Advanced Functional Materials最新文献_第4页

Capping Effect on High‐Active Nucleated‐Zn Toward Hydrogen Evolution‐Free Zn Metal Batteries

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-01-06 DOI: 10.1002/adfm.202421442

Jianping Chen, Wanyu Zhao, Jinlei Zhang, Bowen Zhang, Ke Ye, Shangyu Liu, Jun Zhong, Xiaoli Zhao, Zhenghui Pan, Xiaowei Yang

{"title":"Capping Effect on High‐Active Nucleated‐Zn Toward Hydrogen Evolution‐Free Zn Metal Batteries","authors":"Jianping Chen, Wanyu Zhao, Jinlei Zhang, Bowen Zhang, Ke Ye, Shangyu Liu, Jun Zhong, Xiaoli Zhao, Zhenghui Pan, Xiaowei Yang","doi":"10.1002/adfm.202421442","DOIUrl":"https://doi.org/10.1002/adfm.202421442","url":null,"abstract":"Aqueous Zn‐ion batteries are promising for large‐scale energy storage due to low cost and high safety. However, aqueous electrolyte induces severe side reactions at Zn anode, especially hydrogen evolution reaction (HER). Herein, it is first revealed that the freshly nucleated‐Zn (FN‐Zn) atoms during plating process show higher reactivity and stronger adsorption of proton than metallic Zn anode by X‐ray absorption near edge structure (XANES) and corresponding extended X‐ray absorption fine structure (EXAFS), and density functional theory simulations, promoting the decomposition of H2O. Then, a universal and effective capping effect strategy is proposed to alleviate HER by electrostatically shielding FN‐Zn activity. Specifically, sodium benzenesulfonate (SBS) is selected as a typical example by screening and comparing a series of electrolyte additives, in which sulfonate group with high coordination energy can be preferentially capped on FN‐Zn to reduce its reactivity. Consequently, the symmetrical cell with SBS not only generates negligible amounts of H2 by in situ electrochemical‐gas chromatography but also can be up to 2550 h at 1 mA cm−2. More importantly, the capping effect on HER‐free Zn anode is verified by coin full cells exhibiting capacity retention of≈87.1% after 1000 cycles and large‐area (4 × 6 cm2) pouch cells with desired performance.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"126 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transparent, Anti-Fouling and Mechanically Stable Coating with Hybrid Architecture Inspired by Corn Bracts-Coating Strategy

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-01-06 DOI: 10.1002/adfm.202418795

Yixue Wang, Rui Sun, Wei Zhao, Xinbo Lu, Weiqiang Xiao, Fandong Meng, Xiaoli Zhan, Jianguo Lu, Feng Gao, Qinghua Zhang

{"title":"Transparent, Anti-Fouling and Mechanically Stable Coating with Hybrid Architecture Inspired by Corn Bracts-Coating Strategy","authors":"Yixue Wang, Rui Sun, Wei Zhao, Xinbo Lu, Weiqiang Xiao, Fandong Meng, Xiaoli Zhan, Jianguo Lu, Feng Gao, Qinghua Zhang","doi":"10.1002/adfm.202418795","DOIUrl":"https://doi.org/10.1002/adfm.202418795","url":null,"abstract":"In the quest for advanced coatings suitable for foldable electronics and photovoltaic systems, there is a pressing need for materials that combine transparency with durability. To address this, innovative special horizontal stripes transparent (SHT) coating is prepared by capillary gravity self-assembly methods. This coating is derived from the structural principles of corn bracts and is created through the crosslinking of epoxy hydrophobic modified SiO2 with an epoxy organosilicon prepolymer, bridged by a double terminal amino polydimethylsiloxane. The special pattern of the surface makes the SHT coating more transparent than glass, and the special bionic structure is proven to be highly durable under extreme temperature fluctuations, withstanding tests from 150 to −20 °C over 192 h, and enduring 30 days of ultraviolet radiation exposure at 365 nm with an intensity of 30 W m−2. Moreover, even after 3000 cycles of scissors abrasion, the SHT maintained its anti-fouling properties and mechanical resilience. It also demonstrated remarkable chemical stability across a range of solvents. The SHT coating can be easily applied to various flexible and rigid substrates using a brush, the SHT coating is poised to find broad applications in the realm of foldable optical devices.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"35 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142935253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoengineered Surfaces for Robust Droplet TENGs: Mitigating Contamination and Improving Longevity

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-01-06 DOI: 10.1002/adfm.202419050

Ying Ge, Huaifang Qin, Jingjing Wang, Jingjing Zhang, Zunkang Zhou, Yao Meng, Zanying Huang, Ke Yang, Zuliang Du, Peng Cui, Gang Cheng

{"title":"Nanoengineered Surfaces for Robust Droplet TENGs: Mitigating Contamination and Improving Longevity","authors":"Ying Ge, Huaifang Qin, Jingjing Wang, Jingjing Zhang, Zunkang Zhou, Yao Meng, Zanying Huang, Ke Yang, Zuliang Du, Peng Cui, Gang Cheng","doi":"10.1002/adfm.202419050","DOIUrl":"https://doi.org/10.1002/adfm.202419050","url":null,"abstract":"The droplet triboelectric nanogenerator (D-TENG) harnesses energy from natural water droplets, though its performance and lifespan can be compromised by contamination on the functional layer. Water molecules have a strong affinity for polymer surfaces, which increases surface tension and the sliding-off angle, leading to greater droplet adhesion. As these droplets evaporate, they leave behind residues, such as calcium (Ca) and magnesium (Mg) salts, that obscure the polymer surface, thereby diminishing the electrification area and altering droplet dynamics—resulting in decreased electrical output. This study presents a micro-nanostructured D-TENG with advanced anti-fouling capabilities. By adding a layer of metal nanoparticles to the polymer surface, followed by ion etching and fluorination grafting, water retention and ion accumulation are effectively minimized. The anti-fouling D-TENG demonstrates a fourfold increase in electrical output compared to its predecessor. Following 10 000 droplet interactions, the output of the original D-TENG drops by 53%, whereas the anti-fouling variant only experiences a 7% reduction. These enhancements provide significant insights for D-TENG applications and contribute to the development of anti-fouling strategies.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"36 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 2D Shaping 3D Strategy to Construct Hierarchical Microstructures Based on Heterogeneous Wettability

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-01-06 DOI: 10.1002/adfm.202420550

Huizeng Li, Kaixuan Li, Xinye Yu, Weidong Zhao, An Li, Zheren Cai, Renxuan Yuan, Quan Liu, Wanling Liu, Mingzhu Li, Yanlin Song

{"title":"A 2D Shaping 3D Strategy to Construct Hierarchical Microstructures Based on Heterogeneous Wettability","authors":"Huizeng Li, Kaixuan Li, Xinye Yu, Weidong Zhao, An Li, Zheren Cai, Renxuan Yuan, Quan Liu, Wanling Liu, Mingzhu Li, Yanlin Song","doi":"10.1002/adfm.202420550","DOIUrl":"https://doi.org/10.1002/adfm.202420550","url":null,"abstract":"Through rational design and elaborate preparation, simple materials can be evolved into microstructures with 3D morphology. Benefiting from their unique morphology and composition, these 3D microstructures exhibit exceptional optic/electric properties that surpass those of their building blocks. Self‐assembly relies on control of liquid behavior and morphology, and can efficiently aggregate building blocks into ordered microstructures. However, under the principle of surface energy minimization, the self‐assembled microstructures are constrained by limited morphology and monotonous component. Herein, the assembly of microstructures with controllable morphology and composite components is achieved, through effectively controlling 3D liquid behaviors and morphologies using 2D heterogeneous wettability. It is revealed that the heterogeneous wettability surface can induce stepwise liquid behaviors, which rapidly split suspension into isolated liquid bridges, then gradually shrink for 3D assembly. Through surface wettability control, this strategy not only extends into a printing‐like approach to deposit microstructures on target surface, but also facilitates the fabrication of composite microstructures with multi‐components. Taking advantage of the 3D morphology, the heterogeneous wettability, and the multi‐components, the resulting composite microstructures exhibits ultra‐sensitive detection capability. It is anticipated that this 2D‐shaping‐3D strategy opens a facile avenue to fabricate hierarchical microstructures for optic/electronic and sensing applications.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"27 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence of Relativistic Field‐Derivative Torque in Nonlinear THz Response of Magnetization Dynamics

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-01-06 DOI: 10.1002/adfm.202414582

Arpita Dutta, Christian Tzschaschel, Debankit Priyadarshi, Kouki Mikuni, Takuya Satoh, Ritwik Mondal, Shovon Pal

{"title":"Evidence of Relativistic Field‐Derivative Torque in Nonlinear THz Response of Magnetization Dynamics","authors":"Arpita Dutta, Christian Tzschaschel, Debankit Priyadarshi, Kouki Mikuni, Takuya Satoh, Ritwik Mondal, Shovon Pal","doi":"10.1002/adfm.202414582","DOIUrl":"https://doi.org/10.1002/adfm.202414582","url":null,"abstract":"Understanding the complete light‐spin interactions in magnetic systems is the key to manipulating the magnetization using optical means at ultrafast timescales. The selective addressing of spins by THz electromagnetic fields via Zeeman torque is one of the most successful ultrafast means of controlling magnetic excitations. Here it is showed that this traditional Zeeman torque on the spins is not sufficient, rather an additional relativistic field‐derivative torque is essential to realize the observed magnetization dynamics. This is accomplished by exploring the ultrafast nonlinear magnetization dynamics of rare‐earth, Bi‐doped iron garnet when excited by two co‐propagating THz pulses. First, by exciting the sample with an intense THz pulse and probing the magnetization dynamics using magneto‐optical Faraday effect, the collective exchange resonance mode is found between rare‐earth and transition metal sublattices at 0.48 THz. Further, the magnetization dynamics are explored via the THz time‐domain spectroscopic means. It is found that the observed nonlinear trace of the magnetic response cannot be mapped to the magnetization precession induced by the Zeeman torque, while the Zeeman torque supplemented by an additional field‐derivative torque follows the experimental evidences. This breakthrough enhances the comprehension of ultra‐relativistic effects and paves the way toward novel technologies harnessing light‐induced control over magnetic systems.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"12 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure Engineering by Picosecond Laser Lithography Boosts Highly Reversible Zn Anode

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-01-06 DOI: 10.1002/adfm.202417546

Shengkang Zhan, Zixuan Liu, Fanghua Ning, Xiaoyu Liu, Ye Dai, Shigang Lu, Yongyao Xia, Jin Yi

{"title":"Structure Engineering by Picosecond Laser Lithography Boosts Highly Reversible Zn Anode","authors":"Shengkang Zhan, Zixuan Liu, Fanghua Ning, Xiaoyu Liu, Ye Dai, Shigang Lu, Yongyao Xia, Jin Yi","doi":"10.1002/adfm.202417546","DOIUrl":"https://doi.org/10.1002/adfm.202417546","url":null,"abstract":"The practical application of aqueous zinc ion batteries (AZIBs) is impeded by the instability of the Zn anode|electrolyte interface, including dendrite growth, hydrogen evolution reaction (HER), and corrosion. Herein, the periodical micro‐nano structure is constructed on the surface of Zn anode through picosecond laser lithography (PLL) technology. This micro‐nano surface structure is conductive to obtain hydrophobicity for diminishing direct contact between the electrolyte and Zn anode, enhancing the corrosion resistance of the Zn anode. Simultaneously, the low surface energy and reconstructed electric field are achieved through laser‐induced texture microstructure, leading to the oriented Zn2+ deposition along the (002) plane. As a result, the lower electrochemical polarization and long cycling stability of 1400 h for Zn||Zn symmetric cell is achieved at 4 mA cm−2 and 2 mAh cm−2. The average coulombic efficiency (CE) of the Zn||Cu cell is enhanced to 99.83% at 2 mA cm−2, while the Zn||MnO2 cell delivers a capacity retention of 68.7% after 600 cycles at 1 A g−1. Consequently, the advantages of micro‐nano structure can highlight the importance of surface structure design for the development of stable Zn anode.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"73 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transmission-Reflection-Integrated Programmable Metasurface for Simultaneous and Independent Control of Bidirectional Incident Waves

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-01-06 DOI: 10.1002/adfm.202419681

Jun Yang, Yin Li, Jun Wei Wu, Jun Yan Dai, Si Ran Wang, Hui Dong Li, You Jia Chen, Qiang Cheng

{"title":"Transmission-Reflection-Integrated Programmable Metasurface for Simultaneous and Independent Control of Bidirectional Incident Waves","authors":"Jun Yang, Yin Li, Jun Wei Wu, Jun Yan Dai, Si Ran Wang, Hui Dong Li, You Jia Chen, Qiang Cheng","doi":"10.1002/adfm.202419681","DOIUrl":"https://doi.org/10.1002/adfm.202419681","url":null,"abstract":"The flexible control of electromagnetic (EM) waves across the entire spatial domain is a long-standing aspiration in metasurface research, driven by its potential to enhance signal coverage and channel capacity. However, most existing full-space metasurfaces are restricted to manipulating incidence within one specific half-space, failing to exploit the EM potential across the entire space. This paper introduces a novel bidirectional transmission-reflection-integrated metasurface (BTRIM) for simultaneous and independent control of full-space incident waves. By dynamically adjusting diode states, the BTRIM can switch among simultaneous and independent forward/backward reflection, forward transmission-reflection (TR), and backward TR functions, each with an independent 1-bit phase response. The core innovation lies in integrating transmission and reflection within a single structure, enabling the metasurface to function at the same frequency and polarization within a compact design. Simulations and experimental validation are conducted to demonstrate BTRIM's ability to implement various wave functions and enhance signal intensity for users in both indoor and outdoor environments. The agreement between simulation and experimental results validates the BTRIM's capacity to simultaneously and independently regulate EM waves from all spatial directions, offering new insights into full-space wave manipulation. This breakthrough creates opportunities for applications in EM sensing, channel enhancement, and next-generation communication systems.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"203 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlling Crystallization Dynamics of the Perovskite by Restricted Assembly Strategy Enables High‐Performance Solar Cells

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-01-06 DOI: 10.1002/adfm.202421910

Haozhe Zhang, Qu Yang, Zhuojun Jiang, Xuncheng Liu, Cheng Liu, Zonghao Liu, Xingyu Gao, Hui Shen, Zhenhuang Su, Xiu Gong

{"title":"Controlling Crystallization Dynamics of the Perovskite by Restricted Assembly Strategy Enables High‐Performance Solar Cells","authors":"Haozhe Zhang, Qu Yang, Zhuojun Jiang, Xuncheng Liu, Cheng Liu, Zonghao Liu, Xingyu Gao, Hui Shen, Zhenhuang Su, Xiu Gong","doi":"10.1002/adfm.202421910","DOIUrl":"https://doi.org/10.1002/adfm.202421910","url":null,"abstract":"Multifunctional polymer materials are extensively applied to regulate the crystallization process of perovskite films. However, a comprehensive understanding of the correlations among spatial structure of polymers, crystallization modulation, and device performance is still lacking. Here, a restricted assembly strategy is proposed to prepare high‐quality perovskite films by systematically studying the effect of space configurations of polymers on modulating the crystallization of cesium lead triiodide (CsPbI3) perovskite. The results confirm the importance of high backbone coplanar space configurations in promoting nucleation, accelerating phase transitions, and enhancing crystalline orientation. The polymer with the high backbone coplanar structure not only facilitates the formation of uniform and dense nucleation sites by precisely controlling the spatial distribution of colloidal particles but also enhances the crystal orientation through the orientational growth induced by the coplanar structure. As a result, the efficiency of the CsPbI3 solar cells increases from 17.84% to 20.39%. Additionally, the unencapsulated devices show excellent storage and operational stability.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"55 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Electrolyte Decomposition on Copper Corrosion in Li6PS5Cl‐Based All‐Solid‐State Batteries

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-01-06 DOI: 10.1002/adfm.202420474

Ohmin Kwon, Juhui Kang, Suhyeon Kim, Taeho Yoon

{"title":"Impact of Electrolyte Decomposition on Copper Corrosion in Li6PS5Cl‐Based All‐Solid‐State Batteries","authors":"Ohmin Kwon, Juhui Kang, Suhyeon Kim, Taeho Yoon","doi":"10.1002/adfm.202420474","DOIUrl":"https://doi.org/10.1002/adfm.202420474","url":null,"abstract":"All‐solid‐state batteries (ASSBs) with sulfide‐based electrolytes, such as argyrodite (Li₆PS₅Cl, LPSCl), offer significant advantages regarding safety and energy density. However, conventional Cu current collectors with LPSCl suffer from corrosion, necessitating a deeper understanding of appropriate mechanisms and strategies to address them. This study investigates the impact of electrolyte decomposition on Cu degradation in sulfide‐based ASSBs. Accelerated experiments reveal that LPSCl decomposition forms an ineffective passive layer on Cu, resulting in significant corrosion above 2 V during delithiation. In addition, the corrosion potential implies that sulfide and chlorine species are involved in the corrosion reaction. Comparative analyses with Ni current collectors, which are known for their resistance to the corrosive species, demonstrate superior stability to Cu. Corrosion‐prevention strategies are proposed based on the elucidated mechanisms, with the Pilling–Bedworth ratio explaining why certain metal sulfide layers formed during electrolyte decomposition may fail to effectively prevent corrosion. These insights support the development of targeted protective strategies and alternative current collector materials to enhance the durability and performance of sulfide‐based ASSBs.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"2 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fe2O3 Hollow Multishelled Structure Endowed Temporal Sequential Mass Release for Apoptosis/Ferroptosis‐Induced Combined Cancer Therapy

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-01-06 DOI: 10.1002/adfm.202419892

Ke Xu, Bin Guan, Yujie Cui, Linlin Qin, Hao Li, Hongfei Cheng, Dan Wang, Yuming Zhu, Gening Jiang, Siming Jiang, Decai Zhao, Zhao Li

{"title":"Fe2O3 Hollow Multishelled Structure Endowed Temporal Sequential Mass Release for Apoptosis/Ferroptosis‐Induced Combined Cancer Therapy","authors":"Ke Xu, Bin Guan, Yujie Cui, Linlin Qin, Hao Li, Hongfei Cheng, Dan Wang, Yuming Zhu, Gening Jiang, Siming Jiang, Decai Zhao, Zhao Li","doi":"10.1002/adfm.202419892","DOIUrl":"https://doi.org/10.1002/adfm.202419892","url":null,"abstract":"Cisplatin (CDDP) combined with pemetrexed (MTA) is commonly employed in the treatment of advanced non‐small cell lung cancer. However, conventional clinical administration methods fail to achieve precise spatiotemporal delivery within the tumor microenvironment (TME), resulting in inadequate control of local drug concentrations and impeding the synergistic efficacy of chemotherapeutic drugs. Aiming to address this issue, Fe2O3 hollow multi‐shelled structure (HoMS) nanocarriers with spatiotemporally controlled release properties and co‐encapsulated CDDP and MTA into this nanocarrier are developed. The confined microenvironment provided by Fe2O3‐HoMS enables a targeted and temporal sequential drug release tailored to clinical requirements. Furthermore, chemotherapy‐induced DNA damage leads to apoptosis, accompanied by a substantial generation of reactive oxygen species (ROS). The disruption of ROS homeostasis subsequently activates the ferroptosis pathway mediated by Fe2O3‐HoMS. In summary, Fe2O3‐HoMS exhibits a highly controlled and temporal sequential release of two chemotherapeutic drugs in TME, and the HoMS nanocarriers are further involved in the regulation of ferroptosis, realizing a triple sequential delivery system comprising CDDP‐MTA‐Fe2+ and thus significantly enhancing the anti‐tumor efficacy against lung cancer. This study proposes a novel approach for temporal sequential drug delivery by optimizing nanocarrier design, addressing the clinical challenge of precisely controlled drug release within tumors.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"7 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0