Drug and alcohol dependence最新文献

{"title":"Dyadic cannabis use, alcohol use and relationship satisfaction: A daily diary study","authors":"Margy Y. Chen,&nbsp;Tiffany A. Ito,&nbsp;Angela D. Bryan","doi":"10.1016/j.drugalcdep.2024.112466","DOIUrl":"10.1016/j.drugalcdep.2024.112466","url":null,"abstract":"<div><h3>Objective</h3><div>Intimate relationships are important contexts for understanding individuals’ substance use patterns and trajectories. Using a dyadic daily diary design reporting over 14 consecutive days, the present study examined the association between cannabis use, alcohol use, and momentary relationship satisfaction among adult couples</div></div><div><h3>Method</h3><div>Eligible individuals on Prolific were invited to participate. We identified 33 couples where both partners participated. Participants completed a baseline survey and a 14-day daily diary study assessing their daily cannabis use, alcohol use, and relationship satisfaction. Multilevel modeling was used, within an Actor-Partner Interdependence Model (APIM), to evaluate the individual and interactive effects of one’s own use and their partner’s use on relationship satisfaction</div></div><div><h3>Results</h3><div>Significant actor and partner effects of alcohol and cannabis use were found using both baseline and daily report data. For individuals who use cannabis more heavily among sampled couples, cannabis and alcohol co-use was associated with reduction in their own next-day relationship satisfaction while alcohol-only use was significantly associated with increased next-day satisfaction. There were no significant effects of one’s own or their partner’s effects for individuals who use cannabis more lightly.</div></div><div><h3>Conclusions</h3><div>Findings replicate and extend prior research by demonstrating the dynamic nature of dyadic substance use and highlighting the unique impact of alcohol and cannabis co-use on daily relationship functioning.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"264 ","pages":"Article 112466"},"PeriodicalIF":3.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Misrepresentation of MDMA in the United States, 1999–2023","authors":"Eric L. Sevigny ,&nbsp;Sylvia Thyssen ,&nbsp;Earth Erowid ,&nbsp;Russell Lea","doi":"10.1016/j.drugalcdep.2024.112467","DOIUrl":"10.1016/j.drugalcdep.2024.112467","url":null,"abstract":"<div><h3>Background and aims</h3><div>The misrepresentation of illicit drugs in unregulated markets increases the risk of adverse health events. This study analyzed drug checking data to compare represented, expected, and actual content of alleged MDMA samples, estimate trends in the quality of the MDMA supply, document the presence of adulterants, compare patterns of adulteration, and validate drug checking against law enforcement data.</div></div><div><h3>Method</h3><div>The study analyzed 4719 alleged MDMA samples submitted to the DrugsData drug checking service between 1999–2023. Measures captured characteristics and quality of the MDMA supply, including represented content, expected and actual content, sample form, and specific adulterants. Tests of association were conducted using Pearson’s chi-square or Spearman’s rho, and tests for trends were performed using joinpoint regression.</div></div><div><h3>Finding</h3><div>Most samples (75 %) were expected to contain MDMA, but this varied significantly by represented content (p&lt;0.001). About half the samples (48 %) contained MDMA-only, which also varied significantly by represented content (p&lt;0.001). MDMA-only prevalence declined from 1999–2009 (57.4–15.2 %, p&lt;0.05), recovered from 2009–2017 (15.2–56.0 %, p&lt;0.05), and increased more moderately from 2017–2023 (56.0–74.1 %, p&lt;0.05). Overall, 199 unique adulterants were detected in the MDMA supply across 25 years. We confirmed robust correlations in adulterant prevalence trends between drug checking and law enforcement seizure data.</div></div><div><h3>Conclusions</h3><div>While users typically expected alleged MDMA samples to contain only MDMA, more than half of the submitted MDMA samples were misrepresented in some manner. Despite high levels of misrepresentation, MDMA quality has stabilized at relatively high levels in recent years</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"264 ","pages":"Article 112467"},"PeriodicalIF":3.9,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric performance of tools to measure internalized drug use stigma among people who use drugs and people on medication-assisted treatment in Dar es Salaam, Tanzania","authors":"Stacy M. Endres-Dighe ,&nbsp;Linda B. Mlunde ,&nbsp;Emmanuel Oga ,&nbsp;Jessie K. Mbwambo ,&nbsp;Zawadi Shomari ,&nbsp;Judith Mkufya ,&nbsp;Elizabeth Nguma ,&nbsp;Lucy C. Teemba ,&nbsp;Khalida Saalim ,&nbsp;Laura Nyblade","doi":"10.1016/j.drugalcdep.2024.112469","DOIUrl":"10.1016/j.drugalcdep.2024.112469","url":null,"abstract":"<div><h3>Background</h3><div>People who use drugs (PWUD) and people who use medication-assisted treatment (MAT) to treat opioid use disorder face severe stigma. Stigma may manifest in delayed health-seeking behaviors, which adversely affects health and increases disease risk. Few validated measures assess internalized drug use stigma or MAT disclosure concerns in sub-Saharan Africa. This study examines the performance of internalized drug use stigma scales and characterizes the prevalence of these stigmas among PWUD and people who use MAT in Dar es Salaam, Tanzania.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional survey among 250 PWUD and 251 MAT clinic clients. Internalized drug use and MAT disclosure concerns were measured using scales adapted to the Tanzanian context. We conducted exploratory factor analysis to identify latent constructs and evaluate reliability of the scales. We then used confirmatory factor analysis to assess construct validity and reliability.</div></div><div><h3>Results</h3><div>The six-item internalized drug use stigma scale (IDUSS) was unidimensional, reflected acceptable goodness-of-fit, and acceptable reliability (Cronbach’s α = 0.79). The eight-item internalized drug use stigma scale for people using MAT (IDUSS-MAT) was bidimensional. Allowing error terms of related items to covary improved goodness-of-fit. The IDUSS-MAT demonstrated acceptable reliability (Cronbach’s α = 0.79). Among PWUD and MAT clinic clients, higher levels of stigma were associated with increased depression and reduced social support and quality of life.</div></div><div><h3>Conclusions</h3><div>Both the IDUSS and IDUSS-MAT demonstrated good construct validity and acceptable reliability. These validated scales provide the foundation for collecting data to inform the development of stigma reduction interventions in Tanzania and among similar Sub-Saharan populations of PWUD and the tools needed to assess those interventions.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"264 ","pages":"Article 112469"},"PeriodicalIF":3.9,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142483961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Labour productivity losses from premature death due to alcohol in Spain (2002–2018): Estimation and comparative analysis with tobacco-related estimates","authors":"Juan Oliva-Moreno ,&nbsp;Marta Trapero-Bertran ,&nbsp;Luz Maria Peña-Longobardo","doi":"10.1016/j.drugalcdep.2024.112462","DOIUrl":"10.1016/j.drugalcdep.2024.112462","url":null,"abstract":"<div><h3>Aim</h3><div>To estimate premature deaths, years of potential labour productivity lost, and productivity losses attributable to alcohol consumption in Spain (2002–2018) and, compare these losses with those from tobacco consumption.</div></div><div><h3>Methods</h3><div><strong>Using</strong> the human capital approach, data on employment, wages and mortality were analysed from national sources. Alcohol-related mortality risks were drawn from the Spanish Ministry of Health. Labour productivity losses were calculated based on working-age mortality (35–64 years), with adjustments for productivity growth and discount rates. Sensitivity analyses were conducted to validate the findings.</div></div><div><h3>Results</h3><div>Between 2002 and 2018, premature deaths and productivity losses related to alcohol consumption decreased significantly, with losses declining from 1959 million euros in 2002–936 million euros in 2018, representing a 52.2 % reduction. Although there was also a favourable trend in this area, productivity losses due to tobacco-related deaths amounted to 68.6 %.</div></div><div><h3>Conclusion</h3><div>This study reveals a marked decline in alcohol-related labour productivity losses in Spain over the analysed period. Nevertheless, tobacco and alcohol continue to pose a greater economic burden, highlighting the need for sustained public health efforts targeting both alcohol and tobacco consumption to mitigate productivity losses.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"264 ","pages":"Article 112462"},"PeriodicalIF":3.9,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation into the biomolecular bases of blunted cocaine-induced glutamate release within the nucleus accumbens elicited by adolescent exposure to phenylpropanolamine","authors":"Casey A. Wilson ,&nbsp;Bailey W. Miller ,&nbsp;Rachel M. Renton ,&nbsp;Kevin D. Lominac ,&nbsp;Karen K. Szumlinski","doi":"10.1016/j.drugalcdep.2024.112465","DOIUrl":"10.1016/j.drugalcdep.2024.112465","url":null,"abstract":"<div><div>Globally, phenylpropanolamine (PPA) is a prevalent primary active ingredient in over-the-counter cough and cold, as well as weight-loss medications. Previously, we showed that a sensitization of cocaine-induced glutamate release within the nucleus accumbens (NAC) and the expression of cocaine-conditioned reward is not apparent in adult mice with a prior history of repeated PPA exposure during adolescence. As NAC glutamate is a purported driver of cocaine reward and reinforcement, the present study employed <em>in vivo</em> microdialysis and immunoblotting approaches to inform as to the receptor and transporter anomalies that might underpin the disrupted glutamate response to cocaine in adolescent PPA-exposed mice. For this, male and female C57BL/6<!--> <!-->J mice were pretreated, once daily, with either 0 or 40<!--> <!-->mg/kg PPA during post-natal days 35–44. Adolescent PPA pretreatment significantly altered the expression of mGlu2/3 and α2 receptors in the NAC, with less robust changes detected for EAAT2, D2 receptors, DAT and NET. However, we detected no overt change in the capacity of these receptors or transporters to affect extracellular glutamate levels in adolescent PPA-pretreated mice. The present findings contrast with the pronounced changes in the capacity of mGlu2/3 receptors, EAAT, DAT and NET to regulate NAC extracellular glutamate reported previously for juvenile PPA-pretreated mice, indicating further that the long-term biochemical consequences of PPA depend on the critical period of neurodevelopment during which an individual is PPA-exposed, although the specific biomolecular changes underpinning the cocaine phenotype produced by adolescent PPA remain to be elucidated.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"264 ","pages":"Article 112465"},"PeriodicalIF":3.9,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142483960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing web-based interventions for alcohol use screening and alcohol education administered by village health volunteers in the community setting","authors":"Polathep Vichitkunakorn ,&nbsp;Chutarat Sathirapanya ,&nbsp;Napakkawat Buathong ,&nbsp;Phoomjai Sornsenee ,&nbsp;Sitthichok Chaichulee ,&nbsp;Teerohah Donraman","doi":"10.1016/j.drugalcdep.2024.112461","DOIUrl":"10.1016/j.drugalcdep.2024.112461","url":null,"abstract":"<div><h3>Background</h3><div>Given technology’s rising importance in addressing alcohol issues, this study aimed to compare the effectiveness of web-based interventions and that of traditional paper-based methods for alcohol use screening and education administered by village health volunteers (VHVs) in Thailand.</div></div><div><h3>Methods</h3><div>This cluster randomised controlled trial was conducted in two Thai villages with similar demographics and alcohol-use patterns. The villages were randomly assigned to either a web-based or a paper-based intervention group. The web-based group accessed screenings and interventions through a digital platform designed to facilitate participant interaction and data collection, whereas the paper-based group used conventional face-to-face screenings, paper questionnaires, and printed educational materials.</div></div><div><h3>Results</h3><div>Of the 1396 participants, those in the web-based group (n = 421) demonstrated a significantly higher likelihood of abstaining from or discontinuing alcohol use by the third session compared to those in the paper group (n = 975) (adjusted odds ratio 1.88–8.11). Additionally, satisfaction among VHVs regarding the ease of use and data accuracy was notably higher in the web-based group, with scores averaging 20 % higher than those in the control group.</div></div><div><h3>Conclusion</h3><div>Web-based interventions are more effective and efficient than traditional methods and provide a promising tool for expanding alcohol use disorder screening and education. This approach not only enhances participation rates but also improves the accuracy and reliability of health data collection.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"264 ","pages":"Article 112461"},"PeriodicalIF":3.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142483959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time course of kratom effects via ecological momentary assessment, by product type, dose amount, and assayed alkaloid content","authors":"Kirsten E. Smith ,&nbsp;Leigh V. Panlilio ,&nbsp;Abhisheak Sharma ,&nbsp;Christopher R. McCurdy ,&nbsp;Jeffrey D. Feldman ,&nbsp;Sushobhan Mukhopadhyay ,&nbsp;Siva Rama Raju Kanumuri ,&nbsp;Michelle A. Kuntz ,&nbsp;Katherine Hill ,&nbsp;David H. Epstein","doi":"10.1016/j.drugalcdep.2024.112460","DOIUrl":"10.1016/j.drugalcdep.2024.112460","url":null,"abstract":"<div><h3>Background and aims</h3><div>Using ecological momentary assessment (EMA), we undertook a natural experiment wherein kratom-product variability was a tool to assess kratom dose-response relationships based on product form and alkaloid level.</div></div><div><h3>Methods</h3><div>Between July-November 2022, 357 US kratom consumers (56.6 % male, 90.2 % non-Hispanic white) completed 15 days of EMA; 348 participants submitted samples of the products used most often during EMA. These were assayed for ten alkaloids using ultra-performance liquid chromatography-tandem mass spectrometry. Self-reported kratom effects were modeled as a function of kratom amount and alkaloid content.</div></div><div><h3>Results</h3><div>Participants used over 220 brands. The most-reported product forms were loose powder (55.8 %) and encapsulated powder (26.8 %); extracts were used less (419 uses across 9.48 % of participants). Of the 12,244 use-event entries, 7726 had follow-up data (15–180<!--> <!-->minutes after use) on felt effects. Effects were stronger in participants with a higher average amount per use. Within-person dose-response relationships were obscured by highly-consistent within-person dosages. Effects of loose powder decreased over three hours; effects of extracts started higher but decreased more rapidly. Dose-response relationships for specific alkaloids could not be reliably established because total alkaloid content and relative levels of specific alkaloids showed limited variability between products. Higher levels of corynoxine alkaloids were associated with slightly stronger effects, possibly an artifact of modeling data with low alkaloid variability.</div></div><div><h3>Conclusions</h3><div>Alkaloid content was surprisingly consistent across kratom products, and participants were consistent in the amount they used across events. Firm conclusions about alkaloid-effect relationships for kratom will require experimenter-controlled manipulations of agent and dose.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"264 ","pages":"Article 112460"},"PeriodicalIF":3.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased prevalence of alcohol use and related sociodemographic factors in an urban district of Shanghai, China: Evidence from three cross-sectional surveys (2010–2021)","authors":"Li Cao ,&nbsp;Xiaolin Qian ,&nbsp;Liangfeng Wang ,&nbsp;Yun Chen ,&nbsp;Zhenmei Pu ,&nbsp;Deng Niu ,&nbsp;Jianhua Shi ,&nbsp;Haiyan Gu ,&nbsp;Chaowei Fu","doi":"10.1016/j.drugalcdep.2024.112452","DOIUrl":"10.1016/j.drugalcdep.2024.112452","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol use contributes considerably to the global impact of disease. However, limited research has been conducted recently to explore the changes in the prevalence of alcohol use, especially in urban Shanghai, China.</div></div><div><h3>Objectives</h3><div>To estimate the prevalence changes of alcohol use and explore related sociodemographic factors among urban residents of Xuhui district, Shanghai, China.</div></div><div><h3>Methods</h3><div>Using a multistage probability proportionate-to-size sampling method, three waves of household investigations via a structured questionnaire were conducted in Xuhui district, Shanghai, China, between 2010 and 2021. Data were collected by face-to-face interviews among residents aged 15 or older who responded to the 2010, 2015, and 2021 Health Status and Health Service Utilization Survey. Age and sex standardized prevalence of alcohol use was calculated, and the linear trend was tested using logistic regression models. Multilevel mixed-effects logistic regression models with robust covariance matrix estimators were used to estimate related factors of alcohol use.</div></div><div><h3>Results</h3><div>A total of 24 552 participants aged 15–109 years were included. The standardized overall prevalence of current regular alcohol use statistically declined from 8.8 % in 2010 to 5.5 % in 2021. This decreasing trend was statistically significant, especially among men aged 30–59 and ≥ 75 years old. However, the prevalence of overall alcohol use, regardless of frequency, increased from 19.6 % in 2015 to 24.0 % in 2021. Multivariate regression analysis showed that men had a significantly higher likelihood of regular alcohol use than women. Also, age was positively related to regular alcohol use, while education level was negatively related to this behavior.</div></div><div><h3>Conclusions</h3><div>Alcohol use was still common, although a significant decreasing trend in the prevalence of regular alcohol use was observed overall, in this study population. The findings call for strengthened health education and alcohol control in the context of the harmful effects of alcohol use at any level.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"264 ","pages":"Article 112452"},"PeriodicalIF":3.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142483958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"A way to liberate myself\": A qualitative study of perceived benefits and risks of chemsex among gay, bisexual, and other men who have sex with men in Almaty, Kazakhstan","authors":"Nikolay Lunchenkov ,&nbsp;Nadezhda Cherchenko ,&nbsp;Kuanysh Altynbekov ,&nbsp;Assel Terlikbayeva ,&nbsp;Sholpan Primbetova ,&nbsp;Denis Gryazev ,&nbsp;Elena German ,&nbsp;Uluk Batyrgaliev ,&nbsp;Janina Isabel Steinert","doi":"10.1016/j.drugalcdep.2024.112464","DOIUrl":"10.1016/j.drugalcdep.2024.112464","url":null,"abstract":"<div><h3>Background</h3><div>In Kazakhstan, the HIV epidemic has a significant impact on marginalized groups such as gay, bisexual and other men who have sex with men (GBMSM), exacerbated by homophobic attitudes (in society) and (resulting) minority stress. This stress often leads to coping behaviors such as chemsex - the use of synthetic stimulants to enhance sexual experiences. Our study explores the motivations and perceived risks associated with chemsex among GBMSM in Almaty.</div></div><div><h3>Methods</h3><div>We conducted semi-structured in-depth interviews with 21 chemsex participants self-identified as GBMSM in Almaty, Kazakhstan. Participants were recruited through community-based organizations to ensure a diverse sample in terms of age and ethnicity. Thematic analysis was used to identify key themes related to motivations and risks.</div></div><div><h3>Results</h3><div>Participants practiced chemsex to seek liberation from societal norms and personal inhibitions, increase sexual pleasure, and escape daily stressors. Chemsex sessions provided intensified sexual experiences, emotional comfort, and social connections, challenging constraints on sexual behavior. Participants recognized significant risks, including mental and physical health issues, social stigma, and violence victimisation. Despite these risks, the desire for the perceived benefits of chemsex, particularly feelings of freedom and happiness, underscored its appeal.</div></div><div><h3>Conclusions</h3><div>The study reveals a complex dynamic in which chemsex serves as a coping mechanism for minority stress, a source of sexual liberation, and a social connector for GBMSM in Kazakhstan, while also posing significant health risks. These findings emphasize the need for targeted harm reduction strategies, mental health support, and community-building efforts that are responsive to the experiences and needs of GBMSM who engage in chemsex.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"264 ","pages":"Article 112464"},"PeriodicalIF":3.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Housing instability increases for stimulant-involved overdose deaths after linking surveillance data to electronic health records in Kentucky","authors":"Daniel R. Harris ,&nbsp;Dana Quesinberry ,&nbsp;Nicholas Anthony ,&nbsp;Jungjun Bae ,&nbsp;Anna L. Smith ,&nbsp;Chris Delcher","doi":"10.1016/j.drugalcdep.2024.112455","DOIUrl":"10.1016/j.drugalcdep.2024.112455","url":null,"abstract":"<div><h3>Background</h3><div>According to the U.S. Centers for Disease Control and Prevention, approximately 10.2 % of fatal overdoses in 2022 were among people experiencing homelessness or housing instability. In the United States, the majority of all drug overdoses now involve stimulants.</div></div><div><h3>Methods</h3><div>We linked stimulant-involved fatal overdose records occurring between 2017 and 2021 from Kentucky’s Drug Overdose Fatality Surveillance System to the electronic health records (EHR) of the state’s largest safety-net hospital network. We used State Unintentional Drug Overdose Reporting System (SUDORS) definitions of homelessness or housing instability to establish baseline estimates before linking decedents to medical records. After linkage, we augmented SUDORS data with structured administrative billing codes, semi-structured address data, and unstructured clinical notes identifying homelessness from the EHR.</div></div><div><h3>Results</h3><div>There were 313 individuals with stimulant-involved fatal overdoses linked to at least one medical encounter in the EHR (2017–2021). Thirty-three individuals (10.5 %) were identified as having unstable housing according to SUDORS. After linkage, 130 individuals (41.5 %) had evidence of housing instability. For this period, these 313 individuals represent 8.0 % of stimulant-involved overdoses in KY or 38.5 % of stimulant-involved overdoses from residents of the primary and secondary catchment area of our healthcare network.</div></div><div><h3>Conclusions</h3><div>The single-site increase in observed housing instability in stimulant-involved fatal overdoses suggests that increased data linkage between state medicolegal death investigation system and EHRs would significantly improve the public health surveillance of overdoses.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"264 ","pages":"Article 112455"},"PeriodicalIF":3.9,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}