Hepatic Fibrosis Predicts the Prognosis of Patients with Acute Ischemic Stroke Through the Mediation of Cardioembolism.

IF 2.8 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Current vascular pharmacology Pub Date : 2025-02-24 DOI:10.2174/0115701611343296250218111614

Mingyue Zhao, Jiexi Huang, Tian Zeng, Minyue Zhang, Jiaqi Huang, Yufan Gao, Haobo Xie, Shengqi Li, Yilin Chen, Jiahan Xu, Yanchu Wang, Shenyi Lin, Yiyun Weng, Guangyong Chen

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Abstract

Background: Hepatic fibrosis, a chronic pathological condition, is associated with adverse outcomes in stroke patients. Cardioembolism (CE) is a common etiology of stroke, yet the association between hepatic fibrosis and CE remains understudied.

Aim: This study aims to investigate the association between hepatic fibrosis and CE-induced stroke, as well as its impact on stroke patient prognosis.

Methods: This retrospective study included 344 acute ischemic stroke (AIS) patients who underwent thrombolytic therapy. Hepatic fibrosis was assessed using the Fibrosis-4 (FIB-4) index and the Aspartate Aminotransferase-Platelet Ratio Index (APRI). Mediation analysis examined the role of CE in the association between hepatic fibrosis and 3-month functional outcomes.

Results: Among 344 patients, 319 were classified using the Trial of Org 10172 in Acute Stroke Treatment criteria. Severe fibrosis (FIB-4 ≥ 2.01) was observed in 131 patients (38.08%), and CE was identified in 79 patients. FIB-4 was an independent predictor of CE (OR: 2.038, 95%CI: 1.507- 2.757, p < 0.001) and poor 3-month functional outcome (OR: 1.477, 95%CI: 1.103-1.978, p = 0.009) after adjusting for confounders. The effect of FIB-4 on poor 3-month functional outcomes was partially mediated by CE, with a mediation proportion of 30.63%.

Conclusions: Hepatic fibrosis is a significant predictor of short-term functional outcomes in AIS, particularly cardioembolic stroke. The association between hepatic fibrosis and stroke outcomes is partially mediated through CE. These findings highlight the importance of assessing hepatic fibrosis in stroke patients, particularly those with CE etiology.

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肝纤维化通过心脏栓塞介导预测急性缺血性脑卒中患者预后。

背景：肝纤维化是一种慢性病理状态，与脑卒中患者的不良结局相关。心脏栓塞（CE）是卒中的常见病因，但肝纤维化与CE之间的关系仍未得到充分研究。目的：本研究旨在探讨肝纤维化与ce所致脑卒中的关系及其对脑卒中患者预后的影响。方法：本回顾性研究纳入344例接受溶栓治疗的急性缺血性卒中（AIS）患者。采用纤维化-4 （FIB-4）指数和天冬氨酸转氨酶-血小板比率指数（APRI）评估肝纤维化。中介分析检验了CE在肝纤维化和3个月功能预后之间的关联中的作用。结果：在344例患者中，319例患者在急性脑卒中治疗标准中采用了Org 10172试验。131例（38.08%）患者出现严重纤维化（FIB-4≥2.01），79例患者出现CE。校正混杂因素后，FIB-4是CE （OR: 2.038, 95%CI: 1.507- 2.757, p < 0.001）和3个月功能预后不良（OR: 1.477, 95%CI: 1.103-1.978, p = 0.009）的独立预测因子。CE部分介导FIB-4对3个月功能预后不良的影响，其中介比例为30.63%。结论：肝纤维化是AIS患者短期功能预后的重要预测指标，尤其是心栓性卒中。肝纤维化与脑卒中预后之间的关联部分通过CE介导。这些发现强调了评估脑卒中患者肝纤维化的重要性，特别是那些有CE病因的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current vascular pharmacology 医学-外周血管病

CiteScore

9.20

自引率

4.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Vascular Pharmacology publishes clinical and research-based reviews/mini-reviews, original research articles, letters, debates, drug clinical trial studies and guest edited issues to update all those concerned with the treatment of vascular disease, bridging the gap between clinical practice and ongoing research. Vascular disease is the commonest cause of death in Westernized countries and its incidence is on the increase in developing countries. It follows that considerable research is directed at establishing effective treatment for acute vascular events. Long-term treatment has also received considerable attention (e.g. for symptomatic relief). Furthermore, effective prevention, whether primary or secondary, is backed by the findings of several landmark trials. Vascular disease is a complex field with primary care physicians and nurse practitioners as well as several specialties involved. The latter include cardiology, vascular and cardio thoracic surgery, general medicine, radiology, clinical pharmacology and neurology (stroke units).