医学上的性别肯定似乎对跨性别妇女和跨性别成人使用有问题的物质有保护作用：来自life研究的发现

IF 3.6 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence Pub Date : 2025-08-22 DOI:10.1016/j.drugalcdep.2025.112852

Jack Andrzejewski , Heather L. Corliss , Heather A. Pines , Ravi Goyal , Eileen V. Pitpitan , Britt Skaathun , Andrea L. Wirtz , Sari L. Reisner , American Cohort to Study HIV Acquisition among Transgender Women (LITE) Study Group

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引用次数: 0

摘要

目的探讨医学上和法律上的性别确认与跨女性成人问题药物使用的关系。方法对纵向队列（The LITE Study）数据进行分析（n = 1186）。参与者在2018年3月至2020年8月期间入组，随访2年。我们在12个月时测试了基线医学和法律性别确认与问题药物使用（DAST-10≥3）和问题酒精使用（AUDIT-C≥4）之间的关系。我们使用泊松回归来估计校正患病率（aPR）和95%置信区间（CI）。结果患者平均年龄31.0岁（标准差为11.2）。在种族和民族方面，55.8%为非拉丁裔白人，13.0%为非拉丁裔黑人/非裔美国人，17.1%为拉丁裔，14.1%为亚洲人，美国印第安纳州/阿拉斯加原住民，夏威夷原住民/太平洋岛民，或多种族。暴露者中，75.1%的人满足医学性别确认需求，16.4%的人没有寻求医学性别确认，8.5%的人不满足医学性别确认需求，19.5%的人所有身份证与他们选择的姓名/性别相符。在随访中，24.1%的人有问题药物使用，27.6%的人有问题酒精使用。与未满足医学性别确认需求的参与者相比，满足医学性别确认需求的参与者在随访中出现问题药物使用的可能性更小（aPR=0.70, 95% CI=0.49, 0.99）。与那些没有寻求医学性别确认的人相比，满足需求（aPR=0.72, 95% CI=0.57——91）和未满足需求（aPR=0.68, 95% CI=0.47——97）的人出现问题性饮酒的可能性较小。结论医学性别肯定对不良药物使用具有保护作用。增加获得医疗性别确认的机会可能会改善渴望此类服务的跨性别成年人的药物使用结果。

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Medical gender affirmation appears protective against problematic substance use among transgender women and transfeminine adults: Findings from The LITE Study

Objective

To estimate the association between medical and legal gender affirmation with problematic substance use among transfeminine adults.

Methods

Data from a longitudinal cohort (The LITE Study) were analyzed (n = 1186). Participants were enrolled between March 2018 and August 2020 and followed for 2 years. We tested the association between baseline medical and legal gender affirmation with problematic drug use (DAST-10 ≥3) and problematic alcohol use (AUDIT-C≥4) at 12-months. We used Poisson regression to estimate adjusted prevalence ratios (aPR) and 95 % confidence intervals (CI).

Results

Mean age was 31.0 years (standard deviation=11.2). For race and ethnicity, 55.8 % were non-Latinx, white, 13.0 % were non-Latinx Black/African American, 17.1 % were Latinx, and 14.1 % were Asian, American Indiana/Alaskan Native, Native Hawaiian/Pacific Islander, or multiracial. For exposures, 75.1 % had met need for medical gender affirmation, 16.4 % did not seek medical gender affirmation, 8.5 % had unmet need for medical gender affirmation, and 19.5 % had all IDs match their chosen name/gender. At follow-up, 24.1 % had problematic drug use, and 27.6 % had problematic alcohol use. Participants with met need for medical gender affirmation were less likely to have problematic drug use at follow-up (aPR=0.70, 95 %CI=0.49˗0.99) compared to those with unmet need. Compared to those who did not seek medical gender affirmation, those with met need (aPR=0.72, 95 %CI=0.57˗0.91) and unmet need (aPR=0.68, 95 %CI=0.47˗0.97) were less likely to have problematic alcohol use.

Conclusion

Medical gender affirmation appears protective against problematic substance use. Increasing access to medical gender affirmation may improve substance use outcomes among transfeminine adults who desire such services.

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来源期刊

Drug and alcohol dependence 医学-精神病学

CiteScore

7.40

自引率

7.10%

发文量

409

审稿时长

41 days

期刊介绍： Drug and Alcohol Dependence is an international journal devoted to publishing original research, scholarly reviews, commentaries, and policy analyses in the area of drug, alcohol and tobacco use and dependence. Articles range from studies of the chemistry of substances of abuse, their actions at molecular and cellular sites, in vitro and in vivo investigations of their biochemical, pharmacological and behavioural actions, laboratory-based and clinical research in humans, substance abuse treatment and prevention research, and studies employing methods from epidemiology, sociology, and economics.