Diabetes research and clinical practice最新文献_第8页

Role of microRNAs in diabetic foot ulcers: Mechanisms and possible interventions 微RNA在糖尿病足溃疡中的作用：机制和可能的干预措施

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-09-14 DOI: 10.1016/j.diabres.2024.111858

Lin Wang, Cong Wang, Caiyan Huang, Zhongyu Zhou, Ruihong Yang, Ying Huang, Zhuangsen Chen, Yanrong Zhang, Shanshan Wang, Kun Feng

{"title":"Role of microRNAs in diabetic foot ulcers: Mechanisms and possible interventions","authors":"Lin Wang, Cong Wang, Caiyan Huang, Zhongyu Zhou, Ruihong Yang, Ying Huang, Zhuangsen Chen, Yanrong Zhang, Shanshan Wang, Kun Feng","doi":"10.1016/j.diabres.2024.111858","DOIUrl":"10.1016/j.diabres.2024.111858","url":null,"abstract":"<div><p>Diabetic foot ulcer (DFU) is a common and serious complication among diabetic patients, and its incidence and difficulty in treatment have placed large burdens on patient health and quality of life. Diabetic foot tissue typically exhibits chronic wounds, ulcers, or necrosis that are difficult to heal, are prone to infection, and, in severe cases, may even lead to amputation. Recent studies have shown that microRNAs (miRNAs) play key roles in the development and healing of DFUs. miRNAs are a class of short noncoding RNA molecules that regulate gene expression to affect cellular functions and physiological processes. miRNAs may be involved in the development of DFUs by regulating cell growth, proliferation, differentiation and apoptosis. miRNAs can also participate in the healing and recovery of DFUs by regulating key steps, such as inflammation, angiogenesis, cell migration and proliferation, tissue repair and matrix remodeling. Therefore, altering the pathological processes of diabetic foot by modulating the expression of miRNAs could improve the recovery and treatment outcomes of patients. This review provides new insights and perspectives for the treatment of DFUs by summarizing the roles of miRNAs in the development and healing of DFUs and the mechanisms.</p></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111858"},"PeriodicalIF":6.1,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S016882272400768X/pdfft?md5=146c9c12e1c1ed205fa3ee8019082cae&pid=1-s2.0-S016882272400768X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early life socioeconomic inequalities and type 2 diabetes incidence: Longitudinal analyses in the Maastricht study 早期生活中的社会经济不平等与 2 型糖尿病发病率：马斯特里赫特研究的纵向分析

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-09-13 DOI: 10.1016/j.diabres.2024.111855

Rachelle Meisters , Annemarie Koster , Jeroen Albers , Bengisu Sezer , Marleen M.J. van Greevenbroek , Bastiaan E. de Galan , Hans Bosma

{"title":"Early life socioeconomic inequalities and type 2 diabetes incidence: Longitudinal analyses in the Maastricht study","authors":"Rachelle Meisters , Annemarie Koster , Jeroen Albers , Bengisu Sezer , Marleen M.J. van Greevenbroek , Bastiaan E. de Galan , Hans Bosma","doi":"10.1016/j.diabres.2024.111855","DOIUrl":"10.1016/j.diabres.2024.111855","url":null,"abstract":"<div><h3>Aim</h3><p>Type 2 diabetes (T2D) is a common chronic disease that disproportionally affects groups with a low socioeconomic position (SEP). This study aimed to examine associations between childhood SEP and incident T2D, independent of adult SEP.</p></div><div><h3>Methods</h3><p>Longitudinal data from The Maastricht Study were used (N=6,727, 55.2 % female, mean (SD) age 58.7(8.7) years). Childhood SEP was determined by asking for the highest completed educational level for the father and mother and childhood income inadequacy. Adult SEP was determined by highest completed educational level, equivalent household income, and occupational position. Incident T2D was self-reported yearly (up to 12 years of follow-up). Associations were studied with Cox regression analyses.</p></div><div><h3>Results</h3><p>In participants without T2D at baseline, 3.7% reported incident T2D over 8.2 (median) years of follow-up. Incident T2D was most common in people with low childhood and adult SEP and lowest in those with high childhood and adult SEP (1.7 vs. 7.5 per 1,000 person years). The association between childhood SEP and incident T2D was mainly explained by adult SEP, except for childhood income inadequacy which was independently associated with incident T2D.</p></div><div><h3>Conclusion</h3><p>Socioeconomic inequalities in childhood and adulthood are risk factors for incident T2D. More attention is needed to reduce childhood poverty and improve adult SEP to reduce the T2D risk.</p></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111855"},"PeriodicalIF":6.1,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168822724007654/pdfft?md5=1276e53380f91467ff70c2873815fa9d&pid=1-s2.0-S0168822724007654-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathophysiological characteristics of subjects with intermediate hyperglycemia and type 2 diabetes identified by 1-hour plasma glucose during an oral glucose tolerance test 在口服葡萄糖耐量试验中，通过 1 小时血浆葡萄糖确定中度高血糖和 2 型糖尿病受试者的病理生理学特征

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-09-10 DOI: 10.1016/j.diabres.2024.111856

Chiara M.A. Cefalo , Alessia Riccio , Teresa Vanessa Fiorentino , Elena Succurro , Gaia Chiara Mannino , Maria Perticone , Angela Sciacqua , Francesco Andreozzi , Giorgio Sesti

{"title":"Pathophysiological characteristics of subjects with intermediate hyperglycemia and type 2 diabetes identified by 1-hour plasma glucose during an oral glucose tolerance test","authors":"Chiara M.A. Cefalo , Alessia Riccio , Teresa Vanessa Fiorentino , Elena Succurro , Gaia Chiara Mannino , Maria Perticone , Angela Sciacqua , Francesco Andreozzi , Giorgio Sesti","doi":"10.1016/j.diabres.2024.111856","DOIUrl":"10.1016/j.diabres.2024.111856","url":null,"abstract":"<div><h3>Aims</h3><p>The International Diabetes Federation (IDF) has recently recommended determination of 1-hour plasma glucose (1-hPG) during an oral glucose tolerance test (OGTT) to diagnose intermediate hyperglycemia (IH) and type 2 diabetes (T2DM). Herein, we investigated the cardiometabolic characteristics of individuals with IH and T2DM according to IDF criteria<strong>.</strong></p></div><div><h3>Methods</h3><p>We studied 3086 individuals stratified on the basis of fasting, 1-hPG and 2-hPG in four groups: 1) normal glucose tolerance (NGT), 2) isolated impaired fasting glucose (iIFG,), 3) IH (fasting glucose < 126 mg/dL, 1-hPG 155–208 mg/dL, and/or 2-hPG 140–199 mg/dL, and 4) newly diagnosed T2DM (fasting glucose, 1-hPG and/or 2-hPG≥126 mg/dL, 209 mg/dL and 200 mg/dL, respectively).</p></div><div><h3>Results</h3><p>Individuals with IH and T2DM exhibited higher adiposity, blood pressure, uric acid, a worse lipid and inflammatory profile and a progressive reduction in Matsuda index of insulin sensitivity, insulinogenic index, and disposition index as compared to the NGT group. Moreover, individuals with IH and T2DM exhibited lower Matsuda, insulinogenic, and disposition indexes as compared to the iIFG group.</p></div><div><h3>Conclusions</h3><p>1-h PG-based criteria for diagnosis of IH and diabetes identify individuals having an unfavorable cardiometabolic risk profile with a progressive reduction in insulin sensitivity associated with impaired β cell function.</p></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111856"},"PeriodicalIF":6.1,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing the different phenotypes of diabetes in pregnancy: Are outcomes worse for women with young-onset type 2 diabetes compared to type 1 diabetes? 比较妊娠期糖尿病的不同表型：与 1 型糖尿病相比，2 型糖尿病年轻患者的预后是否更差？

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-09-06 DOI: 10.1016/j.diabres.2024.111848

Xi May Zhen , Glynis Ross , Amanda Gauld , Alberto Nettel-Aguirre , Stephanie Noonan , Maria Constantino , Arianne Sweeting , Anna-Jane Harding , Adam Mackie , Hend Chatila , Margaret McGill , Timothy Middleton , Ted Wu , Stephen Twigg , Jencia Wong

{"title":"Comparing the different phenotypes of diabetes in pregnancy: Are outcomes worse for women with young-onset type 2 diabetes compared to type 1 diabetes?","authors":"Xi May Zhen , Glynis Ross , Amanda Gauld , Alberto Nettel-Aguirre , Stephanie Noonan , Maria Constantino , Arianne Sweeting , Anna-Jane Harding , Adam Mackie , Hend Chatila , Margaret McGill , Timothy Middleton , Ted Wu , Stephen Twigg , Jencia Wong","doi":"10.1016/j.diabres.2024.111848","DOIUrl":"10.1016/j.diabres.2024.111848","url":null,"abstract":"<div><h3>Aims</h3><p>Pregnancies are increasingly affected by young-onset type 2 diabetes mellitus (YT2DM), an aggressive phenotype associated with a higher vascular risk profile compared to type 1 diabetes mellitus (T1DM). We compared pregnancy outcomes to illuminate areas where differing management guidance might be needed.</p></div><div><h3>Methods</h3><p>This retrospective single-centre study (2010 2019) included 259 singleton pregnancies affected by pregestational T1DM (N = 124) or YT2DM (N = 135) diagnosed at < 40 years. Primary outcomes included preterm delivery, large for gestational age (LGA) infants, and pre-eclampsia.</p></div><div><h3>Results</h3><p>The YT2DM cohort were older, with more obesity, greater apparent sociodemographic disadvantage, and lower measures of pregnancy preparedness. Overweight/obesity were also prevalent in the T1DM cohort (46 % affected). The second/third trimester mean HbA1c measurements were significantly higher in the T1DM cohort. Pre-eclampsia and preterm delivery rates were similar between the cohorts. Significantly lower rates of LGA infants, NICU admission, neonatal hypoglycaemia, and neonatal respiratory distress were seen in the YT2DM cohort (p < 0.05 for all).</p></div><div><h3>Conclusions</h3><p>In pregnancy, YT2DM appears to be the lower-risk cohort compared to T1DM despite higher obesity rates. Gaps in achieving glycaemic targets exist for both subtypes but particularly for T1DM. The relative impact of increasing BMI in pregnancies affected by T1DM requires further elucidation.</p></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111848"},"PeriodicalIF":6.1,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes as a risk factor for MASH progression 糖尿病是 MASH 进展的风险因素。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-09-06 DOI: 10.1016/j.diabres.2024.111846

Sofiya Gancheva , Michael Roden , Laurent Castera

{"title":"Diabetes as a risk factor for MASH progression","authors":"Sofiya Gancheva , Michael Roden , Laurent Castera","doi":"10.1016/j.diabres.2024.111846","DOIUrl":"10.1016/j.diabres.2024.111846","url":null,"abstract":"<div><p>Non-alcoholic (now: metabolic) steatohepatitis (MASH) is the progressive inflammatory form of metabolic dysfunction-associated steatotic liver disease (MASLD), which often coexists and mutually interacts with type 2 diabetes (T2D), resulting in worse hepatic and cardiovascular outcomes. Understanding the intricate mechanisms of diabetes-related MASH progression is crucial for effective therapeutic strategies. This review delineates the multifaceted pathways involved in this interplay and explores potential therapeutic implications.</p><p>The synergy between adipose tissue, gut microbiota, and hepatic alterations plays a pivotal role in disease progression. Adipose tissue dysfunction, particularly in the visceral depot, coupled with dysbiosis in the gut microbiota, exacerbates hepatic injury and insulin resistance. Hepatic lipid accumulation, oxidative stress, and endoplasmic reticulum stress further potentiate inflammation and fibrosis, contributing to disease severity. Dietary modification with weight reduction and exercise prove crucial in managing T2D-related MASH. Additionally, various well-known but also novel anti-hyperglycemic medications exhibit potential in reducing liver lipid content and, in some cases, improving MASH histology. Therapies targeting incretin receptors show promise in managing T2D-related MASH, while thyroid hormone receptor-β agonism has proven effective as a treatment of MASH and fibrosis.</p></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111846"},"PeriodicalIF":6.1,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168822724007563/pdfft?md5=6a5e43215f7dc7665f6b201be7705911&pid=1-s2.0-S0168822724007563-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor: Sex differences in the plasma glucagon responses to a high carbohydrate meal and a glucose drink in type 2 diabetes 致编辑的信：2型糖尿病患者对高碳水化合物膳食和葡萄糖饮料的血浆胰高血糖素反应的性别差异。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-09-05 DOI: 10.1016/j.diabres.2024.111847

Alishba Mujeeb

引用次数: 0

Advancements and best practices in diabetic foot Care: A comprehensive review of global progress 糖尿病足护理的进步与最佳实践：全面回顾全球进展。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-09-05 DOI: 10.1016/j.diabres.2024.111845

Smita Kumbhar , Manish Bhatia

{"title":"Advancements and best practices in diabetic foot Care: A comprehensive review of global progress","authors":"Smita Kumbhar , Manish Bhatia","doi":"10.1016/j.diabres.2024.111845","DOIUrl":"10.1016/j.diabres.2024.111845","url":null,"abstract":"<div><p>Diabetic foot care has become a critical focus in global healthcare due to the rising prevalence of diabetes and its associated complications. This review aims to consolidate recent advancements and best practices in managing diabetic foot conditions, encompassing foot ulcers, neuropathy, vascular disease, and the risk of amputation. Emphasizing a multidisciplinary approach, the review advocates for collaboration among diabetologists, podiatrists, vascular surgeons, and wound care specialists to enhance patient outcomes.</p><p>Key advancements highlighted include innovative wound care techniques like advanced dressings and bioengineered skin substitutes, alongside effective offloading devices to prevent pressure-related injuries. Early detection and intervention strategies for neuropathy and vascular disease are underscored, with a particular focus on vascular evaluation as a baseline investigation, including Ankle-Brachial Index (ABI) and Toe-Brachial Index (TBI) assessments by trained podiatrists and the use of arterial color Doppler/duplex scans for suspected Peripheral Artery Disease (PAD).</p><p>The review also examines the impact of technological innovations such as telemedicine and wearable devices, facilitating enhanced patient monitoring and timely interventions. It stresses the importance of patient education and self-care practices in mitigating complications. Addressing global disparities, the review advocates for accessible and equitable healthcare services across diverse regions.</p><p>Concluding with recommendations for future research and policy initiatives, this review serves as a vital resource for healthcare professionals, policymakers, and researchers committed to advancing diabetic foot care and improving global patient outcomes.</p></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111845"},"PeriodicalIF":6.1,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-carbohydrate diet in children and young people with type 1 diabetes: A randomized controlled trial with cross-over design 1 型糖尿病儿童和青少年的低碳水化合物饮食：交叉设计的随机对照试验。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-09-03 DOI: 10.1016/j.diabres.2024.111844

V. Neuman , L. Plachy , L. Drnkova , S. Pruhova , S. Kolouskova , B. Obermannova , S.A. Amaratunga , K. Maratova , M. Kulich , J. Havlik , D. Funda , O. Cinek , Z. Sumnik

{"title":"Low-carbohydrate diet in children and young people with type 1 diabetes: A randomized controlled trial with cross-over design","authors":"V. Neuman , L. Plachy , L. Drnkova , S. Pruhova , S. Kolouskova , B. Obermannova , S.A. Amaratunga , K. Maratova , M. Kulich , J. Havlik , D. Funda , O. Cinek , Z. Sumnik","doi":"10.1016/j.diabres.2024.111844","DOIUrl":"10.1016/j.diabres.2024.111844","url":null,"abstract":"<div><h3>Aims</h3><p>We investigated whether a short period of tightly controlled low-carbohydrate diet (LCD) leads to higher time in range without increasing the associated risks in children and young people with diabetes (CYPwD).</p></div><div><h3>Methods</h3><p>Thirty-five (CYPwD) were recruited into this randomized controlled cross-over study (20 female; 20 CSII; age 14.5 ± 2.9 years; HbA1c 48.9 ± 9.4 mmol/mol). The interventions were five and five weeks of ready-made food box deliveries of isocaloric diets in random order: either LCD (94.5 ± 4.7 g/day) or recommended carbohydrate diet (RCD) (191 ± 19.2 g/day). The outcomes were continuous glucose monitoring parameters, anthropometric, laboratory and quality of life (QoL) data.</p></div><div><h3>Results</h3><p>Time in range was significantly higher in the LCD than in the RCD period (77.1 % vs. 73.8 %, <em>P</em>=0.008). Times in hyperglycemia and average glycaemia were significantly lower in the LCD. There was no difference between the diets in time in hypoglycemia or glycemic variability. The subjects’ body weight and BMI were significantly lower during the LCD. There was no significant difference in the LDL-cholesterol levels. No significant differences were observed in the self-assessed QoL.</p></div><div><h3>Conclusions</h3><p>Short-term LCD led to an improvement of glycemic parameters without increasing time in hypoglycemia, disturbing the lipid profile or negatively affecting the quality of life of CYPwD.</p></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111844"},"PeriodicalIF":6.1,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracorporeal shock wave therapy (ESWT) favors healing of diabetic foot ulcers: A systematic review and meta-analysis 体外冲击波疗法（ESWT）有利于糖尿病足溃疡的愈合：系统回顾和荟萃分析。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-09-03 DOI: 10.1016/j.diabres.2024.111843

Fangfang Wu , Zhi Qi , Bohan Pan , Ran Tao

{"title":"Extracorporeal shock wave therapy (ESWT) favors healing of diabetic foot ulcers: A systematic review and meta-analysis","authors":"Fangfang Wu , Zhi Qi , Bohan Pan , Ran Tao","doi":"10.1016/j.diabres.2024.111843","DOIUrl":"10.1016/j.diabres.2024.111843","url":null,"abstract":"<div><h3>Aims</h3><p>To investigate the efficacy and safety of extracorporeal shockwave therapy(ESWT) for diabetic foot ulcers(DFUs).</p></div><div><h3>Methods</h3><p>Search in PubMed, EMBASE, the Cochrane Controlled Register of Trials (CENTAL), and Web of Science for randomized controlled trials (RCTs) published before August 8, 2023. All identified studies were screened following the selection criteria. Finally, we employed the STATA 14.0 software for conducting a <em>meta</em>-analysis to evaluate the efficacy and safety of ESWT.</p></div><div><h3>Results</h3><p>A total of ten RCTs with moderate methodological quality were included for data analysis. The findings showed that ESWT was significantly associated with significantly complete healed ulcers (risk ratio [RR]: 1.57, 95 % confidence interval [CI]:1.26 to 1.95) and lower rate of unchanged ulcers (RR: 0.25, 95 %CI: 0.14 to 0.42) compared to controls. Subgroup analysis further revealed that ESWT was better than both hyperbaric oxygen therapy (HOT) and the standard of care (SOC). Moreover, ESWT also significantly improved the average transcutaneous partial oxygen pressure (TcPO2) (mean difference[MD]: 1.71, 95 %CI: 1.22 to 2.19, p < 0.001). However, the rate of ≥ 50 % improved ulcers and treatment-emergent adverse events (TEAEs) were not significantly different between the ESWT and controls.</p></div><div><h3>Conclusions</h3><p>ESWT has shown promising efficacy and a favorable safety profile in the treatment of DFUs.</p></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111843"},"PeriodicalIF":6.1,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucose levels at hospital admission are associated with 5 year mortality 入院时的血糖水平与 5 年死亡率有关。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-08-30 DOI: 10.1016/j.diabres.2024.111840

N. Wah Cheung , Patrick McElduff , Greg Fulcher , Sandy Middleton , Roger Chen , Barbara Depczynski , Jeff Flack , Jen Kinsella , Margaret Layton , Mark McLean , Ann Poynten , Katherine Tonks , Chris White , Vincent Wong , David R Chipps

{"title":"Glucose levels at hospital admission are associated with 5 year mortality","authors":"N. Wah Cheung , Patrick McElduff , Greg Fulcher , Sandy Middleton , Roger Chen , Barbara Depczynski , Jeff Flack , Jen Kinsella , Margaret Layton , Mark McLean , Ann Poynten , Katherine Tonks , Chris White , Vincent Wong , David R Chipps","doi":"10.1016/j.diabres.2024.111840","DOIUrl":"10.1016/j.diabres.2024.111840","url":null,"abstract":"<div><h3>Aim</h3><p>We aimed to determine if hospital admission hyperglycaemia and hypoglycaemia are associated with increased long-term mortality.</p></div><div><h3>Methods</h3><p>A post-hoc analysis of data from a trial of glucose screening in the emergency department was conducted. Data were linked with a death registry up to 5 years after admission. The relationship between admission glucose and mortality was examined by cox regression. Further analyses of people who survived the admission and subsequent 28 days was performed.</p></div><div><h3>Results</h3><p>There were 131,322 patients, of whom 38,712 (29.5 %) died. Mean follow-up was 3·3 ± 1·5 years. Compared to the reference glucose band of 6·1-8·0 mmol/L, there was increased mortality in higher bands, reaching a hazard ratio (HR) of 1·44 (95 %CI 1·34-1·55, p < 0·001) for people with glucose > 20·0 mmol/L. The HR was 1·56 (95 %CI 1·46-1·68, p < 0·001) for people with glucose ≤ 4·0 mmol/L. Similar relationships were observed among 28-day survivors. The relationships were attenuated among people with known diabetes.</p><p>Among 4867 subjects with glucose ≥ 14·0 mmol/L, those diagnosed with diabetes during the admission had lower mortality compared to subjects where the diagnosis was not made (HR 0·53, 95 %CI 0·40-0·72, p < 0·001). This was attenuated among 28-day survivors.</p></div><div><h3>Conclusion</h3><p>Hyperglycaemia and hypoglycaemia on hospital admission are associated with increased long-term mortality.</p></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111840"},"PeriodicalIF":6.1,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0