Diabetes research and clinical practice最新文献_第2页

Body roundness index as a predictor of all-cause and cardiovascular mortality in patients with diabetes and prediabetes.

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-12-13 DOI: 10.1016/j.diabres.2024.111958

Peipei Wang, Yongqiang Fan, Haoyue Gao, Bei Wang

{"title":"Body roundness index as a predictor of all-cause and cardiovascular mortality in patients with diabetes and prediabetes.","authors":"Peipei Wang, Yongqiang Fan, Haoyue Gao, Bei Wang","doi":"10.1016/j.diabres.2024.111958","DOIUrl":"10.1016/j.diabres.2024.111958","url":null,"abstract":"<p><strong>Background: </strong>There are limited population-based studies examining the correlation between body roundness index (BRI) and mortality in diabetes and prediabetes patients.</p><p><strong>Method: </strong>Our final analysis encompassed 15,848 patients with diabetes and prediabetes sourced from the National Health and Nutrition Examination Survey(NHANES) spanning from 2003 to 2018. Cox proportional hazards model and restricted cubic splines (RCS) were utilized to assess the correlation between BRI and both all-cause mortality and cardiovascular mortality.</p><p><strong>Results: </strong>During an average follow-up period of 92.9 months, 2655 participants (12.73 %) died, including 730 (3.44 %) from cardiovascular diseases. RCS demonstrated a U-shaped nonlinear association between BRI with all-cause mortality and cardiovascular mortality, with threshold values of 5.54 and 5.21, respectively. When BRI was below the threshold, a negative correlation was observed between BRI and all-cause mortality (HR 0.87, 95 % CI 0.81-0.93).The correlation with cardiovascular mortality is not significant. Conversely, when BRI was above the threshold, a positive correlation was observed between BRI with all-cause mortality (HR 1.10, 95 % CI 1.06-1.14) and cardiovascular mortality (HR 1.13, 95 % CI 1.07-1.20).</p><p><strong>Conclusion: </strong>Our research indicates that among US adults with diabetes or prediabetes, BRI exhibits a U-shaped relationship with all-cause and cardiovascular mortality, with threshold values of 5.54 and 5.21, respectively.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"111958"},"PeriodicalIF":6.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conservative surgery for forefoot osteomyelitis may increase reulceration-free survival compared to minor amputation in diabetes-related foot disease. 与轻微截肢相比，前足骨髓炎的保守性手术可提高糖尿病足病的无再溃疡存活率。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-12-12 DOI: 10.1016/j.diabres.2024.111949

Gerardo Víquez-Molina, José María Rojas-Bonilla, Javier Aragón-Sánchez

引用次数: 0

Diabetes specialist nurse support, training and 'virtual' advice reduces district nurse visits and improves outcomes for people with diabetes requiring visits for insulin administration.

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-12-06 DOI: 10.1016/j.diabres.2024.111948

Laura Gilligan, Emma Page, Jo Hall, Kelly Ward, William K Gray, Tim W R Briggs, Gerry Rayman

{"title":"Diabetes specialist nurse support, training and 'virtual' advice reduces district nurse visits and improves outcomes for people with diabetes requiring visits for insulin administration.","authors":"Laura Gilligan, Emma Page, Jo Hall, Kelly Ward, William K Gray, Tim W R Briggs, Gerry Rayman","doi":"10.1016/j.diabres.2024.111948","DOIUrl":"10.1016/j.diabres.2024.111948","url":null,"abstract":"<p><strong>Aims: </strong>We evaluated the effectiveness of a community diabetes specialist nurse (cDSN) working with district nurses (DNs) to optimise insulin therapy on DN workload and patient outcomes.</p><p><strong>Methods: </strong>This was an observational clinical improvement study of outcomes pre- and post-introduction of an intervention within a community diabetes service in an areas of England. Patients were followed up for 6 months. The intervention was a cDSN providing advice and support to DNs in safe diabetes management, with a particular focus on insulin use.</p><p><strong>Results: </strong>in total, 148 of 224 patients were reviewed; 130 (87.8 %) were available for follow up 6 months after their first review. Comparing pre- to post-intervention outcomes, number of patients with a hypoglycaemic event reduced from 21/129 to 1/128 (X<sup>2</sup> = 19.71, p < 0.001) as did the number with a hyperglycaemic event; 53/129 to 23/128 (X<sup>2</sup> = 16.48, p < 0.001). Number of DN visits and use of acute hospital services also improved significantly. Estimated cost savings through reduced DN visits, insulin usage, and hospital service use totalled £1.9 million.</p><p><strong>Conclusions: </strong>Significant financial savings and reduced patient harms were identified following our intervention in this cohort. Roll-out to other sites in England is a next step.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"111948"},"PeriodicalIF":6.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance of a safety protocol for scuba diving in people with type 1 diabetes: 20 years of "Diabete Sommerso®" experience.

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-12-06 DOI: 10.1016/j.diabres.2024.111945

Elena Gamarra, Pierpaolo Trimboli, Giovanni Careddu, Andrea Fazi, Valentina Turra, Ambra Morelli, Elena Cimino, Paolo Di Bartolo, Umberto Valentini, Matteo Bonomo

{"title":"Performance of a safety protocol for scuba diving in people with type 1 diabetes: 20 years of \"Diabete Sommerso®\" experience.","authors":"Elena Gamarra, Pierpaolo Trimboli, Giovanni Careddu, Andrea Fazi, Valentina Turra, Ambra Morelli, Elena Cimino, Paolo Di Bartolo, Umberto Valentini, Matteo Bonomo","doi":"10.1016/j.diabres.2024.111945","DOIUrl":"10.1016/j.diabres.2024.111945","url":null,"abstract":"<p><strong>Background and aims: </strong>Scuba diving for people with diabetes was discouraged due to hypoglycemia risks. However, evolving guidelines now enable safe diving for people with diabetes. Among them, the Diabete Sommerso® safety protocol. This study aims to describe data from 20 years of DS activities and evaluate the performance of the protocol in avoiding metabolic complications.</p><p><strong>Research design and methods: </strong>During DS camps, participants are trained to monitor glycemia before and immediately after diving, aiming for stable levels between 150-250 mg/dl. Since 2004, glycemic data from dives conducted with DS/independently by its members have been collected.</p><p><strong>Results: </strong>DS issued diving licenses to 74 type 1 diabetic people. Data are available for 68: median age was 32 years (IQR 22 yrs), diabetes duration 18 years (IQR 16 yrs), HbA1c 7 % (IQR 1 %). 34 used insulin pumps, 43 continuous glucose monitoring. A total of 1179 dives were analyzed, showing a median reduction in glycemia of -38 mg/dl during dives (IQR 92 mg/dl, p < 0.0001). Post-dive hypoglycemia occurred in 23 cases, 45 % of which involved protocol non-adherence. Hypoglycemia prevalence was 1.7 % when the protocol was followed. No severe hypoglycemic episodes occoured during/after diving.</p><p><strong>Conclusions: </strong>Data from 1179 dives indicate that, with adherence to the safety protocol, scuba diving is safe and poses no risk of severe hypoglycemia for people with type 1 diabetes.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"111945"},"PeriodicalIF":6.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of flash glucose monitoring on HbA1c in type 2 diabetes: An individual patient data meta-analysis of real-world evidence.

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-12-04 DOI: 10.1016/j.diabres.2024.111950

Randeep S Heer, Joshua Lovegrove, Zoë Welsh

{"title":"Efficacy of flash glucose monitoring on HbA1c in type 2 diabetes: An individual patient data meta-analysis of real-world evidence.","authors":"Randeep S Heer, Joshua Lovegrove, Zoë Welsh","doi":"10.1016/j.diabres.2024.111950","DOIUrl":"10.1016/j.diabres.2024.111950","url":null,"abstract":"<p><strong>Aims: </strong>There is a growing body of evidence demonstrating the benefit of flash glucose monitoring in type 2 diabetes mellitus (T2DM). This individual patient data meta-analysis aimed to investigate the impact of commencing flash glucose monitoring on HbA1c in people living with T2DM treated with insulin in a real-world setting.</p><p><strong>Methods: </strong>A meta-analysis of eight observational studies which assessed change in HbA1c at 3-6 months following initiating flash glucose monitoring for which Abbott Diabetes Care could provide individual patient data was performed. Studies included adults with T2DM managed with insulin and baseline HbA1c between 8.0 %-12.0 % (64-108 mmol/mol). A one-stage model was created to explore heterogeneity.</p><p><strong>Results: </strong>A total of 803 patients were included in the analysis (mean(SD) age: 62.8(11.4) years, BMI: 32.2(6.8) kg/m<sup>2</sup>, baseline HbA1c 9.0(0.9) % [75 (10) mmol/mol]). Commencement of flash glucose monitoring was associated with an HbA1c reduction of 0.89 % (95 % CI 0.71 to 1.08) (9.8 mmol/mol (95 % CI 7.8 to 11.8)) at 3-6 months. In the one stage model, age, BMI and baseline HbA1c accounted for the substantial heterogeneity observed between studies.</p><p><strong>Conclusions: </strong>Commencement of flash glucose monitoring was associated with a significant reduction in HbA1c at 3-6 months in a real-world setting in T2DM managed with insulin.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"111950"},"PeriodicalIF":6.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Responses to lifestyle interventions among individuals with distinct pre-diabetes phenotypes: A systematic review and Meta-Analysis.

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-12-04 DOI: 10.1016/j.diabres.2024.111939

Jincheng Rong, Mandy Ho, Disheng Zhou, Pui Hing Chau

{"title":"Responses to lifestyle interventions among individuals with distinct pre-diabetes phenotypes: A systematic review and Meta-Analysis.","authors":"Jincheng Rong, Mandy Ho, Disheng Zhou, Pui Hing Chau","doi":"10.1016/j.diabres.2024.111939","DOIUrl":"10.1016/j.diabres.2024.111939","url":null,"abstract":"<p><strong>Aims: </strong>To assess responses to lifestyle interventions (LIs) among individuals with distinct pre-diabetes phenotypes (isolated impaired fasting glucose [i-IFG], isolated impaired glucose tolerance [i-IGT], and combined IFG + IGT) for reducing diabetes incidence, reversing pre-diabetes, and improving glycemic control and insulin sensitivity.</p><p><strong>Methods: </strong>PubMed, Embase, Cochrane Library, and Web of Science were searched until December 6th, 2023. We included randomized controlled trials examining responses to LIs (including diet and/or physical activity) among adults with i-IFG, i-IGT, and IFG + IGT. Outcomes included diabetes incidence, normoglycemia incidence, fasting plasma glucose (FPG), 2-hour plasma glucose (2 h-PG), hemoglobin A1c, fasting insulin (FI), and homeostasis model assessment-insulin resistance (HOMA-IR). Random-effects meta-analyses were performed to estimate risk ratios (RRs) and mean differences.</p><p><strong>Results: </strong>Twenty-seven studies were included. Meta-analysis of 10 studies that performed stratified analyses by pre-diabetes phenotype found that LIs significantly reduced diabetes incidence in i-IGT (RR = 0.69 [0.56; 0.85], I<sup>2</sup> = 14 %) and IFG + IGT (RR = 0.56 [0.48; 0.66], I<sup>2</sup> = 0 %) but not in i-IFG (RR = 0.85 [0.66; 1.11], I<sup>2</sup> = 0 %; p<sub>subgroup</sub> = 0.02). Meta-analysis of 20 studies using IGT for participant recruitment showed that LIs significantly decreased diabetes incidence, increased normoglycemia incidence, and improved FPG, 2 h-PG, FI and HOMA-IR.</p><p><strong>Conclusions: </strong>LIs are effective for IGT (with or without IFG), but tailored LIs are needed for i-IFG to prevent diabetes.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"111939"},"PeriodicalIF":6.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term weight change, incident cardiovascular disease and all-cause mortality among diabetic adults.

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-12-02 DOI: 10.1016/j.diabres.2024.111946

Xue Bai, Lei Zhang, Xiaoxiao Ji, Kening Chen, Xueshi Di, Fangjieyi Zheng, Peng Bai, Wenquan Niu

{"title":"Long-term weight change, incident cardiovascular disease and all-cause mortality among diabetic adults.","authors":"Xue Bai, Lei Zhang, Xiaoxiao Ji, Kening Chen, Xueshi Di, Fangjieyi Zheng, Peng Bai, Wenquan Niu","doi":"10.1016/j.diabres.2024.111946","DOIUrl":"10.1016/j.diabres.2024.111946","url":null,"abstract":"<p><p>We aimed to explore the impact of weight change from young to middle adulthood on incident cardiovascular disease (CVD) and all-cause mortality in US diabetic adults. All study subjects aged 40-79 years were from the US National Health and Nutrition Examination Survey (NHANES) 1988-2018, and they were non-pregnant and had complete data on self-reported weight at age 25 and 10 years before baseline enrollment over average 29.4 years. CVD events occurring from 10 years ago to baseline enrollment were recorded. Relative to stable non-obesity group, the strongest association was noted for the weight-losing group, followed by the stable-obesity group and weight-gaining group over following 10 years. Referring to the stable-obesity group identified significance for the stable non-obesity group. If total population had maintained non-obese from young to middle adulthood, 12 % of CVD cases could have been averted. Relative to the stable non-obesity group, subjects who maintained obese between young and middle adulthood had an increased risk of all-cause mortality. Our findings indicated that the risk for incident CVD and all-cause mortality was potentially reinforced in diabetic adults who were obese at age 25 but non-obese at midlife and who remained stable obese vis-à-vis those with stable non-obesity.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"111946"},"PeriodicalIF":6.1,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The road to achieving diabetes education in schools.

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-12-01 Epub Date: 2024-11-29 DOI: 10.1016/j.diabres.2024.111944

引用次数: 0

Corrigendum to "Risk factors of first and recurrent genitourinary tract infection in patients with type 2 diabetes treated with SGLT2 inhibitors: a retrospective cohort study" [Diabetes Res. Clin. Pract. 186 (2022) 109816]. 对 "接受 SGLT2 抑制剂治疗的 2 型糖尿病患者首次和复发泌尿生殖道感染的风险因素：一项回顾性队列研究 "的更正 [Diabetes Res. Clin. Pract. 186 (2022) 109816]。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-12-01 Epub Date: 2024-11-24 DOI: 10.1016/j.diabres.2024.111925

Yi-Hsuan Lin, Chia-Hung Lin, Yu-Yao Huang, An-Shun Tai, Shih-Chen Fu, Szu-Tah Chen, Sheng-Hsuan Lin

引用次数: 0

Utilisation of blood glucose test strips in insulin-requiring people with diabetes mellitus using continuous glucose monitoring in Saxony-Anhalt – Analysis of health insurance data 萨克森-安哈尔特州使用连续血糖监测的糖尿病患者对胰岛素需求者血糖试纸的使用情况--医疗保险数据分析。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-12-01 DOI: 10.1016/j.diabres.2024.111935

Sara Lena Lückmann , Antonia Förster , Stephanie Heinrich , Christian Buhtz , Gabriele Meyer , Rafael Mikolajczyk , Steffen Fleischer

{"title":"Utilisation of blood glucose test strips in insulin-requiring people with diabetes mellitus using continuous glucose monitoring in Saxony-Anhalt – Analysis of health insurance data","authors":"Sara Lena Lückmann , Antonia Förster , Stephanie Heinrich , Christian Buhtz , Gabriele Meyer , Rafael Mikolajczyk , Steffen Fleischer","doi":"10.1016/j.diabres.2024.111935","DOIUrl":"10.1016/j.diabres.2024.111935","url":null,"abstract":"<div><h3>Aims</h3><div>Continuous glucose measurement (CGM) systems are increasingly utilised by people with diabetes mellitus (DM) and less is known about usage behaviour. Therefore, this study aims to analyse additionally utilisation of blood glucose measurement (BGM) for insurants who are using CGM.</div></div><div><h3>Methods</h3><div>The study used secondary data, health claims data from the AOK Saxony-Anhalt (Germany), from 2016 to 2021, analysing a sample of 52,296 individuals with insulin-requiring DM.</div></div><div><h3>Results</h3><div>Nearly all CGM users reduced their utilisation of BGM test strips. 2,306 persons with CGM long-time utilisation, about half showed a mean usage behaviour, nearly one third did not use test strips anymore, about 8 % stopped using CGM, 9 % were intense users. A high test strip utilisation beside CGM was associated with younger age, T1DM, a high number of test strip before starting CGM, no contact with a general practitioner, and no enrolment in a disease management program.</div></div><div><h3>Conclusions</h3><div>Great differences in reductions and usage behaviour was revealed between insurants. The results can be used to better identify and offer more tailored CGM to people with DM, and to better tailor CGM trainings.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"218 ","pages":"Article 111935"},"PeriodicalIF":6.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0