Global, regional, and national burden of type 1 diabetes mellitus and chronic kidney disease due to type 1 diabetes mellitus in children aged 0–14 years from 1990 to 2021

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-08-23 DOI:10.1016/j.diabres.2025.112432

Jiang Li , Jingbin Zhang

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引用次数: 0

Abstract

Background

Type 1 diabetes mellitus (T1DM) and chronic kidney disease(CKD) due to T1DM pose a substantial global health burden. However, the epidemiology of T1DM and CKD due to T1DM in children aged 0–14 years remains poorly quantified worldwide. We aimed to evaluate the global burden and trends of these conditions in this pediatric population.

Methods

Using the Global Burden of Disease (GBD) 2021 data, we evaluated the incidence, prevalence, and disability-adjusted life years (DALYs) of T1DM and CKD due to T1DM among children aged 0–14 years from 1990 to 2021.

Results

From 1990 to 2021, the global incidence number of T1DM in children aged 0–14 years increased, and the age-standardized incidence rate(ASIR) increased. The prevalence increased, the age-standardized prevalence rate(ASPR)increased, but the age-standardized DALYs rate(ASDR) decreased. The ASIR, ASPR, and ASDR of CKD due to T1DM decreased. At the same time, health inequality analysis reveals a worsening of disparities among different countries.

Conclusion

The global burden of T1DM and CKD due to T1DM among children aged 0–14 years is facing new challenges, highlighting the urgent need to reinforce and develop more effective public health policies and clinical prevention strategies.

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1990年至2021年全球、地区和国家0-14岁儿童1型糖尿病和由1型糖尿病引起的慢性肾脏疾病负担

背景1型糖尿病（T1DM）和由T1DM引起的慢性肾脏疾病（CKD）构成了巨大的全球健康负担。然而，在世界范围内，0-14岁儿童T1DM和由T1DM引起的CKD的流行病学仍然缺乏量化。我们的目的是评估儿科人群中这些疾病的全球负担和趋势。方法利用全球疾病负担（GBD） 2021数据，评估1990年至2021年0-14岁儿童T1DM和由T1DM引起的CKD的发病率、患病率和残疾调整生命年（DALYs）。结果1990 - 2021年，全球0-14岁儿童T1DM发病人数增加，年龄标准化发病率（ASIR）增加。患病率升高，年龄标准化患病率（ASPR）升高，但年龄标准化DALYs率（ASDR）降低。T1DM所致CKD的ASIR、ASPR、ASDR均降低。与此同时，卫生不平等分析显示，不同国家之间的差距正在加剧。结论全球0-14岁儿童T1DM和CKD负担面临新的挑战，迫切需要加强和制定更有效的公共卫生政策和临床预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.