Advanced Functional Materials最新文献_第2页

A Comprehensive Review on Zinc-Based MOFs and Their Derivatives for Alkali-Ion Batteries: Synthesis, Applications, and Future Prospects 碱离子电池用锌基mof及其衍生物的合成、应用及展望

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-12 DOI: 10.1002/adfm.202508749

Qianhong Huang, Tingyang Xie, Yuhong Luo, Jian-En Zhou, Yongbo Wu, Xiaoming Lin, Huachao Yang

{"title":"A Comprehensive Review on Zinc-Based MOFs and Their Derivatives for Alkali-Ion Batteries: Synthesis, Applications, and Future Prospects","authors":"Qianhong Huang, Tingyang Xie, Yuhong Luo, Jian-En Zhou, Yongbo Wu, Xiaoming Lin, Huachao Yang","doi":"10.1002/adfm.202508749","DOIUrl":"https://doi.org/10.1002/adfm.202508749","url":null,"abstract":"With the development of electrochemical energy conversion and storage, alkali-ion batteries (AIBs) have become a popular research topic due to their cost-effectiveness, high safety, and environmental friendliness. One strategy to optimize the efficiency of AIBs is to focus on the development and enhancement of their components. Metal-organic frameworks (MOFs), as innovative functional materials, have offered great possibilities to investigate high-performance electrode materials for AIBs with advantages including compositional designability, structural diversity, and high porosity. Among all kinds of transition-metal-based MOFs, zinc-based MOFs (Zn-MOFs) have garnered significant interest because of their superior physicochemical characteristics. Herein, this review summarizes the recent applications of Zn-MOFs and their derivatives in AIBs. An overview of the synthesis strategies of pristine Zn-MOFs and their derived porous carbon materials, metal oxides, metal sulfides, and metal selenides are presented. Then, their promising applications in AIBs, i.e., lithium-ion batteries (LIBs), sodium-ion batteries (SIBs), and potassium-ion batteries (PIBs) are highlighted. Next, the paper summarizes the main charge-storage mechanisms and degradation mechanisms of Zn-MOFs and their derivatives when they are used in AIBs. Further, the research ideas on the future industrialization of Zn-MOFs-based materials are discussed. To close, the existing challenges and future opportunities are presented.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"27 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Transparent Semicrystalline Polymer Used in Thermally Responsive Smart Window Application 用于热响应智能窗口应用的透明半晶聚合物

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-12 DOI: 10.1002/adfm.202506061

Jiacheng Fan, Thomas Wakuta, HyeonJi Hong, Ying Liu, Yu-Ching Chen, Rongke Xu, Yuxuan Guo, Jianghan Wu, Isabelle Winardi, Ting-Hsuan Wu, Zhixin Xie, Yuan Meng, Qibing Pei

{"title":"A Transparent Semicrystalline Polymer Used in Thermally Responsive Smart Window Application","authors":"Jiacheng Fan, Thomas Wakuta, HyeonJi Hong, Ying Liu, Yu-Ching Chen, Rongke Xu, Yuxuan Guo, Jianghan Wu, Isabelle Winardi, Ting-Hsuan Wu, Zhixin Xie, Yuan Meng, Qibing Pei","doi":"10.1002/adfm.202506061","DOIUrl":"https://doi.org/10.1002/adfm.202506061","url":null,"abstract":"Thermally responsive smart windows based on phase-changing polymers usually face challenges such as low transmittance at room temperature and limited solar modulation when demanded. A clear poly(SA) or CPSA composed of poly(stearyl acrylate) (poly(SA)) and ethoxylated trimethylolpropane triacrylate is introduced. High optical transparency and high crystallinity at ambient temperature are achieved by ultraviolet curing at a high temperature to suppress the crystallite domain size to the nanometer range. Adding poly(hydroxyethyl methacrylate) (poly(HEMA)) in the formula produces a micrometer-size phase-separated terpolymer system where the CPSA phase retains its crystallinity. The refractive index of the poly(HEMA) phase is tuned to match that of the CPSA phase, and the terpolymer film is transparent at 20 °C with visible transmittance up to 91.4%. Above the transition temperature of 42 to 46 °C, CPSA crystal melting leads to light scattering at the phase boundaries, creating an opaque appearance. The transmittance modulation is 81.4%, 87.7%, and 76.5% for solar (300–2500 nm), visible (380–780 nm), and near-infrared (780–2500 nm) spectrum, respectively. Furthermore, a styrofoam chamber covered with the terpolymer smart window can effectively reduce the chamber interior temperature increase by 8.5 °C compared to the reference glass window.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"22 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temperature Compensated Graphene Nanomechanical Resonators 温度补偿石墨烯纳米机械谐振器

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-12 DOI: 10.1002/adfm.202415708

Jaesung Lee, Hsin-Ying Chiu, Liang Zhao, Jie Shan, Philip X.-L. Feng

{"title":"Temperature Compensated Graphene Nanomechanical Resonators","authors":"Jaesung Lee, Hsin-Ying Chiu, Liang Zhao, Jie Shan, Philip X.-L. Feng","doi":"10.1002/adfm.202415708","DOIUrl":"https://doi.org/10.1002/adfm.202415708","url":null,"abstract":"We report the experimental demonstration of temperature compensated bilayer graphene two-dimensional (2D) nanomechanical resonators operating in temperature range of 300 to 480 K. By using both microspectroscopy and scanning spectromicroscopy techniques, spatially visualized undriven thermomechanical motion is conveniently used to monitor both the resonance frequency and temperature of the device via noise thermometry while the device is photothermally agitated. Thanks to engineerable naturally integrated temperature compensation of the graphene and gold clamps that minimize variations of built-in tension in a wide temperature range, very small linear TCfs of ≈−39 and −84 ppm K−1 are achieved in the graphene nanomechanical resonators. The measured TCfs are orders of magnitude smaller than those in other 2D resonant nanoelectromechanical systems (NEMS). The intricately coupled thermal tuning and strain effects are further examined, elucidating that TCf can be further improved by optimizing device dimensions, which can be exploited for engineering highly stable NEMS resonators and oscillators for signal transduction and sensing applications.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"11 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 2D Perovskite Photodetector for NIR Range and Weak-Light Imaging Applications via Thermal Regulation 一种基于热调节的用于近红外范围和弱光成像的二维钙钛矿光电探测器

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-12 DOI: 10.1002/adfm.202505180

Lifang Wu, Qianwen Cao, Hongyu Li, Xiaojie Liu, Wanbo Li, Tianhao Wu, Xingli Zou, Jiang Cheng, Lu Li, Chengxi Zhang, Nemygina Elizaveta, Alexey B. Tarasov, Hongliang Dong, Sardor B. Donaev, Katsuhiro Akimoto, Shenghao Wang

{"title":"A 2D Perovskite Photodetector for NIR Range and Weak-Light Imaging Applications via Thermal Regulation","authors":"Lifang Wu, Qianwen Cao, Hongyu Li, Xiaojie Liu, Wanbo Li, Tianhao Wu, Xingli Zou, Jiang Cheng, Lu Li, Chengxi Zhang, Nemygina Elizaveta, Alexey B. Tarasov, Hongliang Dong, Sardor B. Donaev, Katsuhiro Akimoto, Shenghao Wang","doi":"10.1002/adfm.202505180","DOIUrl":"https://doi.org/10.1002/adfm.202505180","url":null,"abstract":"2D halide perovskites have attracted significant attention in photodetectors due to their inherent stability and outstanding optoelectronic properties. Owing to strong quantum confinement effects in low-n phases (n < 5), pure Pb-based 2D perovskites typically exhibit large bandgaps (> 1.6 eV), limiting their photodetection to the ultraviolet–visible region and leading to insufficient near-infrared (NIR) response. In the present work, the 2D PEA2FA4Pb5I16 perovskite with superior crystallinity, a thicker perovskite absorption layer, and suppressed n = 2 phase presence, is fabricated via a thermal regulation method, enabling the development of a self-power, high-sensitivity NIR photodetector. The 2D perovskite photodetector exhibits excellent operational characteristics, including an extremely low noise current of less than 3 pA Hz−1/2, and a high on/off switching ratio of up to 2 × 105. A notable responsivity of 0.325 A W−1 at 800 nm is achieved. Consequently, the 2D perovskite photodetector is capable of successfully acquiring high-resolution images under weak NIR illumination (0.1 µW cm−2). These findings accentuate the tremendous potential of 2D perovskites in NIR weak light imaging, such as autonomous driving, machine vision, medical diagnostics, and other emerging fields.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"19 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selenium-Doped Biomass-Based Nanoparticles Drive Agricultural Emulsions toward a Novel “Offense-Defense Integration” Strategy 硒掺杂生物质纳米颗粒驱动农业乳剂走向新型“攻防一体化”战略

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-12 DOI: 10.1002/adfm.202509254

Yingjian Ma, Pengkun Yan, Ze Lv, Fengyu Li, Rui Zhao, Xinyu Guo, Jun Zhang, Yucheng Gu, Yong Xu, Xuemin Wu

{"title":"Selenium-Doped Biomass-Based Nanoparticles Drive Agricultural Emulsions toward a Novel “Offense-Defense Integration” Strategy","authors":"Yingjian Ma, Pengkun Yan, Ze Lv, Fengyu Li, Rui Zhao, Xinyu Guo, Jun Zhang, Yucheng Gu, Yong Xu, Xuemin Wu","doi":"10.1002/adfm.202509254","DOIUrl":"https://doi.org/10.1002/adfm.202509254","url":null,"abstract":"Pesticide formulations with enhanced efficiency and environmental sustainability are crucial for modern agriculture. An agricultural Pickering emulsion (Pro-Pickering), stabilized by selenium (Se)-doped zein nanoparticles, developed for delivering the model fungicide prochloraz (Pro) using a multifunctional approach is presented. Its interfacial transfer efficiency is significantly improved, with rain wash resistance enhanced by 27% compared to commercial emulsifiable concentrates (Pro-EC). Pro-Pickering delivers Pro to eliminate fungi while incorporating nano-Se to activate endogenous disease resistance mechanisms, thereby strengthening long-term defense capabilities. Compared to commercial emulsion concentrates with unimodal fungicidal activity, Pro-Pickering is 48.8% more effective against Botrytis cinereal, demonstrating the advantage of “simultaneous attack and defense.” Joint multiomics analyses revealed that nano-Se in Pro-Pickering enhanced cucumber resistance to B. cinerea by activating jasmonic acid (JA)-mediated immunity, upregulating amino acid metabolism for defense compounds, and mitigating oxidative stress via glutathione metabolism. Additionally, it sustained photosynthetic efficiency for energy supply and reinforced JA biosynthesis through α-linolenic acid metabolism, collectively strengthening immune defense. Furthermore, the preliminary toxicity assessments indicate that the formulation has relatively low impact on non-target organisms, making it suitable for eco-friendly and sustainable agricultural practices. This work provides scope for developing plant disease management strategies using eco-friendly, sustainable approaches.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"51 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking the Capacity Limit for WO3 Anode-Based Li-Ion Batteries Using Photo-Assisted Charging 光辅助充电技术突破WO3阳极基锂离子电池容量极限

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-12 DOI: 10.1002/adfm.202501498

Rabia Khatoon, Mudasar Nazir, Richard T. Baker, Mathew Billing, Shumaila Babar, Suela Kellici, Steve Dunn, Muhammad Tariq Sajjad

{"title":"Breaking the Capacity Limit for WO3 Anode-Based Li-Ion Batteries Using Photo-Assisted Charging","authors":"Rabia Khatoon, Mudasar Nazir, Richard T. Baker, Mathew Billing, Shumaila Babar, Suela Kellici, Steve Dunn, Muhammad Tariq Sajjad","doi":"10.1002/adfm.202501498","DOIUrl":"https://doi.org/10.1002/adfm.202501498","url":null,"abstract":"The capacity of a metal ion battery is limited by fundamental parameters. Various strategies have been employed to maximise energy storage, including manufacturing control and investigating the components within the battery system. Recent developments have focused on incorporating photoactive materials into battery architectures to enhance energy density. However, challenges remain in material selection and processing for high-performance electrodes. Here, we show that hydrothermally produced WO3 is a safe, low-cost material with excellent photo-battery performance. Under illumination, the battery achieves a capacity of 1150 mAh g⁻¹ at 0.1C and 800 mAh g⁻¹ at 1C, exceeding the theoretical limit (693 mAh g⁻¹). The battery exhibits excellent cycling stability, retaining a capacity of 623 mAh g⁻¹ after 400 cycles at 1C. Using Randles-Sevcik and electrochemical impedance spectroscopy, we show that enhanced carrier mobility contributes to the observed capacity beyond the theoretical limit. The photo-conversion efficiency of the battery is 5.96%. Our results demonstrate that light can be used to enhance the capacity of an ion battery system beyond its theoretical limit. This approach can significantly boost the energy storage density of various metal-ion batteries. Moreover, in systems with inherently slow metal-ion diffusion, such as multi-valent systems, photoenhanced charging can make these technologies more competitive.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"31 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking Unprecedented Gravimetric Capacitance in Thick Electrodes Through Conformal Densification of Robust MXene Hydrogels 通过坚固的MXene水凝胶的保形致密化，解锁厚电极中前所未有的重量电容

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-12 DOI: 10.1002/adfm.202511313

Boya Zhang, Zhitan Wu, Fangbing Li, Yu Long, Jinyang Yu, Yawen Liu, Quan-Hong Yang, Ying Tao

{"title":"Unlocking Unprecedented Gravimetric Capacitance in Thick Electrodes Through Conformal Densification of Robust MXene Hydrogels","authors":"Boya Zhang, Zhitan Wu, Fangbing Li, Yu Long, Jinyang Yu, Yawen Liu, Quan-Hong Yang, Ying Tao","doi":"10.1002/adfm.202511313","DOIUrl":"https://doi.org/10.1002/adfm.202511313","url":null,"abstract":"Transition metal carbides/nitrides (MXenes), with intrinsic high density and pseudo-capacitance, along with the capability for liquid-phase assembly mediated by highly tunable colloidal chemistries, are promising candidates for developing thick electrodes toward high-energy devices. However, the manufacture of high-performance thick MXene electrodes faces fundamental challenges, including nanosheet restacking, 3D structural collapse, and surface oxidation. Here, a robust MXene gelation strategy induced by aniline (ANI) and hydrochloric acid is proposed, producing a skeleton-reinforced hydrogel that enables conformal densification via capillary shrinkage with minimal active site loss. During gelation, ANI absorbs onto MXene surfaces and polymerizes, simultaneously reinforcing the 3D network through covalent bonding while forming temporary hydrophobic layers to protect active sites. Subsequent thermal treatment effectively removes the surface-bound ANI and its oligomers, restoring the active sites for capacitive energy storage. At a thickness of 225 µm, the resulting electrode achieves a record gravimetric capacitance (395 F g−1) among reported MXene electrodes over 40 µm, even surpassing that of a 7 µm MXene film, and delivers a high areal capacitance of 16.1 F cm−2. This work provides a new insight for assembling robust MXene architectures toward practical MXene-based devices.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"596 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical Control of the Thermal Conductivity in BaTiO3 BaTiO3热导率的光学控制

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-12 DOI: 10.1002/adfm.202425424

Claudio Cazorla, Carlos Escorihuela-Sayalero, Jesús Carrete, Jorge Íñiguez-González, Riccardo Rurali

{"title":"Optical Control of the Thermal Conductivity in BaTiO3","authors":"Claudio Cazorla, Carlos Escorihuela-Sayalero, Jesús Carrete, Jorge Íñiguez-González, Riccardo Rurali","doi":"10.1002/adfm.202425424","DOIUrl":"https://doi.org/10.1002/adfm.202425424","url":null,"abstract":"Achieving dynamic control over thermal conductivity remains a formidable challenge in condensed matter physics and materials science, particularly due to the limitations of traditional approaches like structural modifications and doping, which yield static and often irreversible effects. In this study, a solution is demonstrated to this conundrum through light-driven manipulation of thermal conductivity in the archetypal ferroelectric BaTiO3 (BTO). We analyze, using first-principles simulations, how photoinduced charge injection triggers a ferro-to-paraelectric phase transition, yielding ultrafast, reversible changes in thermal transport properties. These results reveal a substantial reduction in lattice thermal conductivity, especially at low photoexcited charge densities, as the material undergoes a polar-to-nonpolar transformation. This reduction is primarily due to the suppression of low-frequency phonon modes, which limits heat flow as a result of enhanced phonon–phonon scattering. These findings underscore a step forward in tunable thermal conductivity, offering new prospects for efficient thermal management in advanced electronics and energy-harvesting applications.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"9 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding the Diversity of Linkages in Covalent Organic Frameworks Through Staudinger Cycloaddition: Synthesis of Cis-β-Lactam and Cis-β-Thiolactam COFs 通过Staudinger环加成扩大共价有机框架中键的多样性：顺式β-内酰胺和顺式β-硫内酰胺COFs的合成

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-12 DOI: 10.1002/adfm.202423244

Naranchimeg Zorigt, Florian Auras, Leila Khazdooz, Ahmadreza Khosropour, Alireza Abbaspourrad

{"title":"Expanding the Diversity of Linkages in Covalent Organic Frameworks Through Staudinger Cycloaddition: Synthesis of Cis-β-Lactam and Cis-β-Thiolactam COFs","authors":"Naranchimeg Zorigt, Florian Auras, Leila Khazdooz, Ahmadreza Khosropour, Alireza Abbaspourrad","doi":"10.1002/adfm.202423244","DOIUrl":"https://doi.org/10.1002/adfm.202423244","url":null,"abstract":"The strategic incorporation of diverse functional groups into covalent organic frameworks (COFs) can expand their use across various applications. Here, a novel application of the Staudinger cycloaddition is presented to synthesize crystalline cis-β-lactam substituted COFs from two-parent, 1,3,6,8-tetraphenylpyrene-based, imine-linked COFs. The resulting cis-β-lactam-linked COFs are microporous and show excellent chemical stability across a broad range of pH levels and excellent thermal stability up to 443–556 °C. These cis-β-lactam COFs are then converted into their thiolactam analogs using Lawesson's reagent. The resulting thionated β-lactam COFs are found to be capable of Hg2+ capture with capacities up to 7.8 × 102 mg g−1 and are reusable, retaining a removal efficiency of up to 64% over four cycles. This is the first time that the Staudinger cycloaddition reaction has been used to functionalize COFs, this new route to heteroatom substituted COFs opens potential applications such as heavy metal ion capture.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"19 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Cascade Catalytic Reaction–Assisted Apoptosis/Calcicoptosis/Ferroptosis Induction with Microsphere-Aggregated Hydrogels in Triple-Negative Breast Cancer Therapy 微球聚集水凝胶在三阴性乳腺癌治疗中的自级联催化反应辅助凋亡/钙衰/铁衰诱导

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-12 DOI: 10.1002/adfm.202420430

ChaeRim Hwang, Yeoung Eun Choi, Song Yi Lee, Mrinmoy Karmakar, Qiaojun Hao, Junmin Lee, Hyun-Jong Cho

{"title":"Self-Cascade Catalytic Reaction–Assisted Apoptosis/Calcicoptosis/Ferroptosis Induction with Microsphere-Aggregated Hydrogels in Triple-Negative Breast Cancer Therapy","authors":"ChaeRim Hwang, Yeoung Eun Choi, Song Yi Lee, Mrinmoy Karmakar, Qiaojun Hao, Junmin Lee, Hyun-Jong Cho","doi":"10.1002/adfm.202420430","DOIUrl":"https://doi.org/10.1002/adfm.202420430","url":null,"abstract":"Cisplatin-loaded hyaluronic acid-dopamine microsphere (MS) is interconnected by metal ion (e.g., calcium ion and iron ion)-catechol coordination and polydopamine linkages to form an MS-aggregated hydrogel (MAH) system to enable convenient peritumoral injection and efficient tumor infiltration in triple-negative breast cancer (TNBC) therapy. Cisplatin (inhibition of DNA replication and cellular H2O2 generation), calcium peroxide (self-generation of H2O2), and ferrous sulfate (conversion of H2O2 to OH radicals) are integrated into the MAH system for chemo/cascade chemodynamic therapy. Reactive oxygen species (ROS) are produced by calcium peroxide and ferrous sulfate, which can assist Ca2+ overload in inducing calcicoptosis in cancer cells. Both iron and calcium ions increase the degree of lipid peroxidation, leading to enhanced ferroptosis in cancer cells. Cisplatin and ROS generation induces apoptosis in cancer cells. Viscoelastic modulation for prolonged therapeutic delivery with enhanced tumor penetration of the jammed MAH system is demonstrated physicochemically and mechanically. Anticancer capabilities are also assessed in 4T1 cells and orthotopic 4T1 tumor mouse models. Remarkably, the MAH system strongly inhibited the recurrence of residual 4T1 tumors in a mouse model. These findings indicate that the MAH system can be applied for the ROS-assisted induction of multiple apoptosis/calcicoptosis/ferroptosis pathways in TNBC therapy.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"223 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0