Drug and alcohol dependence最新文献

{"title":"Sleep disturbance is associated with greater subjective and neural negative emotionality in people with alcohol use disorder","authors":"Erica N. Grodin ,&nbsp;Dylan E. Kirsch ,&nbsp;Wave Ananda Baskerville ,&nbsp;Lara A. Ray","doi":"10.1016/j.drugalcdep.2026.113084","DOIUrl":"10.1016/j.drugalcdep.2026.113084","url":null,"abstract":"<div><h3>Background</h3><div>Sleep disturbance is ubiquitous in alcohol use disorder (AUD). Sleep disturbance within AUD has been mapped onto the three-stage addiction cycle. The Addictions Neuroclinical Assessment (ANA) is a neuroscience-based framework, which measures functional domains that correspond to the stages of the addiction cycle. The present study investigated the relationship between sleep disturbance and AUD neuroclinical phenomenology and underlying neurobiology.</div></div><div><h3>Methods</h3><div>In two independent studies, participants completed assessments of sleep disturbance through the Pittsburgh Sleep Quality Index (PSQI; n = 115) or the Insomnia Severity Index (ISI; n = 102). A subset of individuals (n = 52) completed a functional magnetic resonance imaging scan to assess the neurobiology of the incentive salience and negative emotionality domains.</div></div><div><h3>Results</h3><div>Both studies found that sleep disturbance was associated with negative emotionality (ps≤0.001), but not incentive salience (ps&gt;0.14) or executive function (p = 0.62). Individuals with sleep disturbance had greater activation in the frontal pole, anterior cingulate, medial frontal cortex, and posterior cingulate cortex when viewing negative vs. neutral images, compared to those without sleep disturbance, indicating an underlying neural substrate for the heightened negative emotionality neuroclinical profile.</div></div><div><h3>Conclusions</h3><div>These results suggest that sleep disturbances in AUD are associated with a neurofunctional profile of enhanced negative emotionality and identify a potential neurobiology underlying this association. These findings suggest that sleep disturbance may be a promising treatment target to improve negative emotionality in this group.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"281 ","pages":"Article 113084"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The intersectionality of cannabis use and depression symptoms on functional brain topology in adults","authors":"Che Liu ,&nbsp;Janna Cousijn ,&nbsp;Emese Kroon ,&nbsp;Francesca M. Filbey","doi":"10.1016/j.drugalcdep.2026.113082","DOIUrl":"10.1016/j.drugalcdep.2026.113082","url":null,"abstract":"<div><h3>Background</h3><div>Although behavioral and epidemiological studies demonstrate high co-morbidity between cannabis use and depression, the underlying neurobiological mechanisms of this relationship remain poorly understood.</div></div><div><h3>Methods</h3><div>This study evaluated the interaction between cannabis use and depression on brain resting state functional connectivity using graph theory network properties in 223 individuals who currently use cannabis (26.8 ± 8.1 years, 61.9 % males) and 172 controls (25.0 ± 6.8 years, 48.3 % males).</div></div><div><h3>Results</h3><div>Graph theory analyses showed that the cannabis group relative to the control group had shorter characteristic path length, higher global efficiency and transitivity as well as increased local efficiency and clustering coefficient in salience, frontoparietal, and subcortical networks. Depression symptoms significantly moderated the effect of group on global measures, such that the effect of cannabis use status on characteristic path length, global efficiency and transitivity weakened in those with higher depression scores. Post-hoc analyses indicated a dose-response relationship such that the higher cannabis use frequency, the shorter characteristic path length, higher global efficiency, and transitivity; but no significant moderating effect of depression symptoms emerged on these associations.</div></div><div><h3>Conclusions</h3><div>These findings suggest that the co-occurrence of depression symptoms and cannabis use, compared to cannabis use alone, may be associated with less efficient and less integrated brain network function. Among those who use cannabis, the effects of cannabis use frequency on these global measures do not vary with depression symptoms, suggesting that depression’s moderating effect is conditional on cannabis use status, not dose. These findings underscore the complex interplay between cannabis use and depression in altering functional brain organization.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"281 ","pages":"Article 113082"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the initiation of strong chū-hai consumption and the incidence of hazardous and harmful alcohol use in Japan: An online survey-based cohort study","authors":"Takashi Yoshioka ,&nbsp;Ryuhei So ,&nbsp;Tomohiro Shinozaki ,&nbsp;Matthew Rossheim ,&nbsp;Shiori Tsutsumi ,&nbsp;Satoshi Funada ,&nbsp;Ayame Hanada ,&nbsp;Tetsuji Minami ,&nbsp;Takahiro Tabuchi","doi":"10.1016/j.drugalcdep.2026.113075","DOIUrl":"10.1016/j.drugalcdep.2026.113075","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the association between the initiation of strong <em>chū-hai</em>—an inexpensive Japanese ready-to-drink beverage with high-alcohol-content—consumption and the newly incident hazardous and harmful alcohol use among individuals who consume alcohol.</div></div><div><h3>Methods</h3><div>This cohort study is based on a three-year longitudinal internet survey conducted in Japan from 2022 to 2024. Respondents who completed all three annual surveys, did not drink strong <em>chū-hai</em> in 2022<em>,</em> and consumed alcohol without presenting hazardous or harmful alcohol use in both 2022 and 2023, were included. The outcome was defined as having newly developed hazardous and harmful alcohol use in 2024, defined as a score of ≥ 8 on the Alcohol Use Identification Test. We fitted a multivariable logistic regression model to examine confounder-adjusted association between initiating strong <em>chū-hai</em> consumption and the incidence of hazardous and harmful alcohol use.</div></div><div><h3>Results</h3><div>Of 5358 respondents from 33,000 surveyed in 2022, approximately 10 % (n = 533) initiated strong <em>chū-hai</em> consumption in 2023. In 2024, the prevalence of hazardous and harmful alcohol use was higher for those who initiated strong <em>chū-hai</em> consumption (7.7 %) than those who did not (3.1 %). Multivariable analysis revealed that initiating strong <em>chū-hai</em> consumption was associated with higher odds of hazardous and harmful alcohol use the year following (adjusted odds ratio 1.90, 95 % confidence interval 1.19–3.06, <em>p</em> = 0.008).</div></div><div><h3>Conclusions</h3><div>The initiation of strong <em>chū-hai</em> consumption was associated with the incidence of hazardous and harmful alcohol use. Considering the global increase in sales of ready-to-drink alcoholic beverages, our findings serve as an important caution for policymakers worldwide.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"281 ","pages":"Article 113075"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146135650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Achieving SVR is associated with long term reduced hazardous alcohol use for people who inject drugs receiving HCV treatment: The HERO study","authors":"Emily Waters ,&nbsp;Jessica Obeysekare ,&nbsp;Snehal Lopes ,&nbsp;Irene Pericot-Valverde ,&nbsp;Brianna L. Norton ,&nbsp;Judith I. Tsui ,&nbsp;Shruti H. Mehta ,&nbsp;Lynn E. Taylor ,&nbsp;Paula J. Lum ,&nbsp;Judith Feinberg ,&nbsp;Arthur Y. Kim ,&nbsp;Kimberly Page ,&nbsp;Jessica Anderson ,&nbsp;Cristina Murray-Krezan ,&nbsp;Moonseong Heo ,&nbsp;Alain H. Litwin ,&nbsp;the HERO Study Group","doi":"10.1016/j.drugalcdep.2026.113081","DOIUrl":"10.1016/j.drugalcdep.2026.113081","url":null,"abstract":"<div><h3>Background/Aims</h3><div>People who inject drugs (PWID) have high rates of HCV infection. Concurrent alcohol use is associated with higher rates of HCV and acceleration of HCV-related liver disease. This study analyzed alcohol use among PWID both during and after treatment of HCV with direct-acting antivirals.</div></div><div><h3>Approach/Results</h3><div>We conducted a secondary analysis of the HERO study, a multisite pragmatic randomized trial, in which PWID with active drug use (n = 755) were assigned to either patient navigation or modified directly observed therapy models of HCV care. Alcohol use was measured using the modified Addiction Severity Index (ASI) and the Alcohol Use Disorders Identification Test-Concise (AUDIT-C). Linear mixed-effects models were used to analyze changes in alcohol use between baseline, treatment (weeks 4, 8, and 12), and after-treatment follow-up visits (weeks 24, 72, 120, 168). Overall, there were no significant differences in ASI or AUDIT-C scores by sustained virological response (SVR) or treatment arm. Among patients who achieved SVR, there was a significant reduction in AUDIT-C scores at all follow-up visits compared to baseline (all, p &lt; 0.05). Among those with high AUDIT-C score at baseline, there were significant reductions in drinking at all visits compared to baseline in both treatment arms (all, p ≤ 0.001).</div></div><div><h3>Conclusions</h3><div>Among PWID who achieved SVR or with high AUDIT-C scores at baseline, there was a significant reduction in AUDIT-C scores at all visits after baseline. The treatment period for HCV may represent a unique opportunity to address dual causes of liver disease, especially for individuals with hazardous alcohol use.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"281 ","pages":"Article 113081"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot trial of using ecological momentary intervention to deliver tetris for alcohol craving among women","authors":"Christine K. Hahn ,&nbsp;Alexandra N. Brockdorf ,&nbsp;Jeffrey M. Pavlacic ,&nbsp;Christopher L. Metts ,&nbsp;Kathleen T. Brady ,&nbsp;Michaela Hoffman ,&nbsp;Constance Guille ,&nbsp;Michael E. Saladin ,&nbsp;Sudie E. Back","doi":"10.1016/j.drugalcdep.2026.113052","DOIUrl":"10.1016/j.drugalcdep.2026.113052","url":null,"abstract":"<div><div>Innovative and accessible interventions are critical to address rising rates of alcohol misuse and low rates of alcohol treatment engagement among women. Ecological momentary interventions (EMI) that use technology to deliver interventions in real-time may be a promising avenue to reduce barriers to alcohol interventions for women and ensure they receive intervention when they need it most. Craving is a key proximal predictor of alcohol use that may be beneficial to target using EMI. Tetris is a visuospatial task that may disrupt craving by placing competing demands on visual working memory. This study tested a Tetris EMI for craving and alcohol use among women who reported alcohol misuse. Forty women completed a two-week experimental EMA protocol involving a daily interval-contingent survey assessing past-day alcohol craving and consumption, as well as four daily signal-contingent surveys assessing momentary craving. Participants assigned to the intervention condition (<em>n</em> = 20) were prompted to complete Tetris for four minutes in response to momentary craving and those assigned to the control condition (<em>n</em> = 20) were prompted to wait four minutes before re-rating craving. Participants also completed baseline and post-experimental questionnaires. Results indicated that the Tetris EMI was highly acceptable and generally feasible. The EMI predicted average decreases in momentary craving for those who reported high levels of recognition of possible harms related to their drinking and readiness to change. However, the EMI did not lead to decreases in average daily craving or drinking. Findings suggest craving is a modifiable target for EMIs among women who are more ready for treatment.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"281 ","pages":"Article 113052"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of structural brain differences in cocaine use disorder: Integrating multilevel frequentist, Bayesian, and coordinate-based meta-analyses","authors":"Augusto Martins Lucas Bittencourt ,&nbsp;Bernardo Penteado Favero ,&nbsp;Camila Haas ,&nbsp;Eduardo Tavares Portolan ,&nbsp;Enzo Gallardo ,&nbsp;Leonardo Melo Rothmann ,&nbsp;Rodrigo Grassi-Oliveira ,&nbsp;Thiago Wendt Viola","doi":"10.1016/j.drugalcdep.2026.113064","DOIUrl":"10.1016/j.drugalcdep.2026.113064","url":null,"abstract":"<div><h3>Background</h3><div>Cocaine Use Disorder (CUD) has been associated with differences in gray matter (GM) measures, but prior meta-analyses have yielded inconsistent results due to methodological variability, publication bias, and selective reporting. To address these gaps, this study integrates multilevel frequentist, Bayesian, and coordinate-based approaches to provide a comprehensive, anatomically resolved synthesis of structural neuroimaging findings in CUD.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines (PROSPERO: CRD42024585260), 47 studies were included that compared GM indices between individuals with CUD and healthy controls. Multilevel random-effects meta-analyses were conducted to quantify cortical and subcortical group differences while accounting for clinically relevant moderators. Bayesian hierarchical models were used to conduct sensitivity analyses addressing potential reporting bias, and a coordinate-based Activation Likelihood Estimation (ALE) analysis evaluated spatial convergence across voxel-based morphometry studies.</div></div><div><h3>Results</h3><div>The analyses indicated that CUD showed lower GM measures in prefrontal and temporal cortical regions, particularly the ITG and the rostral middle frontal gyrus. Subcortical analyses showed lower GM volume in the amygdala, hippocampus, thalamus, pallidum, nucleus accumbens, brainstem, and cerebellum. Longer duration of cocaine use and greater clinical severity were associated with larger negative effect-size estimates for cortical measures. Bayesian regularization yielded consistent cortical effect-size estimates across sensitivity analyses, whereas the coordinate-based ALE analysis identified no clusters surviving family-wise error correction.</div></div><div><h3>Conclusions</h3><div>Together, results from this meta-analysis identify consistent patterns of GM differences across cortico-subcortical regions in individuals with CUD. These findings provide an integrated neuroanatomical reference framework that may inform future longitudinal studies and the evaluation of candidate neuroimaging biomarkers.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"281 ","pages":"Article 113064"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term use of Benzodiazepines and Z-drugs: A register-based cohort study in Taiwan","authors":"Meng-Chiao Chou ,&nbsp;Yueh-Pin Lin ,&nbsp;Chun-Hung Pan ,&nbsp;Sheng-Siang Su ,&nbsp;Shang-Ying Tsai ,&nbsp;Chiao-Chicy Chen ,&nbsp;Chian-Jue Kuo","doi":"10.1016/j.drugalcdep.2026.113078","DOIUrl":"10.1016/j.drugalcdep.2026.113078","url":null,"abstract":"<div><h3>Background</h3><div>Benzodiazepines (BZDs) and Z-drugs are commonly prescribed for anxiety and insomnia, but their long-term use remains a public health concern. Evidence from Asia remains limited. This study investigated trajectories and predictors of long-term use in Taiwan by using a population-based cohort.</div></div><div><h3>Methods</h3><div>We conducted a register-based cohort study by using a nationally representative sample from Taiwan’s National Health Insurance Research Database (NHIRD), covering a 20-year period from January 1, 2000, to December 31, 2019 after a 1-year washout. Incident users were identified and followed to evaluate long-term use patterns on the basis of two discontinuation thresholds: 90 days and 365 days. Cox regression models were used to estimate adjusted hazard ratios (aHRs) for long-term use by demographic, physical, and psychiatric factors.</div></div><div><h3>Results</h3><div>Among 896,163 incident users, 3.8% progressed to long-term use under the 90-day definition, increasing to 14.7% under the 365-day definition. Under the 90-day definition, clonazepam and hypnotic BZDs showed the highest persistence (10.3% and 8.4%). More than 70% of initiations occurred in nonpsychiatric specialties. Long-term use was associated with male sex, older age, and higher Charlson Comorbidity Index; strong predictors included cancer, pneumonia, moderate-to-severe renal disease, alcohol- or drug-induced mental disorders, and personality disorders.</div></div><div><h3>Conclusion</h3><div>In Taiwan, most BZD and Z-drug use is short-term, and their usage patterns are affected by both clinical and system-level factors. These findings highlight the need for risk-based monitoring, cross-specialty prescribing oversight, and further research into treatment substitution strategies.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"281 ","pages":"Article 113078"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impulsivity as a dynamic mechanism linking young adult sleep and drinking behavior during naturally occurring drinking episodes","authors":"Jack T. Waddell ,&nbsp;Andrea M. Wycoff ,&nbsp;Mary Beth Miller","doi":"10.1016/j.drugalcdep.2026.113054","DOIUrl":"10.1016/j.drugalcdep.2026.113054","url":null,"abstract":"<div><h3>Background</h3><div>Impulsivity is implicated in theories linking sleep and drinking behavior. While well-studied across individuals, research regarding sleep, impulsivity, and drinking in real-world contexts is lacking. This study tested a theoretical pathway wherein better-than-average sleep predicts decreased impulsivity while drinking, which then predicts lesser drinking and negative alcohol consequences experienced during drinking episodes.</div></div><div><h3>Method</h3><div>Young adults (<em>N</em> = 131) completed 21 days of ecological momentary assessment, including morning reports, self-initiated drink reports after first drink, and follow-up drinking reports 60/120<!--> <!-->min later. Past-day drinking quantity, negative alcohol consequences, and sleep (duration, nighttime awakenings, and morning readiness to start day) were measured each morning. Impulsivity (urgency, lack of premeditation, lack of perseverance, and sensation seeking) was measured during drink initiation/follow-up reports.</div></div><div><h3>Results</h3><div>In two of the four multilevel mediation models (one for each facet of impulsivity), better sleep (higher morning readiness and longer sleep duration) predicted decreased state impulsivity (lack of premeditation and sensation seeking) while drinking, which indirectly predicted fewer negative consequences via lighter drinking quantity. Above and beyond state impulsivity while drinking, higher morning readiness indirectly predicted fewer negative consequences via lighter drinking quantity. Increased urgency also indirectly predicted negative consequences via heavier drinking quantity but was unrelated to sleep. Findings were unchanged when accounting for cumulative sleep debt, except relations between morning readiness and sensation seeking while drinking.</div></div><div><h3>Conclusions</h3><div>Dampened state impulsivity while drinking may explain protective associations between good sleep health and less risky drinking. Sleep interventions may be effective at reducing impulsivity while drinking and alcohol-related harms.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"280 ","pages":"Article 113054"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives on collaboration between drug courts and MOUD providers: Impact of interagency implementation strategies","authors":"Ekaterina Pivovarova ,&nbsp;Faye S. Taxman ,&nbsp;Barbara Andraka-Christou ,&nbsp;Alexandra Boland ,&nbsp;Dara Drawbridge ,&nbsp;David Smelson ,&nbsp;Stephenie C. Lemon ,&nbsp;Peter D. Friedmann","doi":"10.1016/j.drugalcdep.2026.113065","DOIUrl":"10.1016/j.drugalcdep.2026.113065","url":null,"abstract":"<div><h3>Background</h3><div>Effective working relationships between drug courts and community providers are critical to improving access to medications for opioid use disorder (MOUD), but collaboration is often inadequate. We adapted and piloted a package of implementation strategies (Clinical Organizations and Legal Agency Alliance Building; COLAAB) designed to enhance collaboration between recovery courts and MOUD agencies. COLAAB activities included structured interagency meetings, agency tours, academic liaison, and development of local resource guides.</div></div><div><h3>Methods</h3><div>After the implementation of COLAAB in three courts, we conducted semi-structured interviews (n = 24) with drug court and MOUD staff to assess the impact of COLAAB on collaboration, communication, and referrals. Data were analyzed using a modified iterative categorization approach.</div></div><div><h3>Results</h3><div>Drug court and MOUD agency staff perceived COLAAB as facilitating interagency relationships and referrals to MOUD, increasing MOUD agencies’ understanding of drug courts, improving communication quality, strengthening understanding and trust in MOUD providers and drug courts, and reducing time to referrals to MOUD. COLAAB also increased the MOUD agency staff’s awareness of other community providers and helped build their potential referral networks. COLAAB may have also enhanced drug court staff’s willingness to speak with clients about MOUD and MOUD provider staff’s willingness to discuss clients’ criminal legal involvement.</div></div><div><h3>Discussion</h3><div>Our pilot study provides preliminary evidence that court-MOUD agency collaborations can be enhanced through active learning about one another’s practices and services, participation in regularly scheduled meetings or activities, and the identification and use of resources that support efficient interagency referral processes.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"280 ","pages":"Article 113065"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily patterns of substance use among young adults who vape nicotine and cannabis: Latent class analysis of smartphone-based daily diary data","authors":"Deanna M. Halliday ,&nbsp;Lisbeth Lund ,&nbsp;Pamela M. Ling ,&nbsp;Nhung Nguyen","doi":"10.1016/j.drugalcdep.2026.113060","DOIUrl":"10.1016/j.drugalcdep.2026.113060","url":null,"abstract":"<div><h3>Introduction</h3><div>Using multiple tobacco and cannabis products is common among young adults and raises concerns about addiction and health risks. Few studies address daily use patterns of multiple products on the same day. We used daily diaries to identify patterns of substance use and associated factors among young adults who reported vaping nicotine and cannabis.</div></div><div><h3>Methods</h3><div>We collected smartphone-based daily diaries from 113 California young adults (mean age=23.8) who vaped nicotine or cannabis for 20 +  days in the past month. For 30 consecutive days, participants reported their daily use of nicotine/tobacco, cannabis, alcohol, craving for nicotine and cannabis vaping, and mood. We used multilevel latent class analysis to identify daily substance use patterns and mixed-effects logistic regression to identify factors associated with these patterns, controlling for baseline covariates (e.g., demographics, nicotine/cannabis dependence).</div></div><div><h3>Results</h3><div>Three latent classes emerged: Class 1 – “Nicotine vaping days” (52.7 % of the assessments), Class 2 – “Nicotine and cannabis co-vaping days” (39.9 %), and Class 3 -“Combustible tobacco and cannabis use days” (7.4 %). Higher levels of feeling sad on a given day were associated with increased likelihood of that day belonging to Class 1 (adjusted OR = 1.11, 95%CI95 %CI = 1.01 – 1.23). Higher cravings for cannabis vaping on a given day were associated with increased likelihood of that day belonging to Class 2 (adjusted OR = 1.81, 95 % CI = 1.63 – 2.01).</div></div><div><h3>Conclusion</h3><div>Interventions should be tailored to varying daily substance use patterns among young adults who vape. Efforts targeting vaping cessation may also address combustible product use.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"280 ","pages":"Article 113060"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146108927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}