Health-related quality of life trajectories of patients in heroin-assisted treatment

IF 3.6 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence Pub Date : 2025-08-15 DOI:10.1016/j.drugalcdep.2025.112839

Francesca Melis , Charlotte Castel , Desiree Eide , Thomas Clausen

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Abstract

Background

This study investigates health-related quality of life (HRQoL) in individuals with opioid use disorder enrolled in heroin-assisted treatment (HAT). While HRQoL in opioid maintenance treatment has been studied, less is known while in HAT. This study aim is to describe HRQoL in HAT, identify different HRQoL trajectories, and examine factors associated with class memberships.

Methods

This longitudinal cohort study is based on the multi-center Norwegian HAT project. The sample includes all consenting individuals enrolled in treatment from January 2022 to October 2024 (n = 108). HRQoL was assessed using the EuroQol EQ-5D-5L, and demographics were collected at baseline and multiple time points. Latent class linear mixed models were employed to identify HRQoL trajectory classes and explore differences in class memberships.

Results

At admission, participants demonstrated significant HRQoL difficulties across all dimensions, with severity levels higher than those of the general Norwegian population, particularly in Pain/Discomfort and Anxiety/Depression. Latent class analysis identified three distinct groups: the largest group (82 %) had a stable HRQoL trajectory, while smaller groups (8 % and 10 %) showed decline and improvement, respectively. Social support, clinic location, parental origin and at least one chronic symptoms were significant predictors of class membership.

Conclusion

The diverse, lower HRQoL profiles emphasize the need for personalized healthcare and support, making the HAT setting potentially valuable for such tailored care. Treatment participation helps most maintain fairly high HRQoL. The findings confirm the critical role of supportive relationships and effective chronic condition management in HRQoL outcomes.

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海洛因辅助治疗患者的健康相关生活质量轨迹

本研究调查了参与海洛因辅助治疗（HAT）的阿片类药物使用障碍患者的健康相关生活质量（HRQoL）。虽然对阿片类药物维持治疗中的HRQoL进行了研究，但对HAT中的HRQoL知之甚少。本研究的目的是描述HAT中的HRQoL，确定不同的HRQoL轨迹，并检查与类成员相关的因素。方法采用挪威多中心HAT项目进行纵向队列研究。样本包括从2022年1月到2024年10月登记治疗的所有同意个体（n = 108）。使用EuroQol EQ-5D-5L评估HRQoL，并在基线和多个时间点收集人口统计数据。使用潜在类别线性混合模型识别HRQoL轨迹类别，并探讨类别隶属度的差异。结果入院时，参与者在所有方面都表现出明显的HRQoL困难，严重程度高于普通挪威人群，特别是在疼痛/不适和焦虑/抑郁方面。潜类分析确定了三个不同的组：最大的组（82%）有稳定的HRQoL轨迹，而较小的组（8%和10%）分别表现出下降和改善。社会支持、诊所位置、父母出身和至少一种慢性症状是班级成员的显著预测因子。结论不同的、较低的HRQoL概况强调了个性化医疗保健和支持的需求，使得HAT设置对这种量身定制的护理具有潜在的价值。参与治疗有助于大多数人维持相当高的HRQoL。研究结果证实了支持性关系和有效的慢性疾病管理在HRQoL结果中的关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug and alcohol dependence 医学-精神病学

CiteScore

7.40

自引率

7.10%

发文量

409

审稿时长

41 days

期刊介绍： Drug and Alcohol Dependence is an international journal devoted to publishing original research, scholarly reviews, commentaries, and policy analyses in the area of drug, alcohol and tobacco use and dependence. Articles range from studies of the chemistry of substances of abuse, their actions at molecular and cellular sites, in vitro and in vivo investigations of their biochemical, pharmacological and behavioural actions, laboratory-based and clinical research in humans, substance abuse treatment and prevention research, and studies employing methods from epidemiology, sociology, and economics.