Drug and alcohol dependence最新文献

{"title":"Persistent Behavioral Effects of Repeated Adolescent Exposure to Heroin and Delta-9-Tetrahydrocannabinol (THC) Vapor","authors":"Arnold Gutierrez * , Nora Alammari , Michael Taffe","doi":"10.1016/j.drugalcdep.2024.111426","DOIUrl":"10.1016/j.drugalcdep.2024.111426","url":null,"abstract":"","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"267 ","pages":"Article 111426"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct and Mediating Effects of Text-Message Delivered Cannabis Use Disorder Treatment With Young Adults: A Large Randomized Clinical Trial","authors":"Michael Mason * , Douglas Coatsworth , Nathaniel Riggs , Michael Russell , Jeremy Mennis , Nikola Zaharakis , Aaron Brown","doi":"10.1016/j.drugalcdep.2024.111465","DOIUrl":"10.1016/j.drugalcdep.2024.111465","url":null,"abstract":"","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"267 ","pages":"Article 111465"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of glucocorticoid and nicotinic acetylcholine receptors in the reward-enhancing effects of nicotine in the ICSS procedure in male and female rats","authors":"Ranjithkumar Chellian,&nbsp;Azin Behnood-Rod,&nbsp;Adriaan W. Bruijnzeel","doi":"10.1016/j.drugalcdep.2024.112531","DOIUrl":"10.1016/j.drugalcdep.2024.112531","url":null,"abstract":"<div><div>Tobacco use disorder is a chronic disorder that affects more than one billion people worldwide and causes the death of millions each year. The rewarding properties of nicotine are critical for the initiation of smoking. Previous research has shown that the activation of glucocorticoid receptors (GRs) plays a role in nicotine self-administration in rats. However, the role of GRs in the acute rewarding effects of nicotine are unknown. In this study, we investigated the effects of the GR antagonist mifepristone and the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine on the reward-enhancing effects of nicotine using the intracranial self-stimulation (ICSS) procedure in adult male and female rats. The rats were prepared with ICSS electrodes in the medial forebrain bundle and then trained on the ICSS procedure. Nicotine lowered the brain reward thresholds and decreased response latencies similarly in male and female rats. These findings suggest that nicotine enhances the rewarding effects of ICSS and has stimulant properties. Treatment with the GR antagonist mifepristone did not affect the reward-enhancing effects of nicotine but increased response latencies, suggesting a sedative effect. Mecamylamine prevented the nicotine-induced decrease in brain reward thresholds and response latencies, but did not affect the brain reward thresholds or response latencies of the control rats. These findings suggest that the rewarding effects of nicotine are mediated via the activation of nAChRs, and that the activation of GRs does not contribute to the acute rewarding effects of nicotine. These studies enhance our understanding of the neurobiological mechanisms underlying tobacco use disorder.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"267 ","pages":"Article 112531"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic differences in modes of cannabis use among pregnant individuals in Northern California","authors":"Kelly C. Young-Wolff ,&nbsp;Catherine A. Cortez ,&nbsp;Joshua R. Nugent ,&nbsp;Alisa A. Padon ,&nbsp;Judith J. Prochaska ,&nbsp;Sara R. Adams ,&nbsp;Natalie E. Slama ,&nbsp;Aurash J. Soroosh ,&nbsp;Monique B. Does ,&nbsp;Cynthia I. Campbell ,&nbsp;Deborah Ansley ,&nbsp;Carley Castellanos ,&nbsp;Qiana L. Brown","doi":"10.1016/j.drugalcdep.2024.112546","DOIUrl":"10.1016/j.drugalcdep.2024.112546","url":null,"abstract":"<div><h3>Background</h3><div>The potential risks of prenatal cannabis use may vary depending on how cannabis is administered, but little is known about modes of prenatal cannabis use. This study characterized prevalence and sociodemographic correlates of modes of prenatal cannabis use in California.</div></div><div><h3>Methods</h3><div>This cross-sectional study included patients with pregnancies between January 1, 2021 and December 31, 2022 in a large healthcare system (3507 pregnancies [3454 individuals]) who self-reported prenatal cannabis use and mode of use (smoke, vape, edibles, dabs, and topicals) during universal screening at entrance to prenatal care. Multivariable regression models examined the relationship between sociodemographic characteristics and modes of use.</div></div><div><h3>Results</h3><div>Smoking was the most common mode (71.1 %), followed by edibles (32.6 %), vaping (22.2 %), dabs (9.9 %), and topicals (4.6 %); 29.9 % endorsed multiple modes. Those who used edibles were the least likely to use daily (28.2 %), while those who dabbed (54.3 %) or used &gt; 1 mode (45.3 %) were the most likely to use daily. In multivariable models, smoking was generally more common and edibles less common among those who were younger, non-Hispanic Black, and living in more deprived neighborhoods, vaping was more common among Hispanic individuals and less common among non-Hispanic Black individuals and those living in more deprived neighborhoods, and dabbing was more common among those who were younger and Hispanic.</div></div><div><h3>Conclusion</h3><div>Modes of cannabis use during early pregnancy varied by sociodemographic characteristics. Future research is needed to test whether the risks of adverse outcomes or likelihood of persistent use during pregnancy vary depending on how cannabis is administered during pregnancy.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"267 ","pages":"Article 112546"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the association between fentanyl use and perceived adequacy of methadone dose: A retrospective cohort study","authors":"Samantha Young ,&nbsp;Janet Raboud ,&nbsp;Zoë Dodd ,&nbsp;Kora DeBeck ,&nbsp;MJ Milloy ,&nbsp;Dean Wilson ,&nbsp;Kanna Hayashi ,&nbsp;Ahmed M. Bayoumi ,&nbsp;Nadia Fairbairn","doi":"10.1016/j.drugalcdep.2024.112547","DOIUrl":"10.1016/j.drugalcdep.2024.112547","url":null,"abstract":"<div><h3>Background</h3><div>People exposed to fentanyl may report that the dose of methadone in the commonly accepted therapeutic range feels too low. We examined self-reported methadone dose adequacy.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study of individuals prescribed methadone at a dose of at least 60<!--> <!-->mg daily using data from three community-recruited prospective cohort studies of people who use drugs in Vancouver, Canada from December 2016 through March 2020. We used multivariable generalized estimating equations to estimate the relationship between type of opioid exposure – measured using urine drug tests and categorized as: (1) fentanyl-positive, (2) fentanyl-negative opioid-positive, and (3) fentanyl- and opioid-negative, and report of their methadone dose being too low.</div></div><div><h3>Results</h3><div>In total, 1732 observations from 616 participants were included, of which 914 (52.8 %) observations had a fentanyl-positive, 178 (10.3 %) had a fentanyl-negative opioid-positive, and 640 (37.0 %) had a fentanyl- and opioid-negative urine drug test. Compared with those with a fentanyl-positive urine drug test, in the adjusted model those with a fentanyl- and opioid-negative urine drug test were significantly less likely to report their methadone dose as too low (adjusted odds ratio [AOR]=0.57, 95 % CI 0.41–0.81), while there was no significant association among those with a fentanyl-negative opioid-positive urine drug test (AOR=0.92, 95 % CI 0.59–1.43).</div></div><div><h3>Conclusions</h3><div>We found that exposure to non-fentanyl opioids while on methadone was not associated with feeling the dose was too low compared with individuals exposed to fentanyl. Our findings support adequate titration of methadone for individuals with continued exposure to unregulated opioids including fentanyl.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"267 ","pages":"Article 112547"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain severity contributes to worse outcomes in opioid use disorder recovery than pain status","authors":"William H. Craft ,&nbsp;Candice L. Craft ,&nbsp;Allison N. Tegge ,&nbsp;Liqa N. Athamneh ,&nbsp;Jeffrey S. Stein ,&nbsp;Diana R. Keith ,&nbsp;Anne Le Moigne ,&nbsp;Angela M. DeVeaugh-Geiss ,&nbsp;Howard D. Chilcoat ,&nbsp;Warren K. Bickel","doi":"10.1016/j.drugalcdep.2024.112530","DOIUrl":"10.1016/j.drugalcdep.2024.112530","url":null,"abstract":"<div><h3>Background</h3><div>Opioid use disorder (OUD) continues to pose a significant challenge to public health in the United States. Chronic pain and OUD are highly comorbid conditions, yet few studies have examined the relative associations of pain status and severity toward multidimensional OUD recovery outcomes (e.g., psychopathology and withdrawal).</div></div><div><h3>Methods</h3><div>Participants (N = 214) were from the RECOVER-LT study, conducted 4.2-years after completion of a clinical trial program assessing extended-release buprenorphine. Group differences by pain status (i.e., chronic, acute, or no pain) were evaluated in this cross-sectional data set using analysis of variance and Fisher’s exact test. Linear regression was utilized to understand the associations between average pain severity and recovery outcomes. Model selection was performed to examine the relative importance of pain status and average pain severity to recovery outcomes.</div></div><div><h3>Results</h3><div>A majority of the sample endorsed chronic pain (73.8 %). The multivariate regression analysis with model selection found that higher average pain severity (<em>p</em> &lt; .001), but not pain status, was significantly associated with the multidimensional recovery outcomes greater total number of DSM-5 OUD symptoms, higher opioid withdrawal score, reduced physical quality of life, higher depressive symptoms, negative affect, and greater psychological distress. Pain status and average pain severity were not associated with past 7- or 30-day opioid use (<em>p</em> &gt; 0.001).</div></div><div><h3>Conclusions</h3><div>These findings highlight pain severity, but not pain status, as a key dimension of OUD recovery. This suggests a need for integration of OUD treatment and pain management, particularly for individuals experiencing elevated pain severity regardless of pain status.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"267 ","pages":"Article 112530"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Describing Patterns of Drug Use and Service Delivery at Supervised Consumption Sites in Canada","authors":"Colin Steensma * ,&nbsp;Isac Lima ,&nbsp;Ledia Gamil ,&nbsp;Michelle Ross","doi":"10.1016/j.drugalcdep.2024.111429","DOIUrl":"10.1016/j.drugalcdep.2024.111429","url":null,"abstract":"","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"267 ","pages":"Article 111429"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and Facilitators to Injectable Opioid Agonist Treatment Engagement: A Qualitative Study of Patient Experiences in Vancouver, Canada","authors":"Samara Mayer * ,&nbsp;Nadia Fairbairn ,&nbsp;Al Fowler ,&nbsp;Ryan McNeil","doi":"10.1016/j.drugalcdep.2024.111435","DOIUrl":"10.1016/j.drugalcdep.2024.111435","url":null,"abstract":"","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"267 ","pages":"Article 111435"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptations to Contingency Management for Alcohol Use Do Not Increase Efficacy in Individuals who Engage in Pre-Treatment Drinking Consistent with Non-Response","authors":"Michael McDonell * ,&nbsp;Mohammad Keshtkar ,&nbsp;Katherine Palmer ,&nbsp;Diana Tyutyunnyk ,&nbsp;Julianne Jett ,&nbsp;Sara Parent ,&nbsp;Rachael Beck ,&nbsp;Naomi Chaytor ,&nbsp;Sean Murphy ,&nbsp;Solmaz Amiri ,&nbsp;Douglas Weeks ,&nbsp;Sterling McPherson ,&nbsp;Richard Ries ,&nbsp;John Roll","doi":"10.1016/j.drugalcdep.2024.111447","DOIUrl":"10.1016/j.drugalcdep.2024.111447","url":null,"abstract":"","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"267 ","pages":"Article 111447"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engaging the Great Circle: A Qualitative Study of the Confederated Tribes of Grand Ronde's Mobile Medication Unit","authors":"Kim Hoffman * ,&nbsp;Chantell Smith-Graves ,&nbsp;Kelly Rowe ,&nbsp;Jennifer Worth ,&nbsp;Kellie Pertl ,&nbsp;James Laidler ,&nbsp;P. Todd Korthuis ,&nbsp;Dennis McCarty","doi":"10.1016/j.drugalcdep.2024.111451","DOIUrl":"10.1016/j.drugalcdep.2024.111451","url":null,"abstract":"","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"267 ","pages":"Article 111451"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}