芬太尼时代青少年和年轻人非致命性用药过量的横断面多样本研究。

IF 3.6 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence Pub Date : 2025-10-11 DOI:10.1016/j.drugalcdep.2025.112921

Amy M. Yule , Amy S.B. Bohnert , Ty A. Ridenour , Barrett Montgomery , Timothy E. Wilens , Maureen Walton , Erin E. Bonar , Lisa Saldana , Lynn E. Fiellin , Danica K. Knight , Yang Yang , Jason Williams , Sazid Khan , Liann Tucker , Feker Wondimagegnehu , Kym Ahrens

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引用次数: 0

摘要

导言：2019年至2022年期间，尽管药物使用量有所下降，但青少年和年轻人（AYA）的过量死亡人数却不成比例地增加。我们检查了非致死性用药过量的发生率以及与用药过量史相关的特征。方法：AYA在2020年至2023年期间纳入了来自六个州的儿童福利、医疗保健和法律环境的五项阿片类药物使用障碍预防研究。基线时评估非致死性用药过量史、人口统计学和临床特征。在所有研究中，过量用药史的评估在措辞上略有不同，但大多数其他措施都是标准化的。以人口统计学控制变量（年龄、性别、种族）作为协变量，对各危险因素进行logistic回归，计算终生用药过量的优势比（OR），并按样本单独报告。结果：样本量为137 ~ 929（总N = 1856）。样本的特征范围为年龄M = 16.2-26.4，女性为11.7- 91.9%。在种族方面，样本中白人占35%到89.4%，黑人占17.3到89.4%。非致死性用药过量史从6.6%到41.4%不等。所有样本中与过量用药史相关的统计学显著特征包括阿片类药物滥用史（or范围为1.98至6.73）和有药物使用问题的家庭成员（or范围为1.27至2.05）。在一些样本中，频繁和早期开始使用酒精和大麻也与过量使用史有关。结论：AYA的过量预防干预措施应包括关注滥用阿片类药物的AYA和有药物使用史的家庭。

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Cross sectional multi-sample study of nonfatal overdose in adolescents and young adults in the fentanyl era

Introduction

Overdose deaths disproportionately increased among adolescents and young adults (AYA) between 2019 and 2022, despite declining substance use. We examined the prevalence of nonfatal overdose and characteristics associated with overdose history in AYA.

Methods

AYA enrolled between 2020 and 2023 in five opioid use disorder prevention studies in child welfare, healthcare, and legal settings from six states were included in this analysis. Nonfatal overdose history, demographic, and clinical characteristics were assessed at baseline. Across studies, overdose history was assessed with slight variations in wording, but most other measures were standardized. Odds ratios (OR) of lifetime overdose were calculated with logistic regression for each risk factor with demographic control variables (age, sex, race) included as covariates, and reported separately by sample.

Results

Sample sizes ranged from 137 to 929 (total N = 1856). Characteristics across samples ranged from M = 16.2–26.4 years for age, and 11.7–91.9 % for female sex. For race, samples ranged from 35 % to 89.4 % White and 17.3–89.4 % Black. History of nonfatal overdose ranged from 6.6 % to 41.4 %. Statistically significant characteristics associated with overdose history in all samples included history of opioid misuse (ORs ranging from 1.98 to 6.73) and family members with a substance use problem (ORs range from 1.27 to 2.05). Frequent and early onset alcohol and cannabis use was also associated with overdose history in several samples.

Conclusions

Overdose prevention interventions for AYA should include a focus on AYA who misuse opioids and families with a history of substance use problems.

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来源期刊

Drug and alcohol dependence 医学-精神病学

CiteScore

7.40

自引率

7.10%

发文量

409

审稿时长

41 days

期刊介绍： Drug and Alcohol Dependence is an international journal devoted to publishing original research, scholarly reviews, commentaries, and policy analyses in the area of drug, alcohol and tobacco use and dependence. Articles range from studies of the chemistry of substances of abuse, their actions at molecular and cellular sites, in vitro and in vivo investigations of their biochemical, pharmacological and behavioural actions, laboratory-based and clinical research in humans, substance abuse treatment and prevention research, and studies employing methods from epidemiology, sociology, and economics.