Doklady of the National Academy of Sciences of Belarus最新文献

Mechanochemical structural nanoengineering of heterooxide photocatalysts TiO2/ V2O5 capable to accumulating photoinduced charges 能够累积光诱导电荷的杂氧化物光催化剂 TiO2/ V2O5 的机械化学结构纳米工程

Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-207-213

V. B. Shcherbakova, T. V. Sviridova, D. Sviridov, V. E. Agabekov

引用次数: 0

Analysis of the radiation effect on the activity of thyroid blood transport systems: connection with the features of thyroid status 分析辐射对甲状腺血液运输系统活性的影响：与甲状腺状态特征的联系

Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-229-237

T. A. Mityukova

{"title":"Analysis of the radiation effect on the activity of thyroid blood transport systems: connection with the features of thyroid status","authors":"T. A. Mityukova","doi":"10.29235/1561-8323-2024-68-3-229-237","DOIUrl":"https://doi.org/10.29235/1561-8323-2024-68-3-229-237","url":null,"abstract":"Thyroid-binding proteins play an important role in regulating thyroid status. However, the question of the radiation effect on the functional state of thyroid blood transport systems remains insufficiently studied. The aim of the work was to assess the indicators of thyroid status and thyroid blood transport in persons exposed to radiation as a result of the Chernobyl accident. The task of the work was also to analyze the results of an oral test for thyroxine pharmacokinetics in patients with thyroid carcinoma who received radioiodine therapy. Screening studies conducted 5−6 years after the Chernobyl accident indicate the radiation effect on the free thyroxine content in the blood and the functional activity of thyroid protein transport in children and adolescents living in the territories of the Khoiniki district of the Gomel region. The dose-dependent effect of an absorbed dose of 131I was also detected in children and adolescents displaced from the 30 km zone of the Chernobyl accident. The results of an oral test for thyroxine pharmacokinetics demonstrate an increase in the free T4 content against the background of a stable total T4 fraction in patients with thyroid carcinoma who received high dose loads as a result of radioiodine therapy. The conducted studies confirm the possibility of the influence of a high dose of 131I on thyroid blood transport systems and on the ratio of free and bound fractions of thyroid hormones in the blood.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":" 1250","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141668790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of VEGF gene polymorphism on the survival of a patient with non-small cell lung cancer 血管内皮生长因子基因多态性对非小细胞肺癌患者生存期的影响

Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-220-228

M. N. Shapetska, A. Mikhalenka, A. Shchayuk, L. V. Mirilenko, L. V. Gorbatenko, A. Kilchevsky

{"title":"Effect of VEGF gene polymorphism on the survival of a patient with non-small cell lung cancer","authors":"M. N. Shapetska, A. Mikhalenka, A. Shchayuk, L. V. Mirilenko, L. V. Gorbatenko, A. Kilchevsky","doi":"10.29235/1561-8323-2024-68-3-220-228","DOIUrl":"https://doi.org/10.29235/1561-8323-2024-68-3-220-228","url":null,"abstract":"Currently, much attention is paid to studying the vascular endothelial growth factor (VEGF) that stimulates angiogenesis, as a potential target for antiangiogenic therapy. The purpose of this work was to study the effect of polymorphic variants rs2010963 (G-634C), rs699947 (A-2578C), and rs3025039 (C+936T) of the VEGF gene, encoding a vascular endothelial growth factor, on the overall (OS) and adjusted survival (AS) of patients with non-small cell lung cancer (NSCLC) at stages I–III. The effect of VEGF rs699947 polymorphic variants on the extent of tumor spread was shown. A connection between AS and polymorphic variants rs2010963 (G-634C) and rs699947 (A-2578C) was established. The one-year adjusted survival (AS) in the -634G/C genotype carriers was 81.9 ± 3.9 %; in the -634G/G genotype carriers – 92.8 ± 2.5 %; and p = 0.016 was the significance level. Two-year AS was as follows: in the carriers of the -634G/C genotype was 70.4 ± 4.6 %; in the carriers of the -634G/G genotype – 84.3 ± 3.5 %; and p = 0.015. Three-year AS: in the carriers of the -634G/ genotype C was 63.0 ± 4.9 %; in the carriers of the -634G/G genotype – 76.7 ± 4.1 %; and p = 0.029. One-year and two-year AS in the carriers of the -2578A/A genotype was significantly higher than in the carriers of the -2578C/C genotype (p = 0.015 and p = 0.042 respectively). The identified influence of the polymorphic variants rs2010963 and rs699947 on the survival of NSCLC patients during the first three years after the established diagnosis shows a need to use knowledge about the genetic characteristics of a tumor during therapy.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"106 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Production traits of pigs of intrabreed type “Pripyatsky” in Landrace breed at breeding enterprises 育种企业陆地猪种 "普里皮亚季 "杂交猪的生产特征

Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-255-264

I. Sheiko, R. I. Sheiko, N. V. Pristupa, E. A. Yanovich, V. N. Zayats, M. V. Krasovskaya

{"title":"Production traits of pigs of intrabreed type “Pripyatsky” in Landrace breed at breeding enterprises","authors":"I. Sheiko, R. I. Sheiko, N. V. Pristupa, E. A. Yanovich, V. N. Zayats, M. V. Krasovskaya","doi":"10.29235/1561-8323-2024-68-3-255-264","DOIUrl":"https://doi.org/10.29235/1561-8323-2024-68-3-255-264","url":null,"abstract":"To meet the population’s demand for meat pork, breeding programs aimed at breeding and selection of pigs with high reproductive, fattening and meat traits were carried out for several decades. Over the years, a number of new types, lines and breeds of pigs were created and tested in the world. It should be noted that the gene pool of foreign super-meat breeds (Pietrain; Duroc; Danish, French, German, Canadian Landrace and Yorkshire) was used to some extent in the development of new domestic meat genotypes of pigs. A rational use of the genetic potential of farm animals allows accelerating the selection to improve their reproductive, fattening and meat traits. The Republic of Belarus arranged its own production of high-value animals represented by intrabreed type-pigs in the Landrace breed with the following productivity indicators: prolificacy – 12.5 animal units, milk yield – 65.5 kg, number of piglets at weaning – 11.6 animal units, litter weight at weaning at the age of 30 days – 91.6 kg, meat content in carcass – 65–67 %, well adapted to the technological conditions of breeding and industrial complexes, providing the overall need of pig breeding in obtaining high-quality pork; saving foreign currency for import; the possibility of exporting finished products to CIS countries.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":" 431","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141669456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

De novo design and virtual screening of potential Bcr-Abl tyrosine kinase inhibitors using deep learning and molecular modeling technologies 利用深度学习和分子建模技术从头设计和虚拟筛选潜在的 Bcr-Abl 酪氨酸激酶抑制剂

Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-196-206

А. М. Андрианов, К. В. Фурс, А. Д. Карпенко, Т. Д. Войтко, А. В. Тузиков, A. M. Andrianov, K. V. Furs, A. D. Karpenko, Timofey D. Vaitko, Corresponding Member, A. Tuzikov

{"title":"De novo design and virtual screening of potential Bcr-Abl tyrosine kinase inhibitors using deep learning and molecular modeling technologies","authors":"А. М. Андрианов, К. В. Фурс, А. Д. Карпенко, Т. Д. Войтко, А. В. Тузиков, A. M. Andrianov, K. V. Furs, A. D. Karpenko, Timofey D. Vaitko, Corresponding Member, A. Tuzikov","doi":"10.29235/1561-8323-2024-68-3-196-206","DOIUrl":"https://doi.org/10.29235/1561-8323-2024-68-3-196-206","url":null,"abstract":"De novo design and virtual screening of small-molecule compounds with a high potential inhibitory activity against the Bcr-Abl tyrosine kinase playing a key role in the pathogenesis of chronic myeloid leukemia (CML) were carried out by an integrated computational approach including technologies of deep learning and molecular modeling. As a result, according to the calculation data we identified 5 compounds exhibiting low values of binding free energy to the enzyme comparable with those predicted for imatinib, nilotinib and ponatinib, anticancer drugs widely used in the clinic to treat patients with CML. It was shown that these compounds are able to form stable complexes with the ATP-binding sites of the Bcr-Abl tyrosine kinase and its mutant form T315I, which is confirmed by the analysis of the profiles of binding affinity and intermolecular interactions responsible for their energy stabilization. Based on the obtained data, these compounds, which have been generated by the deep learning neural network, are assumed to form promising basic structures for development of new effective drugs for treatment of patients with CML.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141669073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

About one strengthening of the Massera’s existence theorem of periodic solutions of linear differential periodic systems 关于线性微分周期系统周期解的马塞拉存在定理的一次强化

Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-188-195

A. Demenchuk, A. V. Konuh

引用次数: 0

Asymptotic method for solving the problem of transition process optimization in a three-tempo singularly perturbed system 解决三时刻奇异扰动系统中过渡过程优化问题的渐近方法

Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-183-187

A. I. Kalinin, L. I. Lavrinovich

引用次数: 0

Composite coatings of poly(methyl methacrylate) with silicon dioxide nanoparticles for capacitive sensors of nickel content control in water 聚（甲基丙烯酸甲酯）与二氧化硅纳米颗粒的复合涂层，用于控制水中镍含量的电容式传感器

Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-247-254

D. V. Sapsaliou, G. Melnikova, A. V. Aksiuchyts, T. Tolstaya, D. A. Kotov, S. Chizhik

{"title":"Composite coatings of poly(methyl methacrylate) with silicon dioxide nanoparticles for capacitive sensors of nickel content control in water","authors":"D. V. Sapsaliou, G. Melnikova, A. V. Aksiuchyts, T. Tolstaya, D. A. Kotov, S. Chizhik","doi":"10.29235/1561-8323-2024-68-3-247-254","DOIUrl":"https://doi.org/10.29235/1561-8323-2024-68-3-247-254","url":null,"abstract":"Pollution of the environment, in particular water sources, with heavy metals is a serious environmental problem. In this regard, it is relevant to develop new sensor systems that allow rapid tests and are not inferior in analytical parameters to classical methods for detecting heavy metals. Promising materials for creating such sensor systems are composite coatings based on polymer compounds with inorganic nanoparticles. The article presents the results of using poly(methyl methacrylate) (PMMA) coatings and PMMA nanocomposites with silicon dioxide nanoparticles (SiO2 NPs) to develop capacitive sensors for analyzing the content of Ni2+ ions in water. The structural and morphological characteristics of a conductive nickel layer and nanostructured films based on poly(methyl methacrylate) were studied using atomic force microscopy. Based on the experimental data on the dependence of the capacitance characteristics of sensors on the concentration of Ni2+ in solutions, the operating characteristics of sensors were established: response time is 5 min; working range of concentrations of Ni2+ ions: 1 ‧ 10–3 – 50 mM; lower detection limit ≈ 0.06 mg/l (maximum nickel concentration limit in water is 0.1 mg/l). It has been shown that the formation of a coating of the composition PMMA + NPs-SiO2 (1 : 41.7 mol) on a conductive nickel layer using the spin-coating method leads to increasing the sensitivity of a sensor and its service life (up to seven cycles).","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"120 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

About two new families of acanthodian fishes (Acanthodii) 关于刺鳑鲏鱼（Acanthodii）的两个新科

Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-214-219

D. P. Plax

引用次数: 0

Numerical modeling of microclimate of re-waterlogged lands of Belarusian Polesie 白俄罗斯波列西再涝土地小气候数值模拟

Doklady of the National Academy of Sciences of Belarus Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-238-246

引用次数: 0