How does methamphetamine affect the brain? A systematic review of magnetic resonance imaging studies

IF 3.6 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence Pub Date : 2025-09-01 DOI:10.1016/j.drugalcdep.2025.112862

G.X.H. Liu , M. Tayebi , B. Bristow , J. Wang , Y. Lin , G. Newburn , P. Condron , P. McHugh , W. Schierding , S. Holdsworth , M. Scadeng

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Abstract

Methamphetamine (METH) is an addictive psychostimulant that is associated with significant physical and psychological harm. Magnetic resonance imaging (MRI) is a non-invasive imaging modality used to identify structural and functional brain changes. We conducted a systematic review to identify and appraise the existing literature on brain MRI differences associated with METH exposure. A comprehensive literature search was conducted on PubMed, Web of Science, and Scopus. Any study that evaluated the brain in people who used or had been exposed to METH using MRI were included. Data were collected on study design, participant demographics, METH use parameters, MRI acquisition details, and key findings. One hundred and eighty-one studies with 11997 participants were included in our review. Nearly all were conducted in adults/adolescents (164/181, 91 %), and most studies were cross-sectional (142/181, 78 %). Task-based functional MRI was the most common modality used (62/181, 34 %), followed by structural MRI (47/181, 26 %). Quality appraisal scores ranged from 40 – 100 % (mean 90 %). Overall, METH is associated with numerous differences in brain structure and function, including lower grey matter volume and thickness in frontal and limbic regions and lower fractional anisotropy in various white matter structures, with differences in socio-emotional functioning, decision-making and learning processes, and cognitive performance. Targeted multi-modal MRI sequences may be useful in further clarifying the brain differences associated with METH use and evaluating the use of potential therapeutic agents.

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甲基苯丙胺如何影响大脑？磁共振成像研究的系统综述。

甲基苯丙胺（冰毒）是一种令人上瘾的精神兴奋剂，与严重的身体和心理伤害有关。磁共振成像（MRI）是一种用于识别大脑结构和功能变化的非侵入性成像方式。我们进行了一项系统综述，以识别和评估与甲基安非他明暴露相关的脑MRI差异的现有文献。在PubMed、Web of Science和Scopus上进行了全面的文献检索。任何使用核磁共振成像对使用或接触过冰毒的人的大脑进行评估的研究都包括在内。收集的数据包括研究设计、参与者人口统计、冰毒使用参数、MRI获取细节和主要发现。我们的综述纳入了191项研究，涉及11997名参与者。几乎所有的研究都是在成人/青少年中进行的（164/181,91%），大多数研究是横断面的（142/181,78%）。任务型功能MRI是最常用的检查方式（62/181,34%），其次是结构MRI（47/181, 26%）。质量评价分数范围从40 - 100%（平均90%）。总的来说，冰毒与大脑结构和功能的许多差异有关，包括额叶和边缘区域的灰质体积和厚度较低，各种白质结构的分数各向异性较低，以及社会情感功能、决策和学习过程以及认知表现的差异。靶向多模态MRI序列可能有助于进一步阐明与甲基苯丙胺使用相关的大脑差异，并评估潜在治疗剂的使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug and alcohol dependence 医学-精神病学

CiteScore

7.40

自引率

7.10%

发文量

409

审稿时长

41 days

期刊介绍： Drug and Alcohol Dependence is an international journal devoted to publishing original research, scholarly reviews, commentaries, and policy analyses in the area of drug, alcohol and tobacco use and dependence. Articles range from studies of the chemistry of substances of abuse, their actions at molecular and cellular sites, in vitro and in vivo investigations of their biochemical, pharmacological and behavioural actions, laboratory-based and clinical research in humans, substance abuse treatment and prevention research, and studies employing methods from epidemiology, sociology, and economics.