Advanced Functional Materials最新文献_第3页

Enhanced Control of Tomato Bacterial Wilt Using a Triple-Responsive Nanopesticide with Self-Supplying Reactive Oxygen Species 自供活性氧纳米三重反应农药对番茄青枯病的防治效果研究

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-11 DOI: 10.1002/adfm.202504824

Zhaoyang Zhang, Jiaqing Li, Chang Yu, Dan Sun, Jiayin Wang, Danming Zhao, Mohamed Mmby, Kangsheng Ma, Hongju Ma, Hu Wan, Jianhong Li, Shun He

{"title":"Enhanced Control of Tomato Bacterial Wilt Using a Triple-Responsive Nanopesticide with Self-Supplying Reactive Oxygen Species","authors":"Zhaoyang Zhang, Jiaqing Li, Chang Yu, Dan Sun, Jiayin Wang, Danming Zhao, Mohamed Mmby, Kangsheng Ma, Hongju Ma, Hu Wan, Jianhong Li, Shun He","doi":"10.1002/adfm.202504824","DOIUrl":"https://doi.org/10.1002/adfm.202504824","url":null,"abstract":"Tomato production, a vital component of global horticulture, is threatened by bacterial wilt caused by Ralstonia solanacearum. To address this, a triple-responsive nanoplatform (Ber@MON@CuO2@HPC) integrating berberine chloride (Ber), copper peroxide (CuO2) nanoparticles, mesoporous organosilica nanoparticles (MONs), and hydroxypropyl cellulose (HPC) encapsulation is presented. Ber@MON@CuO2@HPC enables efficiently controlled release and self-supply of reactive oxygen species (ROS), enhancing antibacterial efficacy. The system demonstrates pH-, glutathione-, and cellulase-responsive release, ensuring on-demand delivery of berberine chloride with a loading capacity of 12.0%. HPC encapsulation significantly reduces the contact angle, improving foliar adhesion and retention. In vitro antibacterial assays reveal that despite an 88% reduction in the berberine chloride dosage, Ber@MON@CuO2@HPC achieves a 1.84-fold increase in efficacy compared with that using free berberine chloride. Mechanistically, the nanoplatform induces ROS-mediated bacterial membrane disruption, cytoplasmic leakage, and nucleoid degradation, accompanied by a significant downregulation of key R. solanacearum pathogenesis (phcA, hrpB, pehC, and epsE)- and mobility (filA)-related genes. Greenhouse experiments further validate its effectiveness in reducing disease severity. Moreover, MON@CuO2@HPC exhibits excellent biocompatibility with no adverse effects on tomato plant growth. This study presents a sustainable nanopesticide strategy combining stimuli-responsive controlled-release and self-supplying ROS antibacterial mechanisms, offering an effective approach for plant disease management while minimizing pesticide input.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"6 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Intelligent Hyperthermia System with Photothermal Temperature Wall Effect for Programmable Gated Drug Release in Wound Healing 一种具有光热温度壁效应的可编程门控释药创面修复智能热疗系统

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-11 DOI: 10.1002/adfm.202422554

Haibo Wang, Chen Lyu, Chunyang Zhang, Dongzhi Yang, Xiaoyue Wang, Jun Nie, Guiping Ma

{"title":"An Intelligent Hyperthermia System with Photothermal Temperature Wall Effect for Programmable Gated Drug Release in Wound Healing","authors":"Haibo Wang, Chen Lyu, Chunyang Zhang, Dongzhi Yang, Xiaoyue Wang, Jun Nie, Guiping Ma","doi":"10.1002/adfm.202422554","DOIUrl":"https://doi.org/10.1002/adfm.202422554","url":null,"abstract":"Traditional photothermal therapy (PTT) inevitably causes thermal damage and uncontrolled drug release (DR) owing to the continuous increase and fluctuation in the photothermal temperature. Herein, a photothermal temperature wall (PTW)-gated drug-release system is developed for use in the safe PTT of wounds. This system is implemented via two modules integrated within a hydrogel: i) photothermal color-changing (PCC) microcapsules with PTW effects, and ii) temperature-sensitive drug-loaded microspheres for gradient PTW-programed DR. The PTW effect is realized via the dynamic “on-off” dual-modal switching of the photothermal properties, and it can be regulated by adjusting the molecular chain lengths of the saturated fatty alcohols and near-infrared power density employed. The drug-release threshold of temperature-sensitive microspheres can also be tailored by varying the mass ratio of N-isopropylacrylamide-co-N-hydroxymethylacrylamide (shell) to gelatin-co-agarose (core). Consequently, the personalized programed release of thrombin, vancomycin, and basic fibroblast growth factor (bFGF) to address the respective drug requirements during the hemostasis, inflammation, and proliferation stages of infected mouse wounds, is realized. This leads to a highly efficient wound healing rate (99.9%) within 15 days. Therefore, this system holds promise as a viable candidate for use in personalized drug delivery during wound treatment.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"13 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering Mesenchymal Stem Cells with Antioxidant Catalase-Loaded Metal–Organic Frameworks for Targeted Spinal Cord Injury Therapy 具有抗氧化过氧化氢酶负载金属-有机框架的工程间充质干细胞用于脊髓损伤靶向治疗

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-11 DOI: 10.1002/adfm.202500726

Shiyun Xian, Shuguang Yang, Zhouzhou Liao, Yujie Jiang, Yifei Leng, Jinchuang Ning, Honglin Gao, Zecong Xiao, Xintao Shuai

{"title":"Engineering Mesenchymal Stem Cells with Antioxidant Catalase-Loaded Metal–Organic Frameworks for Targeted Spinal Cord Injury Therapy","authors":"Shiyun Xian, Shuguang Yang, Zhouzhou Liao, Yujie Jiang, Yifei Leng, Jinchuang Ning, Honglin Gao, Zecong Xiao, Xintao Shuai","doi":"10.1002/adfm.202500726","DOIUrl":"https://doi.org/10.1002/adfm.202500726","url":null,"abstract":"Spinal cord injury (SCI) therapy is challenging because of the associated irreversible neurological deficits. These deficits are caused by primary damage and secondary pathological processes such as oxidative stress and inflammation. Although mesenchymal stem cells (MSC) demonstrate potential in SCI treatment by promoting tissue repair and neuroprotection, the high reactive oxygen species (ROS) levels in the SCI microenvironment compromise their therapeutic efficacy. In this study, an MSC-based cell–drug conjugate (CDC) system is developed by conjugating catalase (CAT)-loaded metal–organic frameworks (MOF) to MSC, generating a C@M-MSC platform. The C@M-MSC system maintains MSC viability, preserves stemness, and mitigates ROS-induced cellular damage. Furthermore, C@M-MSC substantially modulates the inflammatory microenvironment by reducing inflammatory cytokine production and shifting microglial polarization toward the anti-inflammatory M2 phenotype. In vivo studies confirm the targeted accumulation of C@M-MSC in SCI lesions. This accumulation improves motor functioning, bladder control, and neuronal recovery. Thus, the C@M-MSC system is a versatile therapeutic strategy that mitigates oxidative stress and enhances tissue repair, offering potential applications beyond SCI. It offers a foundation for broader clinical applications in regenerative medicine and can be integrated with other therapeutic strategies.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"42 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-Scale Biomimetic Strategy: Robust Woven Wires with Photo-Thermal De-Icing and Spontaneous De-Wetting 多尺度仿生策略：具有光热除冰和自发除湿的坚固编织线

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-11 DOI: 10.1002/adfm.202423043

Kun Zhang, Jinsong Huang, Shengqi Lu, Yan Hu, Wei Pan, Liming Liu

{"title":"Multi-Scale Biomimetic Strategy: Robust Woven Wires with Photo-Thermal De-Icing and Spontaneous De-Wetting","authors":"Kun Zhang, Jinsong Huang, Shengqi Lu, Yan Hu, Wei Pan, Liming Liu","doi":"10.1002/adfm.202423043","DOIUrl":"https://doi.org/10.1002/adfm.202423043","url":null,"abstract":"The irreversible transition from the Wenzel to the Cassie–Baxter state of superhydrophobic surfaces under negative temperatures and high humidity significantly degrades their anti-icing performance. Moreover, large-scale preparation of superhydrophobic surfaces with high mechanical durability remains challenging. In this study, inspired by the photothermal properties of coral and the reinforcement structures of mountain slopes, an anti-icing mesh (AIM) with submillimeter overlapping peaks/ridges and coral-shaped micro-/nanostructures assembled onto woven wires is fabricated using one-step laser micromachining. The resulting AIM exhibited an ice adhesion strength of 14.5 kPa and solar-assisted de-icing times of 123 s (0.1 Wcm−2) and 302 s (0.05 Wcm−2) in frozen-rain environment. These properties are attributed to its hollow micro-skeleton and subwavelength porous nano-gaps formed by melted polydimethylsiloxane and dispersed carbon black nanoparticles. The AIM maintained a water rolling angle of 8° even after 10,000 abrasion cycles, as tested using the standardized ASTM D4060 method. The robustness mechanism is further analyzed through a quantitative assessment of micromorphology evolution and interface wetting states. Additionally, transmission cables encapsulated with intact or damaged AIM are tested to simulate real-world de-icing applications, demonstrating its strong anti-icing potential as a scalable fabrication method with effective freezing delay, photothermal de-icing capability, and exceptional durability.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"65 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Stability Dual Janus Li-Alloy Anode via Single-Step Surface Solution Etching 高稳定性双Janus锂合金阳极单步表面溶液蚀刻

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-11 DOI: 10.1002/adfm.202509835

Xinyu Ji, Haitao Zhu, Yanpeng Guo, Zhaoming Tong, Yao Liu, Xinqi Wei, Shuhao Wang, Xizheng Liu, Xiaoxiong Xu, Jiu Lin, Yanming Cui, Yun Zhang, Tianyou Zhai, Huiqiao Li

{"title":"High-Stability Dual Janus Li-Alloy Anode via Single-Step Surface Solution Etching","authors":"Xinyu Ji, Haitao Zhu, Yanpeng Guo, Zhaoming Tong, Yao Liu, Xinqi Wei, Shuhao Wang, Xizheng Liu, Xiaoxiong Xu, Jiu Lin, Yanming Cui, Yun Zhang, Tianyou Zhai, Huiqiao Li","doi":"10.1002/adfm.202509835","DOIUrl":"https://doi.org/10.1002/adfm.202509835","url":null,"abstract":"Alloying Li with electrochemically-inert elements represents a compelling scalable solution to mitigate rampant dendrite proliferation and parasitic side reactions. However, current approaches predominantly involve melting excess Li with inert elements to yield dense Li-rich alloys, which fail to address long-term cycling degradation for their similar electrochemical behaviors to metallic Li. Here, a single-step surface solution etching strategy through selective Li removal is proposed to engineer a compositional and structural dual-Janus lithium-silver alloy (DJ-LiAg) anode, featuring a Li-free porous LiAg surface architecture and a Li-rich dense LiAg-Li bottom reservoir. Symmetric cells using such a DJ-LiAg anode demonstrate unprecedented cycling stability over 4000 h, far exceeding the bare Li (≈760 h) as well as monolithic LiAg-Li (m-LiAg) alloys (≈980 h). Full cells paired with high-loading LiFePO4 cathodes (2 mAh cm−2) and DJ-LiAg anode retain 85.9% capacity after 500 cycles at 2 C, outperforming pristine m-LiAg (23.4%). This strategy demonstrates universal applicability across various Li-based alloy systems and enables precise control of the Janus-surface thickness, facilitating N/P ratio tuning for commercialization. By integrating roll-to-roll compatibility with etching efficiency, the work establishes a scalable paradigm for high-performance lithium alloy design which bridges the gap between high energy density, interfacial stability, and industrial feasibility.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"8 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topologically Guided Nanowire Arrays on Teflon Cloth for Bending-Stable Photodetector Integration and Optical Communication 弯曲稳定光电探测器集成与光通信的聚四氟乙烯布拓扑引导纳米线阵列

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-11 DOI: 10.1002/adfm.202510972

Wanglong Mao, Meng Pang, Weixuan He, Hanyu Liu, Xiangtao Chen, Zhanhao Liang, Qiming Yang, Shubin Yi, Yao Wang, Yumengmeng Xu, Yanbin Chen, Pinyun Ren, Guofu Zhou, Jinyou Xu

{"title":"Topologically Guided Nanowire Arrays on Teflon Cloth for Bending-Stable Photodetector Integration and Optical Communication","authors":"Wanglong Mao, Meng Pang, Weixuan He, Hanyu Liu, Xiangtao Chen, Zhanhao Liang, Qiming Yang, Shubin Yi, Yao Wang, Yumengmeng Xu, Yanbin Chen, Pinyun Ren, Guofu Zhou, Jinyou Xu","doi":"10.1002/adfm.202510972","DOIUrl":"https://doi.org/10.1002/adfm.202510972","url":null,"abstract":"The integration of nanowires into flexible optoelectronics remains constrained by the incompatibility of lattice-matching epitaxy with amorphous substrates and performance degradation from post-growth assembly. Herein, a universal strategy is proposed for large-scale oriented growth of nanowires on arbitrary substrates. By decoupling alignment from conventional lattice-matching paradigms through topological guidance of amorphous nanogrooves, large-area horizontally-aligned metal phthalocyanine nanowires with consistent crystallographic axes are achieved on challenging substrates, including flexible Teflon cloth, printing paper, rigid glass, silicon wafer, and iron foil. In situ integrated flexible photodetectors using CuPc nanowire arrays on Teflon cloths exhibit broadband sensitivity (400–1100 nm), detectivity up to 10⁹ Jones, and millisecond response speeds. Mechanical robustness is demonstrated with stable operation under high bending stress (0.75 cm curvature radius) and over 1000 bending cycles. A 9 × 9 photodetector array showcases scalability, featuring consistent photoresponse across all pixels. A prototype optical communication system validates real-world applicability, decoding Morse code signals at high speed (0.1 ms for dot) and translating light pulses into alphanumeric characters without latency or errors. This strategy bridges lab-scale nanowire growth and deployable flexible optoelectronics, combining substrate-agnostic alignment, in situ device fabrication, system-level scalability, and bending-stable operation to address integration challenges in nanowires-based wearable technologies.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"12 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

La-Doped LaFeCoOOH Bifunctional Materials for Oxygen Evolution Reaction and Supercapacitors la掺杂LaFeCoOOH双功能材料的析氧反应和超级电容器

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-11 DOI: 10.1002/adfm.202507282

Le Gao, Yue Yao, Yongheng Ma, Jiajun Huang, Yun Chen, Li Chen, Lishan Jia

{"title":"La-Doped LaFeCoOOH Bifunctional Materials for Oxygen Evolution Reaction and Supercapacitors","authors":"Le Gao, Yue Yao, Yongheng Ma, Jiajun Huang, Yun Chen, Li Chen, Lishan Jia","doi":"10.1002/adfm.202507282","DOIUrl":"https://doi.org/10.1002/adfm.202507282","url":null,"abstract":"Developing efficient multifunctional materials for the oxygen evolution reaction (OER) and supercapacitors has become essential for storing and converting energy. Taking advantage of the structural flexibility of metal–organic frameworks (MOFs), bifunctional electrochemical nanomaterial LaFeCoOOH with high performance is successfully synthesized by doping rare earth La atoms in transition metals. La doping modifies the coordination environment of active sites and material morphology, modulates the energy structure, improves material conductivity, and optimizes the adsorption and desorption performance of oxygen intermediates. LaFeCoOOH demonstrates exceptional electrocatalytic activity for OER, achieving a remarkably low overpotential of 177 mV at 10 mA cm−2 current density in 1 m KOH alkaline electrolyte. The material exhibits outstanding operational stability, maintaining consistent performance for over 1000 h at an elevated current density of 100 mA cm−2 under identical alkaline conditions. Furthermore, LaFeCoOOH electrode displays superior electrochemical energy storage capabilities, demonstrating an impressive specific capacitance of 3508 mF cm−2 at 1 mA cm−2 current density. When configured as an asymmetric supercapacitor (LaFeCoOOH//Activated Carbon (AC)) using 6 m KOH electrolyte, the device achieves an exceptional energy density of 118.52 µWh cm−2 while delivering a power density of 1700 µW cm−2, highlighting its dual functionality for both energy conversion and storage applications. Hence, this study provides a new perspective for the exploration of new multifunctional transition metal composites modified with rare earth elements for energy storage and conversion applications.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"602 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Converting the Negative Ni-Mn Synergy into Positive in Lower-Coordination Layered Double Hydroxide/Metal-Organic Framework Heterojunction for Efficient Water and Urea Electrooxidation 低配位层状双氢氧化物/金属-有机骨架异质结中Ni-Mn负协同转化为正协同的高效水尿素电氧化

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-11 DOI: 10.1002/adfm.202506007

Qiuping Huang, Chenghua Sun, Dongling Xie, Jianan Wang, Bo Huang, Dan Wen, Dunmin Lin, Chenggang Xu, Wenhao Wu, Tianjie Qiu, Jinqi Wu, Guang-Jie Xia, Yian Wang, Fengyu Xie, Wenhan Guo

{"title":"Converting the Negative Ni-Mn Synergy into Positive in Lower-Coordination Layered Double Hydroxide/Metal-Organic Framework Heterojunction for Efficient Water and Urea Electrooxidation","authors":"Qiuping Huang, Chenghua Sun, Dongling Xie, Jianan Wang, Bo Huang, Dan Wen, Dunmin Lin, Chenggang Xu, Wenhao Wu, Tianjie Qiu, Jinqi Wu, Guang-Jie Xia, Yian Wang, Fengyu Xie, Wenhan Guo","doi":"10.1002/adfm.202506007","DOIUrl":"https://doi.org/10.1002/adfm.202506007","url":null,"abstract":"Developing efficient and robust earth-abundant bifunctional electrocatalysts for the anodic oxygen evolution reaction (OER) and urea oxidation reaction (UOR) is crucial for promoting sustainable H2 generation via water or urea electrolysis. In this study, a bifunctional lower-coordination NiMn-bimetallic layered double hydroxide/metal-organic framework (LC-NiMn-LMF) nanoheterojunction electrocatalyst is reported. The X-ray photoelectron spectroscopy (XPS) and X-ray absorption fine structure (XAFS) analysis confirm the presence of abundant low-coordination atoms (LCAs) in LC-NiMn-LMF. The optimized LC-NiMn-LMF achieves a low overpotential of 232 mV for OER and a low potential of 1.33 V for UOR at 10 mA cm−2. Moreover, it demonstrates a low voltage of 1.885 V at 500 mA cm−2 and excellent durability for 100 h (500 mA cm−2) in an anion exchange membrane water electrolyzer. Mechanistic studies reveal that the improved catalytic performance arises from the synergistic interaction between adjacent LCAs, specifically Ni in LDH and Mn in MOF. This interaction effectively suppresses the overoxidation of Mn ions into inactive Mn(IV) valence state and stabilizes reaction intermediates, enhancing the intrinsic activity. This work offers a promising strategy for designing multifunctional electrocatalysts for advanced water and urea electrolysis technologies.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"176 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pollen-Inspired Aptamer Delivery System for Multi-Target Therapy in Rheumatoid Arthritis 花粉激发的适体传递系统用于类风湿性关节炎的多靶点治疗

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-11 DOI: 10.1002/adfm.202425323

Wenxin Yang, Zhengrong Chen, Ying Qu, Peng Ye, Yong Tang, Qixiu Yu, Ziyang Zhang, Qijie Dai, Ce Dou, Fei Luo

{"title":"Pollen-Inspired Aptamer Delivery System for Multi-Target Therapy in Rheumatoid Arthritis","authors":"Wenxin Yang, Zhengrong Chen, Ying Qu, Peng Ye, Yong Tang, Qixiu Yu, Ziyang Zhang, Qijie Dai, Ce Dou, Fei Luo","doi":"10.1002/adfm.202425323","DOIUrl":"https://doi.org/10.1002/adfm.202425323","url":null,"abstract":"In rheumatoid arthritis (RA), the complex interplay of inflammatory mediators and cellular mechanisms presents challenges for effective treatment. Current therapies, often targeting singular pathways, achieve limited clinical remission. This study introduces a multifunctional therapeutic strategy using a pollen-inspired aptamer delivery system (tk-Apt@pollen) designed for dual targeting of neutrophil extracellular traps (NETs) and tumor necrosis factor-alpha (TNFα). Engineered sunflower pollen grains, modified with methoxy polyethylene glycol (mPEG) and thioketal (TK), encapsulate aptamers that inhibit DEK protein activity and TNFα-mediated inflammation. This dual mechanism disrupts NETs formation, mitigates reactive oxygen species (ROS) levels, and inhibits osteoclastogenesis. In vitro assays demonstrated the system's ability to inhibit NET production, reduce osteoclast activation, and achieve controlled aptamer release in response to ROS. In vivo, tk-Apt@pollen significantly reduces joint inflammation and bone erosion in a collagen-induced arthritis mouse model, outperforming free aptamers. This study highlights tk-Apt@pollen as a promising approach to address the multifaceted pathology of RA, providing insights into designing multi-target therapies for chronic inflammatory diseases.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"12 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulating the Hydrolysis of TiCl4 during the Chemical Bath Deposition of TiO2 Electron Transport Layer for High-Performance Carbon-Based CsPbI3 Perovskite Solar Cells 高性能碳基CsPbI3钙钛矿太阳能电池中TiO2电子传输层化学浴沉积过程中对TiCl4水解的调控

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-11 DOI: 10.1002/adfm.202510897

Zhe Xing, Gaofeng Li, Qixian Zhang, Jiaxing Liu, Liwei Fan, Huiren Xu, Weiping Li, Huicong Liu, Haining Chen

{"title":"Regulating the Hydrolysis of TiCl4 during the Chemical Bath Deposition of TiO2 Electron Transport Layer for High-Performance Carbon-Based CsPbI3 Perovskite Solar Cells","authors":"Zhe Xing, Gaofeng Li, Qixian Zhang, Jiaxing Liu, Liwei Fan, Huiren Xu, Weiping Li, Huicong Liu, Haining Chen","doi":"10.1002/adfm.202510897","DOIUrl":"https://doi.org/10.1002/adfm.202510897","url":null,"abstract":"TiO2 is widely utilized as an electron transport layer (ETL) in perovskite solar cells (PSCs) due to its suitable band structure, facile fabrication process, and high-temperature stability. Compared to the other methods, the chemical bath deposition (CBD) method enables the preparation of uniform TiO2 films under low-temperature conditions. However, during the deposition process, vigorous hydrolysis reactions and reactive intermediates lead to the formation of large agglomerated particles and oxygen vacancies, resulting in poor TiO2 ETL and low-performance devices. Herein, sulfanilamide (SA) is introduced into the CBD solution to smoothen the hydrolysis reactions of TiCl4 during the CBD processes. The ─SO2NH2 group of SA molecules renders the hydrolysis process more stable through coordination with titanium ions. The TiO2 films prepared using this method exhibit lower defect state densities and optimized energy band structures. As a result, the PCE of the carbon-based CsPbI3 PSCs without a hole transport layer fabricated based on this strategy increases from 17.66% to 19.03%.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"10 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0