Diabetes research and clinical practice最新文献

{"title":"Sex-specific associations of sedentary behaviour and physical activity with placental and fetal IL-6 in pregnant women with obesity. Impact on neonatal adiposity in the DALI randomised controlled trial.","authors":"Pedro Acosta-Manzano, David J Hill, Barbara Leopold-Posch, Gernot Desoye, Mireille N M van Poppel","doi":"10.1016/j.diabres.2026.113292","DOIUrl":"https://doi.org/10.1016/j.diabres.2026.113292","url":null,"abstract":"<p><strong>Aims: </strong>To investigate: i) the association of sedentary time (ST) and moderate-to-vigorous physical activity (MVPA) during pregnancy with placental interleukin-6 (IL-6) expression and cord venous IL-6 content in women with obesity; and ii) cord venous markers mediating the relationship of ST/MVPA and placental IL-6 with neonatal adiposity.</p><p><strong>Methods: </strong>Among 134 participants, ST and MVPA were assessed using accelerometry at three gestational periods. Placental IL-6 mRNA was quantified using Nanostring technology. Cord blood concentrations of glucose, leptin, insulin, C-peptide and IL-6 were determined. Neonatal fat percentage was calculated from skinfold measurements.</p><p><strong>Results: </strong>Increasing MVPA from inclusion (<20 weeks) to 24-28 or 35-37 weeks, and reducing ST to 24-28 weeks, were associated with higher IL-6 expression in female placentas (p < 0.05). Increasing MVPA from inclusion to 24-28 weeks was associated with lower cord venous IL-6 levels in male fetuses (p = 0.006). Lower cord glucose and insulin concentrations and insulin resistance mediated the association between increased placental IL-6 and reduced neonatal adiposity (p < 0.05).</p><p><strong>Conclusions: </strong>In women with obesity, increasing MVPA and reducing ST during pregnancy is associated with higher IL-6 expression in female placentas and lower cord IL-6 in male fetuses. Higher placental IL-6 expression is linked to reduced fetal insulinemia and insulin resistance, contributing to lower neonatal adiposity.</p><p><strong>Twitter summary/social media: </strong>In pregnant women with obesity, higher moderate-vigorous physical activity and lower sedentary time upregulate placental IL-6 expression, which in turn is related to lower neonatal adiposity through reduced fetal insulinemia and insulin resistance.</p><p><strong>Clinical trial registration number: </strong>ISRCTN70595832.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"113292"},"PeriodicalIF":7.4,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of GLP-1 receptor agonists in type 1 diabetes: a systematic review and meta-analysis.","authors":"Ramya Kateel, Amrita Parida, Bharti Chogtu, Sadhana N Holla","doi":"10.1016/j.diabres.2026.113270","DOIUrl":"https://doi.org/10.1016/j.diabres.2026.113270","url":null,"abstract":"<p><p>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly explored as adjuncts in Type 1 Diabetes Mellitus (T1DM), though concerns regarding hypoglycaemia and diabetic ketoacidosis (DKA) limit their adoption. To comprehensively evaluate their safety, we conducted a systematic review and meta-analysis following PRISMA guidelines. Major databases were searched through June 2025. Outcomes included hypoglycaemia, DKA, gastrointestinal adverse events, and study withdrawals. Twenty-five studies (23 RCTs, 2 observational) were included. Updated pooled data established a neutral risk for overall hypoglycaemia (RR 1.01; Moderate certainty) and serious adverse events (RR 0.89; Moderate certainty). Furthermore, no significant increase was observed for severe hypoglycaemia (RR 0.74; Low certainty) or DKA (RR 0.60; Very Low certainty), though statistical imprecision warrants cautious interpretation. However, GLP-1 RAs significantly increased nausea (RR 2.89) and vomiting (RR 3.10), driving a twofold increase in early treatment withdrawal (RR 2.02; Moderate certainty). Subgroup analysis revealed that overall tolerability significantly improves after six months of therapy. In conclusion, in pooled analyses, GLP-1 RAs were not associated with increased severe hypoglycaemia or DKA, although evidence remains limited. However, a substantial early gastrointestinal burden necessitates cautious patient selection and stepwise dose-titration to maximize patient tolerability and long-term adherence.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"113270"},"PeriodicalIF":7.4,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Albuminuria trajectories following intensive lifestyle intervention with or without bariatric surgery in adolescents with and at risk of type 2 diabetes.","authors":"Kanchana Perera, John Baker, Kate Smallman, Karen Pickering, Patricia Harry, Diana Anderson, Brandon Orr-Walker, Richard Babor, David Simmons","doi":"10.1016/j.diabres.2026.113296","DOIUrl":"https://doi.org/10.1016/j.diabres.2026.113296","url":null,"abstract":"<p><strong>Aim: </strong>Albuminuria reflects early renal injury and may precede type 2 diabetes, particularly among Māori and Pacific adolescents in New Zealand who experience a high burden of severe obesity. Evidence for renal benefits of bariatric surgery in adolescents is limited. We examined the effect of intensive lifestyle intervention, with or without bariatric surgery, on urine albumin-creatinine ratio (UACR).</p><p><strong>Methods: </strong>Adolescents aged 15-17 years with BMI ≥ 35 kg/m² completed a 12-week very-low-calorie diet (VLCD) programme. Screening HbA1c identified prediabetes or type 2 diabetes, and eligible participants were offered bariatric surgery. UACR was measured at up to 14 time points over 36 months. Longitudinal mixed-effects models assessed trajectories of log-UACR, adjusting for time, surgery status, and weight change, with participant-level random intercepts.</p><p><strong>Results: </strong>Twenty adolescents (11 female; 19 Māori or Pacific; 8 prediabetes and 9 type-2 diabetes) were enrolled; seven underwent surgery. Over follow-up (6-36 months), a significant time × surgery interaction was observed (p < 0.001). At 36-months, surgical participants had an 86 (95% CI 72-92)%, reduction in UACR, whereas non-surgical participants showed no significant change (+2; 95% CI - 7 to + 12)%.</p><p><strong>Conclusions: </strong>Bariatric surgery combined with lifestyle intervention was associated with sustained reductions in albuminuria, suggesting a potential renoprotective effect in high-risk adolescents.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"113296"},"PeriodicalIF":7.4,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of exercise training on bone health in elderly people with type 2 diabetes without osteoporosis: A randomised clinical trial.","authors":"Stefano Balducci, Jonida Haxhi, Lorenza Mattia, Martina Vitale, Luca Pugliese, Giuseppe Argento, Massimo Sacchetti, Giorgio Orlando, Lucilla Bollanti, Nicolina Di Biase, Giuseppe Lucisano, Antonio Nicolucci, Giuseppe Pugliese","doi":"10.1016/j.diabres.2026.113303","DOIUrl":"https://doi.org/10.1016/j.diabres.2026.113303","url":null,"abstract":"<p><strong>Aims: </strong>To assess the effects of exercise on non-invasive measures of bone health in elderly individuals with type 2 diabetes without osteoporosis.</p><p><strong>Methods: </strong>In this randomized clinical trial, 200 elderly individuals with type 2 diabetes without osteoporosis were randomized 1:1 to a two-year, specifically-designed exercise training program (Exercise group) or standard care (Control group). Coprimary outcomes were trabecular bone score (TBS), a surrogate measure of bone quality, and bone mineral density (BMD) at three sites. Secondary outcomes were other bone measures and muscle and physical function parameters.</p><p><strong>Results: </strong>The coprimary endpoints increased in the Exercise group and decreased in the Control group. Significant between-group differences were observed for TBS (mean, 0.016 [95% confidence interval, 0.011-0.021], p < 0.0001, which disappeared after adjusting for abdominal fat indices), and lumbar spine (0.014 [0.005-0.024], p = 0.004), femoral neck (0.017 [0.006-0.028], p = 0.003), and total hip (0.020 [0.010-0.030], p=<0.0001) BMD. Significant between-group differences were observed also for other bone measures, body composition, muscle strength and quality, physical performance, and cardiorespiratory fitness. There were no between-group differences in adverse events.</p><p><strong>Conclusions: </strong>A two-year exercise training improved several non-invasive measures of bone health, together with muscle and physical function parameters, potentially reducing fracture risk in people with type 2 diabetes.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"113303"},"PeriodicalIF":7.4,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A mobile device-based ecological momentary assessment (Mobile-EMA) in adolescents and young adults (AYA) with diabetes: a systematic review and meta-analysis.","authors":"Amit Shapira, Margaret C Penman, Stefan Schneider, Atif Adam, Alexandria E Cronin, Lori M Laffel","doi":"10.1016/j.diabres.2026.113302","DOIUrl":"https://doi.org/10.1016/j.diabres.2026.113302","url":null,"abstract":"<p><strong>Aims: </strong>Mobile ecological momentary assessment (mobile-EMA) enables real-time contextualization of glucose excursions, yet compliance rates in adolescents and young adults (AYA) with diabetes has not been estimated. This systematic review and meta-analysis evaluated mobile-EMA protocols and participant compliance in this population.</p><p><strong>Methods: </strong>Ovid MEDLINE, Embase, Web of Science Core Collection, and CINAHL were searched through November 7, 2024. Eligible studies included English-language publications of AYA with type 1 or type 2 diabetes (T1D or T2D) using mobile-EMA. Three reviewers extracted data on protocols and compliance. Of 991 abstracts screened, 57 underwent full-text review and 9 met inclusion criteria. Protocol characteristics and quality reporting were evaluated using the Checklist for Reporting EMA Studies.</p><p><strong>Results: </strong>Across nine studies (N = 703), most (68%) used participants' personal smartphones. Common measures included glucose, diabetes self-care, and psychosocial. Nearly all studies used time-based sampling over 4-30 days. The pooled compliance rate was 70% (95% CI: 60-79%). Higher prompting was associated with greater compliance (β = 0.0701, SE = 0.0183, p = 0.009), whereas study length and participant burden were not.</p><p><strong>Conclusions: </strong>Evidence on mobile-EMA in AYA with diabetes remains limited. Protocol variability and moderate compliance underscore the need to optimize EMA sampling strategies.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"113302"},"PeriodicalIF":7.4,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends of selected diabetic foot deformities and risk factors: an exploratory analysis from a tertiary diabetes clinic.","authors":"Iztok Štotl, Rok Blagus, Vilma Urbančič-Rovan","doi":"10.1016/j.diabres.2026.113299","DOIUrl":"https://doi.org/10.1016/j.diabres.2026.113299","url":null,"abstract":"<p><strong>Aims: </strong>While classical diabetic foot risk factors are well established, their temporal progression remains insufficiently understood, particularly for deformities. Therefore, we aimed to analyze trends in selected diabetic foot risk factors and to design a practical monitoring model for long-term clinical use.</p><p><strong>Methods: </strong>From 51,001 routine foot examinations at tertiary diabetes clinic (1998-2024), we included 14,436 screenings from 3,049 patients with complete data. Using generalized estimating equations, we modelled the temporal trends in the prevalence of six diabetes-related complications.</p><p><strong>Results: </strong>Loss of Protective Sensation (LOPS) significantly increased the odds (adjusted for age at diagnosis, sex, diabetes type, and duration) of five complications: fat pad atrophy (OR = 2.12), toenail deformity (OR = 2.44), toe deformities (OR = 2.57), callus (OR = 3.66), and xerosis (OR = 2.27). Toenail deformity was the most prevalent complication, while fat pad atrophy showed the steepest relative increase over time. Female sex was a risk factor for specific deformities and fat pad atrophy but protective against xerosis (OR = 0.76).</p><p><strong>Conclusion: </strong>The developed models provide clinically actionable risk trajectories, revealing distinct patterns by complication type, LOPS status, and demographic factors. These findings can directly support targeted screening protocols and inform resource allocation.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"113299"},"PeriodicalIF":7.4,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipidomics analysis to assess metabolic complications in familial partial lipodystrophy type 2.","authors":"Julie Koue-Chon-Lim, Habtamu B Beyene, Corey Giles, Guillaume Treiber, Natalie A Mellett, Amy Liang, Michelle Cinel, David Couret, Muriel Cogne, Olivier Meilhac, Mathilde Simonson, Bryan Veeren, Peter J Meikle, Estelle Nobécourt, Kevin Huynh","doi":"10.1016/j.diabres.2026.113297","DOIUrl":"https://doi.org/10.1016/j.diabres.2026.113297","url":null,"abstract":"<p><strong>Aims: </strong>Familial Partial Lipodystrophy type 2 (FPLD2) is a severe form of metabolic syndrome associated with marked insulin resistance and complications like lipoatrophic diabetes. The aim of this study was to use lipidomics to better understand metabolic complications in FPLD2 and the benefit of the lipidomic-derived metabolic BMI score (mBMI) to characterize metabolic risk.</p><p><strong>Methods: </strong>A total of 115 adults with FPLD2 due to the LMNA 'Reunionese' variant and 289 unaffected age and sex matched adults were enrolled. Lipidomic analysis (787 lipid species) was performed using liquid chromatography-tandem mass spectrometry.</p><p><strong>Results: </strong>For FPLD2 subjects, among the 181 significant lipids species, ceramides, triglycerides, diacylglycerol were higher and plasmalogen, phosphatidylcholine, sphingolipids were lower regarding the control group (P < 0.05). The lipidomic signature of type 2 diabetes was reproduced in the control group with type 2 diabetes but also in lipoatrophic diabetes. We found mBMI was higher in the FPLD2 group especially individuals whose BMI fell within the normal range.</p><p><strong>Conclusion: </strong>Lipidomic analyses reveal different species in control and FPLD2 groups, and the signature for type 2 diabetes coincide with the one for lipoatrophic diabetes. Moreover, the mBMI can be useful to assess metabolic health in FPLD2, especially individuals with normal BMI.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"113297"},"PeriodicalIF":7.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot observational study on glycemic trajectories during ascent, stay, and descent in a 45-day high-altitude exposure.","authors":"Bin Zhang, Mengzi Sun, Zijing Yang, Tingting Wang, Ruihua Xu, Lin Shi, Youfa Wang, Wen Peng","doi":"10.1016/j.diabres.2026.113295","DOIUrl":"https://doi.org/10.1016/j.diabres.2026.113295","url":null,"abstract":"<p><strong>Aims: </strong>To characterize glycemic dynamics and heterogeneity in response patterns during a 45-day high-altitude expedition among healthy adults.</p><p><strong>Methods: </strong>In this longitudinal observational study, eight healthy adults underwent continuous glucose monitoring (CGM) during ascent (2,800 to 4,531 m), stay, and descent. Glycemic metrics (mean glucose, variability indices, time-in-range) were analyzed across altitude-defined phases. Unsupervised clustering was employed to identify glycemic response patterns.</p><p><strong>Results: </strong>Mean glucose exhibited a mild U-shaped trend, with transient elevation and peak glycemic variability (CV = 17.3%) at extreme altitude. Time-in-range remained >97%. Cluster analysis revealed two distinct patterns: a stable, low-variability group (Cluster 1) and a high-variability group (Cluster 2) with amplified excursions and delayed recovery.</p><p><strong>Conclusions: </strong>Short-term high-altitude exposure induces mild, reversible disturbances in glucose regulation, with significant inter-individual heterogeneity. CGM effectively captures these dynamic changes and identifies distinct adaptive patterns, highlighting its utility for monitoring metabolic stress and population-specific responses in extreme environments.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"113295"},"PeriodicalIF":7.4,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between famine exposure and type 2 diabetes mellitus over the last three decades: a systematic review and meta-analysis.","authors":"Awakash Turkar, Kakali Purkayastha, Ram Surath Kumar, Shweta Tanwar, Vishal Deo, Sneh Shalini, Mansi Tomar, Sanghamitra Pati","doi":"10.1016/j.diabres.2026.113286","DOIUrl":"https://doi.org/10.1016/j.diabres.2026.113286","url":null,"abstract":"<p><p>Early-life nutritional deprivation from famine may increase lifelong vulnerability to Type 2 Diabetes Mellitus (T2DM). This Systematic Review and Meta-Analysis evaluated studies published over the past three decades to assess and appraise the association between famine exposure across developmental stages and T2DM risk. PubMed, Embase, Web of Science, and the Cochrane Library identified observational studies published between 1995 and 2025. Studies reporting risk estimates or data enabling calculation of risk ratios (RRs) were included, followed by pooled estimates were generated. Methodological quality was assessed using the Newcastle-Ottawa Scale. Subgroup analyses, meta-regression and sensitivity analyses were conducted to explore heterogeneity. Of 6311 identified articles, 40 met the inclusion criteria. Overall, famine exposure was associated with 43 % higher risk of T2DM (95 % CI: 1.30-1.56; I² = 96.7 %). The pooled risk increased to 47 % in studies published between 2016 and 2025. Longer famine duration (RR = 1.79) and females (RR = 1.52) showed comparatively higher risk. Higher famine severity and exposures during the fetal stage indicated greater susceptibility. Thus, famine exposure is consistently associated with increased risk of T2DM, particularly with prolonged or severe exposure and among women. Nutritional deprivation during key developmental periods may have lasting metabolic effects.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"113286"},"PeriodicalIF":7.4,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of time-restricted eating on glycemic control and variability in individuals with overweight/obesity and prediabetes: A secondary analysis of the RESET randomized controlled trial.","authors":"Christina Kloura, Marie Møller Jensen, Trine Spragge Ekblond, Hanne Enghoff Pedersen, Anne Raben, Kim Katrine Bjerring Clemmensen, Kristine Færch, Martin Bæk Blond, Jonas Salling Quist","doi":"10.1016/j.diabres.2026.113276","DOIUrl":"https://doi.org/10.1016/j.diabres.2026.113276","url":null,"abstract":"<p><strong>Aim: </strong>The aim of this exploratory analysis was to investigate effects of time-restricted eating (TRE) on glycemic control and variability in adults with prediabetes.</p><p><strong>Methods: </strong>This study utilized data from the Restricted Eating Time (RESET) randomized controlled trial. A subset of 46 participants with prediabetes, allocated to either a 10-hour TRE intervention (n = 20) or the control group (n = 26), was analyzed. Changes in continuous glucose monitoring derived outcomes, fasting glucose and glycosylated hemoglobin (HbA1c), at 6 weeks and 3 months were assessed using a linear mixed-effects model.</p><p><strong>Results: </strong>There were no between-group differences in fasting glucose or HbA1c after 6 weeks and 3 months. The 24-hour and daytime coefficient of variation was reduced within the TRE group after 6 weeks but not after 3 months. Nighttime average sensor glucose was lower in the TRE compared with the control group after 6 weeks [-0.3 mmol/L (-0.6 to -0.1)], but this effect was not maintained after 3 months [-0.1 mmol/L (-0.4 to 0.2)].</p><p><strong>Conclusion: </strong>TRE may have a small short-term beneficial effect on nighttime glucose levels in adults with prediabetes. Larger long-term TRE studies are warranted.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"113276"},"PeriodicalIF":7.4,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}