Drug and alcohol dependence最新文献

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Decrease in injection and rise in smoking and snorting of heroin and synthetic opioids, 2000–2021 2000-2021 年海洛因和合成类阿片注射量减少,吸食和鼻吸量增加
IF 3.9 2区 医学
Drug and alcohol dependence Pub Date : 2024-08-15 DOI: 10.1016/j.drugalcdep.2024.111419
{"title":"Decrease in injection and rise in smoking and snorting of heroin and synthetic opioids, 2000–2021","authors":"","doi":"10.1016/j.drugalcdep.2024.111419","DOIUrl":"10.1016/j.drugalcdep.2024.111419","url":null,"abstract":"<div><h3>Background</h3><p>Injecting, smoking, and snorting heroin/synthetic opioids is each associated with unique health risks. It is unclear how route of administration (ROA) preferences have shifted during the opioid epidemic.</p></div><div><h3>Methods</h3><p>Using 2000–2021 admissions data from SAMHSA TEDS-A, we analyzed trends in heroin/synthetic opioid ROA preferences and factors associated with these preferences.</p></div><div><h3>Results</h3><p>7,881,318 heroin/synthetic opioid admissions reported injection, smoking, or snorting preference. Nationally, injection peaked in 2014 (69.9 %) and nadired in 2021(52.2 %), snorting nadired in 2014 (24.9 %) and peaked in 2021 (36.4 %), and smoking rose steadily from 2.5 % in 2005 to a peak of 11.4 % in 2021. From 2000–2021, the number of states with ≥10 % smoking rates grew from 2 to 27 (highest: 57.0 % in Arizona in 2021). In 2021, increased adjusted prevalence ratios (APR) of non-injection versus injection use were associated with older age at first opioid use (APR 1.52 [95 % CI: 1.51, 1.54] for those 30+ relative to ≤20), and all race/ethnicities relative to non-Latino White individuals (highest: Black individuals, APR 1.77 [1.75, 1.78]). Geography strongly predicted smoking versus snorting (Mountain APR 6.91 [6.64, 7.19], Pacific APR 6.61 [6.35, 6.88], reference: New England).</p></div><div><h3>Conclusions</h3><p>ROA preferences of heroin/synthetic opioids have changed substantially since 2000, with: 1) recent decreases in injection nationally; 2) increased smoking, particularly in the western US; and, 3) recent increased snorting in the eastern US. Smoking is now prevalent and growing. Public health implications include an increasing number of smoking-related fatal overdoses and the probable reduction of injection-specific morbidity and increase in smoking-specific morbidity.</p></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142096733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Within-person and between-person associations of access to environmental reward with alcohol and cannabis use and consequences among young adults 人内和人与人之间获得环境奖励与年轻人使用酒精和大麻及其后果的关系
IF 3.9 2区 医学
Drug and alcohol dependence Pub Date : 2024-08-14 DOI: 10.1016/j.drugalcdep.2024.112417
{"title":"Within-person and between-person associations of access to environmental reward with alcohol and cannabis use and consequences among young adults","authors":"","doi":"10.1016/j.drugalcdep.2024.112417","DOIUrl":"10.1016/j.drugalcdep.2024.112417","url":null,"abstract":"<div><h3>Background</h3><p>Recent behavioural economic models of substance use suggest that low access to environmental reward may increase risk for heavy substance use and associated harms. Most prior studies of these associations have been cross-sectional and have focused on alcohol. The current study extends this research using longitudinal data to examine the within-person and between-person associations of environmental reward access with both alcohol and cannabis outcomes.</p></div><div><h3>Method</h3><p>Young adults (<em>N</em> = 119, 64.71 % female) completed an online survey at three time points, spaced six months apart. The survey included measures of alcohol and cannabis use and consequences, and two facets of environmental reward access: reward probability (i.e., likelihood of experiencing environmental reward) and environmental suppression (i.e., diminished availability of environmental reward).</p></div><div><h3>Results</h3><p>Multilevel models revealed that at the between-person level (i.e., averaged across time points), greater environmental suppression (but not reward probability) was significantly associated with more frequent cannabis use, and greater reward probability (but not environmental suppression) was significantly associated with heavier alcohol use. Higher environmental suppression (but not reward probability) was also associated with greater alcohol and cannabis consequences at the between-person level, over and above level of use. A significant within-person association also was observed, wherein participants reported relative increases in cannabis consequences during time periods when they also reported relative decreases in the availability of environmental reward.</p></div><div><h3>Conclusions</h3><p>Results highlight environmental suppression as a risk factor for more frequent cannabis use and for both alcohol and cannabis consequences, and provide novel support for a within-person association between environmental suppression and cannabis consequences over time. Findings may inform contextual interventions for young adult substance use.</p></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0376871624013425/pdfft?md5=8551b7c574778c0a7fd76afcf8cc76bf&pid=1-s2.0-S0376871624013425-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Buprenorphine treatment and clinical outcomes under the opioid use disorder cascade of care 丁丙诺啡治疗和阿片类药物使用障碍级联护理的临床结果
IF 3.9 2区 医学
Drug and alcohol dependence Pub Date : 2024-08-13 DOI: 10.1016/j.drugalcdep.2024.112389
{"title":"Buprenorphine treatment and clinical outcomes under the opioid use disorder cascade of care","authors":"","doi":"10.1016/j.drugalcdep.2024.112389","DOIUrl":"10.1016/j.drugalcdep.2024.112389","url":null,"abstract":"<div><h3>Background</h3><p>Challenges to engagement and retention on buprenorphine undermine treatment of individuals with opioid use disorder (OUD). Under the OUD Cascade of Care framework, we sought to identify patient characteristics and treatment response associated with superior clinical outcomes.</p></div><div><h3>Methods</h3><p>A retrospective cohort study of specialty buprenorphine treatment patients entering treatment (n=19,487) based on EHR records from a large multi-state buprenorphine treatment network (2011–2019). Person-level care episodes were evaluated across treatment intake, engagement (i.e. 2+ visits in the month following intake), and retention at 6, 12, and 24 months. Time to achieving 90 days of continuous opioid abstinence was assessed using Cox proportional hazards regressions models and also assessed as a predictor of long-term retention.</p></div><div><h3>Results</h3><p>Most patients engaged (82.4 %), but retention steadily declined over 6-month (38.7 %), 12-month (26.2 %), and 24-month (17.1 %) timepoints. Opioid-positive baseline tests were associated with lower hazards of achieving continuous abstinence for both buprenorphine-positive (aHR=0.33, p&lt;.001) and buprenorphine-negative (aHR=0.49,p&lt;.001) intakes. Opioid abstinence was associated with buprenorphine-positive baseline testing (aHR=1.59,p&lt;.001), especially for those testing opioid-negative (aHR=1.82,p&lt;.001). Patients who achieved and sustained abstinence at 6 months in care were 4.1 and 5.5 times as likely to achieve 12-month and 24-month retention, respectively, compared to patients with intermittent opioid use.</p></div><div><h3>Conclusion</h3><p>Treatment discontinuation was concentrated early in care and buprenorphine and opioid status at intake were prognostic of achieving and sustaining abstinence. Early abstinence was associated with higher likelihood of subsequent stage progression. Implementing interventions to support early clinical stability for high-risk patients is critical to improve clinical outcomes.</p></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monitoring illicit pentobarbital availability in the United States: A National Drug Early Warning System briefing 监测美国非法戊巴比妥的供应情况:国家毒品预警系统简报
IF 3.9 2区 医学
Drug and alcohol dependence Pub Date : 2024-08-13 DOI: 10.1016/j.drugalcdep.2024.112402
{"title":"Monitoring illicit pentobarbital availability in the United States: A National Drug Early Warning System briefing","authors":"","doi":"10.1016/j.drugalcdep.2024.112402","DOIUrl":"10.1016/j.drugalcdep.2024.112402","url":null,"abstract":"<div><h3>Background</h3><p>Pentobarbital is a Schedule II/III short-acting barbiturate with limited medical use in humans. Veterinary professionals use pentobarbital to euthanize dogs, cats, and other companion animals. Pentobarbital is also utilized in capital punishment and small amounts are illegally shipped or diverted to assist in suicides. However, five kilograms of pentobarbital smuggled in from Mexico was recently seized by an organized crime drug enforcement task force (along with fentanyl, heroin, and cocaine), which may suggest a shift in illicit supply. We investigated potential indicators of illicit pentobarbital use or availability in the US to help determine whether this drug is becoming an emerging public health concern.</p></div><div><h3>Methods</h3><p>The National Drug Early Warning System requested information on pentobarbital from its sentinel surveillance sites and collaborators and conducted a search of current literature.</p></div><div><h3>Results</h3><p>In early 2024, multiple batches of counterfeit pills (e.g., pressed as “M30s” to represent oxycodone) confiscated near the Southwest border tested positive for pentobarbital plus combinations of fentanyl, fentanyl analogs, and xylazine. Other indicators suggest pentobarbital is being smuggled in powder form and possibly sold as another drug such as heroin. One national drug analysis program detected pentobarbital in 217 drug submissions from 2020 to 2023, and there were at least 12 fatal exposures linked to use from 2020 to 2022.</p></div><div><h3>Conclusion</h3><p>Continued monitoring of illicit use and availability is needed as pentobarbital may continue to appear on the illicit market. Unknown exposure can occur if the drug is mixed into counterfeit pills or sold in powder form represented to be another drug.</p></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142021553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuropathology of deaths due to acute alcohol toxicity in Australia, 2011–2022 2011-2022 年澳大利亚因急性酒精中毒死亡的神经病理学情况
IF 3.9 2区 医学
Drug and alcohol dependence Pub Date : 2024-08-13 DOI: 10.1016/j.drugalcdep.2024.111407
{"title":"Neuropathology of deaths due to acute alcohol toxicity in Australia, 2011–2022","authors":"","doi":"10.1016/j.drugalcdep.2024.111407","DOIUrl":"10.1016/j.drugalcdep.2024.111407","url":null,"abstract":"<div><h3>Background</h3><p>A major alcohol-related harm is structural pathology affecting the brain. The study aimed to: 1. Determine the frequency and nature of neuropathology amongst cases of death due to acute alcohol toxicity; 2. Compare diagnoses of brain atrophy with pathology in other organs; 3. Determine the demographic, clinical and organ pathology correlates of brain atrophy.</p></div><div><h3>Methods:</h3><p>Retrospective study of 500 cases of death attributed to acute alcohol toxicity in Australia, 2011–2022. Data on clinical characteristics, toxicology, neuropathology and other organ pathology were retrieved from police reports, autopsies, toxicology and coronial findings.</p></div><div><h3>Results</h3><p>Mean age was 49.5 years, 69.4 % were male, with alcohol use problems documented in 70.2 %. Brain atrophy was diagnosed in 60 cases (12.0 %), most commonly in the cerebellum (32 cases, 6.4 %). Atrophy at other sites was present in 37 (7.4 %). The presence of brain atrophy was lower than other major pathologies: cardiomegaly (32.6 %, p&lt;.001), nephro/arteriosclerosis (30.2 %, p&lt;.001), and chronic obstructive pulmonary disease (21.8 %, p&lt;.001) but not hepatic cirrhosis (11.9 % p=1.0). Those diagnosed with atrophy were older (53.4<!--> <!-->v 49.0 years, p&lt;.001)<strong>,</strong> more likely to have documented alcohol problems (85.0<!--> <!-->v 68.2 %, Odds ratio: OR 2.53) and seizure history (10.0<!--> <!-->v 3.0 %, OR 2.92), to have cardiomegaly (43.3<!--> <!-->v 31.0 %, OR 1.90, COPD (48.3<!--> <!-->v 18.2 %, 3.57) and nephro/arteriosclerosis (50.0 <!--> <!-->v 27.4 %, OR 2.27).</p></div><div><h3>Conclusions:</h3><p>Despite the majority of cases having a history of alcohol problems, the level of neuropathology amongst cases of death due to acute alcohol toxicity was comparatively low.</p></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0376871624003302/pdfft?md5=6550cec1650d59f40a564e1fc2c23d21&pid=1-s2.0-S0376871624003302-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141990622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The cascade of care for commercially-insured persons with opioid use disorder and comorbid HIV and HCV infections 对患有阿片类药物使用障碍并合并艾滋病毒和丙型肝炎病毒感染的商业保险参保者的一系列护理措施
IF 3.9 2区 医学
Drug and alcohol dependence Pub Date : 2024-08-12 DOI: 10.1016/j.drugalcdep.2024.112410
{"title":"The cascade of care for commercially-insured persons with opioid use disorder and comorbid HIV and HCV infections","authors":"","doi":"10.1016/j.drugalcdep.2024.112410","DOIUrl":"10.1016/j.drugalcdep.2024.112410","url":null,"abstract":"<div><h3>Background</h3><p>Opioid use disorder (OUD) significantly impacts individual and public health and exacerbated further by concurrent infectious diseases. A syndemic approach is needed to address the intertwined OUD, HIV, and HCV epidemics, including the expanded use of medications for opioid use disorder (MOUD).</p></div><div><h3>Methods</h3><p>To identify MOUD scale-up opportunities, we conducted a retrospective cohort study, representing commercially insured persons, and created the OUD care continuum, including HIV and HCV influences in adults (18–64 years) newly diagnosed with OUD in 2019 using Merative MarketSan data.</p></div><div><h3>Results</h3><p>Among 124,467,633 individuals, the prevalence of OUD was 0.4 % (95 % CI: 0.36 %-0.46 %; N = 497,871), with 327,277 (65.7 %, 95 % CI: 65.60 %-65.87 %) newly diagnosed in 2019. Among these newly diagnosed individuals (54 % men, mean age 44±0.01), 53,568 (27.0 %, 95 % CI: 26.4 %-27.5 %) were prescribed MOUD, with retention rates at 1, 3, and 6 months being 89.0 % (95 % CI: 88.2 %-89.8 %), 66.0 % (95 % CI: 64.8 %-67.2 %), and 50.3 % (95 % CI: 48.3 %-51.6 %), respectively. Buprenorphine was the most prescribed MOUD (79.6 %, 95 % CI: 78.6 %-80.7 %), followed by XR-NTX (14.9 %, 95 % CI:14.0 %-15.8 %) and methadone (5.5 %, 95 % CI: 4.9 %-6.1 %). Six-month retention was highest for methadone (73.4 %, 95 % CI: 73.0 %-73.8 %), however, followed by buprenorphine (55.7 %, 95 % CI: 55.3 %-57.1 %) and substantially lower for XR-NTX (12.6 %, 95 % CI: 10.6 %-14.6 %). Screening for HIV and HCV was low among OUD enrollees (11.1 %, 14.4 %), slightly higher for MOUD initiators (18.0 %, 21.6 %). Being prescribed MOUD was correlated with HCV infection (AOR: 2.54; 95 % CI: 2.41–2.68), HCV/HIV coinfection (AOR: 1.89; 95 % CI: 1.41–2.53), and hospitalization for OUD-related services (AOR: 1.14; 95 % CI: 1.11–1.17), yet hospitalization for OUD-related services was positively correlated with XR-NTX (AOR: 2.72; 95 % CI: 2.56–2.85) prescription and negatively with methadone (AOR: 0.19; 95 % CI: 0.16–0.23) prescription. Having HIV was negatively correlated with being prescribed methadone (AOR: 0.33; 95 % CI: 0.13–0.86).</p></div><div><h3>Conclusions</h3><p>Substantial gaps in the OUD cascade persist, underscoring better implementation opportunities for MOUD prescription in hospital-based settings and expanding access to methadone beyond highly regulated sites given its low coverage yet high treatment retention.</p></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142002359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of a waiting list control design on alcohol consumption among online help-seekers: A randomised controlled trial 候补名单控制设计对在线求助者饮酒量的影响:随机对照试验
IF 3.9 2区 医学
Drug and alcohol dependence Pub Date : 2024-08-11 DOI: 10.1016/j.drugalcdep.2024.112409
{"title":"Effects of a waiting list control design on alcohol consumption among online help-seekers: A randomised controlled trial","authors":"","doi":"10.1016/j.drugalcdep.2024.112409","DOIUrl":"10.1016/j.drugalcdep.2024.112409","url":null,"abstract":"<div><h3>Background</h3><p>Indirect evidence suggests that using waiting list control designs in behavioural research may have unintended consequences. The aim of this study was to estimate the effects of a waiting list design on alcohol consumption among individuals who had looked online for help.</p></div><div><h3>Methods</h3><p>A two-arm randomised controlled trial was employed. The intervention group was informed that they belonged to the intervention group and would receive immediate access to a digital alcohol intervention. The waiting list control group was informed that they belonged to the group that had to wait four weeks to be given access to the intervention and in the meantime, they would be given a summary of their drinking. However, both groups received immediate access to the same digital alcohol intervention; the experimental contrast was thus between being told to wait or not.</p></div><div><h3>Results</h3><p>We randomised 3388 participants (intervention: 1692, waiting list: 1696). Data were available for 954 participants at 1-month follow-up. We found no strong evidence that alcohol consumption differed between groups, but the evidence pointed towards the intervention group reporting lowering weekly alcohol consumption compared to the waiting list control group (IRR = 0.95, 95 % CI = 0.83; 1.08, probability of effect = 78.8 %).</p></div><div><h3>Conclusion</h3><p>We found no strong evidence that being informed that access to an intervention would be delayed produced differential self-reported alcohol consumption compared to being informed that access would be immediate. We did find a difference in engagement with the intervention materials, indicating that the experimental manipulation was successful.</p></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0376871624013346/pdfft?md5=8c6f73a4776b97aca84d6dad75ab6c78&pid=1-s2.0-S0376871624013346-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141993419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of access condition on substance use disorder-like phenotypes in male and female rats self-administering MDPV or cocaine 接触条件对自服 MDPV 或可卡因的雄性和雌性大鼠药物使用障碍样表型的影响
IF 3.9 2区 医学
Drug and alcohol dependence Pub Date : 2024-08-11 DOI: 10.1016/j.drugalcdep.2024.112408
{"title":"Effects of access condition on substance use disorder-like phenotypes in male and female rats self-administering MDPV or cocaine","authors":"","doi":"10.1016/j.drugalcdep.2024.112408","DOIUrl":"10.1016/j.drugalcdep.2024.112408","url":null,"abstract":"<div><p>Substance use disorder (SUD) is a heterogeneous disorder, where severity, symptoms, and patterns of use vary across individuals. Yet, when rats self-administer cocaine under short-access conditions, their behavior tends to be well-regulated, though individual differences can emerge with long- or intermittent-access. In contrast, significant individual differences emerge when rats self-administer 3,4-methylenedioxypyrovalerone (MDPV), even under short-access conditions, wherein ~30 % of rats exhibit high levels of drug-taking. This study assessed SUD-like phenotypes of male and female rats self-administering MDPV or cocaine by comparing level of drug intake, responding during periods of signaled drug unavailability, and sensitivity to footshock punishment to determine whether: (1) under short-access conditions, rats that self-administer MDPV will exhibit a more robust SUD-like phenotype than rats that self-administer cocaine; (2) female rats will have a more severe phenotype than male rats; and (3) compared to short-access, long- and intermittent-access to MDPV or cocaine self-administration will result in a more robust SUD-like phenotype. Compared to cocaine, rats that self-administered MDPV exhibited a more severe phenotype, even under short-access conditions. Long- and intermittent-access to cocaine and MDPV temporarily altered drug-taking patterns but did not systematically change SUD-like phenotypes. Behavioral and quantitative autoradiography studies suggest phenotypic differences are not due to expression of dopamine transporter, dopamine D<sub>2</sub> or D<sub>3</sub> receptors, or 5-HT<sub>1B</sub>, 5-HT<sub>2A</sub>, or 5-HT<sub>2C</sub> receptors. This study suggests individuals who use synthetic cathinones may be at greater risk for developing a SUD, and short-access MDPV self-administration may provide a useful method to study the transition to disordered substance use in humans.</p></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141979567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated behavioral interventions for adults with alcohol use disorder: A systematic review 针对酒精使用障碍成人的综合行为干预:系统回顾
IF 3.9 2区 医学
Drug and alcohol dependence Pub Date : 2024-08-10 DOI: 10.1016/j.drugalcdep.2024.111406
{"title":"Integrated behavioral interventions for adults with alcohol use disorder: A systematic review","authors":"","doi":"10.1016/j.drugalcdep.2024.111406","DOIUrl":"10.1016/j.drugalcdep.2024.111406","url":null,"abstract":"<div><h3>Background</h3><p>This systematic review synthesized evidence from randomized controlled trials (RCTs) on the effects of integrated behavioral interventions for adults with alcohol use disorder (AUD).</p></div><div><h3>Methods</h3><p>A comprehensive search of three databases was conducted in 2022, utilizing terms related to alcohol/substance use disorders and integrated interventions. The sample included adults aged ≥18 years at low, moderate, or high risk for AUD, and had at least two other mental health conditions. Only RCTs were included and screened using Covidence. The quality of the study was evaluated using Cochrane risk of bias tool.</p></div><div><h3>Results</h3><p>Across all 11 studies, the total AUD participants were 1543 aged 18 or older. Integrated intervention led to significant reductions in heavy drinking compared to usual care or other interventions. Measures included percent days of alcohol use, grams of alcohol consumed, and increased days of abstinence. Three studies compared integrated treatments with Twelve-Step Facilitation, indicating a better abstinence rate among participants in the integrated group at the end of treatment. Comparisons between delivery modes demonstrated more significant reductions in alcohol consumption with interventionists. Integrated interventions were also compared with various other treatments, including brief intervention, telephone and individual counseling, and psychological education. Participants in the integrated group showed greater improvement in alcohol consumption and depression compared to those in the standalone intervention group.</p></div><div><h3>Conclusions</h3><p>Integrated behavioral interventions effectively reduce alcohol consumption, decrease heavy drinking and promote alcohol abstinence. However, there is limited evidence to determine whether these interventions are more effective than usual care for individuals with AUD.</p></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0376871624003296/pdfft?md5=9220374d28cc3c47324a7d3efc42cd2d&pid=1-s2.0-S0376871624003296-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142006934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum regarding previously published articles 关于以前发表的文章的更正。
IF 3.9 2区 医学
Drug and alcohol dependence Pub Date : 2024-08-10 DOI: 10.1016/j.drugalcdep.2024.111411
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