added” for FTC participation. In an area of practice characterized by low rates of success, identifying effective, real-world interventions for families is significant.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112904"},"PeriodicalIF":3.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment and recovery from opioid use disorder: The role of pain severity in individuals with moderate to severe pain","authors":"Allison N. Tegge ,&nbsp;Marco A.R. Ferreira ,&nbsp;Peter M. Garafola ,&nbsp;Shuangshuang Xu ,&nbsp;Michael Farrell ,&nbsp;John Marsden ,&nbsp;Ken Lee ,&nbsp;Anne Le Moigne ,&nbsp;Frank Gray ,&nbsp;Warren K. Bickel","doi":"10.1016/j.drugalcdep.2025.112902","DOIUrl":"10.1016/j.drugalcdep.2025.112902","url":null,"abstract":"<div><h3>Background</h3><div>Pain is a frequent comorbidity among individuals with opioid use disorder (OUD), yet its impact on treatment outcomes is unclear. This study examined associations between pain severity and OUD treatment outcomes, including abstinence, craving, retention, and psychological functioning, in participants receiving long-acting buprenorphine (BUP-XR).</div></div><div><h3>Methods</h3><div>This secondary data analysis investigates participants from a BUP-XR phase 3 program: randomized clinical trial (NCT02357901; N = 192), open-label study (NCT02510014; N = 410); and a longitudinal observational follow-up (NCT03604861; N = 350). Pain was measured using the Brief Pain Inventory (BPI) at each treatment visit. Additional measures included demographics, opioid use, participant retention, opioid withdrawal, craving, depression, and quality of life. Analyses were performed on the full sample and the subgroup of individuals with moderate-to-severe pain (BPI≥4).</div></div><div><h3>Results</h3><div>Participants averaged 40 years old, predominantly male (67 %) and White (66 %). Pain decreased after starting BUP-XR, and the reduction in pain continued throughout treatment (<em>p-values</em>&lt;.001). For individuals with moderate-to-severe pain, greater concurrent pain severity was associated with lower abstinence rates (odds ratios: [0.801,0.852]; <em>p-values</em>&lt;.001) in two datasets. Pain was not associated with participant retention. Lastly, greater pain severity was associated with worse physical quality of life (<em>p-values</em>&lt;.001) and opioid withdrawal (<em>p-values</em>&lt;.001), and greater depression (<em>p-values</em>&lt;.001) and opioid craving (<em>p-values</em>&lt;.001). Collectively, these findings are well replicated across three studies.</div></div><div><h3>Conclusions</h3><div>Pain severity is a clinically relevant predictor of opioid use and psychosocial outcomes, but not treatment retention, in patients receiving BUP-XR. Routine pain severity monitoring may provide valuable insight into patient trajectories and support more tailored treatment approaches in OUD.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112902"},"PeriodicalIF":3.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preferences for clinical trial participation among people who use drugs in rural Oregon and Appalachian Ohio","authors":"Kathryn E. Lancaster ,&nbsp;Caroline W. Koudelka ,&nbsp;Miriam R. Elman ,&nbsp;Madison N. Enderle ,&nbsp;Sarann Bielavitz ,&nbsp;Angela T. Estadt ,&nbsp;Ryan R. Cook ,&nbsp;P. Todd Korthuis ,&nbsp;April M. Young","doi":"10.1016/j.drugalcdep.2025.112894","DOIUrl":"10.1016/j.drugalcdep.2025.112894","url":null,"abstract":"<div><h3>Background</h3><div>Rural communities in the United States face significant challenges in participating in clinical trials, despite being heavily impacted by opioid and injection drug use epidemics. Barriers such as transportation, stigma, and limited resources often deter rural people who use drugs (PWUD) from engaging in research. Discrete choice experiments (DCEs) can help identify trial design features that support participation by eliciting participant preferences.</div></div><div><h3>Methods</h3><div>We selected DCE attributes and attribute levels through literature review and qualitative interviews. Peer-based Retention of People who Use Drugs in Rural Research (PROUD-R²) study participants in rural Oregon and Appalachian Ohio completed the DCE at their baseline visit. We used conditional logit models to estimate preference weights.</div></div><div><h3>Results</h3><div>Overall, 478 participants completed the DCE and most (71 %; n = 337) were from Oregon. The majority were male (63 %; n = 299) and were white (85 %; n = 404). Overall, transportation support, particularly travel reimbursement (preference weight=0.87; p &lt; 0.01; relative utility versus videochat=1.15), was the most valued feature for clinical trial participation. Participants also preferred shorter appointments (relative utility of 1-hour versus 3-hour=0.44) and evening over morning appointments (relative utility=0.29).</div></div><div><h3>Conclusions</h3><div>Rural PWUD preferences underscore the need to redesign clinical trial protocols with equity and feasibility at the forefront. Direct transportation support emerged as the top priority, reflecting how rural poverty and isolation limit access. Preferences for shorter and later-day appointments suggest a need for low-burden, flexible scheduling. Incorporating participant-centered features can improve trust, enrollment, and retention, ensuring rural PWUD are included in research that addresses their needs.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112894"},"PeriodicalIF":3.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Within-subject, double-blind, human laboratory examination of opioid response profiles in males and females across three harmonized studies","authors":"Robert LeComte ,&nbsp;Nicole Brown ,&nbsp;William Davis ,&nbsp;Emma Pattillo ,&nbsp;Jennifer D. Ellis ,&nbsp;Andrew S. Huhn ,&nbsp;Claudia M. Campbell ,&nbsp;Patrick H. Finan ,&nbsp;Cecilia L. Bergeria ,&nbsp;Kelly E. Dunn","doi":"10.1016/j.drugalcdep.2025.112898","DOIUrl":"10.1016/j.drugalcdep.2025.112898","url":null,"abstract":"<div><div>Opioid use disorder (OUD) poses significant individual and public health challenges and understanding whether opioids engender different effects in patient samples is imperative to determining unique risk factors for developing OUD. These analyses examined whether participant sex was associated with different experiences of opioids. Participants with little or no prior opioid experience (N = 160) were enrolled into one of three randomized, double-blind, placebo-controlled human laboratory studies that were harmonized together for these analyses. The effects of the opioid agonist hydromorphone (4<!--> <!-->mg, oral) and placebo were compared in males and females as a first step towards determining how demographic characteristics may be associated with different opioid response profiles. Data included self-report ratings, staff observed ratings, and physiological responses. Results found hydromorphone produced expected self-reported and observed agonist effects with few differences. Females reported more energy and were more talkative for a short period after dosing, but then reported and were observed as being sleepy for the rest of the session, whereas males reported more energy that was sustained throughout the session. No interactions between sex and drug were observed. Altogether, these data provide evidence that among persons who had little to no prior experience with opioids, sex did not meaningfully predict different response profiles to the dose of hydromorphone. These findings may serve as the basis for future studies examining sex differences in the onset of other SUDs, later stages of SUDs, and overall trajectories of SUDs.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112898"},"PeriodicalIF":3.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased cigarette craving following prior-day cannabis use among females who smoke combustible cigarettes","authors":"Jimi Huh ,&nbsp;Alicia Allen ,&nbsp;Matthew G. Kirkpatrick ,&nbsp;Raina D. Pang","doi":"10.1016/j.drugalcdep.2025.112897","DOIUrl":"10.1016/j.drugalcdep.2025.112897","url":null,"abstract":"<div><h3>Objective</h3><div>Nicotine-cannabis co-use among adults in the U.S. has become increasingly prevalent, but there is a lack of consensus on mechanisms of co-use. Inconsistent sex differences in nicotine-cannabis use have been documented in cross-sectional or longitudinal studies with sparse observations. There is a need for temporally-granular research to yield informative addiction prevention data. We examined the extent to which prior-day cannabis use is associated with cigarette craving on a given day and whether this association differs between sexes.</div></div><div><h3>Methods</h3><div>In 2020–2022, 225 participants (Mage=43.06; 49.33 % female) completed 4-week Ecological Momentary Assessment (EMA), including measures of cannabis use captured at the end of the day and cigarette craving levels upon waking. Using a subsample of those reporting cannabis use on 1 +  day during the EMA period (n = 101; Mage=42.94; 45.54 % female), we fitted multilevel models to investigate the effects of prior-day cannabis use on next-morning cigarette craving, adjusting for relevant covariates. Subsequently, we tested sex as the effect modifier.</div></div><div><h3>Results</h3><div>In the main effect model, prior-day cannabis use was not associated with cigarette craving the next morning (b=0.05, p = .61). The interaction model revealed a significant interaction (b=-.44, p = .02) such that prior-day cannabis use was associated with elevated next-morning cigarette craving for females (b=.33; p = .03) but not for males (b=-.10; p = .36).</div></div><div><h3>Conclusions</h3><div>Our findings show that prior-day cannabis use is differentially associated with cigarette craving between sexes (i.e., increased cigarette craving in females, but not males). Our study is among the first to demonstrate nuanced cross-level interactions in nicotine-cannabis co-use in ecologically-valid settings.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112897"},"PeriodicalIF":3.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of opioid use disorder with cerebral aneurysm rupture","authors":"Fares Qeadan ,&nbsp;Emma M. Federico ,&nbsp;Benjamin Tingey ,&nbsp;Atif Zafar ,&nbsp;Andrew P. Carlson","doi":"10.1016/j.drugalcdep.2025.112896","DOIUrl":"10.1016/j.drugalcdep.2025.112896","url":null,"abstract":"<div><h3>Background</h3><div>The association between opioid use disorder (OUD) and cerebral aneurysm rupture has been suggested in recent studies. However, these studies are limited to small sample sizes and lack data on medications for opioid use disorder (MOUD). We investigate the association between OUD and cerebral aneurysm rupture in a large database.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted using de-identified electronic health record (EHR) data from Oracle EHR Real-World Data™ (OERWD). Cox proportional hazard regressions were conducted to assess the association between OUD and aneurysm rupture, and the association of MOUD with aneurysm rupture, over different years of follow-up.</div></div><div><h3>Results</h3><div>Patients with OUD (n = 584,125), compared to non-exposures (n = 1752,375) had 54 % higher risk (adjusted hazard ratio (aHR) [95 % confidence interval (CI)]: 1.54 [1.34, 1.76]) of cerebral aneurysm rupture within one year of follow-up and 28 % higher risk (aHR [95 % CI]: 1.28 [1.14, 1.44]) within five years of follow-up. Additionally, patients with OUD and MOUD treatment (n = 83,164), compared to those with OUD but without MOUD (n = 410,466), had 25 % lower risk (aHR [95 % CI]: 0.75 [0.55, 1.01]) of cerebral aneurysm rupture in one year of follow-up and 30 % lower risk (aHR [95 % CI]: 0.70 [0.51, 0.98]) in five years of follow-up.</div></div><div><h3>Conclusions</h3><div>This research identified OUD as a significant risk factor, and MOUD as a protective factor both significant and on the boundary of significance in certain years of follow-up for cerebral aneurysm rupture. These results provide important insight that could encourage future targeted strategies for early intervention and prevention in such patients.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112896"},"PeriodicalIF":3.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does regulating drug precursors affect illicit drug markets? An expanded and updated systematic review","authors":"Luca Giommoni ,&nbsp;Kirsty Stuart Jepsen ,&nbsp;Shannon Murray","doi":"10.1016/j.drugalcdep.2025.112900","DOIUrl":"10.1016/j.drugalcdep.2025.112900","url":null,"abstract":"<div><h3>Background</h3><div>Many countries are placing greater emphasis on regulating precursor chemicals used in illicit drug production. However, the latest review on this topic is 14 years old and limited to North American methamphetamine regulations. This review updates and expands on past work by assessing how precursor regulations affect illicit drug markets.</div></div><div><h3>Method</h3><div>We conducted a systematic review following PRISMA guidelines, searching 13 databases and relevant organizational websites for grey literature. Eligible studies quantitatively assessed precursor regulations' impact on drug supply, demand, or related harms. Due to intervention variability, we used narrative synthesis. Bias risk was evaluated with the EPOC Risk of Bias Tool.</div></div><div><h3>Results</h3><div>Twenty-six studies met the inclusion criteria, published between 2003 and 2023, focusing on methamphetamine (n = 23), cocaine (n = 3), and heroin (n = 1). Most were from the USA (n = 20), with others from Canada (n = 1), Mexico (n = 1), Australia (n = 3), and the Czech Republic (n = 1). The studies assessed 12 outcomes across 37 interventions, 14 of which were effective and 23 ineffective. Effective interventions led to impacts such as a 100 % price increase, a 40 % purity reduction, and a 43 % drop in past-month drug use, lasting from months to seven years. Ineffective interventions shared three issues: targeting unused chemicals, focusing on small-scale operations, or failing as suppliers adapted to new sources or routes.</div></div><div><h3>Conclusions</h3><div>Precursor regulations can reduce the supply, use, and harms of heroin, cocaine, and methamphetamine. However, they are not a one-size-fits-all solution. Their effectiveness depends on how they are designed and the context in which they are implemented.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112900"},"PeriodicalIF":3.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral inflammation and PSD-95 levels are associated with structural brain changes in individuals with nicotine dependence using e-cigarettes","authors":"Yehong Fang ,&nbsp;Yunkai Sun ,&nbsp;An Xie ,&nbsp;Yi Liu ,&nbsp;Ling Li ,&nbsp;Jinsong Tang ,&nbsp;Yanhui Liao","doi":"10.1016/j.drugalcdep.2025.112901","DOIUrl":"10.1016/j.drugalcdep.2025.112901","url":null,"abstract":"<div><h3>Background</h3><div>The prevalence of electronic cigarette (e-cig) consumption has risen among adolescents and young adults, but its associations with systemic inflammation and brain structure remain unclear.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 215 participants categorized into four groups: individuals who use e-cigs exclusively (n = 48), those who exclusively use traditional cigarettes (n = 51), those who use both e-cigs and traditional cigarettes (n = 45), and healthy controls (HCs) (n = 71) group. Peripheral blood levels of high-sensitivity C-reactive protein (hs-CRP), glial cell marker S100β, neuron-specific enolase, and postsynaptic density protein-95 (PSD-95) were quantified. Gray matter volume (GMV) was assessed using voxel-based morphometry.</div></div><div><h3>Results</h3><div>Significant differences in GMV were observed in the right superior temporal gyrus (STG), Heschl’s gyrus, thalamus, and cerebellum. Individuals who used e-cigs exclusively exhibited higher GMV in the right STG compared to those who used both e-cigs and traditional cigarettes but no significant difference relative to those who used traditional cigarettes exclusively. Peripheral levels of PSD-95, S100β, and hs-CRP also varied significantly across groups. Compared to HCs, individuals who used e-cigs had higher S100β, lower PSD-95, and lesser GMV in the right thalamus. Significant correlations were observed between these biomarkers and GMV in the right STG and thalamus. Additionally, PSD-95 levels were associated with nicotine dependence severity in those who used traditional cigarettes.</div></div><div><h3>Conclusions</h3><div>These findings suggest e-cig consumption is associated with differences in brain structure and peripheral inflammatory markers, highlighting a potential relationship between systemic inflammation and brain GMV.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112901"},"PeriodicalIF":3.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}