Drug and alcohol dependence最新文献

{"title":"Associations between white matter asymmetry and communication skills in children with prenatal alcohol exposure","authors":"Mohammad Ghasoub ,&nbsp;Chloe Scholten ,&nbsp;Meaghan Perdue ,&nbsp;Madison Long ,&nbsp;Curtis Ostertag ,&nbsp;Preeti Kar ,&nbsp;Carly McMorris ,&nbsp;Christina Tortorelli ,&nbsp;W.Ben Gibbard ,&nbsp;Deborah Dewey ,&nbsp;Catherine Lebel","doi":"10.1016/j.drugalcdep.2025.112674","DOIUrl":"10.1016/j.drugalcdep.2025.112674","url":null,"abstract":"<div><h3>Background</h3><div>Prenatal alcohol exposure (PAE) occurs in ~10 % of pregnancies and can cause behavioral and neurological deficits, including alterations to white matter pathways involved in language processing. Language and communication skills are generally left-lateralized in the brain, and this asymmetry is associated with better performance in typically developing individuals, while alterations to this association are found in children with language challenges. However, the degree of asymmetry and its relationship with language skills remain poorly understood in children with PAE.</div></div><div><h3>Methods</h3><div>200 datasets collected from 98 children (46 with PAE) aged 4–8 years were included here. Language skills were assessed using the Children’s Communication Checklist, 2nd edition (CCC-2) parent report. Diffusion MRI was used to examine white matter microstructure and asymmetry in five major language white matter pathways. Measures of white matter microstructure were extracted (fractional anisotropy and mean diffusivity), and a laterality index was calculated. Linear mixed models were used to test associations between language scores and white matter laterality, and whether PAE moderates this relationship.</div></div><div><h3>Results</h3><div>Children with PAE had lower language scores than controls across all CCC-2 indices. Both groups had similar patterns of white matter asymmetry; however, leftward white matter lateralization was associated with worse language scores in children with PAE, but better language scores in unexposed children.</div></div><div><h3>Conclusion</h3><div>Our findings show alterations to the white matter asymmetry-language relationship in children with PAE. This may indicate an altered language processing mechanism that could underlie language deficits observed in many individuals with PAE.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"272 ","pages":"Article 112674"},"PeriodicalIF":3.9,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel intervention to improve food insecurity among individuals with opioid use disorder: A randomized clinical trial","authors":"Stacey C. Sigmon ,&nbsp;Sydney R. Batchelder ,&nbsp;Gary J. Badger","doi":"10.1016/j.drugalcdep.2025.112673","DOIUrl":"10.1016/j.drugalcdep.2025.112673","url":null,"abstract":"<div><h3>Objective</h3><div>Food insecurity (FI) is 4–7 times greater among individuals with opioid use disorder (OUD) than the general population and is associated with increased risk for licit and illicit drug use, sexual and drug risk behaviors, infectious disease, and a two-fold odds of premature death. In this randomized study, we evaluated a novel, mail-based meal delivery intervention for improving household FI and other outcomes among individuals with OUD.</div></div><div><h3>Methods</h3><div>Fifty adults with FI and OUD were randomized to one of two 12-week experimental conditions: Nutritional Education (NE) involved brief education and assistance with contacting community-based FI-related resources. NE +  Meal Delivery (NE+MD) involved the same education plus weekly premade meals directly from a commercial service. The primary outcome of household FI was measured at monthly assessments, with secondary measures of depression symptoms, quality of life, and biochemically-verified drug use.</div></div><div><h3>Results</h3><div>The NE+MD intervention was associated with significant improvements in household FI, with rates of FI significantly lower in the NE+MD vs. NE group at all post-intake timepoints (54.6–62.5 % and 90.5–95.2 % among NE+MD and NE groups, respectively; p’s &lt; .05). NE+MD participants rated the enjoyment and convenience of meals at 80.7 and 92.8, respectively (range: 0–100). Improvements in FI were also associated with improvements in depression, quality of life and illicit opioid abstinence.</div></div><div><h3>Conclusion</h3><div>This study supports the feasibility, acceptability and initial efficacy of a novel NE+MD intervention for improving household FI among individuals with OUD and provides new preliminary evidence that FI may be associated with participants’ mental and physical health.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"271 ","pages":"Article 112673"},"PeriodicalIF":3.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Covariates in studies examining longitudinal relationships between substance use and mental health problems among youth: A meta-epidemiologic review","authors":"Jillian Halladay ,&nbsp;Steph Kershaw ,&nbsp;Emma K. Devine ,&nbsp;Lucinda Grummitt ,&nbsp;Rachel Visontay ,&nbsp;Samantha J. Lynch ,&nbsp;Chris Ji ,&nbsp;Lauren Scott ,&nbsp;Marlee Bower ,&nbsp;Louise Mewton ,&nbsp;Matthew Sunderland ,&nbsp;Tim Slade","doi":"10.1016/j.drugalcdep.2025.112665","DOIUrl":"10.1016/j.drugalcdep.2025.112665","url":null,"abstract":"<div><h3>Introduction</h3><div>This meta-epidemiological review examines covariate selection and reporting practices in observational studies analyzing longitudinal relationships between youth substance use and mental health problems (internalizing and externalizing).</div></div><div><h3>Methods</h3><div>Sixty-nine studies published in high-impact journals from 2018 to 2023 were included. Studies were included if they explored prospective relationships between substance use and mental health among youth (12–25 years) and used repeated measures designs. Data extraction focused on study characteristics, covariates and their selection methods, and reporting practices.</div></div><div><h3>Results</h3><div>There were 574 covariates included across studies; 33 were included as moderators and 18 were included as mediators. At the study level, the most common covariate domains included demographics (90 % of included studies had at least one demographic, mostly sex), substance-related variables (67 %; mostly alcohol or smoking), internalizing symptoms (39 %; mostly depression), family-related variables (29 %; mostly parental substance use or mental illness), and externalizing symptoms (19 %; mostly conduct). 93 % of studies had unique sets of lower-order covariates. Across all studies (n = 69), only 35 % provided details for how, and why, all covariates were selected with only 12 % reporting selecting covariates <em>a priori</em>, and none being pre-registered. Only 60 % mentioned confounding and only 13 % mentioned risk of confounding in their conclusions.</div></div><div><h3>Conclusions</h3><div>The findings highlight the need for improved covariate selection and reporting practices. Establishing a core set of covariates and adhering to standardized reporting guidelines would enhance the comparability and reliability of research findings in this field. Researchers can use this review to identify and justify the inclusion and exclusion of commonly reported covariates when analyzing relationships between youth substance use and mental health problems.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"271 ","pages":"Article 112665"},"PeriodicalIF":3.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The continuing care project: A multi-arm randomised controlled trial of a continuing care telephone intervention following residential substance use treatment","authors":"Peter J. Kelly ,&nbsp;Frank P. Deane ,&nbsp;Amanda L. Baker ,&nbsp;Camilla Townsend ,&nbsp;James R. McKay ,&nbsp;Tayla J. Degan ,&nbsp;Erin Nolan ,&nbsp;Kerrin Palazzi ,&nbsp;Gerard Byrne ,&nbsp;Briony Osborne ,&nbsp;Johanna Meyer ,&nbsp;Laura Robinson ,&nbsp;Christopher Oldmeadow ,&nbsp;Kenny Lawson ,&nbsp;Andrew Searles ,&nbsp;Joanne Lunn ,&nbsp;Jason Nunes ,&nbsp;Isabella Ingram","doi":"10.1016/j.drugalcdep.2025.112668","DOIUrl":"10.1016/j.drugalcdep.2025.112668","url":null,"abstract":"<div><h3>Background</h3><div>Previous research suggests telephone-delivered continuing care interventions are effective in reducing rates of substance use. This study assessed the effectiveness of telephone-delivered continuing care for people who had stayed in a residential alcohol and other drug (AOD) treatment facility for at least 4-weeks.</div></div><div><h3>Methods</h3><div>Participants were 277 (20 – 71 years; <em>M</em> = 38 years, <em>SD</em> = 10.4; 58 % male) individuals attending residential AOD treatment. Following discharge participants were randomised to: i) 12 weekly telephone sessions; ii) 4 weekly telephone sessions; or iii) no telephone sessions (control group). A multi-centre prospective, randomised, open, blinded endpoint (PROBE) design compared three study arms with follow up at 3- and 6-months. Primary outcome was the odds of complete abstinence and the days of AOD use for those not completely abstinent at 6-months.</div></div><div><h3>Results</h3><div>At 6-months follow-up, the odds of being completely abstinent in the past month was not significantly different between the three study arms (<em>p</em> &gt; 0.6) and the number of days abstinent was not significantly different (<em>p</em> &gt; 0.4). Participants across all arms were more likely (<em>p</em> &lt;  0.001) to be completely abstinent compared to baseline [12-session <em>OR</em> = 12.86 (5.4, 30.9); 4-session <em>OR</em> = 9.52 (4.0, 22.4); Control <em>OR</em> = 7.02, (3.4, 14.7)].</div></div><div><h3>Conclusions</h3><div>The results suggest that the residential programs are associated with positive long-term impacts among participants who complete at least 4 weeks of treatment. Further continuing care research should include those who do not remain in treatment for at least 4 weeks, as they may be likely to benefit the most.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"272 ","pages":"Article 112668"},"PeriodicalIF":3.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harms associated with prescription drug misuse in Ireland: A national observational study of trends in treatment demand, non-fatal intentional drug overdoses and drug related deaths 2010–2020","authors":"Louise Durand ,&nbsp;Ella Arensman ,&nbsp;Paul Corcoran ,&nbsp;Caroline Daly ,&nbsp;Kathleen Bennett ,&nbsp;Suzi Lyons ,&nbsp;Eamon Keenan ,&nbsp;Gráinne Cousins","doi":"10.1016/j.drugalcdep.2025.112669","DOIUrl":"10.1016/j.drugalcdep.2025.112669","url":null,"abstract":"<div><h3>Aims</h3><div>To describe the health-related harms associated with the misuse of benzodiazepines/z-drugs, prescription opioids, gabapentinoids, and psychostimulants in Ireland by examining trends in their involvement in treatment demand, non-fatal intentional drug overdoses (IDOs), and drug related deaths (DRDs).</div></div><div><h3>Methods</h3><div>A repeated cross-sectional study using data from the National Drug Treatment Reporting System (NDTRS), the National Self-Harm Registry Ireland (NSHRI) and the National Drug Related Deaths Index (NDRDI) between 2010 and 2020. Trends over time (2010–2020) in treatment demand, IDOs and DRDs involving benzodiazepines/z-drugs, prescription opioids excluding opioid agonist therapy drugs, gabapentinoids, or psychostimulants (alone or concurrently), adjusting for age and gender (Negative Binomial Regression).</div></div><div><h3>Findings</h3><div>A total of 102,661 treatment entry cases; 51,126 people presenting with at least one IDO; and 3626 DRDs included. Benzodiazepines/z-drugs were involved in 341 per 1000 treatment entry cases; 408 per 1000 IDOs; and 546 per 1000 DRDs, followed by prescription opioids (36 per 1000 treatment entry cases; 133 per 1000 IDOs; and 207 per 1000 DRDs) and gabapentinoids (5 per 1000 treatment entry cases; 54 per 1000 IDOs; and 118 per 1000 DRDs). Benzodiazepines/z-drugs, and prescription opioid involvement was stable over time with little or no changes observed in treatment demand, IDOs and DRDs. However, NPS-Benzodiazepines (etizolam) involvement in DRDs increased by 47 % annually (Adjusted Rate Ratio (ARR) 1.47, 95 % Confidence Interval (CI) 1.30–1.65, p &lt; 0.0001). Gabapentinoids (primarily pregabalin) associated with a large annual increase in treatment demand (+44 % annually, ARR 1.44, 95 % CI 1.36–1.52, p &lt; 0.0001), DRDs (+35 % annually, ARR 1.35, 95 % CI 1.25–1.46, p &lt; 0.0001), and IDOs (+9 % annually, ARR 1.09, 95 % CI 1.07–1.10, p &lt; 0.0001). Polysubstance use harms increased with respect to treatment demand, IDOs and DRDs over study period.</div></div><div><h3>Conclusions</h3><div>While benzodiazepines account for the greatest overall harm with respect to treatment demand, IDOs and DRDs, gabapentinoids (primarily pregabalin) had the largest annual increase in harm over the study period.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"272 ","pages":"Article 112669"},"PeriodicalIF":3.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug use and needle sharing among adolescents and young adults in Nigeria: A cross-sectional secondary analysis of data from a multi-site clinical trial","authors":"Simisola Agunbiade ,&nbsp;Titilola Gbaja-Biamila ,&nbsp;David Oladele ,&nbsp;Chisom Obiezu-Umeh ,&nbsp;Adesola Zaidat Musa ,&nbsp;Lateef Akeem Blessing ,&nbsp;Kadija Muse Tahlil ,&nbsp;Folahanmi Tomiwa Akinsolu ,&nbsp;Donaldson F. Conserve ,&nbsp;Ebenezer Adeoti ,&nbsp;Hong Xian ,&nbsp;Kevin Kuriakose ,&nbsp;Juliet Iwelunmor ,&nbsp;Oliver Ezechi ,&nbsp;Joseph Tucker","doi":"10.1016/j.drugalcdep.2025.112666","DOIUrl":"10.1016/j.drugalcdep.2025.112666","url":null,"abstract":"<div><h3>Background</h3><div>Adolescents and young adults (AYA, 14–24 years old) have the highest rates of drug use in most low- and middle-income countries. Little is known about the drivers of drug use among AYA in Nigeria and harm reduction services are limited.</div></div><div><h3>Methods</h3><div>A secondary data analysis was performed of the baseline survey of the ‘I-TEST’ study involving AYA in Nigeria. The two primary outcomes of interest were lifetime measures of drug use and needle sharing. Logistic regression analyses were performed to obtain odds ratios for the associations between socio-demographic exposures and the two primary outcomes. Odds ratios were subsequently adjusted for age and sex.</div></div><div><h3>Results</h3><div>1500 AYA survey responses were analysed. Respondents were mostly unemployed, students, and living in southern Nigeria. Drug use was reported by 301/1500(20.3 %) AYA. Among these, 213/301(71.5 %) reported needle sharing. Drug use did not vary by age (OR:0.94, 95 %CI:0.73–1.22) or sex (OR:1.00, 95 %CI:0.77–1.28). AYA in the North-Central zone had higher odds of drug use (OR:1.86, 95 %CI:1.28–2.69) and needle sharing (OR:2.51, 95 %CI:1.07–5.91) compared to AYA in the South-West zone of Nigeria. AYA aged 14–19 had higher odds of needle sharing compared to those aged 20–24 (OR:3.49, 95 %CI:1.94–6.26). Female AYA had higher odds of needle sharing compared to males (OR:5.05, 95 %CI:2.85–8.95).</div></div><div><h3>Conclusions</h3><div>Drug use and needle sharing are common among AYA in Nigeria. There is an urgent need for harm reduction services and research informed by AYA.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"271 ","pages":"Article 112666"},"PeriodicalIF":3.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothetical demand for menthol and non-menthol cigarettes and substitution among people who smoke menthol cigarettes: A within subjects between group randomized controlled trial using the experimental tobacco marketplace","authors":"Amanda J. Quisenberry ,&nbsp;Lovina John ,&nbsp;Richard O’Connor ,&nbsp;Elizabeth G. Klein","doi":"10.1016/j.drugalcdep.2025.112667","DOIUrl":"10.1016/j.drugalcdep.2025.112667","url":null,"abstract":"<div><h3>Introduction</h3><div>The Food and Drug Administration has recently released a final rule enacting a characterizing flavor ban in cigarettes and cigars. Similar efforts have been proposed for e-cigarettes. The aim of this study was to evaluate the effect of a potential menthol cigarette ban, a fruit and mint flavored e-cigarette ban, and the interaction of the two among current adults who smoke menthol cigarettes.</div></div><div><h3>Methods</h3><div>The Experimental Tobacco Marketplace was used to evaluate the within subject purchasing of participants who smoke menthol major name brand (n = 64) and Native manufactured (n = 37) cigarettes when fixed price alternatives and only: 1) menthol cigarettes and mint and fruit flavored e-cigarettes, 2) non-menthol cigarettes and mint and fruit flavored e-cigarettes, 3) menthol cigarettes and tobacco flavored e-cigarettes, and 4) non-menthol cigarettes and tobacco flavored e-cigarettes were available.</div></div><div><h3>Results</h3><div>Participants who smoked major name brand and Native manufactured menthol cigarettes showed greater cigarette demand (Q₀) and less sensitivity to price (α) when menthol cigarettes were available. For those who smoked major name brand cigarettes, the only substitute the emerged was moist snuff when non-menthol cigarettes and fruit and mint e-cigarettes were available. No substitutes were found for those who smoked Native manufactured cigarettes in any flavor availability condition.</div></div><div><h3>Conclusions and relevance</h3><div>Demand for cigarettes is higher when preferred flavor is available. Substitutes for cigarettes among people who smoke menthol cigarettes are minimal and may indicate that removal of menthol from the landscape may not push people who smoke menthol cigarettes to products other than cigarettes.</div></div><div><h3>Data Availability</h3><div>The data utilized in this paper are available by request from corresponding author, AJQ, given the participants in this study did not consent to have their data shared with the public. Following publication of primary and secondary results, the corresponding author will provide de-identified data and a data dictionary for requests.</div></div><div><h3>ClinicalTrials.gov ID and title</h3><div>NCT03897530; Experimental Tobacco Marketplace in Regulating Flavored Tobacco Products in Menthol Cigarette Smokers</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"271 ","pages":"Article 112667"},"PeriodicalIF":3.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissolving contradictory demands: A systematic review of alcohol use of working mothers","authors":"Maree Patsouras ,&nbsp;Cassandra Wright ,&nbsp;Gabriel Caluzzi ,&nbsp;Emmanuel Kuntsche ,&nbsp;Sandra Kuntsche","doi":"10.1016/j.drugalcdep.2025.112664","DOIUrl":"10.1016/j.drugalcdep.2025.112664","url":null,"abstract":"<div><h3>Background</h3><div>Working mothers perform ‘double shifts’ of paid and domestic labour. Increased rates of employment among mothers in high income countries, and the impact of the alcohol industry actively promoting alcohol to working mothers, makes it crucial for preventative efforts to understand the factors driving alcohol use among this population. This systematic review of qualitative and quantitative studies provides an overview of the drinking patterns of working mothers and their predictors.</div></div><div><h3>Methods</h3><div>Four databases were systematically searched in August 2024. The population of interest were adult women in high income countries, who were both mothers of at least one dependent child and employed in any capacity. The methodological quality was assessed using the Mixed Methods Appraisal Tool. Following a convergent integrated approach, narrative synthesis was conducted for all studies.</div></div><div><h3>Results</h3><div>Of the 4623 records maintained for screening, 22 articles (15 quantitative and 7 qualitative) were included. Working mothers were more often drinkers and consumed a higher quantity per occasion (including binge and risky drinking) in comparison to mid-life women and non-working mothers. Alcohol use was also linked to managing emotional states, as a commodity to ‘cope’ with gendered norms. Living in a society with increased gender equity and being partnered or married had a protective effect on heavy drinking and consumed quantity.</div></div><div><h3>Conclusions</h3><div>Working mother’s drinking is governed by gender norms and expectations, and countries who advance policies to improve the acceptability and compatibility of motherhood and employment may reduce working mother’s alcohol use.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"271 ","pages":"Article 112664"},"PeriodicalIF":3.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical pharmacist practitioners prescribing of buprenorphine for opioid use disorder","authors":"Jacob D. Baylis ,&nbsp;Terri L. Jorgenson ,&nbsp;Haley E. Pals ,&nbsp;Catherine S. Hwang ,&nbsp;Michelle D. Colvard ,&nbsp;Veldana Alliu ,&nbsp;Tera Moore ,&nbsp;Lewei A. Lin ,&nbsp;Jessica Wyse ,&nbsp;Eric J. Hawkins ,&nbsp;Hildi J. Hagedorn ,&nbsp;Adam J. Gordon","doi":"10.1016/j.drugalcdep.2025.112663","DOIUrl":"10.1016/j.drugalcdep.2025.112663","url":null,"abstract":"<div><h3>Background</h3><div>Clinical Pharmacist Practitioners (CPPs) have a long history of collaborating with other prescribers for the provision of buprenorphine medication treatment for opioid use disorder (B-MOUD). In January 2023, with the removal of the DATA 2000 X-waiver process, CPPs were allowed to prescribe B-MOUD in states that allow CPP prescriptive authority of controlled substances. We sought to examine CPP prescribing patterns of B-MOUD in a large heath care system in 2023.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study of patients with opioid use disorder (OUD) who received B-MOUD care in 2023 within the Veterans Health Administration (VHA). B-MOUD was defined as a formulation of buprenorphine indicated for OUD. We characterized Veterans who were prescribed B-MOUD by CPPs and examined the characteristics of these prescriptions and the episodes of care (EOC).</div></div><div><h3>Results</h3><div>In 2023, 22,863 Veterans received B-MOUD; 1090 (4.8 %) from a CPP. Veterans prescribed B-MOUD by CPPs were primarily 36–50 years old (n = 419, 38.4 %), male (n = 987, 90.6 %), white (n = 987, 90.6 %), non-Hispanic/Latino (n = 1043, 95.7 %), and in urban areas (n = 648, 59.4 %). 110 CPPs prescribed B-MOUD in 36 states representing 1.9 % of all B-MOUD prescribers in 2023. CPPs prescribed 5258 B-MOUD prescriptions, conducted 339 (2.7 %) initiations, were involved in 1162 (4.2 %) of all EOC throughout the year, and were the sole prescriber for 16.6 % of EOC. CPP-involved EOC had 86.9 % (n = 867) 90-day retention.</div></div><div><h3>Conclusion</h3><div>When they were able to, VHA CPPs were early adopters in prescribing B-MOUD. B-MOUD prescribing by CPPs is an emerging opportunity to further expand access to B-MOUD.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"271 ","pages":"Article 112663"},"PeriodicalIF":3.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in alcohol-cue-induced craving and heart-rate variability in hazardous drinkers","authors":"Insan Firdaus ,&nbsp;Anja C. Huizink ,&nbsp;Annet Kleiboer ,&nbsp;Anna E. Goudriaan ,&nbsp;Anne Marije Kaag","doi":"10.1016/j.drugalcdep.2025.112662","DOIUrl":"10.1016/j.drugalcdep.2025.112662","url":null,"abstract":"<div><div>Alcohol use disorder (AUD) has risen more rapidly in women than men in recent decades. While previous studies identified gender differences in AUD, the mechanisms remain unclear. This study examined gender differences in alcohol cue-induced craving and heart rate variability (HRV) in 114 people who engage in heavy drinking (61 women) using an alcohol-cue reactivity task. We predicts that men will show stronger cue-induced reward cravings, women will have more intense relief cravings. Additionally, it is expected that the relationship between cue-induced craving and HRV will differ by gender: reward craving in men will correspond with increased HRV, whereas relief craving in women will correlate with decreased HRV. The alcohol cue-reactivity task began with a 75-second relaxation exercise, followed by 30-second presentations of alcohol-related pictures and imagery, and a 120-second session of handling an alcohol beverage. Craving was assessed before and after using the desire for alcohol questionnaire (DAQ), and HRV was continuously recorded via electrocardiograph throughout the task. Repeated measures ANOVAs showed significant increases in both relief (p &lt; .05) and reward craving (p &lt; .001) after the alcohol cue-reactivity task, with no gender differences. Exploratory analysis found that HRV decreased in response to alcohol cues for both genders, with men showing a significantly greater decline during the picture phase (p &lt; .05). Additionally, those with higher relief craving had lower HRV during the imagery phase compared to the picture phase, regardless of gender (p = .20). The current study suggests that gender differences in alcohol cue reactivity are more pronounced in HRV than in subjective responses.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"271 ","pages":"Article 112662"},"PeriodicalIF":3.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}