Drug and alcohol dependence最新文献

{"title":"Retraction notice to “The effect of the NLRP1 inflammasome on methamphetamine-induced cognitive impairment in rats” [Drug and Alcohol Dependence 237 (2022) 109537]","authors":"Runyue Fan , Yao Shen , Xiaofang Li , Hu Luo , Peng Zhang , Yingying Liu , Zizhen Si , Wenhua Zhou , Yu Liu","doi":"10.1016/j.drugalcdep.2025.112857","DOIUrl":"10.1016/j.drugalcdep.2025.112857","url":null,"abstract":"","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"275 ","pages":"Article 112857"},"PeriodicalIF":3.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How does methamphetamine affect the brain? A systematic review of magnetic resonance imaging studies","authors":"G.X.H. Liu ,&nbsp;M. Tayebi ,&nbsp;B. Bristow ,&nbsp;J. Wang ,&nbsp;Y. Lin ,&nbsp;G. Newburn ,&nbsp;P. Condron ,&nbsp;P. McHugh ,&nbsp;W. Schierding ,&nbsp;S. Holdsworth ,&nbsp;M. Scadeng","doi":"10.1016/j.drugalcdep.2025.112862","DOIUrl":"10.1016/j.drugalcdep.2025.112862","url":null,"abstract":"<div><div>Methamphetamine (METH) is an addictive psychostimulant that is associated with significant physical and psychological harm. Magnetic resonance imaging (MRI) is a non-invasive imaging modality used to identify structural and functional brain changes. We conducted a systematic review to identify and appraise the existing literature on brain MRI differences associated with METH exposure. A comprehensive literature search was conducted on PubMed, Web of Science, and Scopus. Any study that evaluated the brain in people who used or had been exposed to METH using MRI were included. Data were collected on study design, participant demographics, METH use parameters, MRI acquisition details, and key findings. One hundred and eighty-one studies with 11997 participants were included in our review. Nearly all were conducted in adults/adolescents (164/181, 91 %), and most studies were cross-sectional (142/181, 78 %). Task-based functional MRI was the most common modality used (62/181, 34 %), followed by structural MRI (47/181, 26 %). Quality appraisal scores ranged from 40 – 100 % (mean 90 %). Overall, METH is associated with numerous differences in brain structure and function, including lower grey matter volume and thickness in frontal and limbic regions and lower fractional anisotropy in various white matter structures, with differences in socio-emotional functioning, decision-making and learning processes, and cognitive performance. Targeted multi-modal MRI sequences may be useful in further clarifying the brain differences associated with METH use and evaluating the use of potential therapeutic agents.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112862"},"PeriodicalIF":3.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of ketamine on methamphetamine withdrawal-induced anxiety and drug-seeking behaviors in the rat","authors":"Marco German Ghilotti,&nbsp;Richardo Petrilli Fortuna,&nbsp;Kofi Osei-Abrefa Ayensu,&nbsp;Danielle R. Stern,&nbsp;Ellen M. Unterwald","doi":"10.1016/j.drugalcdep.2025.112861","DOIUrl":"10.1016/j.drugalcdep.2025.112861","url":null,"abstract":"<div><h3>Background</h3><div>The use of methamphetamine has continued to rise in the US. In addition to facilitating dopamine neurotransmission, methamphetamine indirectly increases glutamate release, which activates N-methyl-<span>D</span>-aspartate receptors (NMDARs). Ketamine is a noncompetitive NMDAR antagonist. Ketamine also has actions on α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) and promotes synaptogenesis. Thus, we hypothesized that ketamine may be a potential therapeutic to reduce methamphetamine-seeking behaviors and associated negative affect in a rat model.</div></div><div><h3>Methods</h3><div>Male and female rats underwent methamphetamine or saline intravenous self-administration for 10 sessions, followed by extinction training. Rats received ketamine or saline treatment either prior to 10 daily extinction sessions or only prior to the last extinction session. Anxiety-like behaviors were measured 24<!--> <!-->h after extinction, followed by cue-induced and drug-primed reinstatement two and six days later, respectively.</div></div><div><h3>Results</h3><div>Methamphetamine withdrawal increased anxiety-like behaviors in male rats on the elevated plus maze test compared to rats that self-administered saline. Moreover, anxiety-like behaviors were significantly attenuated by daily ketamine treatment during extinction. Drug-primed, but not cue-induced reinstatement, tested six days after the last extinction session, was significantly attenuated in male rats that received ten or one ketamine injection during extinction compared with rats receiving vehicle during extinction. Ketamine was ineffective in female rats in reducing cue-induced or drug-primed reinstatement.</div></div><div><h3>Conclusions</h3><div>Ketamine may confer sex-specific benefits during methamphetamine withdrawal , particularly by reducing anxiety-like behaviors and attenuating drug-primed reinstatement in males. These results support the potential of ketamine as a targeted adjunct therapy during early methamphetamine abstinence in males.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112861"},"PeriodicalIF":3.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced drinking as a mechanism for alcohol and violence-related intervention effects from Positive Change©","authors":"Andrew J. Rizzo ,&nbsp;Jessalynn R. Ellis ,&nbsp;Ruschelle M. Leone ,&nbsp;Kelly Cue Davis ,&nbsp;Amanda K. Gilmore","doi":"10.1016/j.drugalcdep.2025.112854","DOIUrl":"10.1016/j.drugalcdep.2025.112854","url":null,"abstract":"<div><h3>Purpose</h3><div>Alcohol use and sexual assault (SA) victimization often co-occur on college campuses, and prevention programs should ideally address both of these public health issues with integrated evidence-based interventions. Positive Change© is a web-based intervention with integrated content on alcohol and SA using personalized normative feedback tailored by participant gender identity and sexual orientation. Building from previous program evaluations, the current study examines alcohol use as a mediator for the intervention effects of Positive Change© on alcohol-related consequences, SA victimization likelihood, and SA victimization severity.</div></div><div><h3>Methods</h3><div>College students (n = 165) aged 18–25 who engaged in heavy episodic drinking in the past month were enrolled in a pilot randomized controlled trial of Positive Change©. Participants completed a baseline survey, were randomly assigned to receive Positive Change© (n = 83) or an assessment only control (n = 82) and completed a 3-month follow-up survey.</div></div><div><h3>Results</h3><div>Two separate path analyses were conducted. Drinks per week mediated the effect of Positive Change© to reduce alcohol-related consequences and reduce SA likelihood, but did not mediate reduced SA severity.</div></div><div><h3>Conclusions</h3><div>Findings suggest that brief well-integrated programs utilizing personalized normative feedback for alcohol use and SA may be ideal for reducing alcohol use, which in turn may reduce risk of SA victimization among college students.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"275 ","pages":"Article 112854"},"PeriodicalIF":3.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicaid prescription cap policies and acute care use and mortality among enrollees with opioid use disorder","authors":"Patience M. Dow ,&nbsp;Christopher M. Santostefano ,&nbsp;Landon D. Hughes ,&nbsp;Elizabeth G. Stettenbauer ,&nbsp;Theresa I. Shireman ,&nbsp;Julie M. Donohue ,&nbsp;Lisa Peterson ,&nbsp;Jaclyn M.W. Hughto","doi":"10.1016/j.drugalcdep.2025.112856","DOIUrl":"10.1016/j.drugalcdep.2025.112856","url":null,"abstract":"<div><h3>Background</h3><div>Twelve state Medicaid programs limit the monthly number of covered prescriptions. Such cap policies may force enrollees to forego essential medications with important health consequences. We aimed to determine the impact of cap policies on acute care use and all-cause mortality among enrollees with opioid use disorder (OUD).</div></div><div><h3>Methods</h3><div>Using 2016–2019 T-MSIS Analytical Files, we propensity-score matched enrollees with OUD in 12 states with cap policies and 26 states without cap policies. Outcomes measured over 12 months included emergency department (ED) visits, hospitalization, and all-cause mortality and were analyzed via generalized linear regression models. We conducted subgroup analyses by use of medications for OUD (MOUD) and comorbidity level and sensitivity analyses to examine the role of cap policy characteristics.</div></div><div><h3>Results</h3><div>Unadjusted risks were 64.0 % vs. 62.5 % for ED visits, 27.6 % vs. 27.5 % for hospitalizations, and 3.2 % vs. 2.7 % for mortality in cap states and non-cap states, respectively. After adjustment, hospitalization risk was higher (RR=1.89, 99.5 %CI:1.13,3.16) in cap states than non-cap states whereas ED visits and mortality did not differ. There were largely no outcome differences by cap status in subgroups. Strict prescription limits allowing 3–4 prescriptions monthly (RR=1.90, 95 %CI:1.09,3.30) and lack of MOUD exemptions (RR=2.23, 95 %CI:1.32,3.78) were associated with increased hospitalization risk relative to non-cap states.</div></div><div><h3>Conclusions</h3><div>Medicaid prescription cap policies were associated with increased hospitalization risk, but there were no differences in ED use or all-cause mortality. Cap policies may undermine the health of individuals with OUD and could be counterproductive to state efforts to curb Medicaid spending.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112856"},"PeriodicalIF":3.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis administration is associated with reduced alcohol consumption: Evidence from a novel laboratory co-administration paradigm","authors":"Claire L. Pince ,&nbsp;Vanessa T. Stallsmith ,&nbsp;Cianna J. Piercey ,&nbsp;Katelyn Weldon ,&nbsp;Jesse Ruehrmund ,&nbsp;Gregory Dooley ,&nbsp;L. Cinnamon Bidwell ,&nbsp;Hollis C. Karoly","doi":"10.1016/j.drugalcdep.2025.112860","DOIUrl":"10.1016/j.drugalcdep.2025.112860","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol and cannabis co-use is increasingly prevalent across the U.S., concomitant with trends towards recreational cannabis legalization. While some studies have shown that cannabis co-use is associated with reductions in alcohol consumption (i.e., substitution), others have observed increases in alcohol intake (i.e., complementarity) or no change. This study aims to address this gap in the literature through investigating the effects of legal-market cannabis on alcohol consumption and craving in the laboratory.</div></div><div><h3>Method</h3><div>Leveraging a within-subjects design, we enrolled non-treatment seeking individuals who use both alcohol and cannabis (<em>n</em> = 61) to complete two laboratory sessions, wherein they were provided an alcohol priming drink alone or after self-administering cannabis. Participants were then given the opportunity to self-administer up to 4 additional drinks. We assessed differences in alcohol self-administration and craving between sessions.</div></div><div><h3>Results</h3><div>Cannabis self-administration was associated with a significant reduction in number of drinks self-administered. Further, exploratory analyses revealed that individuals who drank less after using cannabis (“substituters”, <em>n</em> = 23) experienced reductions in craving after using cannabis and alcohol compared to alcohol alone, whereas individuals who drank the same number of drinks after using cannabis show minimal differences in craving. There were no significant group differences in blood-THC concentration post-cannabis use.</div></div><div><h3>Conclusion</h3><div>Results indicate that for some individuals who drink heavily, cannabis may serve as a substitute for alcohol, and craving reduction is a potential mechanism through which this could occur.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112860"},"PeriodicalIF":3.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An individual-level data synthesis of Clinical Trials Network studies to examine the impact of psychosocial treatments for Black people who use cocaine and/or opioids","authors":"A. Kathleen Burlew ,&nbsp;Lesia M. Ruglass ,&nbsp;Adriana Espinosa ,&nbsp;Caravella McCuistian ,&nbsp;Angela M. Haeny ,&nbsp;Ayana Jordan ,&nbsp;Christopher Roundtree ,&nbsp;Joel Lopez ,&nbsp;Ashley Vena ,&nbsp;Antonio A. Morgan-López","doi":"10.1016/j.drugalcdep.2025.112850","DOIUrl":"10.1016/j.drugalcdep.2025.112850","url":null,"abstract":"<div><h3>Objective</h3><div>Cocaine- and opioid-related overdose deaths have increased among Black people, which makes identifying effective treatments for Black people a high priority. We investigated the comparative effectiveness of behavioral treatments among Black adults who use cocaine and/or opioids.</div></div><div><h3>Methods</h3><div>Identified multisite randomized clinical trials (RCTs) of behavioral interventions that targeted substance use, had participants who self-identified as Black, and included cocaine use outcome measures from the National Drug Abuse Treatment Clinical Trials Network (CTN) datashare. We estimated cocaine use and opioid use severity scale scores while considering study-level measurement non-invariance. Then, we estimated the inverse probability of treatment-weighted (IPTW) linear mixed models to assess comparative effectiveness of treatments that address social-contextual factors and those focused solely on substance use (e.g., contingency management (CM)) relative to treatment-as-usual/controls on cocaine use and opioid use severity scores during- and post-treatment.</div></div><div><h3>Results</h3><div>Nine RCTs met inclusion criteria, with a combined sample of 1381 Black adults who used cocaine and/or opioids. The IPTW linear mixed models indicated that cocaine use severity decreased from baseline to end-of-treatment across three treatment groups, with a greater decrease for social-contextual treatments and CM relative to treatment-as-usual/controls. However, this greater reduction was maintained at 12-month follow-ups for social-contextual treatments, while CM worsened relative to TAU/controls. We found decreases in latent opioid use severity with no or minor differences between treatment groups.</div></div><div><h3>Conclusions</h3><div>The findings suggest that addressing social-contextual factors is an essential treatment component for long-term reduction of cocaine use among Black adults.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112850"},"PeriodicalIF":3.6,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical gender affirmation appears protective against problematic substance use among transgender women and transfeminine adults: Findings from The LITE Study","authors":"Jack Andrzejewski ,&nbsp;Heather L. Corliss ,&nbsp;Heather A. Pines ,&nbsp;Ravi Goyal ,&nbsp;Eileen V. Pitpitan ,&nbsp;Britt Skaathun ,&nbsp;Andrea L. Wirtz ,&nbsp;Sari L. Reisner ,&nbsp;American Cohort to Study HIV Acquisition among Transgender Women (LITE) Study Group","doi":"10.1016/j.drugalcdep.2025.112852","DOIUrl":"10.1016/j.drugalcdep.2025.112852","url":null,"abstract":"<div><h3>Objective</h3><div>To estimate the association between medical and legal gender affirmation with problematic substance use among transfeminine adults.</div></div><div><h3>Methods</h3><div>Data from a longitudinal cohort (The LITE Study) were analyzed (n = 1186). Participants were enrolled between March 2018 and August 2020 and followed for 2 years. We tested the association between baseline medical and legal gender affirmation with problematic drug use (DAST-10 ≥3) and problematic alcohol use (AUDIT-C≥4) at 12-months. We used Poisson regression to estimate adjusted prevalence ratios (aPR) and 95 % confidence intervals (CI).</div></div><div><h3>Results</h3><div>Mean age was 31.0 years (standard deviation=11.2). For race and ethnicity, 55.8 % were non-Latinx, white, 13.0 % were non-Latinx Black/African American, 17.1 % were Latinx, and 14.1 % were Asian, American Indiana/Alaskan Native, Native Hawaiian/Pacific Islander, or multiracial. For exposures, 75.1 % had met need for medical gender affirmation, 16.4 % did not seek medical gender affirmation, 8.5 % had unmet need for medical gender affirmation, and 19.5 % had all IDs match their chosen name/gender. At follow-up, 24.1 % had problematic drug use, and 27.6 % had problematic alcohol use. Participants with met need for medical gender affirmation were less likely to have problematic drug use at follow-up (aPR=0.70, 95 %CI=0.49˗0.99) compared to those with unmet need. Compared to those who did not seek medical gender affirmation, those with met need (aPR=0.72, 95 %CI=0.57˗0.91) and unmet need (aPR=0.68, 95 %CI=0.47˗0.97) were less likely to have problematic alcohol use.</div></div><div><h3>Conclusion</h3><div>Medical gender affirmation appears protective against problematic substance use. Increasing access to medical gender affirmation may improve substance use outcomes among transfeminine adults who desire such services.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112852"},"PeriodicalIF":3.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A secondary analysis of the effects of IQOS use on cigarette smoking: Do the effects differ by sex?","authors":"Janet Audrain-McGovern ,&nbsp;Olivia Klapec ,&nbsp;Ariadni Oikonomou ,&nbsp;Priyanka Mistry ,&nbsp;Joseph Smith ,&nbsp;E. Paul Wileyto ,&nbsp;Andrew A. Strasser","doi":"10.1016/j.drugalcdep.2025.112848","DOIUrl":"10.1016/j.drugalcdep.2025.112848","url":null,"abstract":"<div><h3>Introduction</h3><div>Through secondary data analyses, we investigated sex differences in the effects of IQOS, a heated tobacco product, on combustible cigarette smoking.</div></div><div><h3>Methods</h3><div>Adults who smoke cigarettes (N = 118; 21–65 years old) completed a baseline ad-lib smoking period (days 1–5), two laboratory visits (days 6–7), and a 14-day period where they were instructed to switch from smoking cigarettes to using IQOS 3.0 (days 8–21). Models estimated the changes in cigarettes smoked per day (CPD) and the percentage of baseline CPD substituted by HeatSticks during the switch period. Bivariate statistics assessed sex differences in covariates and IQOS-associated effects (i.e., subjective reward, relative reinforcing value, craving relief, and withdrawal relief) for model inclusion.</div></div><div><h3>Results</h3><div>Males and females significantly reduced their CPD to 29.8 % and 21.8 % of their baseline CPD by the end of the switch period, respectively. CPD slopes were significant for males (β =-0.46/day [CI95 % −0.97 to −0.04] p = 0.002) and females (β =-0.83/day [CI95 % −1.34 to −0.31] p &lt; 0.001), although slopes did not significantly differ (p = 0.3). Males and females substituted HeatSticks at 83.2 % and 67.4 % of their baseline CPD across the switch period. The IQOS slopes were significant for males (β =1.136/day [CI95 % 0.59–2.14] p = 0.001) but not females (β =0.64/day [CI95 % −0.67–1.94] p = 0.34), although the slopes did not significantly differ (p = 0.36). There were no significant sex differences in IQOS-associated effects (all p values &gt; 0.05).</div></div><div><h3>Conclusions</h3><div>Males and females do not appear to differ in IQOS-associated effects or the initial substitutability of IQOS for combustible cigarettes.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112848"},"PeriodicalIF":3.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regular cannabis use and promotive attitudes among diverse adolescents in the United States: The role of age and intersecting social positions","authors":"Marla E. Eisenberg ,&nbsp;Ryan J. Watson ,&nbsp;Lauren L. Pieczykolan ,&nbsp;Amy L. Gower","doi":"10.1016/j.drugalcdep.2025.112851","DOIUrl":"10.1016/j.drugalcdep.2025.112851","url":null,"abstract":"<div><h3>Purpose</h3><div>Cannabis use is common in adolescence and has been associated with negative health effects, and higher prevalence has been seen among marginalized youth. Research has not examined regular use or attitudes promoting use, particularly taking an approach grounded in intersectionality and minority stressors. The present study examines how regular cannabis use, perceptions of risk, approval from parents and friends, and peer norms of use differ across multiple social positions.</div></div><div><h3>Methods</h3><div>82,933 8th, 9th, and 11th grade students provided data on the 2022 Minnesota Student Survey, including past 30-day cannabis use (3 + times vs. fewer) and related attitudes. Exhaustive Chi-square Automatic Interaction Detection models tested how youth with combinations of five social positions (i.e., racial and ethnic identity, sexual orientation, gender identity, access to resources, location type) varied on each cannabis-related dependent variable.</div></div><div><h3>Results</h3><div>3.8 % reported regular cannabis use, and attitudes were generally not supportive of use. Regular use was higher among older adolescents (7.8 % of 11th, 1.8 % of 8th grade), and the highest prevalence nodes were characterized by marginalized social positions. For example, 24.8 % of 8th grade students who identified as American Indian/Alaska Native or multiracial, gay/ lesbian/bisexual/queer, and high poverty reported regular use – almost fourteen times higher than the prevalence for 8th grade overall.</div></div><div><h3>Conclusions</h3><div>Both typical adolescent development and marginalization may underlie the observed pattern of findings, and cannabis use may be a coping mechanism to deal with oppression. Prevention activities should account for marginalization and act on multiple levels to address this structural issue.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"276 ","pages":"Article 112851"},"PeriodicalIF":3.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144997329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}