Diabetes research and clinical practice最新文献

{"title":"Changes in diabetes screening and exercise during the COVID-19 pandemic in adults with prediabetes","authors":"Luis A. Rodriguez ,&nbsp;Maher Yassin ,&nbsp;O.Kenrik Duru ,&nbsp;Romain S. Neugebauer ,&nbsp;Susan D. Brown ,&nbsp;Yelba Castellon-Lopez ,&nbsp;Tainayah W. Thomas ,&nbsp;Julie A. Schmittdiel","doi":"10.1016/j.diabres.2025.112195","DOIUrl":"10.1016/j.diabres.2025.112195","url":null,"abstract":"<div><h3>Aims</h3><div>To evaluate changes in type 2 diabetes mellitus (T2DM) screening and exercise during the COVID-19 shelter-in-place, and whether Medicaid patients and racial/ethnic minoritized groups were disproportionally affected.</div></div><div><h3>Methods</h3><div>Retrospective cohort study of 578,585 adults with prediabetes aged ≥ 18–89 years with BMI ≥ 25 (≥23 if Asian) at Kaiser Permanente Northern California from January 2019 to December 2021. We used separate interrupted time-series analyses of aggregated weekly T2DM screening rates, or mean exercise minutes, to evaluate any decrease associated with the shelter-in-place (March 19, 2020, to June 1, 2020). Analyses were performed in 2023–2024.</div></div><div><h3>Results</h3><div>Before Covid, 121/10,000 patients/week were screened for T2DM, and patients exercised 107 min/week. Initially, screening dropped to near zero (by ∼ 96 %) followed by a slow increase of 7.4 (95 % CI: 2.4–12.4, <em>p</em>-value 0.004)/10,000 patients/week during the shelter-in-place. Similarly, exercise decreased initially by 37 (29–45, <em>p</em>-value &lt; 0.001) minutes/week, followed by a slow increase of 3.5 (1.7–5.4, <em>p</em>-value &lt; 0.001) minutes/week during the shelter-in-place. These patterns were similar across racial/ethnic groups; however, Medicaid patients took 1.5 years to resume baseline exercise levels.</div></div><div><h3>Conclusions</h3><div>The shelter-in-place was associated with an abrupt decrease in T2DM screening and exercise among adults with prediabetes. Future mandates should support high-risk populations, especially Medicaid, to maintain T2DM screening and exercise to prevent T2DM progression.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"224 ","pages":"Article 112195"},"PeriodicalIF":6.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to “Risk factors for bone fractures in type 2 diabetes and the impact of once-weekly exenatide: Insights from an EXSCEL post-hoc analysis”","authors":"Man Wang ,&nbsp;Yuli Li ,&nbsp;Feng Sui","doi":"10.1016/j.diabres.2025.112199","DOIUrl":"10.1016/j.diabres.2025.112199","url":null,"abstract":"","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"224 ","pages":"Article 112199"},"PeriodicalIF":6.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of continuous moderate-intensity aerobic exercise on glycemic control according to different phases of the menstrual cycle in females with type 1 diabetes","authors":"Rodrigo Martín-San Agustín ,&nbsp;Alba Cuerda del Pino ,&nbsp;Alejandro José Laguna Sanz ,&nbsp;Paolo Rossetti ,&nbsp;Jorge Bondia ,&nbsp;F.Javier Ampudia-Blasco","doi":"10.1016/j.diabres.2025.112192","DOIUrl":"10.1016/j.diabres.2025.112192","url":null,"abstract":"<div><h3>Aim</h3><div>To assess the effects of continuous moderate-intensity aerobic exercise (CONT) on glycemic control in women with type 1 diabetes (T1D) across different phases of the menstrual cycle.</div></div><div><h3>Methods</h3><div>Twenty-five women with T1D completed two 30-minute CONT sessions: one during the follicular phase and the other during the luteal phase. Glycemic control was assessed during exercise by plasma glucose analysis and at 24 h post-exercise by continuous glucose monitoring.</div></div><div><h3>Results</h3><div>A decline in blood glucose levels was observed after exercise, regardless of menstrual phase, from approximately 155 mg/dL to about 110 mg/dL. In the 24 h following exercise, the incidence of hypoglycemia was low (less than 2 %); in contrast, exercise in the luteal phase tended to increase hyperglycemia compared to the previous 24 h (from 38.2 % to 44.2 %), as well as compared to the follicular phase, with higher mean blood glucose levels observed.</div></div><div><h3>Conclusion</h3><div>CONT has an immediate glucose-lowering effect regardless of menstrual cycle phase. However, while in the follicular phase TIR remains stable, in the luteal phase, it declines, with a corresponding increase in hyperglycemia, supporting the idea that exercise-induced glucose regulation varies across menstrual phases, highlighting the potential need for insulin dose adjustments depending on the cycle’s phase.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"224 ","pages":"Article 112192"},"PeriodicalIF":6.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making Sense: Feasibility of an education program to Empower adults with type 1 diabetes to interpret CGM data","authors":"Georgina Manos ,&nbsp;John Apostolopoulos ,&nbsp;Meaghan Read ,&nbsp;Michelle Cox ,&nbsp;Frank Gao ,&nbsp;Kim Henshaw ,&nbsp;Carolyn Hines ,&nbsp;Alicia Jenkins ,&nbsp;Katerina Kiburg ,&nbsp;Cecilia Pham ,&nbsp;Catriona Sims ,&nbsp;Jane Speight ,&nbsp;Spiros Fourlanos ,&nbsp;Elif Ekinci ,&nbsp;David O’Neal","doi":"10.1016/j.diabres.2025.112171","DOIUrl":"10.1016/j.diabres.2025.112171","url":null,"abstract":"<div><h3>Aims</h3><div>To assess the feasibility and acceptability of a structured education program focused on continuous glucose monitoring (CGM) data interpretation for adults living with type 1 diabetes.</div></div><div><h3>Methods</h3><div>This was a multi-centre before and after feasibility study conducted in Australia. Adults with type 1 diabetes were enrolled in the <em>Making Sense</em> program. This two-week program, designed in consultation with adults living with diabetes, was delivered in a hybrid format involving group sessions and self-directed online modules. Participants were followed for 6-months post-education completion. The primary outcome was feasibility, pre-determined at 75% completion rate following education module enrolment. Secondary outcomes included participant acceptability, psychosocial measures and glycemic outcomes.</div></div><div><h3>Results</h3><div>Between June 2023 and October 2023, 67 participants (median age 54, 70 % female, mean HbA1c 7.2 % (55 mmol/mol)) were enrolled. All used CGM continuously. Sixty-six percent used insulin pumps. Eighty-one percent completed the study and 83 % would recommend the program to other adults with diabetes. Participation was associated with improved well-being, diabetes management satisfaction and reduction in diabetes distress (p &lt; 0.05). HbA1c fell 0.5 % (4.5 mmol/mol) for those &gt; 7.5 % (58 mmol/mol) at baseline (p = 0.006).</div></div><div><h3>Conclusions</h3><div>Our CGM-related education program was feasible and acceptable. Participation may be associated with improvement psychosocial and glycemic outcomes.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"224 ","pages":"Article 112171"},"PeriodicalIF":6.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of basal insulin adherence in people with type 2 diabetes in telemonitoring: Post-hoc analysis of novel data modalities including insulin injection data","authors":"Jannie Toft Damsgaard Nørlev ,&nbsp;Thomas Kronborg ,&nbsp;Morten Hasselstrøm Jensen ,&nbsp;Priyanka Rana ,&nbsp;Peter Vestergaard ,&nbsp;Stine Hangaard","doi":"10.1016/j.diabres.2025.112191","DOIUrl":"10.1016/j.diabres.2025.112191","url":null,"abstract":"<div><h3>Aims</h3><div>Adherence in people with insulin-treated type 2 diabetes (T2D) is not well understood despite it being a prerequisite for preventing complications. This study used insulin injection data from connected insulin pens to examine adherence and characteristics of people with insulin-treated T2D in telemonitoring.</div></div><div><h3>Methods</h3><div>Data from 165 participants were included. We applied a three-step methodology to assess overall adherence, adherence distribution, and dose deviation, using injection data recorded by a connected insulin pen. Additionally, statistical tests were performed to evaluate differences in characteristics between adherent and non-adherent participants.</div></div><div><h3>Results</h3><div>Weekly averaged overall adherence levels ranged between 70.6 % and 79.3 %. Deviation from the recommended dose occurred in 98.8 % of participants, primarily as increased or reduced doses. Non-adherent participants had higher HbA1c (OR = 0.96, 95 % CI = 0.93, 0.99), and total daily insulin dose (OR = 0.99, 95 % CI = 0.98, 0.99), and a lower level of physical activity (OR = 2.55, 95 % CI = 1.23, 5.28) compared to adherent participants.</div></div><div><h3>Conclusions</h3><div>Utilizing insulin injection data our results provide detailed insights into basal insulin adherence behavior, including irregularities and daily dose adjustments. Our findings are necessary for supporting healthcare providers’ preventable efforts and optimizing diabetes care.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"224 ","pages":"Article 112191"},"PeriodicalIF":6.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglycerides to high density lipoprotein cholesterol ratio (TG/HDL), but not triglycerides and glucose product (TyG) index, is associated with arterial stiffness in prediabetes","authors":"Maurizio Di Marco ,&nbsp;Sabrina Scilletta ,&nbsp;Nicoletta Miano ,&nbsp;Stefania Capuccio ,&nbsp;Marco Musmeci ,&nbsp;Stefania Di Mauro ,&nbsp;Agnese Filippello ,&nbsp;Alessandra Scamporrino ,&nbsp;Giosiana Bosco ,&nbsp;Francesco Di Giacomo Barbagallo ,&nbsp;Roberto Scicali ,&nbsp;Salvatore Piro ,&nbsp;Francesco Purrello ,&nbsp;Robert Wagner ,&nbsp;Antonino Di Pino","doi":"10.1016/j.diabres.2025.112189","DOIUrl":"10.1016/j.diabres.2025.112189","url":null,"abstract":"<div><h3>Aims</h3><div>Prediabetes (preD) carries increased risk of cardiovascular (CV) events than normal-glucose-tolerance (NGT). Insulin resistance, a hallmark of preD, is closely linked to CV-risk, making its assessment crucial. Triglycerides-to-high-density-lipoprotein-cholesterol-ratio (TG/HDL) and triglycerides-and-glucose-product (TyG) have emerged as surrogate of insulin resistance. We aimed to evaluate the association of these indexes with CV-risk assessed through arterial stiffness in preD.</div></div><div><h3>Methods</h3><div>377 individuals without diagnosis of diabetes underwent: (1) complete biochemistry and oral-glucose-tolerance-test; (2) CV-risk assessment through arterial stiffness (pulsed-wave-velocity – PWV – and augmentation-index – AugI) and intima-media-thickness (IMT). Participants were split according to current guidelines: NGT (n = 100), preD (n = 216), and newly-diagnosed-type-2-diabetes (ND-T2D) (n = 61).</div></div><div><h3>Results</h3><div>TG/HDL and TyG were higher in preD than NGT, with no difference between preD and ND-T2D regarding TG/HDL. PreD showed higher PWV, AugI, and IMT than NGT. In preD group, after adjusting for major confounders, PWV was correlated with TG/HDL (β = 0.16; <em>P</em> = 0.03), but not with TyG, and there was a trend of association with HOMA-IR (β = 0.19, <em>P</em> = 0.07). In logistic regression, being in the higher tertile of TG/HDL was associated with higher PWV (odds-ratio 2.51, 95 %CI 1.01–6.29, <em>P</em> = 0.048).</div></div><div><h3>Conclusions</h3><div>In preD, TG/HDL was independently associated with PWV, suggesting its possible role as a simple, cost-effective tool for assessing CV risk.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"224 ","pages":"Article 112189"},"PeriodicalIF":6.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-adherence to diabetes microvascular complications follow-up screening in the primary care population: Predictors, associated barriers, and facilitators","authors":"Eva K. Fenwick ,&nbsp;Amudha Aravindhan ,&nbsp;Ngiap Chuan Tan ,&nbsp;Wern Ee Tang ,&nbsp;Lok Pui Ng ,&nbsp;Wei Teen Wong ,&nbsp;Wern Fern Soo ,&nbsp;Shin Wei Lim ,&nbsp;Aurora WD Chan ,&nbsp;Charumathi Sabanayagam ,&nbsp;Isabelle Nooteboom ,&nbsp;Gavin Tan ,&nbsp;Tien Yin Wong ,&nbsp;Ryan Eyn Kidd Man ,&nbsp;Ecosse L. Lamoureux","doi":"10.1016/j.diabres.2025.112193","DOIUrl":"10.1016/j.diabres.2025.112193","url":null,"abstract":"<div><h3>Aims</h3><div>We determined the rates, predictors, and barriers/facilitators of non-adherence to annual follow-up screenings for Diabetic Retinopathy (DR), nephropathy (DN) and foot complications (DFC) screening in primary care patients with type 2 diabetes.</div></div><div><h3>Methods</h3><div>This prospective, mixed-method, clinical study, included 934 patients (mean ± SD age 60.4 ± 9.4 years, 46.9 % women) who underwent DR/DN/DFC screenings (N = 2012 appointments). Logistic regression analysis determined the baseline predictors of non-adherence to follow-up screening (failure to attend annual follow-up screening within ± 4 months). Qualitative interviews on barriers/facilitators of screening adherence were conducted with 36/24 non-adherent/adherent patients and 9 healthcare professionals (HCPs).</div></div><div><h3>Results</h3><div>Non-adherence rates to DR, DFC and DN follow-up screening were 27.6 % (n = 186), 29.8 % (n = 225) and 12.7 % (n = 74), respectively. Predictors included higher total cholesterol (DR); poor self-rated Diabetes Control (DN); and higher satisfaction with diabetes support (DFC and DN). Better self-efficacy was protective (DFC). Poor HCP-patient communication and long waiting times were patient-reported barriers to adherence, while knowledge about benefits of diabetes complications screening was a facilitator. Time constraints prevented HCPs from reinforcing the importance of screening to patients.</div></div><div><h3>Conclusions</h3><div>Non-adherence to diabetic microvascular complications follow-up screening was suboptimal in Singapore and driven by multi-faceted predictors and barriers. Targeted interventions are needed to improve follow-up screening adherence.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"224 ","pages":"Article 112193"},"PeriodicalIF":6.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the association between COVID-19 and new onset diabetes in a regional and national dataset","authors":"Mary E. Lacy ,&nbsp;Aaron P. Smith ,&nbsp;Lindsey R. Hammerslag ,&nbsp;Kory R. Heier ,&nbsp;James Aaron ,&nbsp;Alicia Fields ,&nbsp;John L. Fowlkes ,&nbsp;Simon J. Fisher ,&nbsp;Jeffery Talbert ,&nbsp;Philip A. Kern","doi":"10.1016/j.diabres.2025.112190","DOIUrl":"10.1016/j.diabres.2025.112190","url":null,"abstract":"<div><h3>Aims</h3><div>This study examined new onset diabetes following COVID-19 infection in large datasets.</div></div><div><h3>Methods</h3><div>A retrospective cohort study design was used in three distinct databases: data from a large academic medical center (University of Kentucky Healthcare, UKHC), claims data from privately insured patients in the Merative MarketScan (MarketScan) database, and a subset of the MarketScan database with lab tests. Control groups included patients from the prepandemic timeframe (prepandemic cohort), as well as COVID-era patients without documented COVID infection (COVID − cohort).</div></div><div><h3>Results</h3><div>Incident diabetes in COVID infected patients was higher in all datasets. In the UKHC and MarketScan datasets, the adjusted Hazard ratios (HR) were 3.46 and 2.13 in UKHC and MarketScan. Incident diabetes was elevated even in patients who were treated in the outpatient setting and much higher in patients who were treated in the inpatient setting, especially those who required inpatient interventions. In MarketScan, the HR for developing type 1 diabetes was 1.61.</div></div><div><h3>Conclusions</h3><div>Persons infected with COVID-19 during the initial 18 months of the pandemic demonstrated a higher incidence of new onset diabetes, which was evident in all populations. Diabetes incidence was especially high in an academic center population with higher health disparities, and in patients with a more severe infection with the virus.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"224 ","pages":"Article 112190"},"PeriodicalIF":6.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family history of diabetes mellitus and risk of colorectal cancer: A nationwide cohort study","authors":"Zehui Chen ,&nbsp;Elham Kharazmi ,&nbsp;Qunfeng Liang ,&nbsp;Kristina Sundquist ,&nbsp;Jan Sundquist ,&nbsp;Mahdi Fallah","doi":"10.1016/j.diabres.2025.112187","DOIUrl":"10.1016/j.diabres.2025.112187","url":null,"abstract":"<div><h3>Aims</h3><div>Studies have shown the association between <u>personal history</u> of diabetes mellitus (DM type 1/2) and risk of colorectal cancer (CRC). This study aims to find the association between the <u>family history</u> of diabetes and CRC risk.</div></div><div><h3>Methods</h3><div>This large nationwide cohort study leveraged data from several Swedish nationwide registers (follow-up: 1964–2018) to compare the risk using standardized incidence ratio (SIR).</div></div><div><h3>Results</h3><div>11,784,567 individuals (668,348 with DM) were included and followed for up to 54 years (median = 28 years). Those with a personal history of DM had a 1.4-fold increased risk of CRC compared to those without DM (95 % CI: 1.39–1.45). However, the addition of a family history of DM in 1 FDR or ≥ 2 FDRs did not significantly alter the increased risk of early-onset or late-onset CRC.</div></div><div><h3>Conclusion</h3><div>Leveraging one of the world’s largest family-disease datasets, our cohort study confirmed that personal history of diabetes is associated with an increased risk of colorectal cancer, but we did not find an association between a family history of diabetes and risk of colorectal cancer.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"224 ","pages":"Article 112187"},"PeriodicalIF":6.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The burden of type 2 diabetes in China from 1990 to 2021: A comparative analysis with G20 countries using the global burden of disease study 2021","authors":"Kang An ,&nbsp;Jinyi Zhang ,&nbsp;Xingyou Wang ,&nbsp;Runjuan Qiao ,&nbsp;Zhenmei An","doi":"10.1016/j.diabres.2025.112188","DOIUrl":"10.1016/j.diabres.2025.112188","url":null,"abstract":"<div><h3>Objectives</h3><div>The study aims to evaluate the burden of Type 2 Diabetes (T2D) in China from 1990 to 2021, and compare to it across G20 countries.</div></div><div><h3>Methods</h3><div>We utilized data from the Global Burden of Disease Study 2021 to examine the burden of T2D in China from 1990 to 2021. Prevalence, mortality, disability-adjusted life years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) were calculated. Comparative analyses were conducted with other G20 countries.</div></div><div><h3>Results</h3><div>T2D prevalence in China increased between 1990 and 2021, with rates rising from 3519.8 (3138.3–3910.1) to 6055.5 (5510.1–6614.3) per 100,000. The death rates slightly decreased from 9.3 (8.2–10.5) per 100,000 to 8.7 (7.3–10.3). The DALYs rate increased from 438.7 (358.5–531.5) to 569.8 (435.4–734.2), with increases observed in YLDs and YLLs. Males had a heavier disease burden in China. Compared to G20 countries, China ranked high in prevalence but had relatively better mortality outcomes in older age groups.</div></div><div><h3>Conclusion</h3><div>This study reveals the enormous burden and remarkable control efforts of T2D in China. Comparative analysis emphasizes the importance of tailored public health interventions to address this growing health crisis.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"224 ","pages":"Article 112188"},"PeriodicalIF":6.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}