Advanced Functional Materials最新文献_第4页

An ‘AND’ Logic Gate Nanoreactor for Metabolic Remodeling in Starvation‐Ferroptosis‐Immunotherapy of Pancreatic Cancer 一种用于饥饿-凋亡-胰腺癌免疫治疗代谢重塑的“与”逻辑门纳米反应器

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-27 DOI: 10.1002/adfm.202502221

Yongjuan Li, Bingjie Liu, Jingyun Li, Chenshuo Ruan, Zhiwei Li, Yanjing Li, Yang Yang, Suxin Li, Xianfu Liu, Lin Li, Luhao Li, Kelong Fan, Xiaowei Dang, Ying Cui

{"title":"An ‘AND’ Logic Gate Nanoreactor for Metabolic Remodeling in Starvation‐Ferroptosis‐Immunotherapy of Pancreatic Cancer","authors":"Yongjuan Li, Bingjie Liu, Jingyun Li, Chenshuo Ruan, Zhiwei Li, Yanjing Li, Yang Yang, Suxin Li, Xianfu Liu, Lin Li, Luhao Li, Kelong Fan, Xiaowei Dang, Ying Cui","doi":"10.1002/adfm.202502221","DOIUrl":"https://doi.org/10.1002/adfm.202502221","url":null,"abstract":"Ferroptosis is an emerging therapeutic strategy in pancreatic cancer (PC) therapy. However, existing ferroptosis often concentrate on the generation of lipid peroxide (LPO), ignoring the negative feedback from intracellular anomalous metabolism, such as lactic acid accumulation. Herein, an “AND” logic gate functional nanoreactor is constructed with a combination of curcumin and glucose oxidase (Gox) (NRs@Cur@Gox) for metabolic remodeling‐mediated starvation, ferroptosis, and immunotherapy. In acidic tumor cells, NRs@Cur@Gox is specifically activated to improve the permeability of the membranes, resulting in increased hydrogen peroxide (H2O2) production via the catalysis of Gox. High H2O2 subsequently induces self‐destruction of the nanoreactor, releasing Cur and quinone methides to inhibit the expression of glucose transporter protein 1, generate lactate and deplete glutathione (GSH), respectively. Exhausted intracellular glucose and blockage of extracellular glucose transport interdict tumor cells from the root. Moreover, decreased lactate, increased H2O2, and GSH depletion synergistically activate ferroptosis. Starvation therapy combined with ferroptosis induces significant immunogenic cell death (ICD), promotes cytotoxic T lymphocyte proliferation, and inhibit PC regression. Importantly, the decreased lactate in the tumor microenvironment reverses immunosuppressive tumors into “hot” tumors, reinforcing the immunotherapeutic efficiency of NRs@Cur@Gox. Overall, this study provides a versatile metabolic intervention strategy for PC‐ferroptosis immunotherapy.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"36 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intensified Heterogeneous Growth of High‐Performance CHA Membranes from Hierarchical Zeolite T Seeds 分级沸石T种子制备高性能CHA膜的强化非均相生长研究

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-27 DOI: 10.1002/adfm.202511555

Linzhe Li, Xin Liu, Zihao Rei Gao, Zhanming Gao, Peng Wan, Wenfu Yan, Gaohong He, Cheng He, Jianhua Yang, Michael Tsapatsis

{"title":"Intensified Heterogeneous Growth of High‐Performance CHA Membranes from Hierarchical Zeolite T Seeds","authors":"Linzhe Li, Xin Liu, Zihao Rei Gao, Zhanming Gao, Peng Wan, Wenfu Yan, Gaohong He, Cheng He, Jianhua Yang, Michael Tsapatsis","doi":"10.1002/adfm.202511555","DOIUrl":"https://doi.org/10.1002/adfm.202511555","url":null,"abstract":"A new method for synthesizing high‐performance CHA zeolite membranes from 15 nm hierarchical zeolite T seeds using a small amount of gel is proposed. The growth of CHA membranes from T seeds is confirmed by X‐ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and fast fourier transform (FFT) patterns. Raman spectroscopy, aluminum and silicon mass balance calculation, and thermodynamic stability investigation follow the contribution of OFF dissolution to CHA growth. It is proposed that the facile decomposition of hierarchical T seeds for localized hetero‐growth of CHA membrane is enabled by their hierarchical high surface area mesostructure. In addition, crucial for the CHA growth is the use of a deposited small amount of gel with high precursor concentration. The CHA membrane exhibits the best separation performance among the reported tubular hydrophilic membranes for ethanol dehydration, with a steady‐state water flux of 4.4 and 3.6 kg m−2 h−1 under neutral and pH≈4 conditions, respectively, and a separation factor (S.F.) exceeding 8,000 after 154 h in operation. This work provides new insights into the seeded growth of zeolite membranes, enabling new synthetic pathways with high precursor utilization while ensuring high performance.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"26 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Multifunctionalized CO2‐Fixing Resin Transforms Paper to High‐Strength and Flame‐Retardant Plastic Substitutes 一种多功能二氧化碳固定树脂可将纸张转化为高强度和阻燃塑料替代品

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-27 DOI: 10.1002/adfm.202419554

Junqing Chen, Xinxin Yang, Le Yu, Yongheng Wang, Jingjing Li, Yuying Wu, Luhe Qi, Lu Chen, Jing Huang, Ziyang Lu, Chang Chen, Enlai Gao, He Liu, Chaoji Chen

{"title":"A Multifunctionalized CO2‐Fixing Resin Transforms Paper to High‐Strength and Flame‐Retardant Plastic Substitutes","authors":"Junqing Chen, Xinxin Yang, Le Yu, Yongheng Wang, Jingjing Li, Yuying Wu, Luhe Qi, Lu Chen, Jing Huang, Ziyang Lu, Chang Chen, Enlai Gao, He Liu, Chaoji Chen","doi":"10.1002/adfm.202419554","DOIUrl":"https://doi.org/10.1002/adfm.202419554","url":null,"abstract":"In the plastic industry, replacing petrochemical‐based polymers with naturally occurring bio‐polymers (represented by cellulose), is a very promising route to circumvent the plastic pollution issue. However, the implementation of this is severely hindered by the high water affinity and flammability of such materials. Here, a verstile non‐isocyanate polyurethane (NIPU) formulation composed of a CO2‐based cyclic carbonate compound, a reactive amino‐functionalized silicone oil concurrently capable of providing water‐resistance and a flame‐retardant moiety is designed. Compositing it with conventional cellulose paper (cellulose macrofiber network, CMN), a nonflammable and mechanically strong cellulose macrofiber network‐based biocomposite (CMN‐Biocomposite) can be easily obtained via transcarbamoylation reaction. Other than hydrogen bonding interaction among various components of CMN‐Biocomposite, the intermolecular bond exchange mechanism between the dynamic carbamate moiety and hydroxyl of the cellulose is also experimentally and computationally determined as the governing factor for the high tensile strength of up to 57.9 MPa. Additionally, benefiting from the dynamic nature of the carbamate bond, the CMN‐Biocomposite's processability and biodegradability outperform most petrochemical‐based plastics. The superiority of the proposed synthetic strategy in achieving the long‐term carbon neutrality goal by CO2 fixation and excellent performance for plastic applications make the CMN‐Biocomposite a very promising alternative to conventional plastics.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"22 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Conventional Two‐Electron to Emerging Multi‐Electron Zinc‐Iodine Batteries: Advantages, Challenges, and Future Perspectives 从传统的双电子到新兴的多电子锌碘电池：优势、挑战和未来展望

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-27 DOI: 10.1002/adfm.202511754

Zongyou Jiang, Xing Yang, Jing Zhang, Jiansheng Yang, Bowen Sun, Zhiqiang Sun, Jiaojiao Xue, Jinhai He, Zixu Sun, Hua Kun Liu, Shi Xue Dou

{"title":"From Conventional Two‐Electron to Emerging Multi‐Electron Zinc‐Iodine Batteries: Advantages, Challenges, and Future Perspectives","authors":"Zongyou Jiang, Xing Yang, Jing Zhang, Jiansheng Yang, Bowen Sun, Zhiqiang Sun, Jiaojiao Xue, Jinhai He, Zixu Sun, Hua Kun Liu, Shi Xue Dou","doi":"10.1002/adfm.202511754","DOIUrl":"https://doi.org/10.1002/adfm.202511754","url":null,"abstract":"This review highlights the progress and challenges in the development of aqueous zinc‐iodine batteries (ZiBs), emphasizing the shift from traditional two‐electron systems to advanced multi‐electron configurations. ZiBs are promising due to their abundant raw materials, environmental sustainability, and high theoretical capacity. However, issues like the polyiodide shuttle effect and zinc dendrite formation impede performance and stability. Recent advances in polar materials, catalysts, separators, and iodine‐anchoring compounds aim to enhance cycle life, specific capacity, and discharge voltage. Multi‐electron ZiBs, utilizing higher iodine oxidation states, offer improved energy density and efficiency, with innovations such as halide ions and organic molecules stabilizing high‐valence iodine species for enhanced electron transfer. Future directions include functional group engineering, stabilization of iodine species, material optimization, and AI‐assisted integration, enhancing energy density, lifespan, and cost‐effectiveness for large‐scale and portable applications.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"279 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual‐Structural Models of Porous Polyimide Thermal Insulation Materials: Heat‐Transfer Mechanism, Fabrication, and Modification Strategies 多孔聚酰亚胺绝热材料的双结构模型：传热机制、制造和改性策略

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-27 DOI: 10.1002/adfm.202510818

Yanjin Qu, Jie Liang, Fang Ye, Chen Li, Xiaomeng Fan, Qiang Song

{"title":"Dual‐Structural Models of Porous Polyimide Thermal Insulation Materials: Heat‐Transfer Mechanism, Fabrication, and Modification Strategies","authors":"Yanjin Qu, Jie Liang, Fang Ye, Chen Li, Xiaomeng Fan, Qiang Song","doi":"10.1002/adfm.202510818","DOIUrl":"https://doi.org/10.1002/adfm.202510818","url":null,"abstract":"The excellent intrinsic physicochemical properties of polyimide (PI)‐based materials lead to their popularity in the field of thermal insulation, with widespread use in aerospace, construction, microelectronics, and other areas. This work undertakes a comprehensive review of recent advances in porous PI thermal insulation materials and proposes a novel pore structure‐based classification criterion. First, the analysis of the specific models reveals the characteristics of pore structures and the internal heat transfer mechanism. Second, the main preparation and molding methods of each structure are compiled, and the modification schemes for optimize the thermal insulation effect are listed and analyzed. Finally, a comprehensive discussion on the merits and drawbacks associated with the two distinct structural characteristics is provided. It further explores the optimal application pathways for each characteristic, along with potential avenues for enhancement of the design and the expansion of the application domains. The insights derived from this study are anticipated to serve as a robust theoretical foundation and a crucial technical reference for the design and advancement of high‐performance PI‐class thermal insulation materials.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"246 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ligand‐Field Splitting Parameter Optimization Achieves Synergistic Enhancement of Transition Metal Redox Activity and Structural Stability in High‐Voltage Sodium Layered Oxide Cathodes 配体场分裂参数优化实现了高压钠层状氧化物阴极过渡金属氧化还原活性和结构稳定性的协同增强

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-27 DOI: 10.1002/adfm.202509825

Qiannan Zhou, Yu Li, Shuqiang Li, Zilu Wang, Qiaojun Li, Xueying Lu, Zhixu Qiu, Chuan Wu, Ying Bai

{"title":"Ligand‐Field Splitting Parameter Optimization Achieves Synergistic Enhancement of Transition Metal Redox Activity and Structural Stability in High‐Voltage Sodium Layered Oxide Cathodes","authors":"Qiannan Zhou, Yu Li, Shuqiang Li, Zilu Wang, Qiaojun Li, Xueying Lu, Zhixu Qiu, Chuan Wu, Ying Bai","doi":"10.1002/adfm.202509825","DOIUrl":"https://doi.org/10.1002/adfm.202509825","url":null,"abstract":"Triggering oxygen anionic redox to achieve high‐capacity NaxTMO2 faces a critical challenge because of the irreversible chemo‐mechanical distortion and uncontrollable oxygen release at high voltage. To circumvent this issue, a strategy of stimulating transition metal (TM) redox activity based on the ligand‐field splitting parameter (Δ) is proposed. Specifically, strongly polarized Mg−O−Fe configurations in the O3‐NaNi0.1Fe0.2Mn0.5Mg0.2O2 (O3‐NaNFMMO) is constructed to effectively optimize the electron occupancy state of Fe 3d orbital by reducing its Δ, thereby stimulating the Fe redox activity while alleviating excessive oxygen redox. Additionally, the Mg pillar in Na sites ensures more extractable Na+ and suppresses the Na‐free layers formation at high voltage, which can simultaneously improve the specific capacity and cycling stability. As a result, the designed cost‐effective O3‐NaNFMMO cathode delivers an outstanding specific capacity of 198 mAh g−1 at 0.1 C and high‐voltage cycling stability with 78% capacity retention after 1500 cycles at 5 C. Notably, the thermal degradation and air sensitivity, as the critical barriers to commercialization, are significantly suppressed in O3‐NaNFMMO cathode. This work establishes a universal design principle for high‐performance NaxTMO2 cathodes and offers a scalable pathway toward practical, cost‐effective SIBs.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"18 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scaling CO2 Electroreduction Revolution: Pathways from Laboratory Breakthroughs to Industrial Implementation 扩大二氧化碳电还原革命：从实验室突破到工业实施的途径

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-27 DOI: 10.1002/adfm.202508825

Qun Li, Xiaoyu You, Jiabin Wu, Zhiyong Tang

{"title":"Scaling CO2 Electroreduction Revolution: Pathways from Laboratory Breakthroughs to Industrial Implementation","authors":"Qun Li, Xiaoyu You, Jiabin Wu, Zhiyong Tang","doi":"10.1002/adfm.202508825","DOIUrl":"https://doi.org/10.1002/adfm.202508825","url":null,"abstract":"Electrocatalytic CO2 reduction reaction (CO2RR) offers a sustainable pathway to convert CO2 into value‐added fuels and chemicals using renewable energy. Recent breakthroughs in catalyst engineering and reactor design have achieved industrial‐relevant current density (>1 A cm⁻2) and high Faradaic efficiency (FE) (>80% for C1/C2+ products), but the technology remains constrained to laboratory prototypes. This review critically examines the engineering challenges hindering industrial deployment of CO2RR systems, focusing on three key Operational parameters in scaling implementation electrolyzer architectures: membrane electrode assemblies (MEAs), solid oxide electrolyzer cells (SOECs), and modular stack designs. The operational bottlenecks in scaling these systems, including mass transport limitation, conversion efficiency, and long‐term stability under industrial current densities, are systematically analyzed. By correlating material innovations with reactor engineering strategies, the critical challenges for achieving energy‐efficient CO2 conversion at scale are identified. The review further outlines technological roadmaps addressing material scalability, system durability, sustainability with intermittent renewables, and techno‐economic feasibility. Emphasizing the synergy between electrochemical engineering and industrial manufacturing requirements, this work provides practical guidelines to bridge the lab‐to‐industry gap, accelerating CO2RR commercialization for global carbon neutrality goals.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"26 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi‐Solvent Synergy Strategy Unlocks Anti‐Corrosion and High Reversibility of Zinc Anodes: Paving the Way for Robust and Temperature‐Resilient Zinc‐Iodine Batteries 多溶剂协同策略解锁锌阳极的抗腐蚀和高可逆性：为坚固和温度弹性锌碘电池铺平道路

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-27 DOI: 10.1002/adfm.202512633

Wenjuan Zhang, Yangyang Liu, Xiansheng Luo, Rui Wang, Kuan Zhou, Libei Yuan, Fujun Li, Hongbao Li, Longhai Zhang, Chaofeng Zhang

{"title":"Multi‐Solvent Synergy Strategy Unlocks Anti‐Corrosion and High Reversibility of Zinc Anodes: Paving the Way for Robust and Temperature‐Resilient Zinc‐Iodine Batteries","authors":"Wenjuan Zhang, Yangyang Liu, Xiansheng Luo, Rui Wang, Kuan Zhou, Libei Yuan, Fujun Li, Hongbao Li, Longhai Zhang, Chaofeng Zhang","doi":"10.1002/adfm.202512633","DOIUrl":"https://doi.org/10.1002/adfm.202512633","url":null,"abstract":"Aqueous zinc–iodine (Zn||I2) batteries exhibit significant potential for large‐scale energy storage, but their reversibility and cycle stability remain considerable challenges due to the severe side reactions on Zn anode and the shuttle effects of polyiodide ions. Here, a ternary co‐solvents electrolyte, including diethyl carbonate, ethyl acetate, and H2O, is developed to effectively address the above issues. Specifically, the multi‐solvents cooperatively reconstruct the solvation structure of Zn2+ and disrupt the strong bonding between H2O, markedly suppressing the water‐induced parasitic reactions and reducing the freezing point of the electrolyte. Meanwhile, the reduced H2O content in the hybrid electrolyte significantly inhibits the solubility of iodine and thus impedes polyiodide shuttling. Furthermore, theoretical simulations combined with operando electrochemical quartz crystal microbalance with dissipation monitoring (EQCM‐D) and X‐ray photoelectron spectroscopy reveal that the OTf− anions will be profoundly reduced to produce a F‐rich inorganic–organic solid electrolyte interphase layer (SEI) on the Zn surface under the synergistic effect of the solvent molecules, effectively suppressing the formation of Zn dendrites and anode corrosion caused by active H2O and polyiodide ions. Consequently, the Zn||I2 batteries demonstrate stable operational performance across an extended temperature range from −30 to 50 °C, achieving a maximum lifespan of 20 000 cycles.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"7 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential Compartmentalization of Enzymatic Reactions for Lactate Signaling Across Protocells 乳酸信号传导在原细胞中酶促反应的差异区隔化

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-27 DOI: 10.1002/adfm.202504939

Arianna Balestri, Xinan Huang, Emanuel Lörtscher, Cora‐Ann Schoenenberger, Cornelia G. Palivan

{"title":"Differential Compartmentalization of Enzymatic Reactions for Lactate Signaling Across Protocells","authors":"Arianna Balestri, Xinan Huang, Emanuel Lörtscher, Cora‐Ann Schoenenberger, Cornelia G. Palivan","doi":"10.1002/adfm.202504939","DOIUrl":"https://doi.org/10.1002/adfm.202504939","url":null,"abstract":"Protocells, by breaking down the intricate complexity of eukaryotic cells, are innovative tools for mimicking and understanding cellular phenomena. Protocells based on giant unilamellar vesicles (GUVs) supplemented with active species facilitate in situ biologically relevant enzymatic reactions. However, replicating intercellular communication in synthetic systems remains a major challenge for bottom‐up approaches. Here, this challenge is addressed by creating two different populations of protocells that communicate in a controlled and directional manner. By using double emulsion microfluidics, each protocell type consists of GUVs containing distinct biomolecules and artificial organelles (AOs) with unique structures and functions. A series of chemical reaction networks controlling the activity of the AOs provides the framework for the directional, lactate‐mediated intercellular communication between protocells. The coordinated series of compartmentalized enzymatic reactions demonstrate that the intercellular communication is i) selective for lactate, ii) tunable according to its concentration; and iii) sensitive to the sender/receiver protocell ratio and thus, the distance between them. These protocells capable of collective behavior by intercellular signaling have unique advantages for understanding complex biological processes and serve as a basis for the development of advanced therapeutic strategies by interfacing synthetic protocells with native cells.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"18 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low‐Dielectric and Submicron‐Resolution Photosensitive Polyimide Substrate for Large‐Scale Pattern Customization and Low‐Signal‐Loss Transmission with Nanotesla‐Scale Quantum Sensing Potential 低介电和亚微米分辨率光敏聚酰亚胺衬底用于大规模图案定制和具有纳米特斯拉级量子传感电位的低信号损耗传输

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-06-27 DOI: 10.1002/adfm.202509278

Zhiyuan Peng, An Ye, Yubin Pu, Yutong Tang, Ling Zhang, Yueping Niu, Chunzhong Li

{"title":"Low‐Dielectric and Submicron‐Resolution Photosensitive Polyimide Substrate for Large‐Scale Pattern Customization and Low‐Signal‐Loss Transmission with Nanotesla‐Scale Quantum Sensing Potential","authors":"Zhiyuan Peng, An Ye, Yubin Pu, Yutong Tang, Ling Zhang, Yueping Niu, Chunzhong Li","doi":"10.1002/adfm.202509278","DOIUrl":"https://doi.org/10.1002/adfm.202509278","url":null,"abstract":"Photosensitive polyimide (PSPI) integrates photoresist and dielectric interlayer functions for efficient electronic fabrication, yet suffers from limited resolution and elevated dielectric constants, particularly in advanced integrated circuits (ICs). In this study, through integrated molecular design and component screening, a novel PSPI system incorporating intrinsically low‐polarization photosensitive groups and efficient chemical amplification is found to exhibit low dielectric properties (ɛ = 2.241, tanδ = 0.0137 at 10 GHz), submicron‐level resolution (≈880 nm), low thermal imidization temperature (180°C), and low coefficient of thermal expansion (26 ppm K−1). This PSPI system is fully compatible with modern IC manufacturing processes, and its superior photosensitivity (33.15 mJ cm⁻2) and high contrast (3.03) further support laser direct writing. Moreover, as an encapsulation material and dielectric interlayer in flexible multilayer circuits, the PSPI system demonstrates robust bending durability and enhances high‐frequency signal integrity with minimal parasitic capacitance. Coupled with nanodiamond nitrogen‐vacancy centers, low‐dielectric PSPI‐based circuit boards significantly improve quantum sensing and imaging, providing higher signal fidelity and enabling precise nanotesla‐scale measurements in weak magnetic fields. This breakthrough advances the resolution of PSPI to an unprecedented nanometer scale while maintaining exceptional dielectric performance, establishing it as a pivotal enabler for next‐generation flexible integrated systems requiring precise signal transmission.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"17 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0