个体化阿片类药物过量和阿片类药物使用障碍（mod）教育（TOME）显著增加围产期个体的mod和过量知识：来自一项随机对照试点试验的结果

IF 3.6 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence Pub Date : 2025-07-16 DOI:10.1016/j.drugalcdep.2025.112795

T. John Winhusen , Frankie Kropp , Marcela C. Smid , Jessica L. Young , Todd H. Davies , Daniel Lewis , Carmen Rosa , Maham Dilawar , Elizabeth E. Krans , Candace Hodgkins , Gerald Cochran , Michelle R. Lofwall

{"title":"个体化阿片类药物过量和阿片类药物使用障碍（mod）教育（TOME）显著增加围产期个体的mod和过量知识：来自一项随机对照试点试验的结果","authors":"T. John Winhusen , Frankie Kropp , Marcela C. Smid , Jessica L. Young , Todd H. Davies , Daniel Lewis , Carmen Rosa , Maham Dilawar , Elizabeth E. Krans , Candace Hodgkins , Gerald Cochran , Michelle R. Lofwall","doi":"10.1016/j.drugalcdep.2025.112795","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Overdose is a leading cause of pregnancy-associated mortality in the US. Our personally-tailored opioid-overdose (OOD) and medication for opioid use disorder (MOUD) education intervention has been shown to significantly improve MOUD/OOD knowledge in out-of-treatment persons using illicit opioids. We evaluated the ability of the intervention modified for peripartum (pregnant or within one year postpartum) individuals, the personally-tailored OOD and MOUD education (TOME) intervention, to increase MOUD (primary) and OOD (key secondary) knowledge.</div></div><div><h3>Methods</h3><div>A six-site, two-arm, open-label, trial with 131 peripartum individuals receiving MOUD (methadone or buprenorphine) randomized to TOME, a 15-minute, computer-facilitated, individually-tailored intervention, or Control. TOME participants received education on MOUD and OOD questions they missed in a pre-test. Control participants received SAMHSA handouts on OOD and MOUD. All participants were scheduled for a 3-week post-test.</div></div><div><h3>Results</h3><div>Participants were enrolled in MOUD for an average of 15.6 months (SD=20.4) at baseline, with 30.5 % enrolled in methadone and 69.5 % enrolled in buprenorphine treatment. On the pre-test, participants answered 66.7 % of the MOUD and 82.1 % of the OOD questions correctly on average. Linear regressions indicated that participants’ MOUD (X<sup>2</sup>=33.96, p < 0.001) and OOD (X<sup>2</sup>=45.78, p < 0.001) knowledge increased significantly more in the TOME, relative to Control, group.</div></div><div><h3>Conclusions</h3><div>In a sample of peripartum patients enrolled in MOUD for a substantial length of time, TOME significantly increased MOUD and OOD knowledge. Taken together with past research, these findings suggest that there are gaps in MOUD and OOD knowledge in individuals with opioid use disorder that can be addressed with brief personally-tailored education.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"275 ","pages":"Article 112795"},"PeriodicalIF":3.6000,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Personally-tailored opioid-overdose and medication for opioid use disorder (MOUD) education (TOME) significantly increases MOUD and overdose knowledge in peripartum individuals: Results from a randomized controlled pilot trial\",\"authors\":\"T. John Winhusen , Frankie Kropp , Marcela C. Smid , Jessica L. Young , Todd H. Davies , Daniel Lewis , Carmen Rosa , Maham Dilawar , Elizabeth E. Krans , Candace Hodgkins , Gerald Cochran , Michelle R. Lofwall\",\"doi\":\"10.1016/j.drugalcdep.2025.112795\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Overdose is a leading cause of pregnancy-associated mortality in the US. Our personally-tailored opioid-overdose (OOD) and medication for opioid use disorder (MOUD) education intervention has been shown to significantly improve MOUD/OOD knowledge in out-of-treatment persons using illicit opioids. We evaluated the ability of the intervention modified for peripartum (pregnant or within one year postpartum) individuals, the personally-tailored OOD and MOUD education (TOME) intervention, to increase MOUD (primary) and OOD (key secondary) knowledge.</div></div><div><h3>Methods</h3><div>A six-site, two-arm, open-label, trial with 131 peripartum individuals receiving MOUD (methadone or buprenorphine) randomized to TOME, a 15-minute, computer-facilitated, individually-tailored intervention, or Control. TOME participants received education on MOUD and OOD questions they missed in a pre-test. Control participants received SAMHSA handouts on OOD and MOUD. All participants were scheduled for a 3-week post-test.</div></div><div><h3>Results</h3><div>Participants were enrolled in MOUD for an average of 15.6 months (SD=20.4) at baseline, with 30.5 % enrolled in methadone and 69.5 % enrolled in buprenorphine treatment. On the pre-test, participants answered 66.7 % of the MOUD and 82.1 % of the OOD questions correctly on average. Linear regressions indicated that participants’ MOUD (X<sup>2</sup>=33.96, p < 0.001) and OOD (X<sup>2</sup>=45.78, p < 0.001) knowledge increased significantly more in the TOME, relative to Control, group.</div></div><div><h3>Conclusions</h3><div>In a sample of peripartum patients enrolled in MOUD for a substantial length of time, TOME significantly increased MOUD and OOD knowledge. Taken together with past research, these findings suggest that there are gaps in MOUD and OOD knowledge in individuals with opioid use disorder that can be addressed with brief personally-tailored education.</div></div>\",\"PeriodicalId\":11322,\"journal\":{\"name\":\"Drug and alcohol dependence\",\"volume\":\"275 \",\"pages\":\"Article 112795\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-07-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug and alcohol dependence\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0376871625002480\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug and alcohol dependence","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0376871625002480","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

摘要

背景：在美国，过量服用是导致妊娠相关死亡的主要原因。我们量身定制的阿片类药物过量（OOD）和阿片类药物使用障碍（mod）教育干预已被证明可以显着提高使用非法阿片类药物的治疗外人员的mod /OOD知识。我们评估了围生期（怀孕或产后一年内）个体的干预改进的能力，个性化的OOD和mod教育（TOME）干预，以增加mod（初级）和OOD（关键次要）知识。方法：一项六点、双臂、开放标签、131名围产期患者接受MOUD（美沙酮或丁丙诺啡）的试验，随机分为TOME组、15分钟、电脑辅助、个性化干预组或对照组。TOME参与者接受了关于他们在预测试中错过的mod和OOD问题的教育。对照组的参与者收到了SAMHSA关于OOD和mod的讲义。所有参与者都被安排进行为期3周的后测。结果受试者在基线时平均接受mod治疗15.6个月（SD=20.4），其中30.5%接受美沙酮治疗，69.5%接受丁丙诺啡治疗。在前测中，参与者平均答对了66.7%的mod问题和82.1%的OOD问题。线性回归结果显示，实验组参与者的mod （X2=33.96, p < 0.001）和OOD （X2=45.78, p < 0.001）知识显著高于对照组。结论在一组围生期患者样本中，在相当长的一段时间内，TOME显著增加了MOUD和OOD知识。结合过去的研究，这些发现表明，阿片类药物使用障碍患者在mod和OOD知识方面存在差距，可以通过简短的个性化教育来解决。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Personally-tailored opioid-overdose and medication for opioid use disorder (MOUD) education (TOME) significantly increases MOUD and overdose knowledge in peripartum individuals: Results from a randomized controlled pilot trial

Background

Overdose is a leading cause of pregnancy-associated mortality in the US. Our personally-tailored opioid-overdose (OOD) and medication for opioid use disorder (MOUD) education intervention has been shown to significantly improve MOUD/OOD knowledge in out-of-treatment persons using illicit opioids. We evaluated the ability of the intervention modified for peripartum (pregnant or within one year postpartum) individuals, the personally-tailored OOD and MOUD education (TOME) intervention, to increase MOUD (primary) and OOD (key secondary) knowledge.

Methods

A six-site, two-arm, open-label, trial with 131 peripartum individuals receiving MOUD (methadone or buprenorphine) randomized to TOME, a 15-minute, computer-facilitated, individually-tailored intervention, or Control. TOME participants received education on MOUD and OOD questions they missed in a pre-test. Control participants received SAMHSA handouts on OOD and MOUD. All participants were scheduled for a 3-week post-test.

Results

Participants were enrolled in MOUD for an average of 15.6 months (SD=20.4) at baseline, with 30.5 % enrolled in methadone and 69.5 % enrolled in buprenorphine treatment. On the pre-test, participants answered 66.7 % of the MOUD and 82.1 % of the OOD questions correctly on average. Linear regressions indicated that participants’ MOUD (X²=33.96, p < 0.001) and OOD (X²=45.78, p < 0.001) knowledge increased significantly more in the TOME, relative to Control, group.

Conclusions

In a sample of peripartum patients enrolled in MOUD for a substantial length of time, TOME significantly increased MOUD and OOD knowledge. Taken together with past research, these findings suggest that there are gaps in MOUD and OOD knowledge in individuals with opioid use disorder that can be addressed with brief personally-tailored education.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Drug and alcohol dependence 医学-精神病学

CiteScore

7.40

自引率

7.10%

发文量

409

审稿时长

41 days

期刊介绍： Drug and Alcohol Dependence is an international journal devoted to publishing original research, scholarly reviews, commentaries, and policy analyses in the area of drug, alcohol and tobacco use and dependence. Articles range from studies of the chemistry of substances of abuse, their actions at molecular and cellular sites, in vitro and in vivo investigations of their biochemical, pharmacological and behavioural actions, laboratory-based and clinical research in humans, substance abuse treatment and prevention research, and studies employing methods from epidemiology, sociology, and economics.