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Platelet gel and factors determining its biological activity 血小板凝胶及其生物活性的决定因素
Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-01-07 DOI: 10.29235/15618323-2023-67-6-490-498
V. Y. Galitskaya, M. P. Potapnev, V. I. Asaevich, V. G. Bogdan, S. Kosmacheva, F. N. Karpenko
{"title":"Platelet gel and factors determining its biological activity","authors":"V. Y. Galitskaya, M. P. Potapnev, V. I. Asaevich, V. G. Bogdan, S. Kosmacheva, F. N. Karpenko","doi":"10.29235/15618323-2023-67-6-490-498","DOIUrl":"https://doi.org/10.29235/15618323-2023-67-6-490-498","url":null,"abstract":"A platelet gel (PG) derived from platelet concentrate (PC) is considered as a perspective therapeutic agent with hemostatic and regenerative properties. PG was obtained from PC separated from human peripheral blood by automatic apheresis by adding human thrombin (30 U/ml). We compared the proliferation of human mesenchymal stromal cells (MSCs) in vitro in the presence of PG and the dependence of gel density on excess of fibrinogen, the presence of calcium chloride, calcium gluconate, and aprotinin. PG was formed from CT in the presence of thrombin during 5–10 minutes. PG as gel-like fibrin membrane contained platelets and an admixture of leukocytes, and was capable to enhance the proliferation of MSCs in vitro. The presence of calcium gluconate (10 mg/ml) increased in the presence of PG the rate of MSCs proliferation in vitro. The presence of aprotinin in PG at a concentration of 10–1000 KIU/ml caused a dose-dependent decrease in the rate of gel biodegradation and did not affect the ability of PG to stimulate the proliferation of human MSCs in vitro.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"16 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139448565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modelling the redox imbalance and oxidative stress in the hippocampus at aluminum neurotoxicity and initiating the coenzyme А biosynthesis 模拟铝神经毒性时海马体内的氧化还原失衡和氧化应激，启动辅酶А的生物合成过程
Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-01-07 DOI: 10.29235/1561-8323-2023-67-6-481-489
N. Kanunnikova, D. Semenovich, I. N. Katkovskaya, O. V. Titko, E. P. Lukiyenko, V. Gurinovich, A. Moiseenok
{"title":"Modelling the redox imbalance and oxidative stress in the hippocampus at aluminum neurotoxicity and initiating the coenzyme А biosynthesis","authors":"N. Kanunnikova, D. Semenovich, I. N. Katkovskaya, O. V. Titko, E. P. Lukiyenko, V. Gurinovich, A. Moiseenok","doi":"10.29235/1561-8323-2023-67-6-481-489","DOIUrl":"https://doi.org/10.29235/1561-8323-2023-67-6-481-489","url":null,"abstract":"An Alzheimer-like pathological process was induced in mature female Wistar CRL: (WI) WUBR rats using aluminum chloride (200 mg/kg, intragastrically, 6 weeks) in order to model redox imbalance and oxidative stress (OS) in the hippocampus and study the possibilities of their correction 2 weekly administration of coenzyme A biosynthesis modulators (panthenol – PL, pantethine – PT, homopantothenate – HP) at a dose of 200 mg/kg intragastrically for 2 weeks). Against the background of activation of peroxidation processes and a decrease in acetylcholinesterase activity, a decrease in the reduction potential of glutathione and the level of the acid-soluble fraction of CoA was observed with a simultaneous increase in the activity of glutathione-metabolizing enzymes (GR, GPx, GST), the process of S-glutathionylation of proteins and the level of protein thiols. The consumption of the precursors of CoA biosynthesis in full (PL, PT) or in part (HP) had an antioxidant effect, restored the activity of AChE, the level and reduction potential of glutathione and glutathione-metabolizing enzymes, the process of S-glutathionylation, and stimulated the activity of enzymes generating NADPH+. Taking into account the low modulating effect of coenzyme precursors on the level of CoA in the hippocampus and their high redox pharmacological activity, their non-coenzymatic effect on redox mechanisms leading to an increase in the bioavailability of reducing equivalents and energy status is assumed.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"23 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139448719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure, soft magnetic properties of Fe-based magnetic composites and its practical application 铁基磁性复合材料的结构、软磁特性及其实际应用
Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-01-07 DOI: 10.29235/1561-8323-2023-67-6-508-516
O. F. Demidenko, A. L. Zhaludkevich, A. O. Laryn, G. Govor, Sun Haibo, Dongchu Chen, S. Yankevich
{"title":"Structure, soft magnetic properties of Fe-based magnetic composites and its practical application","authors":"O. F. Demidenko, A. L. Zhaludkevich, A. O. Laryn, G. Govor, Sun Haibo, Dongchu Chen, S. Yankevich","doi":"10.29235/1561-8323-2023-67-6-508-516","DOIUrl":"https://doi.org/10.29235/1561-8323-2023-67-6-508-516","url":null,"abstract":"A multi-stage technique for applying insulating coatings to metal powder particles has been developed in order to create a new class of Fe-based soft magnetic materials with improved characteristics. The density value calculated from the data of X-ray diffraction analysis is approximately 3 % higher than the experimentally measured values, which are 7.4–7.45 g/cm3. The low porosity of the composites is confirmed by the SEM and EDX results. The proposed method of encapsulation of iron powder with an oxide layer is a highly economical method for applying coatings of various chemical compositions to metal powders, and can be widely used in practice to obtain electrical materials. Comprehensive studies of the properties of the obtained samples of powder composite materials based on ABC100.30 iron, the particles of which are encapsulated with phosphorus oxide, have been carried out. It has been established that in a field of 1.5 T, the losses at a frequency of 1 kHz decrease 10 times with an increase in the thickness to 30 nm. The synthesized materials are recommended for use in the development of various types of high-frequency electric motors, generators, chokes, magnetic circuits and electrodes for high-frequency welding and other applications.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"31 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139448570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial and temporal coherence of quasi-periodic components of meteorological fields as a basis for long-term weather forecasts 作为长期天气预报基础的气象场准周期成分的空间和时间一致性
Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-01-07 DOI: 10.29235/1561-8323-2023-67-6-499-507
S. A. Lysenko, V. F. Loginov
{"title":"Spatial and temporal coherence of quasi-periodic components of meteorological fields as a basis for long-term weather forecasts","authors":"S. A. Lysenko, V. F. Loginov","doi":"10.29235/1561-8323-2023-67-6-499-507","DOIUrl":"https://doi.org/10.29235/1561-8323-2023-67-6-499-507","url":null,"abstract":"A new method of teleconnections studding is proposed which is based on the identification of conjugate regions in the global meteorological fields of temperature and pressure by their characteristic coherent quasi-periodic oscillation. This method was implemented in order to select predictors of winter air temperature in Belarus with an advance of 2 months. The degree of coherence of sea level pressure and winter temperature in Belarus on a quasi-8-year cycle was considered as a criterion for the selection of predictors. The forecast was implemented using the advanced deep machine learning model TimesNet and showed rather high metrics of quality for seasonal meteorological forecasting: the correlation coefficient between actual and predicted temperature values was 0.66, and the weighted macro-average values of precision and recall of the forecast in the gradations “normal”, “above normal” and “below normal” were 0.61 and 0.56, respectively.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"33 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139448377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of a nonionic surfactant and anionic polyelectrolyte binary system on the stability of a calcium and magnesium carbonates dispersion 非离子表面活性剂和阴离子聚电解质二元体系对碳酸钙和碳酸镁分散体稳定性的影响
Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-01-06 DOI: 10.29235/1561-8323-2023-67-6-473-480
S. V. Bucha, A. D. Vorobiev, D. V. Cherednichenko, E. V. Vorobieva, E. V. Laevskaya, N. Krutko, H. V. Bondareva
{"title":"Effect of a nonionic surfactant and anionic polyelectrolyte binary system on the stability of a calcium and magnesium carbonates dispersion","authors":"S. V. Bucha, A. D. Vorobiev, D. V. Cherednichenko, E. V. Vorobieva, E. V. Laevskaya, N. Krutko, H. V. Bondareva","doi":"10.29235/1561-8323-2023-67-6-473-480","DOIUrl":"https://doi.org/10.29235/1561-8323-2023-67-6-473-480","url":null,"abstract":"The effect of sodium polyacrylate, polyethylene glycol of various molecular weights, and their mixtures on the dispersion stability of calcium and magnesium carbonates was studied. It was shown that in the presence of a binary system, the light transmission of the dispersion decreases 1.2–1.5 times, the content of fine fraction particles increases by 1.1–1.3 times compared to the individual components. The stability of the dispersion of carbonates depends on the components ratio in the binary system and their molecular weight. The formation of adsorption solvated layers of polyacrylate and polyethylene glycol molecules at the interphase boundary contributes to an increase in the stability of the carbonate dispersion.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"51 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abnormal swelling in water of carboxylic ion exchanger in the forms of ammonium and tetraethylammonium ions 铵离子和四乙基铵离子形式的羧基离子交换剂在水中的异常膨胀
Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-01-06 DOI: 10.29235/1561-8323-2023-67-6-465-472
V. S. Soldatov, E. Kosandrovich, T. V. Bezyazychnaya
{"title":"Abnormal swelling in water of carboxylic ion exchanger in the forms of ammonium and tetraethylammonium ions","authors":"V. S. Soldatov, E. Kosandrovich, T. V. Bezyazychnaya","doi":"10.29235/1561-8323-2023-67-6-465-472","DOIUrl":"https://doi.org/10.29235/1561-8323-2023-67-6-465-472","url":null,"abstract":"A fibrous carboxylic ion exchanger, obtained by post-radiation grafting of polyacrylic acid to polypropylene fiber, in the ammonium form has an abnormally low swelling in water, corresponding to 10 moles of water per equivalent, and in the form of tetraethylammonium ion (NEt4+) – abnormally high 25 moles of water/eq. Considering that NH4+ is a hydrophilic particle and NEt4+ is hydrophobic, this fact seems paradoxical. The article attempts to explain this phenomenon using molecular modeling (ab initio calculations of the structure of hydrate complexes in the HF MO LCAO approximation with the 6-31G basis set) in combination with the Predominant Hydrates Model, which made it possible to calculate the theoretical water sorption isotherms of the ion exchanger and compare them with experimental data. The abnormally low swelling of the ion exchanger in the NH4+-form is caused by the formation of a strong bond between the carboxylate anion and ammonium with a significant degree of covalence due to the superposition of the Coulomb interaction of the ions and the formation of a hydrogen bond between them. The abnormally high swelling of NEt4+-forms is caused by the absence of a strong interaction between cations and carboxylate groups due to the impossibility of their convergence due to steric reasons. The high swelling of the ion exchanger is caused by the absence of blocking of the hydrophilic carboxylate groups of the ion exchanger by hydrogen bonds with the cation. The ion exchanger matrix does not contain a cross agent and does not create a spatial restriction for the high swelling of the ion exchanger.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"60 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On some classes of finite σ-soluble PσT-groups 关于有限σ可溶PσT群的一些类别
Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-01-06 DOI: 10.29235/1561-83232023-67-6-460-464
I. N. Safonova, A. Skiba
{"title":"On some classes of finite σ-soluble PσT-groups","authors":"I. N. Safonova, A. Skiba","doi":"10.29235/1561-83232023-67-6-460-464","DOIUrl":"https://doi.org/10.29235/1561-83232023-67-6-460-464","url":null,"abstract":"Let X be a class of groups. Suppose that with each group G ∈ X we associate some system of its subgroups τ(G). Then τ is said to be a subgroup functor on X if the following conditions are hold: (1) G ∈  τ(G) for each group G ∈ X; (2) for any epimorphism φ: A → B, where A, B ∈ X, and for any groups H ∈ τ(A) and T ∈ τ(B) we have Hφ ∈ τ(B) and Tφ-1 ∈ τ( A). In this paper, were considered some applications of such subgroup functors in the theory of finite groups in which generalized normality for subgroups is transitive.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"61 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139448924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unconditionally monotone and globally stable difference schemes for the Fisher equation 费雪方程的无条件单调和全局稳定差分方案
Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-01-05 DOI: 10.29235/1561-8323-2023-67-6-454-459
P. P. Matus, D. Pylak
{"title":"Unconditionally monotone and globally stable difference schemes for the Fisher equation","authors":"P. P. Matus, D. Pylak","doi":"10.29235/1561-8323-2023-67-6-454-459","DOIUrl":"https://doi.org/10.29235/1561-8323-2023-67-6-454-459","url":null,"abstract":"In this paper, we construct and study unconditionally monotone and globally stable difference schemes for the Fisher equation. It has been shown that constructed schemes inherit the stability property of the exact solution: 0 ≤ u(x, t) ≤ 1, (x, t) ∈ QT = {(x, t) : 0 ≤ x ≤ l, 0 ≤ t < +∞} for a given input data of the problem. The unconditional monotonicity of the difference schemes is proved and the a priori estimate is obtained in the uniform norm for the difference solution. The stable behavior of the difference solution in the nonlinear case takes place under slightly more stringent constraints on the input data: 0,5 ≤ u0 (x), µ1(t), µ2(t) ≤ 1.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"76 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139450389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Belarusian humanitarian knowledge in the XXI century 二十一世纪白俄罗斯的人道主义知识
Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-01-05 DOI: 10.29235/1561-8323-2023-67-6-447-453
A. A. Kavalenia
{"title":"Belarusian humanitarian knowledge in the XXI century","authors":"A. A. Kavalenia","doi":"10.29235/1561-8323-2023-67-6-447-453","DOIUrl":"https://doi.org/10.29235/1561-8323-2023-67-6-447-453","url":null,"abstract":"The article shows the achievements of the Department of Humanitarian Sciences and Arts of the National Academy of Sciences of Belarus at the beginning of the 21st century.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"56 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the production processes on the most typical farms and milk production complexes 评估最典型的牧场和牛奶生产联合企业的生产流程
Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-01-05 DOI: 10.29235/1561-8323-2023-67-6-517-528
P. Kazakevich, U. N. Tsimoshanka, A. A. Muzyka, S. A. Kirikovich, L. N. Sheigratsova, M. P. Puchka, N. N. Shmatko, M. V. Tsimoshanka, A. I. Konek
{"title":"Assessing the production processes on the most typical farms and milk production complexes","authors":"P. Kazakevich, U. N. Tsimoshanka, A. A. Muzyka, S. A. Kirikovich, L. N. Sheigratsova, M. P. Puchka, N. N. Shmatko, M. V. Tsimoshanka, A. I. Konek","doi":"10.29235/1561-8323-2023-67-6-517-528","DOIUrl":"https://doi.org/10.29235/1561-8323-2023-67-6-517-528","url":null,"abstract":"The article presents the results of research, according to an energy assessment, of the most common options for combining spatial planning and technological solutions of buildings and structures, the set of technological equipment used on the most typical operating farms and milk production complexes. The most significant elements of technology and technological equipment, its operating modes, energy consumption by cost elements for the processes of preparation and distribution of feed, manure removal and provision of the required microclimate parameters, determining the intensity level of the production process in various variants of building layout and livestock, have been studied. The results obtained allow us to determine the most effective options for mechanization and automation of the production process and improve the technological methods of their implementation.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"63 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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