Drug and alcohol dependence最新文献

{"title":"Does implementation of office based addiction treatment by a nurse care manager increase the duration of OUD treatment in primary care? A secondary analysis of the PROUD randomized control trial","authors":"Zoe M. Weinstein ,&nbsp;Onchee Yu ,&nbsp;Paige D. Wartko ,&nbsp;Jeffrey H. Samet ,&nbsp;Jennifer F. Bobb ,&nbsp;Jordan M. Braciszewski ,&nbsp;Julia H. Arnsten ,&nbsp;Mark T. Murphy ,&nbsp;Viviana E. Horigian ,&nbsp;Angela L. Stotts ,&nbsp;Donna Beers ,&nbsp;Katharine Bradley","doi":"10.1016/j.drugalcdep.2024.112497","DOIUrl":"10.1016/j.drugalcdep.2024.112497","url":null,"abstract":"<div><h3>Background</h3><div>Implementation of office-based addiction treatment (OBAT) by nurse care managers increases overall use of OUD medication, but it is unknown whether it increases treatment duration among treated patients.</div></div><div><h3>Methods</h3><div>The Primary Care Opioid Use Disorders Treatment (PROUD) trial was a pragmatic, cluster-randomized trial testing whether implementation of OBAT increased OUD treatment in 12 primary care clinics in 6 systems. One of 2 clinics per system was randomized to implement OBAT (intervention), the other, usual care (UC). We evaluated treatment duration for the 3 years after nurses began seeing patients at clinics randomized to intervention vs. UC. The primary sample included patients newly initiating OUD medication; the secondary sample included patients with ongoing OUD medication. The primary outcome was percentage of days with OUD medications after treatment initiation, modeled using linear generalized estimating equations (GEE). Modified Poisson GEE models assessed secondary outcomes (≥80 % of days covered, ≥6 months on treatment).</div></div><div><h3>Results</h3><div>In adjusted analyses, the mean difference between intervention and UC in percent days treated was 6.3 % (95 % CI −9.6 %, 22.1 %) in the primary sample and 2.3 % (95 % CI −36.4 %, 31.8 %) in the secondary sample. There was no significant difference in treatment duration between intervention and UC patients in either primary or secondary outcomes.</div></div><div><h3>Conclusions</h3><div>Implementation of OBAT in this trial did not measurably increase duration of medication treatment among those treated for OUD compared to UC, suggesting that benefits of OBAT, at least in this trial, largely reflect increases in treatment access.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"265 ","pages":"Article 112497"},"PeriodicalIF":3.9,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting the alcohol-aggression link: The impact of alcohol consumption patterns","authors":"Maayan Nagar ,&nbsp;Sharon Rabinovitz","doi":"10.1016/j.drugalcdep.2024.112496","DOIUrl":"10.1016/j.drugalcdep.2024.112496","url":null,"abstract":"<div><div>Laboratory studies have repeatedly reported a link between alcohol and aggression, yet many rely on single-dose administration methods and overlook variations in alcohol consumption patterns. The present study investigates the effects of alcohol on aggressive behavior using a double-blind, placebo-controlled cumulative drinking administration approach that mirrors the natural drinking behaviors often observed in pubs within a laboratory setting. This study also pioneers the examination of how alcohol consumption patterns (light or heavy) moderate the relationship between precise Breath Alcohol Concentration (BrAC) levels and extreme aggressive behavior. Seventy-five individuals who drink alcohol lightly (N=38) and heavily (N=37) were randomly assigned to alcohol (N=33) or placebo (N=42) conditions. Participants drank four drinks successively. Taylor's aggression paradigm was completed twenty minutes after each drink. Multilevel modeling was applied to analyze the effects of precise BrAC and account for within-person variability. Alcohol showed a dose-dependent effect on aggression; as alcohol levels rose, so did aggression (p&lt;.001). Alcohol consumption pattern moderated the effect of cumulative BrAC on aggression, such that the effect was more substantial for as compared with individuals who drink lightly (p=.03). The current study highlights the moderating role of alcohol consumption pattern in the association between precise BrAC levels and extreme aggression, offering insights into individual differences in susceptibility to alcohol-induced aggression, and supporting the I³ meta-theory (Finkel, 2014). The Findings underscore the importance of investigating the interplay between acute and chronic alcohol use on behavior, challenging conventional thresholds for hazardous drinking classification. Implications for future studies, legislators, and policymakers are discussed.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"265 ","pages":"Article 112496"},"PeriodicalIF":3.9,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of supervised consumption service use and acute care utilization in people who inject drugs","authors":"Ayden I. Scheim ,&nbsp;Zachary Bouck ,&nbsp;Zoë R. Greenwald ,&nbsp;Vicki Ling ,&nbsp;Shaun Hopkins ,&nbsp;Matt Johnson ,&nbsp;Ahmed Bayoumi ,&nbsp;Tara Gomes ,&nbsp;Dan Werb","doi":"10.1016/j.drugalcdep.2024.112490","DOIUrl":"10.1016/j.drugalcdep.2024.112490","url":null,"abstract":"<div><h3>Background</h3><div>Supervised consumption service (SCS) use among people who inject drugs may reduce acute care utilization; however, prior studies have been limited by self-reported outcomes and dichotomous exposures.</div></div><div><h3>Methods</h3><div>We conducted a prospective cohort study using linked questionnaire and health administrative data among people who inject drugs in Toronto, Canada (2018–2020). Baseline SCS use frequency was defined by a participant’s self-reported proportion of injections performed at an SCS over the past six months: “all/most” (≥75 %), “some” (26–74 %), “few” (1–25 %), or “none” (0 %). Outcomes measured over the following six months included: emergency department (ED) visits; hospitalizations; ED visits or hospitalizations for opioid-related overdose; and hospitalizations for injection-related infections. The relative effects of varying SCS use levels on study outcomes were estimated using inverse-probability-weighted negative binomial regression models.</div></div><div><h3>Results</h3><div>Of 467 participants, 25.5 %, 30.4 %, 28.7 %, and 15.4 % respectively reported “all/most”, “some”, “few”, and “none” levels of SCS use at baseline. SCS use frequency was not significantly associated with ED visits, hospitalizations, or hospitalizations for injection-related infections. Participants reporting “some” SCS use had a higher rate of ED visits or hospitalizations for opioid-related overdose (versus “few”; rate ratio=2.30, 95 % confidence interval=1.15–4.61).</div></div><div><h3>Conclusions</h3><div>SCS use had little impact on objectively measured acute care utilization, which was high overall. Although preventing overdose mortality is the primary goal of SCS in Canada, resourcing sites to support their clients’ acute healthcare needs may help build a continuum of care for people experiencing marginalization who inject drugs.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"265 ","pages":"Article 112490"},"PeriodicalIF":3.9,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective dopamine D3 receptor partial agonist (±)VK4-40 reduces the reinforcing strength of d-amphetamine but not cocaine in rhesus monkeys responding under a progressive-ratio schedule of reinforcement","authors":"Mia I. Allen ,&nbsp;Emory A. Lewis ,&nbsp;Jianjing Cao ,&nbsp;Amy Hauck Newman ,&nbsp;Michael A. Nader","doi":"10.1016/j.drugalcdep.2024.112494","DOIUrl":"10.1016/j.drugalcdep.2024.112494","url":null,"abstract":"<div><h3>Background</h3><div>Although countless studies have aimed to identify and test novel therapeutics for stimulant misuse, there are still no FDA-approved pharmacotherapies for stimulant use disorders. One potential treatment target is the dopamine D3 receptor (D3R) and studies in rodents have suggested that the novel D3R partial agonist (±)VK4–40 may be effective at decreasing cocaine self-administration. However, no previous studies have examined the efficacy of (±)VK4–40 in reducing cocaine self-administration in nonhuman primates nor the generality of effects by examining self-administration of other stimulants using a within-subjects design.</div></div><div><h3>Methods</h3><div>Experiment 1 examined how acute treatment with (±)VK4–40 (1.7–3.0<!--> <!-->mg/kg, i.v.) influenced cocaine and <em>d</em>-amphetamine self-administration in three rhesus monkeys responding under a progressive-ratio (PR) schedule of reinforcement. In Experiment 2, the reinforcing effects of (±)VK4–40 were evaluated under a PR schedule and compared to cocaine and <em>d</em>-amphetamine.</div></div><div><h3>Results</h3><div>When given as a pretreatment, (±)VK4–40 significantly reduced the reinforcing strength of <em>d</em>-amphetamine but not cocaine. In general, the effects of (±)VK4–40 on <em>d</em>-amphetamine responding were parallel downward shifts in the self-administration dose-response curve. When (±)VK4–40 was substituted for cocaine, it functioned as a reinforcer in 2 of 3 monkeys. However, the reinforcing strength of (±)VK4–40 was significantly lower than cocaine and <em>d</em>-amphetamine, suggesting lower potential for misuse.</div></div><div><h3>Conclusions</h3><div>Overall, these findings support further exploration of D3R partial agonists, including (±)VK4–40, for treatment of <em>d</em>-amphetamine misuse or potentially in combination with <em>d</em>-amphetamine for treatment of cocaine use disorder.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"265 ","pages":"Article 112494"},"PeriodicalIF":3.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between young people, social media use and alcohol use: A prospective cohort study","authors":"Brandon Cheng ,&nbsp;Carmen C.W. Lim ,&nbsp;Juliane Pariz Teixeira ,&nbsp;Matthew J. Gullo ,&nbsp;Gary C.K. Chan ,&nbsp;Jason P. Connor","doi":"10.1016/j.drugalcdep.2024.112478","DOIUrl":"10.1016/j.drugalcdep.2024.112478","url":null,"abstract":"<div><h3>Background and aims</h3><div>Social media use is now a significant part of modern daily life. Little is known about how social media impacts young peoples’ drinking behaviours and drinking-related consequences. This cohort study aims to explore the prospective relationship between social media use and future drinking.</div></div><div><h3>Methods</h3><div>1473 alcohol naïve young people, who at Wave 5 (aged 12–13 years) reported no lifetime alcohol use, were included (social media use, peer alcohol use, and covariates were also reported at Wave 5). At Wave 8 (aged 17–18 years), participants reported alcohol use outcomes, including age of drinking initiation, past month and past week risky consumption (&gt;10 drinks/week), and problem drinking (alcohol-related troubles, injuries, and fights).</div></div><div><h3>Results</h3><div>After controlling for factors known to be associated with alcohol use in young people and applying a conservative significance level (<em>α</em> =.01), results revealed that children who engaged in almost daily social media use at ages 12–13 later reported a younger age of drinking onset (β = −0.56, 95 % <em>CI</em> = −0.74, −0.39, <em>p</em> &lt;.001) and greater problem drinking (β = 0.48, 95 % <em>CI</em> = 0.13, 0.83, <em>p</em> =.008) at ages 17–18, compared to those who never used social media at ages 12–13. Early social media use was not associated with odds of subsequent past-month alcohol use or risky alcohol consumption.</div></div><div><h3>Conclusion</h3><div>Young peoples’ social media use was associated with future drinking behaviours, prompting the need for preventative measures to acknowledge the salient impacts of social media.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"265 ","pages":"Article 112478"},"PeriodicalIF":3.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applying a behavioral economic approach to understanding smoking processes: The indirect effect of past quit experiences","authors":"Jillian Robison ,&nbsp;Elizabeth R. Aston ,&nbsp;Cameron T. Matoska ,&nbsp;Tanya Smit ,&nbsp;Clayton Neighbors ,&nbsp;Michael Businelle ,&nbsp;Michael J. Zvolensky ,&nbsp;Lorra Garey","doi":"10.1016/j.drugalcdep.2024.112492","DOIUrl":"10.1016/j.drugalcdep.2024.112492","url":null,"abstract":"<div><h3>Background</h3><div>The Cigarette Purchase Tasks (CPT) measures the relative reinforcing value of cigarettes (i.e., cigarette demand). Extant work supports a relation between cigarette demand and smoking dependence and abstinence. However, little work has focused on how demand relates to cognitive processes hindering smoking cessation (i.e., negative affect reduction smoking motives and expectancies, perceived barriers for quitting) or explanatory variables (i.e., negative quit-related experiences) that may underlie such relations.</div></div><div><h3>Methods</h3><div>The present study (N=100; 70 % male; <em>M</em>_<em>age</em>=45.34 years, SD=11.02) evaluated the indirect effect of cigarette demand, including intensity (i.e., consumption at zero cost), <em>O</em>_max (i.e., maximum expenditure across prices), and elasticity (i.e., price associated with <em>O</em>_max) on smoking motives, smoking expectancies, and perceived barriers for quitting through negative experiences with past quit attempts.</div></div><div><h3>Results</h3><div>Results indicated statistically significant indirect effects of intensity on negative affect reduction smoking motives (<em>ab</em>=.06, SE=.03, <em>CI</em>_{<em>95 %</em>} [.017,.123]), expectancies for smoking to relieve negative affect (<em>ab</em>=.01, SE=.01, <em>CI</em>_{<em>95 %</em>} [.002,.025], and perceived barriers for quitting (<em>ab</em>=.16, SE=.06, <em>CI</em>_{<em>95 %</em>} [.045,.294]) through past quit challenges. In contrast, <em>O</em>_max and elasticity did not show significant indirect effects, highlighting the uniqueness of intensity relative to <em>O</em>_max and elasticity.</div></div><div><h3>Conclusions</h3><div>Findings suggest intensity may be a useful metric for identifying those at risk for negative quit-related experiences, an important finding given negative experiences are associated with poorer cessation-related outcomes. Future work should replicate and extend these findings across diverse populations and evaluate the temporal relationship between high levels of cigarette demand and cessation related challenges.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"265 ","pages":"Article 112492"},"PeriodicalIF":3.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An investigation of multimodal predictors of adolescent alcohol initiation","authors":"Andrew Moore ,&nbsp;Ben Lewis ,&nbsp;Amanda Elton ,&nbsp;Lindsay M. Squeglia ,&nbsp;Sara Jo Nixon","doi":"10.1016/j.drugalcdep.2024.112491","DOIUrl":"10.1016/j.drugalcdep.2024.112491","url":null,"abstract":"<div><h3>Background</h3><div>Early alcohol initiation is associated with negative, alcohol-related outcomes. While previous work identifies numerous risk factors for early use, the relative contributions of known predictors remains understudied. The current project addresses this gap by 1) prospectively predicting early alcohol initiation using measures of inhibition control, reward sensitivity, and contextual risk factors and 2) interrogating the relative importance of each domain.</div></div><div><h3>Method</h3><div>This study leverages multimodal data from substance-naïve youth enrolled in the Adolescent Brain Cognitive Development (ABCD) Study® (n=11,694). Early initiation was defined as consuming a full standard drink containing alcohol prior to age 16. Propensity scores were used to match alcohol initiators (n=348) with demographically similar non-initiators at a 1:2 ratio (n=696). Independent logistic regressions were conducted for each domain followed by additive, hierarchical models.</div></div><div><h3>Results</h3><div>The model of contextual factors (pseudo-R²=0.086, AUC=0.67) outperformed inhibition control (pseudo-R²=0.021, AUC=0.58) and reward sensitivity measures (pseudo-R²=0.020, AUC=0.59). The hierarchical model containing all measures (pseudo-R²=0.106, AUC=0.69) did not significantly improve the model of contextual factors alone (p&gt;0.05). Examples of significant predictors (p&lt;0.05) include externalizing behaviors, number of substances known, and non-religious alcohol sipping.</div></div><div><h3>Conclusion</h3><div>Contextual risk factors were the strongest predictors of early alcohol use; however, more work is needed to understand the causal nature of this relationship. Measures of inhibition control and reward sensitivity were not adequate in distinguishing initiators from non-initiators. These findings add to a body of evidence that contextual factors play a major role in alcohol initiation while highlighting specific predictor variables that could inform youth alcohol prevention.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"265 ","pages":"Article 112491"},"PeriodicalIF":3.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity and tobacco use among high school students in the United States, 2015–2021","authors":"Cristina S. Barroso ,&nbsp;Joshua Chapman ,&nbsp;Priscila Garza ,&nbsp;Dale S. Mantey","doi":"10.1016/j.drugalcdep.2024.112493","DOIUrl":"10.1016/j.drugalcdep.2024.112493","url":null,"abstract":"<div><h3>Objective</h3><div>The relationship between physical activity and tobacco use among adolescents remains unclear. We examined this relationship using nationally representative data from the United States (U.S.).</div></div><div><h3>Methods</h3><div>We pooled four years of cross-sectional data from the Youth Risk Behavior Surveillance System (2015–2021). Participants were high school students (n = 49,857) in the U.S. Multivariate logistic regression models examined the association between measures of self-reported days of 60+ minutes of physical activity per week (0−7) and past 30-day use of combustible cigarette, e-cigarette, cigar, and smokeless tobacco. We modeled interactions by sex. Covariates included sex, race/ethnicity, grade, other tobacco use, and survey year. Supplemental analyses examined the association between sports participation and tobacco use.</div></div><div><h3>Results</h3><div>An increase in the number of days of physical activity corresponded with lower odds of cigarette smoking (aOR: 0.93; 95 % CI: 0.90 – 0.95) but greater odds of using e-cigarettes (aOR 1.05; 95 % CI: 1.03–1.06) and smokeless tobacco (aOR: 1.07; 95 % CI: 1.04–1.11). There was no association between days of physical activity and cigar smoking. The association between physical activity and e-cigarette use differed by sex (p &lt; 0.001), with the association observed among males (aOR 1.07; 95 % CI: 1.05–1.10) but not females (aOR 1.02; 95 % CI: 0.99–1.04). Sports participation had similar associations.</div></div><div><h3>Conclusions</h3><div>Findings indicate that physically active youth are using non-combustible products at an alarming rate. Findings suggest the need for intervention to reduce e-cigarette and smokeless tobacco use among youth.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"265 ","pages":"Article 112493"},"PeriodicalIF":3.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct populations suppress or escalate intake of cocaine paired with aversive quinine","authors":"Rosalie E. Powers ,&nbsp;Peter A. Fogel ,&nbsp;Jayson H. Reeves ,&nbsp;Pamela Madrid ,&nbsp;Travis M. Moschak","doi":"10.1016/j.drugalcdep.2024.112475","DOIUrl":"10.1016/j.drugalcdep.2024.112475","url":null,"abstract":"<div><h3>Background</h3><div>Only a subset of individuals who encounter illicit drugs become persons with a substance use disorder. Individual differences in aversive reactions to drug-associated phenomena like smoke inhalation and unpleasant taste are predictors for continued use. While several preclinical studies have explored self-administration involving aversive cues, none have simultaneously introduced aversion with the initial drug self-administration. We aimed to develop such a model by pairing intravenous cocaine with intraoral quinine self-administration from the outset and investigate whether repeated exposure to an aversive stimulus would alter its hedonic value under laboratory conditions.</div></div><div><h3>Methods</h3><div>Twenty-seven male and female Sprague Dawley rats self-administered intravenous/intraoral (cocaine/quinine) for 2<!--> <!-->h/day over 14 days. This was followed by a 1-day quinine-only extinction session, a 3-day return to self-administration, and an intraoral infusion session to assess quinine taste reactivity (TR).</div></div><div><h3>Results</h3><div>We identified three distinct groups. The first self-administered very little cocaine, while the second sharply escalated cocaine intake. Both groups had similar aversive TR to quinine, suggesting that the escalating group did not habituate to the aversive cue but pursued drug despite it. We also identified a third group with high initial intake that decreased over time. This decrease predicted high aversive TR, and we argue this group may represent individuals who engage in excessive use on their first encounter and subsequently find self-administration to be aversive.</div></div><div><h3>Conclusions</h3><div>Our novel model yields three distinct groups that differ in self-administration patterns and aversive cue valuation.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"265 ","pages":"Article 112475"},"PeriodicalIF":3.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurostructural features predict binge drinking in emerging adulthood: Evidence from a 5-year follow-up study","authors":"Jose Manuel Pérez-García ,&nbsp;Samuel Suárez-Suárez ,&nbsp;María Soledad Rodríguez González ,&nbsp;Socorro Rodríguez Holguín ,&nbsp;Fernando Cadaveira ,&nbsp;Sonia Doallo","doi":"10.1016/j.drugalcdep.2024.112489","DOIUrl":"10.1016/j.drugalcdep.2024.112489","url":null,"abstract":"<div><h3>Background</h3><div>Binge drinking (BD) involves consuming large amounts of alcohol within a short timeframe, leading to a blood alcohol concentration of 0.08<!--> <!-->g/dL or above. This pattern of alcohol consumption is prevalent among young adults and has significant implications for brain structure and subsequent drinking behaviors.</div></div><div><h3>Methods</h3><div>In this prospective longitudinal study, we employed zero-inflated negative binomial regression models to examine whether various neurostructural features (i.e., volume, surface area, cortical thickness) of brain regions involved in executive and emotional/motivational processes at the age of 18–19 could predict number of BD episodes five years later, at ages 23–24, once participants were expected to complete their university degree. Specifically, we recorded magnetic resonance imaging (MRI) data from 68 students who completed both the baseline MRI and follow-up alcohol use assessment, with the aim of analyzing the predictive value of these neurostructural characteristics five years later.</div></div><div><h3>Results</h3><div>The analysis revealed that a larger surface area in the caudal division of the right middle frontal gyrus was significantly associated with a higher incidence rate of BD episodes (IRR = 2.24, 95 % CI = 1.28–3.91, p = 0.005). Conversely, a smaller surface area in the right caudal anterior cingulate cortex was associated with a higher incidence rate of BD episodes (IRR = 0.61, 95 % CI = 0.44–0.85, p = 0.004).</div></div><div><h3>Conclusions</h3><div>These findings suggest that specific neurostructural characteristics during adolescence can predict BD behaviors in young adulthood. This highlights the potential of neuroimaging to identify individuals at risk for developing problematic alcohol use.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"265 ","pages":"Article 112489"},"PeriodicalIF":3.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}