Advanced Functional Materials最新文献_第5页

Ultrahigh Energy Storage in Relaxor Ferroelectric Ceramics with Core–Shell Grains 具有核壳晶粒的弛豫铁电陶瓷中的超高能量存储

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-03-30 DOI: 10.1002/adfm.202503798

Qizhen Chai, Peng Tan, Leiyang Zhang, Zhaobo Liu, Santan Dang, Zhanhui Peng, Di Wu, Xiaodong Xu, Bohan Xing, Xiaolian Chao, Houbing Huang, Shujun Zhang, Zupei Yang

{"title":"Ultrahigh Energy Storage in Relaxor Ferroelectric Ceramics with Core–Shell Grains","authors":"Qizhen Chai, Peng Tan, Leiyang Zhang, Zhaobo Liu, Santan Dang, Zhanhui Peng, Di Wu, Xiaodong Xu, Bohan Xing, Xiaolian Chao, Houbing Huang, Shujun Zhang, Zupei Yang","doi":"10.1002/adfm.202503798","DOIUrl":"https://doi.org/10.1002/adfm.202503798","url":null,"abstract":"The achievement of record-high energy storage performance in relaxor-ferroelectric bulk ceramics represents a major advancement in the field of dielectric capacitors. Nonetheless, a trade-off between breakdown strength and polarization has typically limited the optimization of overall performance. Here, guided by a rational composition design, K0.5Na0.5NbO3-based bulk ceramics are fabricated with grain core–shell structures and polymorphic nanodomains, leading to a synergistic enhancement of breakdown strength and polarization. This results in an unprecedented recoverable energy density of ≈20.4 J·cm−3 and an energy efficiency of ≈90% at an electric field of ≈1020 kV·cm−1. Additionally, the ceramics exhibits excellent charge–discharge performance, including a high discharge energy density of ≈6.0 J·cm−3 and an ultrashort discharge time of ≈42 ns at 500 kV·cm−1, along with superior reliability and stability. These advancements are expected to provide valuable insights for the exploration and utilization of advanced dielectric materials.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"29 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil Extracellular Traps: Emerging Biomarker and Prototype of Functional Materials

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-03-30 DOI: 10.1002/adfm.202425035

Bo Pang, Liping Wen, Linlin Zheng, Jia Wei, Tengda Xu, Yongyang Song, Juan Li, Shutao Wang

{"title":"Neutrophil Extracellular Traps: Emerging Biomarker and Prototype of Functional Materials","authors":"Bo Pang, Liping Wen, Linlin Zheng, Jia Wei, Tengda Xu, Yongyang Song, Juan Li, Shutao Wang","doi":"10.1002/adfm.202425035","DOIUrl":"https://doi.org/10.1002/adfm.202425035","url":null,"abstract":"Functional biomaterials composed of multiple biomacromolecules have significant advantages over those made from a single type. However, harmoniously integrating various biomacromolecules remains challenging. Neutrophil extracellular traps (NETs), an emerging biological structure released from neutrophils, serve as a natural prototype worth investigating and learning from. NETs consist of intricate biomacromolecules and exhibit web-like microstructure, endowing them with multifaceted roles in both physiological and pathological processes. In this review, research progress is systematically examined on NETs from a materials science perspective. First, the origin and transformation of NETs are introduced, and their functional mechanisms of various NET components are thoroughly dissected rather than conventionally treating NETs as a single entity. Second, given their complex components and functions, NETs are revealed as a potential biomarker for disease prediction. Third, typical characterization technologies for the analysis of NETs are summarized. Fourth, artificial materials inspired by NETs are discussed. In addition, the natural regulatory processes of NETs provide bio-inspired prototypes for the design of advanced functional materials. Finally, perspectives on the opportunities and challenges in advancing NETs are presented as emerging biomarkers and models for the development of bio-inspired materials.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"183 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathogenesis Activated “In Situ Disassembly-Reassembly” Pattern Dual-Scavenges Cell-Free DNA/ROS for Hemorrhagic Stroke Management

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-03-30 DOI: 10.1002/adfm.202424358

Yibin Zhang, Xuegang Niu, Xiaoyu Wang, Yi Wu, Jiangnan Sun, Shen Lin, Fuxin Lin, Yuanxiang Lin, Dezhi Kang, Bin Gao

{"title":"Pathogenesis Activated “In Situ Disassembly-Reassembly” Pattern Dual-Scavenges Cell-Free DNA/ROS for Hemorrhagic Stroke Management","authors":"Yibin Zhang, Xuegang Niu, Xiaoyu Wang, Yi Wu, Jiangnan Sun, Shen Lin, Fuxin Lin, Yuanxiang Lin, Dezhi Kang, Bin Gao","doi":"10.1002/adfm.202424358","DOIUrl":"https://doi.org/10.1002/adfm.202424358","url":null,"abstract":"Intracerebral hemorrhage (ICH) causes uncontrolled neuroinflammation/oxidative stress to aggravate secondary brain injury (SBI) for high mortality and disability but lacks effective pharmacotherapy in clinical practices. This represents an imperative need to discover potential targets and develop advanced therapeutic strategies. Herein, it is discovered that cell-free DNA (cfDNA, a driving factor of inflammation) level in serum positively correlates with SBI severity and it is speculated as a potential targeting molecule. However, traditional cfDNA-scavenging materials are mainly limited within the polycationic type and exist severe side effects. Herein, this work designs a drug delivery nanosystem, which utilizes a pathogenesis-activated sequential disassembly-reassembly process to in situ dual-scavenge cfDNA and ROS for the regulation of neuroinflammation/oxidative stress, thereby reducing SBI and preventing further damage in experimental mice. The findings not only demonstrate the importance of cfDNA in SBI but also provide an advanced pharmacotherapy to enhance therapeutic potential toward the effective alleviation on SBI following ICH.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"5 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

β-Cyclodextrin/Amantadine Co-Assembled Hollow Nanocapsules Realize the Rapid Leaf Adhesion and Bacterial Biofilm Disassembly for Rice and Citrus Protections

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-03-30 DOI: 10.1002/adfm.202422669

Qingchuan Shi, Run Yang, Jinghan Yang, Pan Liu, Juan Liu, Peiyi Wang

{"title":"β-Cyclodextrin/Amantadine Co-Assembled Hollow Nanocapsules Realize the Rapid Leaf Adhesion and Bacterial Biofilm Disassembly for Rice and Citrus Protections","authors":"Qingchuan Shi, Run Yang, Jinghan Yang, Pan Liu, Juan Liu, Peiyi Wang","doi":"10.1002/adfm.202422669","DOIUrl":"https://doi.org/10.1002/adfm.202422669","url":null,"abstract":"A superior bactericide to accomplish its efficient bactericidal function requires breaking through stubborn biofilm barriers and achieving efficient leaf adsorption. To overcome this challenge, supramolecular self-assembly strategies are employed to fabricate multifunctional aggregates. Herein, a versatile supramolecular inclusion—AdA8@β-CD is constructed by loading an amantadine-modified bactericidal structure (AdA8) into β-cyclodextrin (β-CD) via host–guest recognition driving force, which spontaneously self-assembles into biocompatible hollow nanocapsules. This smart optimization not only allows the bactericides to quickly stay on the hydrophobic leaves, preventing their droplets from splashing and bouncing but also improves the performance of removing biofilm barriers. At a lower concentration of 5 µg mL−1, the disruption rate of AdA8@β-CD to Xanthomonas biofilm reaches 78.3%. Moreover, AdA8@β-CD enhances the limitation of bacterial motility and extracellular enzyme secretion, thereby reducing bacterial colonization and pathogenicity. These reformative properties are undoubtedly transmitted to in vivo activity, providing corresponding preventive efficacies of 51.1% and 73.2% against rice bacterial blight and citrus canker at 200 µg mL−1, which are notably better than those of traditional agrochemicals—thiodiazole-copper-20%SC (33.9%/37.4%), kasugamycin (28.7%), and AdA8 itself (43.8%/45.3%). Furthermore, this oligosaccharide-coated bactericide—AdA8@β-CD exhibits good biosafety and is more eco-friendly. This study is instructive for the creation of multifunctional green agrochemicals.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"31 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microporous Polyacylhydrazone Membranes with 3D Interconnected Nanochannels for Accurate Molecular Sieving

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-03-30 DOI: 10.1002/adfm.202504997

Lei Ge, Jiaqi Li, Gaojing Du, Kai Sheng, Jingwei Hou, Binyu Zhou, Yatao Zhang, Bart Van der Bruggen, Junyong Zhu

{"title":"Microporous Polyacylhydrazone Membranes with 3D Interconnected Nanochannels for Accurate Molecular Sieving","authors":"Lei Ge, Jiaqi Li, Gaojing Du, Kai Sheng, Jingwei Hou, Binyu Zhou, Yatao Zhang, Bart Van der Bruggen, Junyong Zhu","doi":"10.1002/adfm.202504997","DOIUrl":"https://doi.org/10.1002/adfm.202504997","url":null,"abstract":"Microporous membranes featuring 3D nanochannels present a compelling avenue for energy-efficient liquid separations, attributable to their tunable interconnected through-pore structures. However, the rational design of 3D-nanochannel membranes that simultaneously achieve high permeance and selectivity remains a challenge, arising from the scarcity of appropriate molecular building blocks and the reliance on empirical synthetic methods. Herein, an innovative 3D polyacylhydrazone (PAH) membrane with unique pore-interconnected structures is constructed on a porous hydrogel using contorted tetrahedral aldehydes (TFS) monomers via an in situ interface-confined strategy. Manipulation of side alkyl chain lengths within terephthalohydrazide (TPH) derivates enabled the enhancement of microporosity and tunable pore environment of PAH nanofilms. Molecular dynamics simulations revealed that TPHEO linkers with higher reactivity and moderate steric hindrance facilitate superior pore interconnectivity and sharpened pore size distributions. The resulting PAH membranes achieved exceptional methanol permeances of 10.1 L m−2 h−1 bar−1 and small molecular weight cut-offs of 310 Da, outperforming the state-of-the-art polyamide membranes. This further translated into an outstanding capability in the fractionation of active pharmaceutical ingredients within organic solvent systems. This work demonstrates the efficacy of rational molecular design in developing high-microporosity membranes with tailored interconnected nanochannels, underscoring the potential of 3D microporous membranes for accurate molecular separations.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"32 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adjustable Room-Temperature Phosphorescence through Tunable Aggregation of Dopants in Polymers and its Application in Hydrazine Hydrate Detection

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-03-30 DOI: 10.1002/adfm.202502811

Yawen Zhang, Mingxue Gao, Ruimin Wu, Yunshu Meng, Nan Li, Zhijian Chen, Manman Fang, Jie Yang, Zhen Li

{"title":"Adjustable Room-Temperature Phosphorescence through Tunable Aggregation of Dopants in Polymers and its Application in Hydrazine Hydrate Detection","authors":"Yawen Zhang, Mingxue Gao, Ruimin Wu, Yunshu Meng, Nan Li, Zhijian Chen, Manman Fang, Jie Yang, Zhen Li","doi":"10.1002/adfm.202502811","DOIUrl":"https://doi.org/10.1002/adfm.202502811","url":null,"abstract":"The development of stimulus-responsive phosphorescent materials has attracted increasing attention owing to their advantages in practical applications. However, those responses to toxic and hazardous chemicals remain rare owing to the lack of suitable design strategies. Herein, a new approach to regulate the room-temperature phosphorescence (RTP) effect of doping systems is developed, in which two polar phenothiazine derivatives functionalized with trifluoroacetyl groups act as phosphorescent guests and polymer matrices with different polarities function as hosts. Regulated by the polymer host, the transition from aggregation to dispersion can be realized for guest molecules, resulting in enhanced RTP. Unlike traditional stimulus-responsive materials, the doped system can undergo a dynamic state transition upon exposure to hydrazine hydrate vapor, thereby activating phosphorescence. Building on these findings, an effective model is established to investigate the effects of the transitions between aggregated and dispersed states. A novel stimulus-responsive sensor is developed to detect hazardous hydrazine hydrates.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"12 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and Reversible Optical Switching of NV+ Centers in Diamond

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-03-30 DOI: 10.1002/adfm.202500817

Marcel Dickmann, Lucian Mathes, Ricardo Helm, Vassily Vadimovitch Burwitz, Werner Egger, Johannes Mitteneder, Christoph Hugenschmidt, Peter Sperr, Maik Butterling, Maciej Oskar Liedke, Andreas Wagner, Joachim Dorner, Thomas Schwarz-Selinger, Günther Dollinger

{"title":"Identification and Reversible Optical Switching of NV+ Centers in Diamond","authors":"Marcel Dickmann, Lucian Mathes, Ricardo Helm, Vassily Vadimovitch Burwitz, Werner Egger, Johannes Mitteneder, Christoph Hugenschmidt, Peter Sperr, Maik Butterling, Maciej Oskar Liedke, Andreas Wagner, Joachim Dorner, Thomas Schwarz-Selinger, Günther Dollinger","doi":"10.1002/adfm.202500817","DOIUrl":"https://doi.org/10.1002/adfm.202500817","url":null,"abstract":"Positive nitrogen-vacancy centers (NV+) in diamond are predicted to exist in conjunction with neutral (NV0) and negative (NV−) centers. However, the existence of NV+ has only been indirectly inferred through a shift of the Fermi level. Evidence of NV+ coexisting with NV0 and NV– in diamond has not yet been observed. In this paper, positron annihilation spectroscopy in combination with in situ light illumination is applied, in order to investigate the presence of NV+ centers in nitrogen implanted and subsequently annealed diamond. Switching of NV+ to NV0 centers is observed with a threshold photon energy of 1.234(8) eV. In complete darkness, a decay of NV0 centers with a decay time of 1.73(22) h can be detected. In conclusion, previously converted NV0 centers are metastable and partially decay in darkness, leading to the reformation of NV+ centers.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"131 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fully Electrically Controlled Low Resistance-Area Product and Enhanced Tunneling Magnetoresistance in the Van Der Waals Multiferroic Tunnel Junction

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-03-30 DOI: 10.1002/adfm.202423855

Xiao-Hui Guo, Jia Zhang, Kai-Lun Yao, Lin Zhu

{"title":"Fully Electrically Controlled Low Resistance-Area Product and Enhanced Tunneling Magnetoresistance in the Van Der Waals Multiferroic Tunnel Junction","authors":"Xiao-Hui Guo, Jia Zhang, Kai-Lun Yao, Lin Zhu","doi":"10.1002/adfm.202423855","DOIUrl":"https://doi.org/10.1002/adfm.202423855","url":null,"abstract":"The development of next-generation spin nanomemory systems faces the challenge of achieving nonvolatile electrical control of magnetic states in magnetic tunnel junctions. Here, a strategy is proposed using trilayer van der Waals heterostructures combining an A-type antiferromagnetic YBr2 bilayer and a ferroelectric Al2Se3 monolayer. Nonvolatile modulation of the ferroelectric polarization direction of Al2Se3 can flip the interlayer magnetic coupling of YBr2 between ferromagnetic and antiferromagnetic states. The interlayer magnetic phase transition is caused by the band structure shift and interfacial charge transfer induced by the polarization field. The TiTe2/2L-YBr2/Al2Se3/TiTe2 multiferroic devices achieve a fully electrically controlled tunneling magnetoresistance with a ratio of up to 11550% and an exceptionally low resistance-area product of 0.28 Ω µm2 by establishing a good P-type Ohmic contact between the TiTe2 electrode and the central heterojunction. There is also a perfect spin filtering effect. This work provides new perspectives for the development of low-power, fast-response, nonvolatile and fully electrically controlled spintronic memory devices.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"22 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Making Photoresponsive Metal–Organic Frameworks an Effective Class of Heterogeneous Photocatalyst

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-03-30 DOI: 10.1002/adfm.202421318

Rui Liu, Hao Wu, Hoi Ying Chung, Yun Hau Ng

{"title":"Making Photoresponsive Metal–Organic Frameworks an Effective Class of Heterogeneous Photocatalyst","authors":"Rui Liu, Hao Wu, Hoi Ying Chung, Yun Hau Ng","doi":"10.1002/adfm.202421318","DOIUrl":"https://doi.org/10.1002/adfm.202421318","url":null,"abstract":"A highly effective photocatalyst is the core component of photocatalytic energy conversion. Recently, photoresponsive metal–organic frameworks (MOFs) photocatalysts have exhibited convincing potential and become the hotspot research direction because of their dramatic advantages in enhancing light-harvesting capability, charge transfer efficiency, and catalytic performance of surface reactions in a photocatalytic system. In-depth interpretations of the photoresponsive MOFs-based photocatalysts have been constructed, and more insightful understandings of these materials can be obtained by advanced characterizations and accurate theoretical studies, which provide a solid platform to predict the mechanism and applications in photocatalysis. This review summarizes the recent advances in photoresponsive MOF-based photocatalysts for solar-to-chemical energy conversion. A general background of photoresponsive MOF photocatalysts is provided initially. A brief discussion of the possible roles of photoresponsive MOFs in photocatalysis is then provided. After that, the advanced characterization techniques for photoresponsive MOF photocatalysts are presented. After obtaining a fundamental understanding of photoresponsive MOF-based photocatalysts, their multifold applications are highlighted. Finally, the future challenges and perspectives of photoresponsive MOF photocatalysts are proposed. This review is expected to motivate the exploration of novel photoresponsive MOF-based photocatalysts and drive future development in this burgeoning field.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"11 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strontium Hexacyanoferrate Nanomedicine Alleviates Ischemic Cardiomyopathy by Regulating Pyroptosis

IF 19 1区材料科学

Advanced Functional Materials Pub Date : 2025-03-30 DOI: 10.1002/adfm.202417939

Xi Li, Yu Yao, Xiangyi Ren, Liying Wang, Minfeng Huo, Jianlin Shi

{"title":"Strontium Hexacyanoferrate Nanomedicine Alleviates Ischemic Cardiomyopathy by Regulating Pyroptosis","authors":"Xi Li, Yu Yao, Xiangyi Ren, Liying Wang, Minfeng Huo, Jianlin Shi","doi":"10.1002/adfm.202417939","DOIUrl":"https://doi.org/10.1002/adfm.202417939","url":null,"abstract":"Ischemic cardiomyopathy remains high mortality and morbidity worldwide due to dysfunctional cell metabolism and programmed death of cardiomyocytes. Restoration of the blocked blood flows is a major therapeutic approach against ischemic cardiomyopathy, which, unfortunately, may cause the burst of oxidative species damaging tissues (ischemic/reperfusion injury, IR). Cardiac antioxidation and revascularization are two major therapeutic aims in treating cardiac IR as well as myocardial infarction (MI). In the present work, strontium hexacyanoferrate (SrHF) nanoparticles are synthesized for alleviating both the cardiac pathologies of MI and IR concurrently. SrHF features high antioxidative catalytic activity, mimicking superoxide dismutase and catalase in eliminating reactive oxygen species for cardiac protection. In vivo, investigation confirms that SrHF has significantly alleviated myocardial functional deterioration and enhanced cardiomyocyte survival. Mechanistic studies demonstrate that SrHF can effectively inhibit cardiac programmed pyroptosis and pathological remodeling through antioxidation and enhance angiogenesis by bioactive strontium ions. The present work provides a promising therapeutic strategy in treating ischemic cardiac pathologies, providing a fundamental basis for clinical translation and application toward cardiovascular diseases.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"36 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0