Advanced Functional Materials最新文献_第3页

MCL1 Inhibitor Augmented the Anti-Glioma Efficacy of Paclitaxel Utilizing a Multifunctional Cascade Nanodrug System 利用多功能级联纳米药物系统，MCL1 抑制剂增强了紫杉醇的抗胶质瘤疗效

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2024-11-20 DOI: 10.1002/adfm.202414499

Rui Zhang, Si Zhang, Zhenyu Zhang, Yunchu Zhang, Linbin Yi, Yongzhong Cheng, Zhiyong Qian, Xin Zan, Xiang Gao

{"title":"MCL1 Inhibitor Augmented the Anti-Glioma Efficacy of Paclitaxel Utilizing a Multifunctional Cascade Nanodrug System","authors":"Rui Zhang, Si Zhang, Zhenyu Zhang, Yunchu Zhang, Linbin Yi, Yongzhong Cheng, Zhiyong Qian, Xin Zan, Xiang Gao","doi":"10.1002/adfm.202414499","DOIUrl":"https://doi.org/10.1002/adfm.202414499","url":null,"abstract":"Despite the importance of chemotherapy as a treatment option for glioma, its efficacy is often compromised by the formidable blood-brain barrier (BBB) and drug resistance. To address these challenges, a novel cascade nanodrug system called A12-PTX@RF-NPs is designed with aims to penetrate the BBB and precisely target glioma. In this nanosystem, the RVG-29 peptide facilitates the BBB penetration while Folic Acid (FA) targets glioma cells through binding to Folate Receptors (FR), followed by receptor-mediated endocytosis subsequently. The incorporation of disulfide bond modifications enables responsive release within the reductive environment of glioma, ensuring successful delivery of chemotherapy drugs. Significantly, a co-treatment approach involving the combination of A12 and PTX is implemented. In vitro and in vivo investigations have provided evidence that this amalgamation effectively induces apoptosis in tumor cells and inhibits their proliferation, thus synergistically eliminating both typical and drug-resistant glioma cells. These findings suggest that the nanodrug system presents a promising therapeutic strategy for glioma treatment, surpassing the limitations of conventional chemotherapy. Specifically, A12-PTX@RF-NPs constructed in this research have demonstrated remarkable targeting capabilities and therapeutic effects in cellular as well as animal models, thereby proposing an innovative strategy for glioma treatment.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"10 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Substitutional Chemistry of MAPbI3: Gaining Control over Material Photostability and Photovoltaic Performance via Pb2+ Replacement MAPbI3 的置换化学：通过 Pb2+ 置换控制材料的光稳定性和光伏性能

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2024-11-20 DOI: 10.1002/adfm.202407571

Marina I. Ustinova, Maxim V. Lobanov, Gennadii V. Shilov, Nadezhda N. Dremova, Azat F. Akbulatov, Lavrenty G. Gutsev, Ivan S. Zhidkov, Ernst Z. Kurmaev, Fedor A. Prudnov, Andrei V. Ivanov, Lyubov A. Frolova, Sergey M. Aldoshin, Pavel A. Troshin

{"title":"Substitutional Chemistry of MAPbI3: Gaining Control over Material Photostability and Photovoltaic Performance via Pb2+ Replacement","authors":"Marina I. Ustinova, Maxim V. Lobanov, Gennadii V. Shilov, Nadezhda N. Dremova, Azat F. Akbulatov, Lavrenty G. Gutsev, Ivan S. Zhidkov, Ernst Z. Kurmaev, Fedor A. Prudnov, Andrei V. Ivanov, Lyubov A. Frolova, Sergey M. Aldoshin, Pavel A. Troshin","doi":"10.1002/adfm.202407571","DOIUrl":"https://doi.org/10.1002/adfm.202407571","url":null,"abstract":"The strategy of partial Pb2+ substitution is applied, in prototypical MAPbI3 perovskite, with a large array of metal cations in order to comprehensively explore their possible incorporation in the perovskite lattice at Pb2+ sites and thus obtain improved photostability of the absorber. An analysis of lattice parameters and optoelectronic properties of MAPb1-xMxI∼3 compositions allowed authors to deduce which metal cations are partially incorporated in the perovskite structure and which are expelled in the form of secondary phases. Curious effects of metal incorporation are observed, such as a decrease in the tetragonal distortion ratio and a change in the band gap. This work reveals that the doping of 11 metal cations significantly improves the photostability of the MAPbI3 films. Multiple MAPb1-xMxI∼3 formulations deliver superior power conversion efficiencies (PCEs) in solar cells. The DFT calculations further demonstrate a complex relationship between the synthetic conditions and doping patterns. The performed study is thus a stepping stone in the development of more stable perovskite absorbers with superior photovoltaic properties.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"8 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Room Temperature Strong Orbital Moments in Perpendicularly Magnetized Magnetic Insulator 垂直磁化磁绝缘体中的室温强轨道力矩

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2024-11-20 DOI: 10.1002/adfm.202414188

Ganesh Ji Omar, Pierluigi Gargiani, Manuel Valvidares, Zhi Shiuh Lim, Saurav Prakash, T. S. Suraj, Abhijit Ghosh, Sze Ter Lim, James Lourembam, A. Ariando

{"title":"Room Temperature Strong Orbital Moments in Perpendicularly Magnetized Magnetic Insulator","authors":"Ganesh Ji Omar, Pierluigi Gargiani, Manuel Valvidares, Zhi Shiuh Lim, Saurav Prakash, T. S. Suraj, Abhijit Ghosh, Sze Ter Lim, James Lourembam, A. Ariando","doi":"10.1002/adfm.202414188","DOIUrl":"https://doi.org/10.1002/adfm.202414188","url":null,"abstract":"The balance between the orbital and spin magnetic moments in a magnetic system is the heart of many intriguing phenomena. Here, experimental evidence of a large orbital moment is shown, which competes with its spin counterpart in a ferrimagnetic insulator thulium iron garnet, Tm3Fe5O12. Leveraging element-specific X-ray magnetic circular dichroism (XMCD), it is established that the dominant contribution to the orbital moment originates from 4f orbitals of Tm. Besides the large Tm orbital moment, intriguingly, the results also reveal a smaller but evident non-zero XMCD signal in the O K edge, suggesting additional spin-orbit coupling and exchange interactions with the nearest neighbor Fe atoms. The unquenched orbital moment is primarily responsible for a significant reduction in g-factor, typically 2 in transition metals, as determined independently using ferromagnetic resonance spectroscopy. The findings reveal a non-linear reduction in the g-factor from 1.7 at 300 K to 1.56 at 200 K in Tm3Fe5O12 thin films. These results provide critical insights into the role of the f orbitals in long-range magnetic order and stimulate further exploration in orbitronics.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"23 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advancement in 2D Metal–Organic Framework for Environmental Remediation: A Review 用于环境修复的二维金属有机框架的最新进展：综述

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2024-11-20 DOI: 10.1002/adfm.202419433

Lun Lu, Liangzhong Li, Mengxu Chu, Cheng Chen, Boya Wang, Jun Wang, Yi Shen, Ruixue Ma, Bisheng Li, Liguo Shen, Hongjun Lin, Banglin Chen

{"title":"Recent Advancement in 2D Metal–Organic Framework for Environmental Remediation: A Review","authors":"Lun Lu, Liangzhong Li, Mengxu Chu, Cheng Chen, Boya Wang, Jun Wang, Yi Shen, Ruixue Ma, Bisheng Li, Liguo Shen, Hongjun Lin, Banglin Chen","doi":"10.1002/adfm.202419433","DOIUrl":"https://doi.org/10.1002/adfm.202419433","url":null,"abstract":"In a time characterized by the increasing interest in metal–organic frameworks (MOFs) as widely researched crystalline porous substances geared toward enhancing device and system capabilities across diverse environmental contexts, 2D MOFs emerge as a noteworthy class of nanomaterials that integrate the benefits of 2D structures with the unique characteristics inherent to MOFs. These 2D MOFs possess ultrathin nanosheet configuration, abundant accessible active sites, and remarkable mechanical flexibility. Such distinctive properties differentiate them from bulk MOFs and other 2D materials, offering the potential to instigate novel environmental phenomena and applications. This review focuses on the latest progress in the application of 2D MOFs within essential water-related ecological fields, including contaminant adsorption, photocatalytic degradation, membrane separation, environmental sensing, and disinfection. A variety of synthesis approaches for 2D MOFs are analyzed, accompanied by a discussion on their effectiveness across different environmental settings. The unique structure and features of 2D MOFs that grant outstanding environmental functionalities are compared with those of bulk MOFs. The environmental ramifications of 2D MOFs are highlighted while outlining future research needs to explore the environmental applications of these innovative materials.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"25 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

X-Ray-Triggered CA IX Inhibition Nanoplatform Promotes Intratumoral Acidosis-Induced Cancer Ferroptosis X射线诱导的CA IX抑制纳米平台促进瘤内酸中毒诱导的癌症铁变态反应

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2024-11-20 DOI: 10.1002/adfm.202417889

Yuanyuan You, Wenxiao Jiang, Renhao Xu, Junbing He, Tianfeng Chen, Qinghua Liu

{"title":"X-Ray-Triggered CA IX Inhibition Nanoplatform Promotes Intratumoral Acidosis-Induced Cancer Ferroptosis","authors":"Yuanyuan You, Wenxiao Jiang, Renhao Xu, Junbing He, Tianfeng Chen, Qinghua Liu","doi":"10.1002/adfm.202417889","DOIUrl":"https://doi.org/10.1002/adfm.202417889","url":null,"abstract":"Radiotherapy-induced ferroptosis is accompanied by an adaptive response to the expression of tumor cell ferroptosis suppressor genes. Herein, a degradable and in situ generated silicomanganese composite system loaded with carbonic anhydrase (CA IX) inhibitor (4-(2-aminoethyl) benzenesulfonamide (ABS) is constructed to form a DSiMn-ABS nanosystem to improve the ferroptosis sensitivity of hypoxic tumor cells and improve the radiotherapy effect. The system can be continuously degraded in the tumor environment and X-rays, releasing Manganese dioxid （MnO2)and ABS; Thereby inhibiting the activity of CA IX, inducing acidification inside tumor cells, regulating the AMP-activating protein kinase (AMPK)/Acetyl-CoA carboxylase(ACC) axis to increase the sensitivity of tumor cells to ferroptosis, and depleting glutathione (GSH) through MnO2 influencing glutathione peroxidase 4 (GPX4) activity, which further inhibits the ferroptosis defense system of tumor cells, and ultimately effectively improves the therapeutic efficiency of radiotherapy. Ultimately, the system can effectively inhibit tumor growth. Therefore, this degradable system can utilize double-sensitized radiotherapy to provide new ideas for tumor radiotherapy.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"11 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Room Temperature Pulsed Laser Deposition of Aluminum Zinc Oxide (AZO): Enabling Scalable Indium-Free Transparent Conductive Oxides 氧化铝锌（AZO）的室温脉冲激光沉积：实现可扩展的无铟透明导电氧化物

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2024-11-20 DOI: 10.1002/adfm.202418069

Joost W. C. Reinders, Jons Bolding, Cristina Roldán-Carmona, Federico Ventosinos, Abhyuday Paliwal, Lidón Gil-Escrig, Francisco Palazon, Michele Sessolo, Kassio P. S. Zanoni, Henk J. Bolink

{"title":"Room Temperature Pulsed Laser Deposition of Aluminum Zinc Oxide (AZO): Enabling Scalable Indium-Free Transparent Conductive Oxides","authors":"Joost W. C. Reinders, Jons Bolding, Cristina Roldán-Carmona, Federico Ventosinos, Abhyuday Paliwal, Lidón Gil-Escrig, Francisco Palazon, Michele Sessolo, Kassio P. S. Zanoni, Henk J. Bolink","doi":"10.1002/adfm.202418069","DOIUrl":"https://doi.org/10.1002/adfm.202418069","url":null,"abstract":"Indium tin oxide (ITO) is the leading transparent electrode material in displays and in photovoltaics. As both these markets are vast and rapidly expanding, the demand for alternative transparent conductive oxides (TCOs) is becoming increasingly urgent due to the limited availability of indium. Herein, aluminum-doped zinc oxide (AZO) is revisited as a promising indium-free TCO candidate. An industrial-scale pulsed laser deposition (PLD) process is developed that produces highly conductive and transparent AZO films at room temperature, without the need for post-deposition annealing. This PLD-AZO films have excellent morphological, electrical, and optical properties, with sheet resistances of ≈ 55–25 Ω ϒ−1 for thin TCO thicknesses (around 100 to 200 nm, respectively), and absorptance from 400 to 1000 nm below 10%. We demonstrate the application of this highly conductive PLD-AZO not only as a bottom contact but also as an effective top contact in perovskite solar cells, highlighting its versatility. The AZO-based devices achieve performance and stabilities equivalent to that of ITO-based. This findings demonstrate the robustness and potential of PLD-deposited AZO layers in enhancing displays and PV production and facilitating the wider adoption of renewable and sustainable TCO alternatives in the expanding photovoltaics and displays markets.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"39 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light-Driven Dynamic Defect-Passivation for Efficient Inorganic Perovskite Solar Cells 光驱动动态缺陷钝化，实现高效无机过氧化物太阳能电池

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2024-11-20 DOI: 10.1002/adfm.202416118

Zhiteng Wang, Qiyong Chen, Huidong Xie, Xiaolong Feng, Yachao Du, Tianxiang Zhou, Rui Li, Junqi Zhang, Lu Zhang, Zhuo Xu, Lili Xi, Qingwen Tian, Shengzhong (Frank) Liu

{"title":"Light-Driven Dynamic Defect-Passivation for Efficient Inorganic Perovskite Solar Cells","authors":"Zhiteng Wang, Qiyong Chen, Huidong Xie, Xiaolong Feng, Yachao Du, Tianxiang Zhou, Rui Li, Junqi Zhang, Lu Zhang, Zhuo Xu, Lili Xi, Qingwen Tian, Shengzhong (Frank) Liu","doi":"10.1002/adfm.202416118","DOIUrl":"https://doi.org/10.1002/adfm.202416118","url":null,"abstract":"Due to its soft lattice characteristics, all-inorganic cesium lead halide (CsPbI3-xBrx) perovskite is vulnerable to external environmental stress such as moisture, polar solvent, illumination. resulting in structural defects (VI, Ii, etc.) and ion mobility. However, most of the prior arts focus on short-term and static passivation, which has a negligible effect on defects formed during solar cell operation. Herein, a photoisomerizable molecule, 1,3,3-trimethylindolino-8′-methoxybenzopyrylospiran (OMe-SP), exhibiting light-driven pre-isomeric (SP) and post-isomeric (PMC) configurations, is employed as an interfacial protective layer on top of CsPbI3-xBrx. The present strategy not only effectively suppresses migration of halogen ions, but also enables sustainable passivation of defects, thereby significantly reducing interfacial charge recombination and retarding perovskite degradation. Consequently, the OMe-SP-modified perovskite solar cells (PSCs) exhibit superior stability, maintaining 91% of their initial efficiency after aging 1032 h under maximum power point (MPP) tracking and continuous one sun illumination. Meanwhile, the OMe-SP-modified cell also achieves an impressive power conversion efficiency of 22.20%, which stands as the highest among all-inorganic perovskite solar cells. Overall, the implementation of this robust strategy provides sustainable defect passivation and continuous suppression of ion migration for achieving both high PCE and stable inorganic perovskite.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"26 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecule-Induced Huge d-p Overlap Enhances Superexchange Interaction for Room-Temperature In-Plane Magnetism and Giant Magneto Band-Structure Effect in Ferromagnetic Clusterphene 分子诱导的巨大 d-p 重叠增强了铁磁簇铼中室温平面内磁性和巨磁带结构效应的超交换相互作用

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2024-11-20 DOI: 10.1002/adfm.202414984

Xiaofeng Liu, Yihang Bai, Weiduo Zhu, Zhao Liu, Zhao Chen, Pengfei Gao, Haidi Wang, Zhongjun Li, Bing Wang, Xingxing Li, Wei Hu, Jinlong Yang

{"title":"Molecule-Induced Huge d-p Overlap Enhances Superexchange Interaction for Room-Temperature In-Plane Magnetism and Giant Magneto Band-Structure Effect in Ferromagnetic Clusterphene","authors":"Xiaofeng Liu, Yihang Bai, Weiduo Zhu, Zhao Liu, Zhao Chen, Pengfei Gao, Haidi Wang, Zhongjun Li, Bing Wang, Xingxing Li, Wei Hu, Jinlong Yang","doi":"10.1002/adfm.202414984","DOIUrl":"https://doi.org/10.1002/adfm.202414984","url":null,"abstract":"The discovery of 2D van der Waals XY ferromagnets is a vital task to access excellent topological spin textures, yet remains a longstanding challenge due to low critical temperatures (TC) and weak in-plane magnetic anisotropy. Here, a novel 2D ferromagnetic clusterphene, (Cr3As2)2Cp3 (Cp = cyclopentadienyl), by using Cr3As2Cp3 cluster self-assembly with Cp as linker is proposed. Via first-principles calculations, it is demonstrated that an enhanced ferromagnetic superexchange interaction between the d orbital is achieved through a salient overlap onto the molecular frontier orbitals of the Cp ligand, producing a room-temperature TC. The (Cr3As2)2Cp3 clusterphene characterizes an ideal XY ferromagnet and a giant magneto band-structure (GMB) effect. Functional groups and element modifications are also introduced to effectively manipulate the magnetic anisotropy and the GMB effect. The results showcase that 2D magnetic cluster-assembled clusterphenes fuel a wide range of possibilities for exploring XY magnetism in reduced dimensions.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"33 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-Inspired Self-Renewing Implant Surfaces With Sequential Biofunctional Adaptation for Infectious Diabetic Tissue Repair 具有序列生物功能适应性的生物启发自我更新植入物表面，用于感染性糖尿病组织修复

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2024-11-20 DOI: 10.1002/adfm.202418092

Bin Cui, Min Wen, Zhe Cai, Yunhui Si, Fei Liu, Yufeng Zheng, Chao Zhang, Zhaojun Jia

{"title":"Bio-Inspired Self-Renewing Implant Surfaces With Sequential Biofunctional Adaptation for Infectious Diabetic Tissue Repair","authors":"Bin Cui, Min Wen, Zhe Cai, Yunhui Si, Fei Liu, Yufeng Zheng, Chao Zhang, Zhaojun Jia","doi":"10.1002/adfm.202418092","DOIUrl":"https://doi.org/10.1002/adfm.202418092","url":null,"abstract":"The clinical success of bioinert, tissue-interfacing metallic implants is greatly jeopardized by complications such as infections, inflammation, and poor regeneration or biointegration, especially concerning diabetics. Implants featuring self-renewable surfaces that sequentially dictate antibacterial/anti-inflammatory, immunomodulatory, and pro-healing/-regenerative functionalities represent an emerging solution. Herein, fusing triple marine bioinspirations, namely the multilayered interlocked interfaces of mollusk shells, the adhesive/reactive chemistries of mussels, and the self-renewing, release-active mucus layers of corals, a self-adaptive interfacial engineering strategy that imparts self-renovating surfaces and temporally-activatable biofunctionalities to various inert biometallic devices is presented. Specifically, sandwich-like multilayered coatings are in situ constructed, comprising a substrate-derived micro/nanostructured prelayer, a mussel-inspired bioadhesive interlayer, and a polyphenol–antibiotic dynamically-crosslinked therapeutic gel toplayer. The dynamic bonds within the gel allowed pH/reactive oxygen species-responsive surface degradation, localized release of multifunctional therapeutics, and conditional exposure of cell-supportive chemical moieties and micro/nanotopographies. Systematic in-vitro, in-ovo, and in-vivo (spanning osseous, subcutaneous, and wound-closure implantations) studies demonstrated that the functionalized bone implants or wound closure staples possessed adaptive biocompatibility (cyto-/hemo/-tissue-compatibility) and biofunctionalities to combat device-associated infections and spur diabetic tissue repair. This study underscores the potential of self-adaptive coating strategies for orchestrating complex (even contradictory) biological functions in addressing challenging medical conditions that require implant intervention.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"21 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organic Nitro Compounds for Batteries 电池用有机硝基化合物

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2024-11-20 DOI: 10.1002/adfm.202416000

Donghong Wang, Qiwang Shao, Xianjia Cao, Mengxuan Qin, Changyou Zhang, Lei Zhu, Shasha Wang, Qing Li, Dongming Liu, Chunyi Zhi

引用次数: 0