Current vascular pharmacology最新文献

{"title":"Steps to Walk Out of, or Side Track, Cardiovascular Disease to Achieve Longevity.","authors":"Antonis A Manolis, Theodora A Manolis, Antonis S Manolis","doi":"10.2174/0115701611363987251012160135","DOIUrl":"https://doi.org/10.2174/0115701611363987251012160135","url":null,"abstract":"<p><p>Aging is a relentless process of gradual physio-biochemical non-reversible deterioration that significantly influences human health, leading to declining cellular function and increasing cellular damage; it is recognized as a major risk factor for atherosclerosis and cardiovascular (CV) disease (CVD), the leading cause of death worldwide. Although aging is inevitable, healthy aging is the key to well-being. Longevity is a desirable yet complex outcome influenced by a wide range of factors, including genetics, lifestyle choices, healthcare access, socio-economic conditions, and other environmental factors. The compromised efficiency of processes that counteract age-associated molecular damage affects CVD susceptibility and expedites the emergence of clinical disease. Recently recognized key resilience mechanisms related to aging may constitute new potential therapeutic targets. Geroscience focuses on the discovery and translation of methods and interventions to curtail or reverse age-related deficits that compromise quality of life for older individuals. The geroscience paradigm, increasingly acknowledged in medical specialties, renders possible the prevention of premature aging, the optimal treatment of geriatric diseases, the reduction of healthcare disparities and prejudices, and the extension of the population's health span. These important geroscience issues, including multimorbidity, frailty, tendency to frequent falls, cognitive and multisensory impairment, cardiac arrhythmias, coronary disease and heart failure, as well as undernutrition, sarcopenia and polypharmacy, are herein discussed, together with recent relevant medical advances. Emphasis is placed on boosting psychology and also on pharmacological and nonpharmacological interventions such as exercise and physical activity, healthy diets and lifestyle that target key components of aging, which might assist in both primary (geroprotection) and secondary prevention (gerotherapeutics) of CV and other diseases posing an enormous challenge in older age. The geroscience paradigm is increasingly recognized in medical specialties, enabling the prevention of premature aging, optimal management of geriatric ailments, reduction of health-care disparities and prejudices, and potential improvement of the population's health-span.</p>","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mast Cells and Cardiovascular Disorders.","authors":"Antonis A Manolis, Theodora A Manolis, Apostolos Vouliotis, Antonis S Manolis","doi":"10.2174/0115701611393333260511094916","DOIUrl":"https://doi.org/10.2174/0115701611393333260511094916","url":null,"abstract":"<p><p>Mastocytosis is a neoplasm characterised by clonal proliferation of mast cells (MCs) in the skin and other organs, including the heart, and symptoms produced by MC-derived mediators. MC activation syndrome (MCAS) relates to increased and inappropriate activation of MCs without clonal proliferation. Mast cells are tissue-resident immune cells strategically located in different cardiac sites, e.g., myocardium, pericardium, aortic valve, and close to nerves, and in atherosclerotic plaques. The mediators (e.g., histamine, tryptase, chymase, cytokines, and chemokines) have roles in inflammation, angiogenesis, tissue remodelling, and fibrosis. They activate different cardiac resident immune cells (e.g., macrophages) and structural cells (e.g., fibroblasts and endothelial cells). MCs participate in atherosclerosis and several cardiovascular diseases (CVD), comprising allergic angina, coronary syndromes, and arrhythmias, by destabilizing and promoting atherosclerotic plaque rupture with its attendant dire consequences. Furthermore, MCs stimulate fibrosis after a myocardial infarction. MCAS is increasingly appreciated as it affects many patients previously noted to have various apparently idiopathic chronic multisystem inflammatory and/or allergic diseases or dystrophisms. Symptoms resulting from mediator release comprise flushing, hypotension, urticaria, angioedema, headache, vomiting, and diarrhea. Diagnosis is rendered by skin and/or bone marrow biopsy. Considering the increasing incidence and prevalence of MC-related diseases, guidance is needed for clinicians or researchers to select efficacious MC stabilizers that could block external stimulus signals into cells, inhibit intracellular signalling pathways, and disrupt degranulation. These novel therapies may soon find their way into the clinical arena. All relevant data and important advances in this recently recognized clinical entity are herein reviewed.</p>","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational and Environment-Related Cardiovascular Disease: A Comprehensive Review of the Literature.","authors":"Antonis S Manolis, Antonis A Manolis, Theodora A Manolis, Apostolos Vouliotis","doi":"10.2174/0115701611431479260401102651","DOIUrl":"https://doi.org/10.2174/0115701611431479260401102651","url":null,"abstract":"<p><p>Work is a social determinant of Cardiovascular (CV) and general health and can both influence and be influenced by health. The type of work, working conditions, and work environment are fundamental social determinants of CV and general health status. Climate change presents an urgent and increasing threat to workers' health, via both direct exposure to environmental risks and the indirect worsening of social and health inequalities. Occupational health, which focuses on the promotion of mental and physical health and well-being of workers, and the avoidance of occupationrelated health risks, is a crucial but less discussed concern and component of human health. Relevant research at the intersection of climate change and occupational health remains scarce. Additionally, mitigation of climate change and adaptation efforts are driving forces for rapid transformations in the workplace, including shifts towards sustainability and circular economy models. These transitions are creating new occupational hazards, including those concerning renewable energy and the circular economy sectors. Investment in occupational health research and surveillance should be increased to address the evolving influences of both climate change and the green transition, to enhance and protect workers' CV and general health. Among the work-related factors that play an important role in patients with CVD, the following seem crucial: work participation, physical and mental work capability, appropriate work, support from and flexibility of the work environment, inter-personal communication, person-centered milieu, and interdisciplinary communication. A moderate leisure-time physical activity combined with moderate occupational physical activity may be a more plausible way to combine these two activities to sustain and/or improve CV health. Such an approach may be able to ameliorate workrelated outcomes in patients with CVD. Finally, lifestyle interventions targeting multiple behaviors are also most important to prevent CVD and attain cardiometabolic health. All these issues of occupational CVD are herein reviewed, and relevant meta-analyses are tabulated and discussed.</p>","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148270657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metalloproteinases 2 and 9 as Biomarkers in Acute Elevation of Blood Pressure.","authors":"Days Oliveira de Andrade, Doroteia Rossi Silva Souza, Moacir Fernandes de Godoy, Tatiana Palotta Minari, Marco Antonio Vieira-da-Silva, Luciana Neves Cosenso-Martin, Jose Fernando Vilela-Martin","doi":"10.2174/0115701611408430251124044623","DOIUrl":"https://doi.org/10.2174/0115701611408430251124044623","url":null,"abstract":"<p><p>Vascular remodeling, a common feature of hypertension and its complications, involves the reconstruction of blood vessel layers through mechanisms of vascular matrix degradation and reorganization. This process is an important step in development, morphogenesis, and tissue repair. Normally, it is regulated by physiological conditions, but when dysregulated, it may contribute to the pathogenesis of several diseases, such as arthritis, cancer, chronic ulcers, and fibrosis. Uncontrolled remodeling of the extracellular matrix (ECM) in the myocardium and vasculature is characteristic of cardiovascular diseases (CVDs). Matrix metalloproteinases (MMPs) have been highlighted as an important class of enzymes with cleavage capacity linked to remodeling processes in CVDs. These proteolytic enzymes are involved in collagen degradation, contribute to the formation and breakdown of various ECM proteins, and participate in cell migration and growth regulation. They are present in several cell types and tissues, including vascular smooth muscle cells, fibroblasts, endothelium, and inflammatory cells. Activation of the renin-angiotensin-aldosterone system affects vascular structure by promoting fibrosis and growth and is also an important regulator of inflammation and vascular remodeling. In this context, this review aims to provide insight into the biological role of MMPs (focusing on MMP-2 and MMP-9) and tissue inhibitors of metalloproteinases (TIMPs) in the development and progression of CVDs, as well as the severe implications of acute blood pressure elevations, such as eclampsia, stroke, and other related conditions, highlighting the varied roles of MMPs in vascular remodeling processes.</p>","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147971304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the Cardiovascular Risk Increased in Patients with Isolated Systolic Hypertension and Anemia?","authors":"Koracevic Goran, Micic Sladjana, Stojanovic Milovan, Zdravkovic Marija, Otasevic Petar, Lovic Dragan, Djindjic Boris, Otasevic Suzana, Jankovic Tomasevic Ruzica, Cvetkovic Predrag, Maricic Bojan","doi":"10.2174/0115701611427759260410142243","DOIUrl":"https://doi.org/10.2174/0115701611427759260410142243","url":null,"abstract":"<p><strong>Introduction: </strong>Isolated systolic hypertension (ISH) is important because of its very high prevalence. Anemia is also a highly prevalent non-communicable disease. The paper aims to answer the study questions: 1) Is there a relation between anemia and dBP?; 2) Is there a link between ISH and anemia?; 3) Are ISH and anemia important due to their prevalence?; 4) Is the cardiovascular risk increased in ISH patients with anemia?5) Is this recognized in HTN guidelines?</p><p><strong>Methods: </strong>Search 1 was done for 'isolated systolic hypertension' and 'anemia' in papers (excluding guidelines). Search 2 was performed for arterial hypertension (HTN) guidelines, to see if there is a part about 'isolated systolic hypertension' and about 'anemia', as well as about their relationship. We performed a SCOPUS, Springer Verlag, Elsevier, PubMed, and Google Scholar search.</p><p><strong>Results: </strong>Diastolic blood pressure is often decreased in anemia, due to abundant pathophysiological mechanisms. Moreover, dBP is often low in both ISH and anemia. Third, anemia and ISH are important due to their high prevalence, especially in the elderly.</p><p><strong>Discussion: </strong>The main result of the study is the identification of the important, clinically relevant, previously undefined problem: anemia in ISH. Cardiovascular risk is increased in ISH patients with anemia. The significance of anemia in ISH is not recognized in HTA guidelines, partially because they need to be concise.</p><p><strong>Conclusion: </strong>The overlooked problem of anemia in ISH needs recognition both in clinical practice, to avoid overzealous dBP reduct.</p>","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Colchicine in Cardiovascular Disease: Anti-Inflammatory Mechanisms and Clinical Utility.","authors":"Antonis A Manolis, Theodora A Manolis, Antonis S Manolis","doi":"10.2174/0115701611401876260416031908","DOIUrl":"https://doi.org/10.2174/0115701611401876260416031908","url":null,"abstract":"<p><p>Current data indicate that low-dose colchicine (0.5 mg/day) may reduce the risk of major adverse cardiovascular (CV) events (MACE) in patients with coronary artery disease and thus can become a new standard, effective, cost-efficient, and well-tolerated therapy for cardiac patients. Various important randomised controlled studies have reported on colchicine's influence on CV outcomes, and meta-analyses of these trials show that colchicine mitigates the risk of recurrent MACE by 25%, resulting in its recent approval by the Food and Drug Administration for the management and prevention of CV disease (CVD). While colchicine reduces MACE risk, its survival benefit remains inconclusive, warranting further long-term investigations. The non-significant decrease in CV death of ~20% is surpassed by a more apparent, borderline non-significant rise in the risk of non-CV death by ~40%. Main populations comprising patients with heart failure, patients submitted to surgical revascularisation, females, elderly persons, and non-Caucasians are under-represented in current trials, limiting the generalisability of such treatment. Thus, colchicine shows promise in curtailing MACE, additional data from large-scale, long-term trials are needed to corroborate such findings before its widespread use in clinical practice to favourably influence the secondary prevention of atherosclerotic CVD. Colchicine may have important advantages in curtailing myocardial infarction in specific high-risk patient groups but uncertainty about the magnitude of the impact on survival remains, particularly in the general population. Unfortunately, this agent is plagued by gastrointestinal side effects, which may deter its use. More data from larger-scale randomised studies will be required.</p>","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal Disease and Cardiovascular Risk Factors.","authors":"Antonis A Manolis, Theodora A Manolis, Antonis S Manolis","doi":"10.2174/0115701611433483260423072408","DOIUrl":"https://doi.org/10.2174/0115701611433483260423072408","url":null,"abstract":"<p><p>Various studies have suggested a bidirectional association between periodontal disease and systemic health conditions. Periodontitis is caused by polymicrobial infection, and it affects 7 - 11% of adults worldwide in an age-dependent manner. Besides its local manifestations, including gingival inflammation, periodontal pocket formation, and alveolar bone loss, periodontitis is linked to several systemic conditions. Emerging evidence points to associations with obesity, diabetes, Cardiovascular (CV) Disease (CVD), chronic renal disease, inflammatory bowel disease, respiratory diseases, rheumatoid arthritis, unfavorable pregnancy outcomes, specific cancers, neurodegenerative disorders, psychological diseases, and autoimmune disorders. These links seem to be mediated by 3 main mechanisms: dysbiotic oral biofilms, chronic low-grade systemic inflammation, and the spreading of periodontal pathogenic microbes throughout the body. The pathophysiologic mechanisms involved comprise high concentrations of pro-inflammatory cytokines (e.g., tumor necrosis factor alpha, interleukin 6), increased C-reactive protein, worsened immune function, oxidative stress, and molecular mimicry. Certain periodontal pathogenic microorganisms (e.g., Porphyromonas gingivalis) play a role in triggering and maintaining systemic inflammatory responses. Importantly, management of periodontitis has led to improvements in various systemic conditions, underscoring the clinical importance of these links. Thus, periodontitis represents more than a local oral disease; it significantly contributes to the overall systemic inflammatory burden, with implications for general and cardiovascular health. Therefore, an organized multidisciplinary approach for the prevention, early detection, and optimal management of periodontal disease is essential for improving both cardiovascular and overall patient outcomes. In this respect, healthcare providers should regard oral health as a crucial and integral component of systemic health.</p>","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan-Saponin-Bentonite Nanocomposites Prevent Doxorubicin-Induced Cardiovascular Toxicity by Inhibiting Oxidative Stress and Apoptosis.","authors":"Nagat Saleh Hossuin Moftha, Amel Mahmoud Soliman, Sohair Ramadan Fahmy, Ayman Saber Mohamed","doi":"10.2174/0115701611427647260318043846","DOIUrl":"https://doi.org/10.2174/0115701611427647260318043846","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiovascular Diseases (CVDs) are the predominant chronic illness among the aged population. One in five people died from CDV in 2022, with approximately 700000 people losing their lives to the condition. Chitosan-saponin-bentonite nanocomposites (CSB-NC ) exhibit antioxidant, anti-inflammatory effects, as well as anti-proliferative and anti-apoptotic properties. The present study aims to examine the cardioprotective effects of CSB-NC against the cardiovascular toxicity associated with doxorubicin (Dox).</p><p><strong>Methods: </strong>Cardiovascular toxicity was induced in rats following the administration of Dox (3 mg/kg body weight, i.p.) on days 2, 4, 6, 8, 10, and 12. Thirty-six rats were divided into six groups, each consisting of six rats. The groups included: control, Dox, Dox + chitosan (60 mg/kg, orally), Dox + bentonite (60 mg/kg, orally), Dox + saponins (60 mg/kg, orally), and Dox + CSB-NC (60 mg/kg, orally).</p><p><strong>Results: </strong>Following CSB-NC treatment, the ST segment of the ECG exhibited partial normalization. CSB-NC reduced the levels of cardiac troponin T, creatine kinase, lactate dehydrogenase, aspartate aminotransferase, malondialdehyde, nitric oxide, DNA fragmentation, and caspase-3, while it elevated glutathione, reduced catalase, nuclear factor erythroid 2-related factor 2 (Nrf2) expression, and Bcell leukemia/lymphoma 2 (Bcl-2). The CSB-NC-treated group exhibited a normal histological structure of cardiac muscle.</p><p><strong>Discussion: </strong>CSB-NC demonstrated a protective effect on the heart against Dox toxicity by enhancing the Nrf2 pathway, supporting the internal antioxidant system, and inhibiting the apoptotic pathway by reducing caspase-3 and stimulating Bcl-2 expression.</p><p><strong>Conclusion: </strong>CSB-NC showed a synergistic protective effect against cardiovascular toxicity induced by Dox when combined with saponin, chitosan, and bentonite.</p>","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Arterial Disease Outcome in Patients with ESRD on Hemodialysis: A Study from a Developing Country.","authors":"Ashraf O Oweis, Sameeha A AllShelleh, Bara' Al-Zu'bi, Batool A AlAjlouni, Haneen A Shawer, Karem H Alzoubi","doi":"10.2174/0115701611379543251206002926","DOIUrl":"https://doi.org/10.2174/0115701611379543251206002926","url":null,"abstract":"<p><strong>Background: </strong>End-stage renal disease (ESRD) patients on hemodialysis are at higher risk for cardiovascular complications due to the increased risk of atherosclerosis. This study aims to evaluate the factors associated with poor outcomes in this group of patients with Peripheral arterial disease (PAD) regarding survival and rates of lower limb amputation, which is an important determinant of morbidity and quality of life.</p><p><strong>Methods: </strong>A retrospective analysis was performed using hospital databases from 2010 to 2021. ESRD patients who were diagnosed with PAD during this period were studied; diagnosis was done through CT-angiography. Predefined endpoints were death and amputation.</p><p><strong>Results: </strong>The mean age for the patients was 65.9 (SD 12.96) and 66.7% were males. Most patients had either DM (84.6%) or HTN (91%). The prevalence of amputation was 44.7%, 32.9% were males (P=0.33); using univariate analysis DM was a strong predictor for amputation (P=0.001) as long as coronary artery disease (P=0.001) while other comorbidities like HTN (P=0.66), heart failure (P=0.86), atrial fibrillation (P=0.81), Dyslipidemia (P=0.95) and stroke (P=0.16) were not associated with amputation. On multivariate analysis, only DM (P=0.003) was associated with a higher prevalence of amputation Time to death was 16.9 months (SDܸ25.6), 11.3 months (SDܸ9.1) for patients with amputation vs. 21.1 (SDܸ32.7) for those without amputation.</p><p><strong>Conclusion: </strong>End-stage renal disease patients with PVD, especially with PVD, have higher mortality, and the majority are diabetic, which necessitates earlier recognition of PVD and modified risk factors like better control of DM and its complications in addition to other risk factors like HTN, dyslipidemia, and metabolic disorders of CKD.</p>","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian Rhythm and Ischemic Stroke: A Hospital-based Study in Shanghai, China.","authors":"Bivek Singh, Hedi An, Ran Xiong, Hongrong Xie, You Yin, Roberto Manfredini, Dongya Huang","doi":"10.2174/0115701611396756260218095305","DOIUrl":"https://doi.org/10.2174/0115701611396756260218095305","url":null,"abstract":"<p><strong>Introduction: </strong>Circadian rhythm influences the clinical spectrum of stroke. Despite extensive research, studies examining the circadian influences on stroke occurrence, focusing on demographic factors and common risk factors, are limited. This study aims to examine the distribution and circadian patterns of ischemic stroke onset times and to analyze demographic factors and risk factors related to stroke timing.</p><p><strong>Methods: </strong>Conducted at Shanghai East Hospital, an affiliated hospital of Tongji University, this study analyzed electronic medical records from 2021 and 2022, screening 1,320 patients. A total of 406 patients met the inclusion criteria: >18 years old, Chinese nationality, diagnosed with acute ischemic stroke, and without liver disease. Stroke occurrences were categorized into six time intervals for Cosinor analysis and chi-square tests.</p><p><strong>Results: </strong>Among 406 patients (62.1% male, mean age 68.7 years), stroke occurrences showed a clear circadian pattern, peaking between 08:00 and 11:59 (36.2%) and occurring predominantly during daylight hours (75.9%). Cosinor analysis confirmed significant circadian rhythmicity. Hypertension (67.5%) and diabetes (33%) were not significantly associated with stroke onset timing. No significant differences in stroke timing were observed across gender or age groups.</p><p><strong>Discussion: </strong>Patients with a history of previous stroke demonstrated a significant association with late afternoon onset (p = 0.038), a pattern infrequently reported in prior studies that may reflect altered vulnerability or treatment-related factors.</p><p><strong>Conclusion: </strong>This study demonstrates a pronounced circadian pattern in ischemic stroke, with a latemorning peak. The observed late-afternoon signal among patients with prior stroke warrants further investigation to clarify underlying mechanisms and implications for prevention strategies.</p>","PeriodicalId":11278,"journal":{"name":"Current vascular pharmacology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}