Association between Statin use and Abdominal Aortic Calcification in Male, Non-diabetic Elderly.

IF 2.8 3区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Meng Wang, Changju Liu, Hongjian Shan
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引用次数: 0

Abstract

Aims: Our study was to investigate the association between statin use and the prevalence of abdominal aortic calcification (AAC).

Methods: The population was enrolled in the 2013-2014 cycle of the National Health and Nutrition Examination Survey (NHANES). The statin use was determined from the questionnaire inquiring the medications taken in the past month. The presence of AAC and severe AAC were assessed based on the AAC score measured by abdominal dual-energy X-ray absorptiometry (DXA). Logistic regression analysis was performed to evaluate the association between statin treatment and AAC after adjustment for potential confounders.

Results: The study included a total of 2074 individuals; the average age 61.6±11.8 years old and 922 (44.5%) were male. AAC (AAC score >0) was present in 35.4% of the population and 12.0% had severe AAC. There were 836 (40.3%) statin users. After adjustment for demographics, lifestyles, comorbidities, and laboratory examinations, statin use was associated with higher odds of AAC (OR 1.28, 95%CI 1.02-1.62; P=0.034) and severe AAC (OR 1.78, 95%CI 1.24-2.55; P=0.002), respectively. Subgroup analysis revealed that the association was stronger in male, non-diabetic participants and those aged >60 years old.

Conclusion: Stain use was associated with a greater presence of AAC and severe AAC. This association was stronger for male, non-diabetic participants and those aged >60 years.

他汀类药物与老年男性非糖尿病患者腹主动脉钙化的关系
目的:我们的研究是调查他汀类药物使用与腹主动脉钙化(AAC)患病率之间的关系。方法:纳入2013-2014年全国健康与营养检查调查(NHANES)。他汀类药物的使用是通过询问过去一个月服用药物的问卷来确定的。根据腹部双能x线吸收仪(DXA)测定的AAC评分,评估是否存在AAC和严重AAC。在调整潜在混杂因素后,进行Logistic回归分析以评估他汀类药物治疗与AAC之间的关系。结果:该研究共纳入2074名个体;平均年龄61.6±11.8岁,男性922例(44.5%)。35.4%的人群存在AAC (AAC评分为b> 0), 12.0%为重度AAC。836名(40.3%)他汀类药物使用者。在对人口统计学、生活方式、合并症和实验室检查进行调整后,他汀类药物的使用与AAC的高发生率相关(OR 1.28, 95%CI 1.02-1.62;P=0.034)和严重AAC (OR 1.78, 95%CI 1.24-2.55;分别P = 0.002)。亚组分析显示,在男性、非糖尿病参与者和年龄在60岁以下的参与者中,这种关联更强。结论:染色剂的使用与AAC的存在和严重的AAC有关。这种关联在男性、非糖尿病参与者和年龄在60岁以下的参与者中更为明显。
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来源期刊
Current vascular pharmacology
Current vascular pharmacology 医学-外周血管病
CiteScore
9.20
自引率
4.40%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Current Vascular Pharmacology publishes clinical and research-based reviews/mini-reviews, original research articles, letters, debates, drug clinical trial studies and guest edited issues to update all those concerned with the treatment of vascular disease, bridging the gap between clinical practice and ongoing research. Vascular disease is the commonest cause of death in Westernized countries and its incidence is on the increase in developing countries. It follows that considerable research is directed at establishing effective treatment for acute vascular events. Long-term treatment has also received considerable attention (e.g. for symptomatic relief). Furthermore, effective prevention, whether primary or secondary, is backed by the findings of several landmark trials. Vascular disease is a complex field with primary care physicians and nurse practitioners as well as several specialties involved. The latter include cardiology, vascular and cardio thoracic surgery, general medicine, radiology, clinical pharmacology and neurology (stroke units).
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