2020年10月至2025年4月，美国所有阿片类药物、海洛因和芬太尼非致命性过量用药趋势。

IF 3.6 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence Pub Date : 2025-09-12 DOI:10.1016/j.drugalcdep.2025.112886

Stephen Liu , Shannon Casillas , Emily Ussery , Michael Sheppard , Alana Vivolo-Kantor

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引用次数: 0

摘要

背景：本研究调查了2020年10月至2025年4月期间疑似非致命性阿片类药物过量的月度趋势，并评估了包括海洛因和芬太尼在内的阿片类药物类型的人口统计学和地理区域是否存在差异。方法：使用疾病预防控制中心的国家综合征监测项目数据，使用药物过量监测和流行病学定义，对急诊科中所有涉及阿片类药物、海洛因和芬太尼的过量用药进行分析。使用Joinpoint回归对所有阿片类药物、海洛因和芬太尼相关的过量用药计数估计平均每月百分比变化（AMPC）。在所有阿片类药物、海洛因和芬太尼相关的过量ED发生率之间，比较了海洛因和芬太尼相关的过量ED发生率之间的人口统计学特征和区域差异。结果：2020年10月至2025年4月，非致死性阿片类药物过量呈下降趋势（AMPC=- 0.5%），夏季用药较多。海洛因过量使用减少（AMPC=- 3.1%）；相反，芬太尼过量用药增加（AMPC= 2.0%）。2020年10月海洛因计数（n = 5571）高于芬太尼计数（n = 913）；然而，在2023年2月，芬太尼（n = 2464）超过海洛因（n = 2341），并在2025年4月保持较高水平。与海洛因相比，芬太尼过量人群的人口学特征相似，除了15-24岁人群中芬太尼的比例高于海洛因（12.8%对5.7%）。海洛因和芬太尼相关的过量服用率分别在芝加哥第5区和西雅图第10区最高。结论：更好地了解按药物类型划分的非致命性阿片类药物过量的趋势、人口统计学和地理特征，有助于提供量身定制的预防信息，但无论阿片类药物类型如何，结果表明，持续的阿片类药物过量逆转药物分布以及与急诊科阿片类药物使用障碍的循证治疗联系在一起。

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Trends of all opioid-, heroin-, and fentanyl-involved nonfatal overdoses in the United States, October 2020 – April 2025

Background

This study examined monthly trends of suspected, nonfatal opioid-involved overdoses from October 2020–April 2025 and assessed whether demographics and geographic region vary between opioid type, including heroin and fentanyl.

Methods

CDC’s National Syndromic Surveillance Program data using the Drug Overdose Surveillance and Epidemiology definitions for all opioid-, heroin-, and fentanyl-involved overdoses in EDs were used. The average monthly percentage change (AMPC) was estimated using Joinpoint regression for counts of all opioid, heroin, and fentanyl-involved overdoses. Demographic characteristics between heroin- vs. fentanyl-involved overdoses and regional differences by region were compared between all opioid-, heroin-, and fentanyl-involved overdose ED rates.

Results

From October 2020 to April 2025, nonfatal opioid-involved overdoses declined (AMPC=-0.5 %) and showed more counts in summer months. Heroin-involved overdoses decreased (AMPC=-3.1 %); conversely, fentanyl-involved overdoses increased (AMPC=2.0 %). Counts of heroin (n = 5571) were higher than fentanyl (n = 913) in October 2020; however, in February 2023, fentanyl (n = 2464) surpassed heroin (n = 2341) and remained higher through April 2025. Demographic characteristics were similar among persons with fentanyl-involved overdose compared with heroin except a higher proportion of fentanyl occurred among individuals aged 15–24 years (12.8 % vs. 5.7 %) compared to heroin. Heroin- and fentanyl-involved overdose rates were highest in Region 5-Chicago and Region 10-Seattle, respectively.

Conclusions

A better understanding of trends, demographics, and geography in nonfatal opioid-involved overdoses by drug type has implications for tailored prevention messages, but regardless of opioid type, results suggest the continued opioid overdose reversal medication distribution and linkage to evidence-based treatment for opioid use disorder in EDs.

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来源期刊

Drug and alcohol dependence 医学-精神病学

CiteScore

7.40

自引率

7.10%

发文量

409

审稿时长

41 days

期刊介绍： Drug and Alcohol Dependence is an international journal devoted to publishing original research, scholarly reviews, commentaries, and policy analyses in the area of drug, alcohol and tobacco use and dependence. Articles range from studies of the chemistry of substances of abuse, their actions at molecular and cellular sites, in vitro and in vivo investigations of their biochemical, pharmacological and behavioural actions, laboratory-based and clinical research in humans, substance abuse treatment and prevention research, and studies employing methods from epidemiology, sociology, and economics.