WITHDRAWN: TNF-α/TLR4/IL-6/NF-κB Signaling Pathway and ROS/NOX4/p38/MDA Signaling Pathway Cross-Talk Involved in the Development of Vertebral Artery Stenosis/Occlusion in Elderly Patients

IF 2.1 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Current vascular pharmacology Pub Date : 2025-04-08 DOI:10.2174/0115701611312760250319050036

Xia Li, Yongjuan Zhao, Hualan Zhou, Youdong Hu, Ying Chen, Dianxuan Guo

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引用次数: 0

Abstract

As a conflict has arisen among the authors, the article has been withdrawn at the request of the authors of the journal Current Vascular Pharmacology.

The publisher sincerely apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

查看原文本刊更多论文

TNF-α/TLR4/IL-6/NF-κB信号通路与ROS/NOX4/p38/MDA信号通路串扰参与老年患者椎动脉狭窄/闭塞的发生

椎动脉狭窄/闭塞由于部分或完全阻断流向大脑的血液而导致缺血性脑细胞损伤。目的：探讨老年椎动脉狭窄/闭塞患者的TNF-α/TLR4/IL-6/NF-κB信号通路和ROS/NOX4/p38/MDA信号通路的变化。方法：测定老年椎动脉狭窄/闭塞患者血液中肿瘤坏死因子-α (TNF-α)、toll样受体4 （TLR4）、白细胞介素6 （IL-6）、核因子κ b （NF-κB）、活性氧（ROS）、烟酰胺腺嘌呤二核苷酸磷酸氧化酶4 （NOX4）、p38丝裂原活化蛋白激酶（p38）、丙二醛（MDA）水平。结果：椎动脉狭窄（VAS） 61-70%组TNF-α、TLR4、IL-6、NF-κB、ROS、NOX4、p38、MDA的表达水平分别高于对照组和VAS 50%-60%组(p结论：TNF-α/TLR4/IL-6/NF-κB和ROS/NOX4/p38/MDA信号通路的相互作用与老年患者椎动脉狭窄/闭塞的发病机制有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current vascular pharmacology 医学-外周血管病

CiteScore

9.20

自引率

4.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Vascular Pharmacology publishes clinical and research-based reviews/mini-reviews, original research articles, letters, debates, drug clinical trial studies and guest edited issues to update all those concerned with the treatment of vascular disease, bridging the gap between clinical practice and ongoing research. Vascular disease is the commonest cause of death in Westernized countries and its incidence is on the increase in developing countries. It follows that considerable research is directed at establishing effective treatment for acute vascular events. Long-term treatment has also received considerable attention (e.g. for symptomatic relief). Furthermore, effective prevention, whether primary or secondary, is backed by the findings of several landmark trials. Vascular disease is a complex field with primary care physicians and nurse practitioners as well as several specialties involved. The latter include cardiology, vascular and cardio thoracic surgery, general medicine, radiology, clinical pharmacology and neurology (stroke units).