Advanced Functional Materials最新文献_第2页

Reversed Electron Transfer in Cu-TiO2@ZnIn2S4 for Boosting Photocatalytic CO2 Reduction 反向电子转移Cu-TiO2@ZnIn2S4促进光催化CO2还原

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-10-17 DOI: 10.1002/adfm.202519072

Chen Zhao, Awu Zhou, Hanbing Li, Jiamei Yu, Na Xing, Jianyu Zhang, Dayu Chen, Jian-Rong Li

{"title":"Reversed Electron Transfer in Cu-TiO2@ZnIn2S4 for Boosting Photocatalytic CO2 Reduction","authors":"Chen Zhao, Awu Zhou, Hanbing Li, Jiamei Yu, Na Xing, Jianyu Zhang, Dayu Chen, Jian-Rong Li","doi":"10.1002/adfm.202519072","DOIUrl":"https://doi.org/10.1002/adfm.202519072","url":null,"abstract":"Spontaneous free-electron transfer significantly affects the photocatalytic performance of carbon dioxide (CO2) reduction. However, the precise regulation of photogenerated electron transfer direction remains a nontrivial endeavor. Herein, a heteroatomic metal-dependent strategy is proposed to direct photogenerated electron transfer to specific catalytic active sites, thus enhancing CO2 photoreduction over Cu-TiO2@ZnIn2S4 (Cu-TiO2@ZIS). The core-shell Cu-TiO2@ZIS heterojunction with high activity is fabricated by in situ growth. Impressively, the optimized Cu-TiO2@ZIS photocatalyst exhibits a remarkable visible light driven CO2-to-carbon monoxide (CO) production rate of 620 µmol g−1 h−1 with selectivity (99.4%), representing a 77.5-fold and 6.3-fold enhancement over pristine TiO2 (8 µmol g−1 h−1) and ZIS (99 µmol g−1 h−1), respectively. In situ characterization and theoretical calculations reveal that the combination of Cu-TiO2 and ZnIn2S4 forms a strong interface electric field and regulates the direction of electron transfer due to the work function difference. Cu sites induce the transfer of photogenerated electrons from ZIS to Cu-TiO2 to generate electron-rich Cu/Ti active sites, increasing the adsorption energy of CO2 on Cu/Ti sites. Moreover, Cu-TiO2@ZIS significantly reduces Gibbs free energy barriers for *COOH intermediate formation, thereby enhancing the photocatalytic performance of CO2 reduction. This work exemplifies a new strategy for designing high-active photocatalysts by manipulating heteroatomic metal-dependent electron transfer.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"27 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stretching Metal─Oxygen Bonds to Decouple Activity and Stability of Water Electrolysis (Adv. Funct. Mater. 40/2025) 拉伸金属-氧键对电解水去耦活性和稳定性的影响。板牙。40/2025)

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-10-17 DOI: 10.1002/adfm.71677

Bin Chen, Zhujun Li, Xiaoyue Fu, Lianqin Wang, Yingjie Feng, Xin Chen, Junfeng Zhang, Yan Yin, Michael D. Guiver

引用次数: 0

Non-Equilibrium Magnon Engineering Enabling Significant Thermal Transport Modulation (Adv. Funct. Mater. 40/2025) 实现显著热传输调制的非平衡磁振子工程。板牙。40/2025)

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-10-17 DOI: 10.1002/adfm.71679

Takamasa Hirai, Toshiaki Morita, Subrata Biswas, Jun Uzuhashi, Takashi Yagi, Yuichiro Yamashita, Varun Kumar Kushwaha, Fuya Makino, Rajkumar Modak, Yuya Sakuraba, Tadakatsu Ohkubo, Rulei Guo, Bin Xu, Junichiro Shiomi, Daichi Chiba, K. Uchida

引用次数: 0

Proton-Electron Dual-Transfer-Channel Nanoreactors for Proton-Coupled Electron Transfer (PCET) in Photocatalytic Polyester Dehydrogenation-Reductive Amination 质子-电子双转移通道纳米反应器用于光催化聚酯脱氢-还原胺化反应

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-10-17 DOI: 10.1002/adfm.202521148

Yi-Wen Han, Run-Yu Liu, Yu-Xin Zhang, Lei Ye, Phuc T.T. Nguyen, Tian-Jun Gong, Xue-Bin Lu, Ning Yan, Yao Fu

{"title":"Proton-Electron Dual-Transfer-Channel Nanoreactors for Proton-Coupled Electron Transfer (PCET) in Photocatalytic Polyester Dehydrogenation-Reductive Amination","authors":"Yi-Wen Han, Run-Yu Liu, Yu-Xin Zhang, Lei Ye, Phuc T.T. Nguyen, Tian-Jun Gong, Xue-Bin Lu, Ning Yan, Yao Fu","doi":"10.1002/adfm.202521148","DOIUrl":"https://doi.org/10.1002/adfm.202521148","url":null,"abstract":"The photocatalytic polyester-to-amino acid transformation is significant for waste upcycling, yet challenging owing to the intricate multiple proton and electron transfer processes required. Herein, a general strategy for synthesizing hollow core-shell Sv-chalcogenide/Ti3C2 nanoreactors (Sv = sulfur vacancies, chalcogenide = CdS/ZnIn2S4/CdIn2S4) is developed via templated epitaxial growth and defect-mediated interfacial bond construction, which act as the strong proton/electron extractor and relay station for tandem proton-coupled electron transfer (PCET) in photocatalytic polyester-to-amino acid dehydrogenation-reductive amination. These nanoreactors integrate spatially segregated proton-electron dual-transfer channels, where the interfacial asymmetrical charge distribution-induced built-in electric field (BIEF) drives directional electron transfer (ET) from chalcogenide to Ti3C2, while the electron-rich interfacial lattice oxygen mediates substrate deprotonation process via nucleophilic abstraction, delivering protons to Ti3C2 and forming Ti3C2(OH)⁺ intermediates to trigger proton transfer (PT). By virtue of dynamically optimized molecular catalytic behavior accomplished through precise regulation of pivotal intermediate adsorption and activation energetics, the representative Sv-CdS/Ti3C2 hollow nanoreactor (HNR) exhibits remarkable performance (10 mmol·g−1·h−1 and 91% selectivity, alanine) and broad applicability for polyester-derived hydroxy acid-to-amino acid transformation. This study establishes a pioneering paradigm for the design of proton-electron dual-transfer-channel photocatalysts and provides novel perspectives for the effective regulation of complex reaction pathways.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"132 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amplifying the Circularly Polarized Luminescence of CsPbBr3 Nanocrystals by Chiral Metal–Organic Frameworks: In-Situ Growth, Chiral Assemble, and Chirality Transfer 手性金属-有机骨架对CsPbBr3纳米晶体圆极化发光的放大：原位生长、手性组装和手性转移

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-10-17 DOI: 10.1002/adfm.202522001

Jiejun Ren, Boheng Dong, Xiaopeng Zhou, Huiping Liu, Churen Zhang, Fan Liu, Liangjun Chen, Yuhua Wang

{"title":"Amplifying the Circularly Polarized Luminescence of CsPbBr3 Nanocrystals by Chiral Metal–Organic Frameworks: In-Situ Growth, Chiral Assemble, and Chirality Transfer","authors":"Jiejun Ren, Boheng Dong, Xiaopeng Zhou, Huiping Liu, Churen Zhang, Fan Liu, Liangjun Chen, Yuhua Wang","doi":"10.1002/adfm.202522001","DOIUrl":"https://doi.org/10.1002/adfm.202522001","url":null,"abstract":"Halide perovskites have risen as promising circularly polarized luminescent (CPL) materials for applications in 3D displays, optical anti-counterfeiting, and information storage. And yet, achieving highly anisotropic CPL emission from achiral halide perovskites remains fraught with challenges. Herein, the helical channels of chiral MOFs (L/D-MOFs) are utilized as chiral templates for the in-situ growth of CsPbBr3 perovskite nanocrystals (NCs), generating CPL-active CsPbBr3@L/D-MOFs materials with high luminescence dissymmetry factors (|glum|, 8.39×10−3) and high photoluminescence quantum yields (QY, 78%). Synchrotron-radiation-based X-ray absorption spectroscopy clearly verifies that the embedded CsPbBr3 NCs inherit the helicity of L/D-MOFs through strong Cd─Br coordination bonds, thereby facilitating chirality transfer from L/D-MOFs to CsPbBr3 NCs. Additionally, the efficient Förster resonance energy transfer (FRET) from chiral L/D-MOFs to CsPbBr3 NCs further amplifies the CPL signal of CsPbBr3 NCs. Benefiting from the excellent CPL properties and tunable emission, the CsPbX3@L/D-MOFs demonstrate great potential in CPL-LEDs. This work proposes a viable strategy for the rational design of high-performance CPL-active perovskite materials and offers profound insights into the chirality transfer mechanism.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"31 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anomalous Stiffening of a Conjugated Polymer During Electrochemical Oxidation 一种共轭聚合物在电化学氧化过程中的反常硬化

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-10-17 DOI: 10.1002/adfm.202519980

Judith Pons i Tarrés, Di Zhu, Chiara Musumeci, Youngseok Kim, Dilara Meli, Hang Yu, Meghna Jha, Bryan D. Paulsen, Ruiheng Wu, Joost Kimpel, Zachary Laswick, Sri Harish Kumar Paleti, Yadong Zhang, Stephen Barlow, Seth R. Marder, Jenny Nelson, Jonathan Rivnay, Christian Müller

{"title":"Anomalous Stiffening of a Conjugated Polymer During Electrochemical Oxidation","authors":"Judith Pons i Tarrés, Di Zhu, Chiara Musumeci, Youngseok Kim, Dilara Meli, Hang Yu, Meghna Jha, Bryan D. Paulsen, Ruiheng Wu, Joost Kimpel, Zachary Laswick, Sri Harish Kumar Paleti, Yadong Zhang, Stephen Barlow, Seth R. Marder, Jenny Nelson, Jonathan Rivnay, Christian Müller","doi":"10.1002/adfm.202519980","DOIUrl":"https://doi.org/10.1002/adfm.202519980","url":null,"abstract":"The mechanical mismatch between semiconductors and biological tissues can be a challenge for the development of conformal bioelectronics. Organic mixed ionic-electronic conductors (OMIECs) such as conjugated polymers with oligoether side chains are promising materials due to their low stiffness, which may minimize adverse immune reactions and thus promote biocompatibility. However, significant volume changes during electrochemical cycling—driven by ion and water ingression and expulsion—can lead to drastic changes in stiffness, complicating device-tissue mechanical matching across redox states. Here, the electromechanical response of a thienothiophene-based conjugated polymer with triethylene glycol side chains is investigated. Electrochemical nanoindentation and atomic force microscopy reveal a modest and reversible increase in elastic modulus at room temperature from ≈70 to more than 120 MPa upon electrochemical oxidation. This unusual mechanical stability is attributed to a reversible increase in π-stacking that compensates for swelling-induced softening. These findings demonstrate that it is feasible to design OMIEC materials with stable mechanical properties across redox states, opening new possibilities for compliant and tissue-matched bioelectronic interfaces that remain mechanically invariant during operation.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"54 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photothermal Heat-Storage Nanostructure-Assisted Water-Electricity Cogeneration System with Dual Solar Energy Inputs and High-Efficiency Heat Utilization 光热储热纳米结构辅助双太阳能输入和高效热利用的水电热电联产系统

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-10-17 DOI: 10.1002/adfm.202514363

Nina Jiang, Zongming Xie, Rude Wu, Zhicheng Ouyang, Huan Liu, Xiaolu Zhuo, Aizheng Chen, Shi-Bin Wang

{"title":"Photothermal Heat-Storage Nanostructure-Assisted Water-Electricity Cogeneration System with Dual Solar Energy Inputs and High-Efficiency Heat Utilization","authors":"Nina Jiang, Zongming Xie, Rude Wu, Zhicheng Ouyang, Huan Liu, Xiaolu Zhuo, Aizheng Chen, Shi-Bin Wang","doi":"10.1002/adfm.202514363","DOIUrl":"https://doi.org/10.1002/adfm.202514363","url":null,"abstract":"Conventional water-electricity cogeneration systems combining solar-driven interface evaporators (SIEs) and solar-thermal-electric generators (STGs) suffer from limited overall efficiency due to their reliance on a single solar energy input. To address this limitation, a novel system is developed with dual solar inputs that simultaneously utilizes conduction heat and steam enthalpy. Au/Ag-Pd nanostructures loaded with phase-change material (Au/Ag-Pd/PCM) are designed as visible-light absorbers, enabling photothermal storage and reduced thermal losses. By constructing Janus nano/micro structures of Au/Ag–Pd/PCM/sulfonated polystyrene on a water supply layer, optimal balance between thermal energy and water content within the SIE is achieved. The optimized SIE is coupled with a STG to form the complete cogeneration system through heat-recovery pathways. Benefiting from the dual solar inputs and efficient heat utilization, the system demonstrates outstanding performance metrics including an evaporation rate of 3.68 kg m−2 h−1, a solar-to-vapor efficiency of 104.82%, and a maximum power density of 1.55 W m−2 in 3.5 wt.% NaCl brine under 1 sun. Outdoor testing of the scaled-up system confirms stable freshwater production (≈15.5 kg m−2 daily) and scalable power generation. This work offers new insights into energy input design and heat recovery mechanisms for enhancing coupled water and electricity generation.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"88 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intensifying Internal Electric Field on ZnO Nanoplates with Polar Surface Exposure and Cu Doping for Efficient Photocatalytic Methane Oxidation to Oxygenates 在ZnO纳米板上强化内部电场，并在极表面曝光和Cu掺杂下进行高效光催化甲烷氧化制氧合物

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-10-17 DOI: 10.1002/adfm.202520271

Dandan Liu, Fan Chen, Yuan He, Lin Hu, Yuling Qin, Rui Shi, Yana Liu, Jiguang Zhang, Yunfeng Zhu, Jun Wang

{"title":"Intensifying Internal Electric Field on ZnO Nanoplates with Polar Surface Exposure and Cu Doping for Efficient Photocatalytic Methane Oxidation to Oxygenates","authors":"Dandan Liu, Fan Chen, Yuan He, Lin Hu, Yuling Qin, Rui Shi, Yana Liu, Jiguang Zhang, Yunfeng Zhu, Jun Wang","doi":"10.1002/adfm.202520271","DOIUrl":"https://doi.org/10.1002/adfm.202520271","url":null,"abstract":"Semiconductor photocatalysis has rendered a potential route for aerobic methane (CH4) conversion to valued-added oxygenates under mild conditions, whereas suffering from low reaction efficiency caused by the high inertness of CH4 molecules and the fast recombination of photogenerated charge carriers. Herein, Cu doped ZnO nanoplates with polar surface exposure are employed as an efficient photocatalyst for CH4 oxidation in the presence of O2, which exhibit the liquid C1 oxygenates yield of 4742.2 µmol g−1 h−1 with a selectivity of 99.6%, outperforming the counterparts with nonpolar surface exposure or without Cu doping. The detailed investigation elucidates that the activity enhancement is largely contributed by the intensified internal electric field, improving the separation of charge carriers and thus supplying sufficient electrons to drive surface redox reactions. More active/adsorption sites are also favorable to be created on Cu doped polar surface of ZnO, facilitating CH4 conversion. Besides, the generation of ·OH radicals is proposed to follow a pathway of O2 → ·OOH → H2O2 →·OH, wherein the doped Cu plays a significant role for O2 reduction and H2O2 dissociation to ·OH, thereby enabling efficient CH4 activation. This work offers new strategies for designing efficient photocatalysts to boost CH4 oxidation under mild conditions.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"1 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

YIG-Inspired Fe 3d Spin Rearrangement to Construct Built-In Electric Field Achieving Fast-Charging Layered Cathode for Wide-Temperature Sodium-Ion Battery yig启发Fe三维自旋重排构建内置电场实现宽温钠离子电池快速充电层状阴极

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-10-17 DOI: 10.1002/adfm.202518348

Lingfeng Shi, Ziwei Liu, Ke Li, Yanbin Ning, Shengwei Dong, Shenglu Geng, Mengjie Zhang, Yulin Ma, Geping Yin, Zhenjiang Yu, Shuaifeng Lou, Hua Huo

{"title":"YIG-Inspired Fe 3d Spin Rearrangement to Construct Built-In Electric Field Achieving Fast-Charging Layered Cathode for Wide-Temperature Sodium-Ion Battery","authors":"Lingfeng Shi, Ziwei Liu, Ke Li, Yanbin Ning, Shengwei Dong, Shenglu Geng, Mengjie Zhang, Yulin Ma, Geping Yin, Zhenjiang Yu, Shuaifeng Lou, Hua Huo","doi":"10.1002/adfm.202518348","DOIUrl":"https://doi.org/10.1002/adfm.202518348","url":null,"abstract":"O3-NaNi1/3Fe1/3Mn1/3O2 cathodes are promising candidates for sodium-ion batteries benefited of the high theoretical capacity. However, the inherently poor electronic conductivity limits rate performance and aggravates O3-P3 phase transition, further weakens phase transition reversibility and results in structural degradation. Herein, a localized electronic regulation strategy inspired by yttrium iron garnet (YIG) is employed to address the issue of sluggish electron transport. Specifically, Y3+ ions are utilized to partially substitute Ni2+ to rearrange the electronic configuration of Fe 3d orbitals, which could trigger a transition from high-spin state (t2g3eg2) to low-spin state (t2g5eg0) as well as narrow the band gap due to the asymmetric splitting of the t2g∗ band near the Fermi level. Moreover, the large ionic radius tends to construct a concentration gradient of Y3+, thereby generating a long-range built-in electric field. Benefiting from the improved electrical conductivity, Y0.25-NFM performs 64 mAh g−1 reversible capacity at 20 C, also the enhanced reversible phase transitions assist Y0.25-NFM maintains 80.9% of initial capacity at 1 C for 500 cycles (44.7% for baseline NFM). The thorough understanding of the dual regulatory effects for Y3+ doping on short & long-range electronic interactions provides a novel strategy to construct outstanding layered oxide cathodes for advanced SIBs.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"132 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimized Lipid Nanoparticles Delivery Enables Efficient Circular RNA-Mediated Forward Programming and Lineage Specification of Induced Pluripotent Stem Cells 优化的脂质纳米颗粒递送使环状rna介导的高效正向编程和诱导多能干细胞的谱系规范成为可能

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-10-17 DOI: 10.1002/adfm.202520042

Kanglu Wu, Hui Xu, Caihua Dong, Di Wu, Renjun Pei, Kai Wang

{"title":"Optimized Lipid Nanoparticles Delivery Enables Efficient Circular RNA-Mediated Forward Programming and Lineage Specification of Induced Pluripotent Stem Cells","authors":"Kanglu Wu, Hui Xu, Caihua Dong, Di Wu, Renjun Pei, Kai Wang","doi":"10.1002/adfm.202520042","DOIUrl":"https://doi.org/10.1002/adfm.202520042","url":null,"abstract":"Directed differentiation of induced pluripotent stem cells (iPSCs) into functionally mature hepatocytes holds great potential for liver regeneration. However, current multi-step protocols are inefficient and often fail to generate fully functional cells. In this study, a lipid nanoparticle (LNP)-mediated circular RNA (circRNA) delivery platform is developed to efficiently program iPSCs into endothelial cells (iECs) and forward-programmed hepatocyte-like cells (cFop-Heps). Systematic formulation screening identifies LNP4 as significantly enhancing circRNA expression compared to commercial alternatives. Mechanistic studies demonstrate that delivery efficiency closely correlates with protein corona composition and dioleoylphosphatidylethanolamine (DOPE)-facilitated membrane fusion, which promotes cellular uptake and endosomal escape. Using this platform, lineage-specific circRNAs encoding transcription factor ETV2 (circ-ETV2) and Liver Enriched Transcription Factors (circ-LETFs) are constructed to drive cell fate conversion. circ-ETV2 induces functional iECs (CD31⁺/CD144⁺) with tube-forming capability, while optimized circ-LETFs generate hepatocyte-like cells that exhibit albumin secretion, lipoprotein uptake, and glycogen storage. Transcriptomic and functional analyses reveal a transient AMOT-Hippo-SNAI2 axis that promotes hepatic specification, whereas inhibition of Hippo signaling pathway suppresses hepatic marker expression. This circRNA-based strategy enables efficient, scalable, and controllable stem cell engineering, offering broad potential applications in liver disease modeling, drug screening, and regenerative medicine.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"47 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0