Diabetes research and clinical practice最新文献_第2页

Autonomic function and hemodynamic changes in type 2 diabetes: insights into sympathetic activation and vascular stiffness 2型糖尿病的自主神经功能和血流动力学改变：交感神经激活和血管僵硬

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-05-22 DOI: 10.1016/j.diabres.2025.112266

Larissa Morete Caieiro da Costa , Tatiana Palotta Minari , Luciana Pellegrini Pisani , Tatiane de Azevedo Rubio , Louise Bounalume Tácito Yugar , Luis Gustavo Sedenho-Prado , Milene Ribeiro , Lúcia Helena Bonalume Tacito , Luciana Neves Cosenso-Martin , Antônio Carlos Pires , Heitor Moreno , José Fernando Vilela-Martin , Juan Carlos Yugar-Toledo

{"title":"Autonomic function and hemodynamic changes in type 2 diabetes: insights into sympathetic activation and vascular stiffness","authors":"Larissa Morete Caieiro da Costa , Tatiana Palotta Minari , Luciana Pellegrini Pisani , Tatiane de Azevedo Rubio , Louise Bounalume Tácito Yugar , Luis Gustavo Sedenho-Prado , Milene Ribeiro , Lúcia Helena Bonalume Tacito , Luciana Neves Cosenso-Martin , Antônio Carlos Pires , Heitor Moreno , José Fernando Vilela-Martin , Juan Carlos Yugar-Toledo","doi":"10.1016/j.diabres.2025.112266","DOIUrl":"10.1016/j.diabres.2025.112266","url":null,"abstract":"<div><h3>Aims</h3><div>This study aimed to investigate the relationship between autonomic function, arterial stiffness, and vascular compliance in patients with type 2 diabetes (T2D).</div></div><div><h3>Methods</h3><div>Eighty-one T2D patients were divided into two groups based on disease duration: <10 years (N = 50) and >10 years (N = 31). Autonomic function was assessed via heart rate variability, and vascular hemodynamics via pulse wave velocity (PWV). Linear and multivariate regression analyses explored associations between autonomic function and vascular parameters.</div></div><div><h3>Results</h3><div>Female participants predominated, accounting for 60 % in the <10 years group and 64.5 % in the >10 years group. Comorbidities were present in 67.7 % of the <10 years group and 70 % of the >10 years group. Biochemical differences were minimal, except for a significant albumin/creatinine ratio in the >10 years group (p = 0.007). Central hemodynamics showed no significant differences, but sympathetic activity correlated with diastolic blood pressure (DBP) during wakefulness (r = 0.45, p = 0.003).</div></div><div><h3>Conclusions</h3><div>While no direct correlation was found between arterial stiffness and autonomic function, increased sympathetic activation was linked to higher DBP. Early screening, lifestyle modifications, and targeted treatments could improve patient outcomes and T2D management.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112266"},"PeriodicalIF":6.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between body roundness index and chronic kidney disease risk in patients with diabetes: A cross-sectional analysis of NHANES 1999–2018 糖尿病患者体圆度指数与慢性肾脏疾病风险的相关性：NHANES 1999-2018的横断面分析

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-05-21 DOI: 10.1016/j.diabres.2025.112274

Sijia Fei , Huan Chen , Yuan Lou , Lixin Guo , Qi Pan

{"title":"Association between body roundness index and chronic kidney disease risk in patients with diabetes: A cross-sectional analysis of NHANES 1999–2018","authors":"Sijia Fei , Huan Chen , Yuan Lou , Lixin Guo , Qi Pan","doi":"10.1016/j.diabres.2025.112274","DOIUrl":"10.1016/j.diabres.2025.112274","url":null,"abstract":"<div><h3>Aims</h3><div>To assess the association between Body Roundness Index (BRI) and chronic kidney disease (CKD) risk in individuals with diabetes.</div></div><div><h3>Methods</h3><div>A cross-sectional analysis of 6,971 individuals with diabetes from NHANES 1999–2018 was conducted. BRI was calculated using waist circumference and height. CKD was defined as eGFR < 60 mL/min/1.73 m<sup>2</sup> or ACR ≥ 30 mg/g. Weighted multivariable logistic regression assessed the BRI–CKD association. Subgroup and mediation analyses assessed heterogeneity and potential pathways.</div></div><div><h3>Results</h3><div>Higher BRI was independently associated with increased CKD risk. In fully adjusted models, each unit increase in BRI corresponded to 10.5 % higher odds of CKD (OR: 1.109; 95 % CI: 1.040–1.183; p = 0.002). Stronger associations were found in males, younger individuals, and those with elevated blood pressure or uric acid. An inverse association was observed in participants with severe proteinuria. Mediation analysis showed partial effects through HbA1c (3.9 %), serum creatinine (27.7 %), and albumin (–26.2 %).</div></div><div><h3>Conclusions</h3><div>BRI is an independent marker of CKD risk in individuals with diabetes and may reflect contributions from glycaemic control, kidney function, and nutritional status. It may serve as a practical tool for CKD risk stratification.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112274"},"PeriodicalIF":6.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of the estimated glucose disposal rate with and mortality risk in patients with atherosclerotic cardiovascular disease: A cohort study from the NHANES 1999–2018 动脉粥样硬化性心血管疾病患者估计葡萄糖处理率与死亡风险的关系：来自NHANES 1999-2018的队列研究

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-05-21 DOI: 10.1016/j.diabres.2025.112263

Guoming Li , Weilin Yang , Zhuoran Kuang , Yefeng Cai , Jingsong You

{"title":"Association of the estimated glucose disposal rate with and mortality risk in patients with atherosclerotic cardiovascular disease: A cohort study from the NHANES 1999–2018","authors":"Guoming Li , Weilin Yang , Zhuoran Kuang , Yefeng Cai , Jingsong You","doi":"10.1016/j.diabres.2025.112263","DOIUrl":"10.1016/j.diabres.2025.112263","url":null,"abstract":"<div><h3>Aim</h3><div>To investigate the association between estimated glucose disposal rate (eGDR) and mortality risk among patients with atherosclerotic cardiovascular disease (ASCVD).</div></div><div><h3>Methods</h3><div>NHANES (1999–2018) data were analyzed using weighted Cox regression and restricted cubic splines (RCS) to assess the association between eGDR and mortality. Improvement in predictive performance was evaluated. Subgroup, mediation, and sensitivity analyses were conducted.</div></div><div><h3>Results</h3><div>Among 4,425 ASCVD patients (67.40 % ≥60 years, 44.66 % female), 1,815 deaths (35.62 %) and 751 CVD deaths (18.48 %) occurred during a median follow-up of 6.9 years. Compared to the highest quartile, the lowest eGDR quartile had HRs of 2.13 and 2.06 for CVD and all-cause mortality, respectively. RCS demonstrated linearity (<em>P</em>-nonlinear > 0.05). Addition of eGDR improved the predictive performance for both CVD and all-cause mortality (<em>P</em> < 0.001), whereas other insulin resistance indicators did not yield comparable improvements. Diabetes status modified its association with CVD mortality (<em>P</em>-interaction = 0.029). Neutrophil-to-lymphocyte ratio and estimated pulse wave velocity were key mediators.</div></div><div><h3>Conclusions</h3><div>Lower eGDR was associated with increased mortality risk in ASCVD, particularly among patients without diabetes. eGDR enhances mortality prediction and may serve as a prognostic marker in ASCVD.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112263"},"PeriodicalIF":6.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type 2 diabetes specialist care in Italy in the AMD Annals initiative 2024: The path is traced AMD年鉴倡议2024在意大利的2型糖尿病专科护理：路径被追踪

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-05-21 DOI: 10.1016/j.diabres.2025.112273

G.T. Russo , S. De Cosmo , A. Nicolucci , V. Manicardi , A. Rocca , G. Lucisano , M.C. Rossi , P. Di Bartolo , G. Di Cianni , R. Candido , AMD Annals Study Group (the full list of participants is reported as supplementary material)

{"title":"Type 2 diabetes specialist care in Italy in the AMD Annals initiative 2024: The path is traced","authors":"G.T. Russo , S. De Cosmo , A. Nicolucci , V. Manicardi , A. Rocca , G. Lucisano , M.C. Rossi , P. Di Bartolo , G. Di Cianni , R. Candido , AMD Annals Study Group (the full list of participants is reported as supplementary material)","doi":"10.1016/j.diabres.2025.112273","DOIUrl":"10.1016/j.diabres.2025.112273","url":null,"abstract":"<div><h3>Aims</h3><div>The AMD Annals initiative, active in Italy since 2006, monitors diabetes care quality, showing continuous improvements through standardized indicators. This report presents the 2024 data on type 2 diabetes (T2D).</div></div><div><h3>Methods</h3><div>Approximately half of the Italian diabetes centers annually extract anonymized electronic medical records data. Process, treatment and outcome indicators, and the Q-score, a validated score of overall care, were evaluated.</div></div><div><h3>Results</h3><div>Data from 301 centers on 680,122 T2D patients (58.6 % men, mean age 69.9 years; 35.9 % > 75 years) were evaluated. HbA1c ≤ 7.0 % was achieved by 55.9 % of patients, LDL < 70 mg/dl by 44.6 %, blood pressure (BP) < 130/80 mmHg by 26.5 %, with 7.7 % meeting multiple targets. Obesity showed a prevalence of 35 %, while smoking was high (17.9 %). Pharmacological treatment improved: 72.0 % used lipid-lowering drugs, 68.8 % BP-lowering, and 97.6 % glucose-lowering drugs. As for innovative drugs, 41.9 % of patients were treated with SGLT2i and 35.5 % with GLP1 RA, with an increasing trend compared to 2023 data. Complication rates remained stable, with a further Q-score improvement.</div></div><div><h3>Conclusions</h3><div>The 2024 data confirm ongoing improvements in T2D care, despite an aging population. Although gaps persist, the path toward aligning practice with guidelines is well established.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112273"},"PeriodicalIF":6.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Which adiposity index is best? Comparison of five indicators and their ability to identify type 2 diabetes risk in a population study 哪种肥胖指数最好？人口研究中5个指标及其识别2型糖尿病风险的能力的比较

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-05-20 DOI: 10.1016/j.diabres.2025.112268

Cunrong Huang , Andre Lopes , Annie Britton

{"title":"Which adiposity index is best? Comparison of five indicators and their ability to identify type 2 diabetes risk in a population study","authors":"Cunrong Huang , Andre Lopes , Annie Britton","doi":"10.1016/j.diabres.2025.112268","DOIUrl":"10.1016/j.diabres.2025.112268","url":null,"abstract":"<div><h3>Aims</h3><div>We compared ability of five adiposity indicators [body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), waist-by-height<sup>0.5</sup> (WHT.5R), and a body shape index (ABSI)] to identify current diabetes and their prospective associations with diabetes.</div></div><div><h3>Methods</h3><div>Baseline data were from 7,979 participants of UK Whitehall II study, of whom 7,488 diabetes-free participants were followed-up (median = 16.0 years) for incident diabetes (n = 940). According to five indices’ cut-points, participants were separately classified into low-value groups and high-value groups. We cross-sectionally investigated ability of the indicators to identify existing diabetes by receiver operating characteristic curve analysis, and explored prospective associations between elevated indices and diabetes using Cox regression analysis.</div></div><div><h3>Results</h3><div>Waist-based indicators were superior to BMI in identifying diabetes. High WHtR (≥0.5) demonstrated the highest multivariable-adjusted HR [2.64 (95 % CI 2.29, 3.03)]. Across all indicators, associations between elevated indicators and diabetes were stronger in younger participants. In combined analyses, “low BMI but high WHtR” had higher risk for diabetes [2.20 (95 % CI 1.65, 2.95)] than “high BMI but low WHtR” [1.34 (95 % CI 1.05, 1.70)].</div></div><div><h3>Conclusion</h3><div>Waist-based indicators are more strongly associated with diabetes than BMI. WHtR, an easy-to-calculate, waist-based index with a sex- and race-independent cut-point, may be useful for diabetes prevention.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112268"},"PeriodicalIF":6.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metformin vs. second-line therapy for delirium prevention in type 2 diabetes: A multinational study. 二甲双胍与二线治疗预防2型糖尿病谵妄：一项多国研究。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-05-20 DOI: 10.1016/j.diabres.2025.112270

Mingyang Sun, Xiaolin Wang, Zhongyuan Lu, Yitian Yang, Shuang Lv, Mengrong Miao, Wan-Ming Chen, Szu-Yuan Wu, Jiaqiang Zhang

{"title":"Metformin vs. second-line therapy for delirium prevention in type 2 diabetes: A multinational study.","authors":"Mingyang Sun, Xiaolin Wang, Zhongyuan Lu, Yitian Yang, Shuang Lv, Mengrong Miao, Wan-Ming Chen, Szu-Yuan Wu, Jiaqiang Zhang","doi":"10.1016/j.diabres.2025.112270","DOIUrl":"https://doi.org/10.1016/j.diabres.2025.112270","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) is a major risk factor for neurocognitive impairment, with delirium predicting dementia. While metformin may offer neuroprotection, prior studies face selection bias. This study examines the association between metformin use and delirium risk compared to dipeptidyl peptidase-4 inhibitors (DPP-4i).</p><p><strong>Methods: </strong>This multinational cohort study analyzed 860,388 T2DM patients using the TriNetX network. After propensity score matching, 84,221 metformin users were compared to 84,221 DPP-4i users. The primary outcome was delirium incidence, with secondary outcomes including all-cause mortality. Cox proportional hazards models estimated adjusted hazard ratios (AHRs), and sensitivity analyses addressed competing risks.</p><p><strong>Results: </strong>Metformin use was linked to a lower risk of delirium (AHR, 0.86; 95% CI, 0.83-0.89) and mortality (AHR, 0.76; 95% CI, 0.74-0.78). Subgroup analyses confirmed consistent delirium risk reduction across age, sex, and glycemic control. Sensitivity analyses upheld this effect, mitigating survival bias concerns.</p><p><strong>Conclusions: </strong>In this large-scale study, metformin use was associated with reduced delirium and mortality risk compared to DPP-4i, reinforcing its role as the preferred first-line T2DM therapy, especially in patients at risk for neurocognitive decline.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"112270"},"PeriodicalIF":6.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-Designing a postpartum diabetes prevention program after gestational diabetes mellitus: A MoSCoW prioritization workshop exercise 共同设计妊娠糖尿病后的产后糖尿病预防方案：莫斯科优先级研讨会演习。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-05-20 DOI: 10.1016/j.diabres.2025.112269

Megan Racey , Paige Alliston , Diana Sherifali , Apishanthi Sriskandarajah , Katelyn Sushko , Lorraine Lipscombe

{"title":"Co-Designing a postpartum diabetes prevention program after gestational diabetes mellitus: A MoSCoW prioritization workshop exercise","authors":"Megan Racey , Paige Alliston , Diana Sherifali , Apishanthi Sriskandarajah , Katelyn Sushko , Lorraine Lipscombe","doi":"10.1016/j.diabres.2025.112269","DOIUrl":"10.1016/j.diabres.2025.112269","url":null,"abstract":"<div><h3>Aims</h3><div>Avoiding Diabetes After Pregnancy Together with Moms (ADAPT-M) is a postpartum lifestyle modification program aimed at preventing type 2 diabetes mellitus (T2DM) after gestational diabetes mellitus (GDM). The purpose of the workshop was to bring together key stakeholders to support the contextual adaptation of ADAPT-M needed for effective implementation.</div></div><div><h3>Methods</h3><div>Participants were invited to a co-design workshop held on June 10th, 2024. Participants engaged in facilitator-led breakout groups to prioritize intervention and implementation components using the MoSCoW method. Data were analyzed using a deductive thematic analysis approach.</div></div><div><h3>Results</h3><div>In total, 27 attendees and eight facilitators participated in the workshop. We identified a total of 11 themes distributed across the four MoSCoW categories. Themes included: comprehensive support and education, cultural sensitivity and inclusivity, integrated and personalized care, communication and accessibility, and community and peer support networks, among others.</div></div><div><h3>Conclusions</h3><div>Our findings support research development that aligns with a core outcome set for diabetes after pregnancy prevention interventions, correlates with current diabetes prevention programs after GDM, and further refines potential changes to ADAPT-M as it is implemented in the real-world setting. Future work can consider these components and co-design methods when developing diabetes prevention programs in high-risk postpartum women with GDM.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112269"},"PeriodicalIF":6.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The diabetic foot: progress in Sub-Saharan Africa 糖尿病足：撒哈拉以南非洲的进展

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-05-20 DOI: 10.1016/j.diabres.2025.112264

Zulfiqarali G. Abbas , Raidah R. Gangji

{"title":"The diabetic foot: progress in Sub-Saharan Africa","authors":"Zulfiqarali G. Abbas , Raidah R. Gangji","doi":"10.1016/j.diabres.2025.112264","DOIUrl":"10.1016/j.diabres.2025.112264","url":null,"abstract":"<div><div>In Sub-Saharan Africa (SSA), the number of people with diabetes mellitus is increasing along with the number of complications linked to the condition. Among all complications, diabetes-related foot complications (DRFC) have the greatest rates of morbidity and mortality, and their incidence will increase in tandem with it.Over the past two decades, the magnitude of DRFC has underscored the challenges within SSA’s healthcare systems, including limited access to diagnostics, specialized healthcare providers, and treatment options. Education and prevention have proven critical in addressing these challenges, as evidenced by programs like ’Step by Step’ and ’Train the Foot Healthcare Professional’. These initiatives not only focus on prevention but also equip healthcare providers with skills in identification, diagnosis, treatment, and holistic management of DRFC, significantly reducing severe complications and improving outcomes. The integration of digital health technologies, including telemedicine and mobile health tools, offers innovative solutions for enhancing access to care, particularly in underserved areas. Governments have a pivotal role in recognizing and addressing the burden of DRFC through policy initiatives, surveillance systems, and public health campaigns. Bridging these gaps requires a coordinated approach, leveraging education, technology, and collaboration to build resilient healthcare systems and improve the management of DRFC in SSA.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112264"},"PeriodicalIF":6.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical, genetic, and proteomic characteristics of type 2 diabetes complicated with exogenous insulin antibody syndrome: a case-control study 2型糖尿病合并外源性胰岛素抗体综合征的临床、遗传和蛋白质组学特征：一项病例对照研究

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-05-20 DOI: 10.1016/j.diabres.2025.112262

Jinjing Wan , Leiluo Geng , Yiwen Fu , Qianting Zhang , Gaopeng Guan , Xue Jiang , Aimin Xu , Ping Jin

{"title":"Clinical, genetic, and proteomic characteristics of type 2 diabetes complicated with exogenous insulin antibody syndrome: a case-control study","authors":"Jinjing Wan , Leiluo Geng , Yiwen Fu , Qianting Zhang , Gaopeng Guan , Xue Jiang , Aimin Xu , Ping Jin","doi":"10.1016/j.diabres.2025.112262","DOIUrl":"10.1016/j.diabres.2025.112262","url":null,"abstract":"<div><h3>Aims</h3><div>Insulin antibodies (IAs) are prevalent in insulin-treated patients with diabetes and may cause immunological dysglycemia, known as exogenous insulin antibody syndrome (EIAS). This study aims to elucidate the clinical, genetic, and proteomic characteristics of patients with concurrent type 2 diabetes (T2D) and EIAS.</div></div><div><h3>Methods</h3><div>This was a case-control study with 177 IA-positive and 177 IA-negative T2D patients receiving insulin therapy. Among the IA-positive group, 46 patients with hypoglycemia and aberrantly elevated molar ratio of insulin to C-peptide (ICPR > 1) were identified as EIAS cases, followed with human leukocyte antigen (HLA) genotyping and plasma proteomic analysis by Olink platform.</div></div><div><h3>Results</h3><div>Patients with EIAS exhibited greater glycemic variability than patients in other groups (IA-positive ICPR ≤ 1 or IA-negative). Higher ICPR was associated with increased glycemic variability in the IA-positive group. DRB1*0405-DQA1*03-DQB1*0401, DRB1*0803-DQA1*0103-DQB1*0601, and DRB1*1501-DQA1*0102-DQB1*0502 are the susceptible HLA haplotypes for EIAS. Additionally, nine differentially expressed proteins were identified in EIAS patients, with GALNT3, IL10, and CCL28 showing promising diagnostic performance.</div></div><div><h3>Conclusions</h3><div>IA-positive patients with remarkably elevated ICPR are prone to glycemic variability and should be evaluated for the diagnosis of EIAS. In this pilot study with limited sample size, EIAS is associated with unique HLA-DR-DQ risk haplotypes and enhanced immunoinflammatory response.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112262"},"PeriodicalIF":6.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of information provided on diabetes distress when using PAID-20, PAID-11 or PAID-5. A registry-based study applying IRT analyses among 10,190 adults with type 1 diabetes in Norway 使用PAID-20、pay -11或pay -5时提供的糖尿病窘迫信息的比较一项基于登记的研究，应用IRT分析了挪威10190名成人1型糖尿病患者

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-05-20 DOI: 10.1016/j.diabres.2025.112267

Anne Haugstvedt , Roy M. Nilsen , Kyrre Breivik , Marjolein M. Iversen , Ragnhild B. Strandberg , Karianne F. Løvaas , Tone V. Madsen , Grethe Å. Ueland , Timothy C. Skinner , Ingvild Hernar

{"title":"Comparison of information provided on diabetes distress when using PAID-20, PAID-11 or PAID-5. A registry-based study applying IRT analyses among 10,190 adults with type 1 diabetes in Norway","authors":"Anne Haugstvedt , Roy M. Nilsen , Kyrre Breivik , Marjolein M. Iversen , Ragnhild B. Strandberg , Karianne F. Løvaas , Tone V. Madsen , Grethe Å. Ueland , Timothy C. Skinner , Ingvild Hernar","doi":"10.1016/j.diabres.2025.112267","DOIUrl":"10.1016/j.diabres.2025.112267","url":null,"abstract":"<div><h3>Aims</h3><div>To 1) evaluate information provided on the latent diabetes distress trait when using the Problem Areas In Diabetes, 20 item (PAID-20), PAID-11 or PAID-5, and 2) evaluate the information provided by each scale item.</div></div><div><h3>Methods</h3><div>Using nationwide registry data from 10,190 individuals with type 1 diabetes in Norway, we applied Item Response Theory (IRT) analyses to compare test information curves for PAID-20, PAID-11, PAID-5 and their scale items.</div></div><div><h3>Results</h3><div>The test information curve for PAID-20 captured an overall broader range of the latent distress trait compared to the other versions. At test information level ≥ 10, the ranges (SD under/above mean) were: PAID-20: −1.30 to 3.32; PAID-11; −1.17 to 2.76; and PAID-5: −0.59 to 2.27. Six PAID-20 items had flat information curves with limited contribution to the latent trait, whereas the PAID-11 included 11 of the 12 items most frequently reported as serious problem areas.</div></div><div><h3>Conclusions</h3><div>The PAID-20 captures most information on the latent diabetes distress trait; however, the PAID-11 provides comparable information and captures the most serious problem areas. The PAID-5 provided limited information and covers limited aspects of distress. Overall, the PAID-11 may be a good choice for assessing diabetes distress in both research and clinical practice.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112267"},"PeriodicalIF":6.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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