Diabetes research and clinical practice最新文献_第2页

Osteocalcin is inversely associated with worse adipose tissue distribution and cardiovascular risk in autoimmune diabetes 骨钙素与自身免疫性糖尿病患者较差的脂肪组织分布和心血管风险成反比

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-24 DOI: 10.1016/j.diabres.2025.112114

Renata Risi , Rocco Amendolara , Angela Balena , Mikiko Watanabe , Davide Masi , Valeria Fassino , Daniela Luverà , Luca D’Onofrio , Angelo Lauria , Simona Zampetti , Lucio Gnessi , Ernesto Maddaloni , Raffaella Buzzetti , On behalf of AD_OWOB study group

{"title":"Osteocalcin is inversely associated with worse adipose tissue distribution and cardiovascular risk in autoimmune diabetes","authors":"Renata Risi , Rocco Amendolara , Angela Balena , Mikiko Watanabe , Davide Masi , Valeria Fassino , Daniela Luverà , Luca D’Onofrio , Angelo Lauria , Simona Zampetti , Lucio Gnessi , Ernesto Maddaloni , Raffaella Buzzetti , On behalf of AD_OWOB study group","doi":"10.1016/j.diabres.2025.112114","DOIUrl":"10.1016/j.diabres.2025.112114","url":null,"abstract":"<div><h3>Background</h3><div>Osteocalcin (OCN), whose release is impaired in diabetes, is suggested to regulate the adipose tissue (AT), being potentially associated with Cardiovascular risk (CVR). We aimed at evaluating whether OCN serum levels are associated with AT health and CVR in a primary CV prevention population with AD.</div></div><div><h3>Methods</h3><div>Body mass composition was assessed in sixty-two people with AD.Serum levels of OCN, adipokines and markers of endothelial dysfunction were measured. Regression models were used to test the association of OCN with markers of AT, endothelial dysfunction and CVR categories as determined by the Steno Type 1 Risk Engine (ST1RE) score.</div></div><div><h3>Results</h3><div>OCN was inversely associated with upper body fat deposition index (UBDFI) (Adj β coefficient −0.484, p value = 0.001). People in medium/high CV risk categories had higher UBFDI and lower OCN, while biomarkers of endothelial dysfunction were not different across CVR classes. A logistic binary regression for ST1RE score showed significant association of OCN with medium/high CVR category: OR [95 % CI for 1 SD increase: 0.541 [0.264––1.108], p = 0.093].</div></div><div><h3>Conclusion</h3><div>OCN is inversely associated with unhealthy AT, supporting the protective role of OCN in AT. Moreover, lower OCN levels are associated with increased CVR in AD population.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"223 ","pages":"Article 112114"},"PeriodicalIF":6.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Characterisation of transfusion-dependent prediabetes using continuous glucose monitoring: The Haemoglycare study" [Diab. Res. Clin. Pract. 222 (2025) 112076].

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-24 DOI: 10.1016/j.diabres.2025.112101

Angela Zanfardino, Gulsum Ozen, Giorgia Ippolito, Domenico Roberti, Silverio Perrotta, Dario Iafusco, Emanuele Miraglia Del Giudice, Maddalena Casale

引用次数: 0

Mechanistic insights into impaired β-oxidation and its role in mitochondrial dysfunction: A comprehensive review

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-23 DOI: 10.1016/j.diabres.2025.112129

Amna Aqeel , Areeba Akram , Minahil Ali , Maryam Iqbal , Mehral Aslam , Rukhma , Fatima Iftikhar Shah

{"title":"Mechanistic insights into impaired β-oxidation and its role in mitochondrial dysfunction: A comprehensive review","authors":"Amna Aqeel , Areeba Akram , Minahil Ali , Maryam Iqbal , Mehral Aslam , Rukhma , Fatima Iftikhar Shah","doi":"10.1016/j.diabres.2025.112129","DOIUrl":"10.1016/j.diabres.2025.112129","url":null,"abstract":"<div><div>Mitochondria, also known as the powerhouse of cells, have an important role in cellular metabolism and energy production. However, during Mitochondrial Dysfunction (MD), it is known to generate reactive oxidative species and induce cellular apoptosis. A number of research findings have linked MD to various diseases, highlighting its critical role in maintaining health and contributing to disease development. In this regard, recent research has revealed that disruptions in lipid metabolism, especially in fatty acid oxidation, are significant contributors to MD. However, the precise mechanisms by which these defects lead to disease remain poorly understood. This review explores how disruptions in lipid metabolism are responsible for triggering oxidative stress, inflammation, and cellular damage, leading to impaired mitochondrial function. By examining specific fatty acid oxidation disorders, such as carnitine palmitoyltransferase deficiency, medium-chain acyl-CoA dehydrogenase deficiency, and very long-chain acyl-CoA dehydrogenase deficiency, this review aims to uncover the underlying molecular pathways connecting lipid metabolism to mitochondrial dysfunction. Furthermore, MD is a common underlying mechanism in a wide array of diseases, including neurodegenerative disorders and metabolic syndromes. Understanding the mechanisms behind mitochondrial malfunction may aid in the development of tailored therapies to restore mitochondrial health and treat intricate health conditions.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"223 ","pages":"Article 112129"},"PeriodicalIF":6.1,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When COVID-19 meets diabetes: A bibliometric analysis 当 COVID-19 遇到糖尿病：文献计量分析

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-23 DOI: 10.1016/j.diabres.2025.112118

Yingli He , Qingcong Zheng , Zhang Zhifang , Nie Xiaofeng , Wu Shenggen , Mengzhou Xue , Chunfu Zheng , Zhijun Liu

{"title":"When COVID-19 meets diabetes: A bibliometric analysis","authors":"Yingli He , Qingcong Zheng , Zhang Zhifang , Nie Xiaofeng , Wu Shenggen , Mengzhou Xue , Chunfu Zheng , Zhijun Liu","doi":"10.1016/j.diabres.2025.112118","DOIUrl":"10.1016/j.diabres.2025.112118","url":null,"abstract":"<div><div>Coronavirus disease 2019 (COVID-19) survivors are concerned about the likelihood of developing further diseases. This study examines the global trends in scientific research on diabetes associated with COVID-19 from several perspectives. Bibliometric analyses are used to undertake a scientific review of the literature. The Web of Science Core Collection (WoSCC) database was used to acquire bibliographic information on diabetes related to COVID-19 from Jan 2020 to Dec. 2023. The visual map was built via advanced CiteSpace 6.2.R6. 7,348 papers were found. Khunti Kamlesh and Rizzo-Manfredi are the most well-known high-yield authors in this area, and the top ten authors collaborate extensively. Most of these papers came from universities. Harvard Medical School has the most publications, followed by Wuhan University and Huazhong University of Science and Technology. China and the United States are the countries with the most publications. Angiotensin-converting enzymes, chronic disease, intensive care unit, viral infection, and gestational diabetes mellitus were scored 0–11, 2, 3, and 4, respectively. Zhou et al.’s work on this topic, which appeared in the prominent medical journal The Lancet, was cited 1,366 times, highlighting its importance. “clinical characteristics,” “diabetes mellitus,” “metabolic syndrome,” and “angiotensin-converting enzyme” were used as keywords for reference co-citation and clustering data identify. Over the last four years, related investigations have focused primarily on observing clinical aspects. This report is important for developing treatment strategies, directing future research, and guiding clinical practice.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"223 ","pages":"Article 112118"},"PeriodicalIF":6.1,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to the Letter regarding ‘Relationship between Life’s Essential 8, vitamin D, and cardiometabolic Outcomes’

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-22 DOI: 10.1016/j.diabres.2025.112120

Qiuting Jia, Yongle Wang, Yihui Kong

引用次数: 0

Loneliness and social isolation as risk factors for type 2 diabetes onset: A systematic review and meta-analysis

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-22 DOI: 10.1016/j.diabres.2025.112124

Yasmin Ezzatvar , Óscar Caballero , Daniel Duclos-Bastias , Rodrigo Yáñez-Sepúlveda , Antonio García-Hermoso

{"title":"Loneliness and social isolation as risk factors for type 2 diabetes onset: A systematic review and meta-analysis","authors":"Yasmin Ezzatvar , Óscar Caballero , Daniel Duclos-Bastias , Rodrigo Yáñez-Sepúlveda , Antonio García-Hermoso","doi":"10.1016/j.diabres.2025.112124","DOIUrl":"10.1016/j.diabres.2025.112124","url":null,"abstract":"<div><h3>Aims</h3><div>This study sought to analyze the association of social isolation and loneliness with the risk of type 2 diabetes onset.</div></div><div><h3>Methods</h3><div>Two authors systematically searched PubMed, EMBASE, and Web of Science databases for studies published until February 2025, assessing the risk of incidence of type 2 diabetes in individuals who are socially isolated or lonely. To quantify the risk of incident diabetes, hazard ratios (HR) for loneliness and social isolation were pooled using a random-effects inverse-variance model with empirical Bayes estimation.</div></div><div><h3>Results</h3><div>Nine prospective cohort studies were included, comprising 1,112,887 individuals (60.5 % female, mean age = 57.1 years), with 50,961 new cases of type 2 diabetes over a mean follow-up of 10.7 years. Loneliness was associated with a 32% increased risk of type 2 diabetes (HR = 1.32 [95 % confidence interval [CI]:1.11–1.57]). Social isolation was linked to a 20% higher risk (HR = 1.20 [95 %CI:1.01–1.43]). The included studies showed fair-to-good methodological quality (mean score: 10.11/14) based on the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies.</div></div><div><h3>Conclusions</h3><div>Social isolation and loneliness are significant risk factors for type 2 diabetes. Addressing social connectedness could be a valuable strategy for diabetes prevention, emphasizing the need to incorporate psychosocial factors into public health initiatives.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"223 ","pages":"Article 112124"},"PeriodicalIF":6.1,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tips for successful use of commercial automated insulin delivery systems: An expert paper of the Italian working group on diabetes and technology.

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-22 DOI: 10.1016/j.diabres.2025.112117

Sergio Di Molfetta, Antonio Rossi, Roberta Assaloni, Roberto Franceschi, Valeria Grancini, Vincenzo Guardasole, Andrea Enzo Scaramuzza, Antonietta Maria Scarpitta, Maddalena Trombetta, Angela Zanfardino, Riccardo Candido, Angelo Avogaro, Valentino Cherubini, Concetta Irace

{"title":"Tips for successful use of commercial automated insulin delivery systems: An expert paper of the Italian working group on diabetes and technology.","authors":"Sergio Di Molfetta, Antonio Rossi, Roberta Assaloni, Roberto Franceschi, Valeria Grancini, Vincenzo Guardasole, Andrea Enzo Scaramuzza, Antonietta Maria Scarpitta, Maddalena Trombetta, Angela Zanfardino, Riccardo Candido, Angelo Avogaro, Valentino Cherubini, Concetta Irace","doi":"10.1016/j.diabres.2025.112117","DOIUrl":"https://doi.org/10.1016/j.diabres.2025.112117","url":null,"abstract":"<p><p>In recent years, automated insulin delivery (AID) systems have transformed diabetes care with demonstrated benefits in glucose control, hypoglycemia risk, and psychosocial outcomes. Given that different systems show peculiarities in terms of components, approved indications of use, type of algorithm, modifiable settings, and additional features, with this expert paper, we aim to provide healthcare professionals with device-specific recommendations for the optimization of insulin therapy and diabetes self-management with the five commercial AID systems most commonly used in Italy. In detail, we provide educational tips and suggestions for adjustment of insulin dosing parameters to address specific glucose patterns as depicted by continuous glucose monitoring data and effectively manage physical activity or exercise.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"112117"},"PeriodicalIF":6.1,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between different triglyceride glucose index-related indicators and overactive bladder

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-22 DOI: 10.1016/j.diabres.2025.112128

Yuhan Huang , Kaiyuan Wang , Wenjing Wang, Xueqian Sun, Shihao Zhao, Yuanyuan Miao, Yuchun Tao , Lina Jin

{"title":"Association between different triglyceride glucose index-related indicators and overactive bladder","authors":"Yuhan Huang , Kaiyuan Wang , Wenjing Wang, Xueqian Sun, Shihao Zhao, Yuanyuan Miao, Yuchun Tao , Lina Jin","doi":"10.1016/j.diabres.2025.112128","DOIUrl":"10.1016/j.diabres.2025.112128","url":null,"abstract":"<div><h3>Background</h3><div>Overactive bladder (OAB) is a syndrome marked by urinary urgency. Given the crucial role of metabolic anomalies in the pathogenesis of OAB, the aim of this study was to investigate the associations between different triglyceride glucose index (TyG)-related indicators and OAB.</div></div><div><h3>Methods</h3><div>9024 participants aged ≥ 20 years from NHANES 2005–2018 were involved. Weighted multivariate logistic regression was employed to assess the relationship between three TyG-related indicators and OAB with subgroup and interaction analyses. In addition, ROC, DeLong’s test and confusion matrix were further utilized to assess the predictive power of different indicators for OAB in the total population versus different subgroups of the population.</div></div><div><h3>Results</h3><div>TyG-related indicators were positively associated with OAB. The associations were statistically different in age and physical activity subgroups (all <em>p</em> for interaction < 0.1). In the whole population, TyG-WHtR demonstrated the highest predictive ability, with the largest AUC of 0.625 (95 %CI: 0.609, 0.641), and was relatively more predictive in the < 60 years and moderate-to-vigorous physical activity subgroups.</div></div><div><h3>Conclusions</h3><div>Positive associations of TyG-related indicators with OAB were observed. TyG-WHtR has the strongest predictive performance for OAB in the total population.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"223 ","pages":"Article 112128"},"PeriodicalIF":6.1,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the metabolic profiles and their cardiovascular event risks of metformin users versus insulin users. A cohort study of people with type 2 diabetes from the UK Biobank

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-21 DOI: 10.1016/j.diabres.2025.112108

Li-Ju Chen , Christian Herder , Ruijie Xie , Hermann Brenner , Ben Schöttker

{"title":"Comparison of the metabolic profiles and their cardiovascular event risks of metformin users versus insulin users. A cohort study of people with type 2 diabetes from the UK Biobank","authors":"Li-Ju Chen , Christian Herder , Ruijie Xie , Hermann Brenner , Ben Schöttker","doi":"10.1016/j.diabres.2025.112108","DOIUrl":"10.1016/j.diabres.2025.112108","url":null,"abstract":"<div><h3>Aim</h3><div>The aims of this study were to compare the metabolic profiles of type 2 diabetes mellitus patients with metformin and insulin monotherapy, to assess the associations of metabolites with major adverse cardiovascular events (MACE) distinctly for metformin-only and insulin-only users, and to test for effect modification by the glucose-lowering treatment.</div></div><div><h3>Methods</h3><div>We included 3,058 metformin-only and 558 insulin-only users from the UK Biobank. Mean concentrations of 249 metabolites of metformin and insulin users were compared with Cohen’s d, their associations with MACE were assessed with Cox regression and interaction terms were tested.</div></div><div><h3>Results</h3><div>Mean VLDL size, HDL size, and concentrations of large and very large HDL molecules differed between insulin-only and metformin-only users. Overall, 75 metabolomic biomarkers were significantly associated with MACE in insulin-only users and 57 in metformin-only users. Significant interaction terms were observed between treatment group and albumin (protective in metformin users only) and 86 lipids/fatty acids, which were all statistically significantly associated with MACE among insulin users only.</div></div><div><h3>Conclusion</h3><div>Metformin and insulin users have different metabolic profiles and a consistent pattern emerged that the metabolic profile of metformin users is favorable compared to the one of insulin users due to a lower associated MACE risk.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112108"},"PeriodicalIF":6.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of arterial stiffness in patients with diabetic retinopathy: A systematic review and meta-analysis.

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-21 DOI: 10.1016/j.diabres.2025.112123

Dimitrios Kazantzis, Konstantinos Papathanasiou, Genovefa Machairoudia, Panagiotis Theodossiadis, Irini Chatziralli

{"title":"Assessment of arterial stiffness in patients with diabetic retinopathy: A systematic review and meta-analysis.","authors":"Dimitrios Kazantzis, Konstantinos Papathanasiou, Genovefa Machairoudia, Panagiotis Theodossiadis, Irini Chatziralli","doi":"10.1016/j.diabres.2025.112123","DOIUrl":"https://doi.org/10.1016/j.diabres.2025.112123","url":null,"abstract":"<p><strong>Background: </strong>Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM). A number of studies have investigated if patients with diabetic retinopathy present altered arterial stiffness compared to diabetic individuals without retinopathy.</p><p><strong>Objectives: </strong>To compare arterial stiffness parameters in participants with diabetic retinopathy (DR) compared to participants with diabetes without retinopathy METHODS: Medline and Scopus were searched for published articles comparing indices of arterial stiffness in participants with DR and in diabetic participants without retinopathy. Standardized Mean Difference (SMD) with 95% confidence interval (CI) was calculated for the comparisons. The study protocol was registered with PROSPERO with registration ID: CRD42023482577.</p><p><strong>Results: </strong>The meta-analysis analyzed 3 arterial stiffness parameters brachial ankle PWV, carotid-femoral PWV and augmentation index (AI). 8 studies were included in the analysis of brachial ankle PWV, 4 in the analysis of carotid-femoral PWV and 4 in the analysis of the augmentation index. Brachial ankle PWV, carotid-femoral PWV and augmentation index were found to be increased in participants with DR compared to diabetic participants without DR (SMD = 0.59, 95 %CI = 0.40-0.79, P < 0.00001, I<sup>2</sup> = 89 %, SMD = 0.86, 95 %CI = 0.55-1.18P < 0.00001, I<sup>2</sup> = 91 % and SMD = 0.23, 95 %CI = 0.13-0.32, P < 0.00001, I<sup>2</sup> = 0 %, respectively).</p><p><strong>Conclusion: </strong>Diabetic participants with DR exhibit increased arterial stiffness compared to diabetic participants without DR.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"112123"},"PeriodicalIF":6.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0