Diabetes research and clinical practice最新文献_第2页

Association of gestational and childhood circulating C-peptide concentrations in the hyperglycemia and adverse pregnancy outcomes follow-up study 妊娠期和儿童期循环c肽浓度与高血糖和不良妊娠结局随访研究的关系

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-01 DOI: 10.1016/j.diabres.2024.111967

Ananthi Rajamoorthi , Hao Zheng , Alicja A. Skowronski , Noelia Zork , Uma M. Reddy , Pei Wen Tung , Allison Kupsco , Dympna Gallagher , Rany M. Salem , Rudolph L. Leibel , Charles A. LeDuc , Vidhu V. Thaker

{"title":"Association of gestational and childhood circulating C-peptide concentrations in the hyperglycemia and adverse pregnancy outcomes follow-up study","authors":"Ananthi Rajamoorthi , Hao Zheng , Alicja A. Skowronski , Noelia Zork , Uma M. Reddy , Pei Wen Tung , Allison Kupsco , Dympna Gallagher , Rany M. Salem , Rudolph L. Leibel , Charles A. LeDuc , Vidhu V. Thaker","doi":"10.1016/j.diabres.2024.111967","DOIUrl":"10.1016/j.diabres.2024.111967","url":null,"abstract":"<div><h3>Aims</h3><div>This study examined the association of gravida C-peptide with progeny islet function and insulin sensitivity in the Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS).</div></div><div><h3>Methods</h3><div>Pregnancy 3rd trimester oral glucose tolerance test (OGTT), cord blood, and offspring OGTT glucose, C-peptide and insulin at age 10–14 years were analyzed for 4,121 mother–child dyads. Gravida fasting and 1-hour C-peptide concentration correlations with cord blood and childhood C-peptide, insulin, insulinogenic index and insulin sensitivity, and insulin resistance [HOMA-IR]), were assessed by multiple linear regression. Maternal covariates included age, gestational age, BMI and glucose at OGTT; child covariates included age, sex, pubertal stage, BMI z score and glucose.</div></div><div><h3>Results</h3><div>Gravida fasting and 1-hour OGTT C-peptide was positively correlated with cord blood C-peptide, offspring OGTT C-peptide and insulin concentrations at fasting, 30 min, 1-hour and 2-hour at 10–14 years of age. Maternal fasting and 1-hour C-peptide concentrations were positively correlated with the insulinogenic index and HOMA-IR but inversely correlated with insulin sensitivity. Maternal C-peptide explained more variance than maternal glucose concentrations (3.0–17.9 % vs 0.2–3.5 %).</div></div><div><h3>Conclusions/Interpretation</h3><div>The correlation between gravida and offspring C-peptide suggests that without crossing the placenta, insulin may influence the offspring pancreatic beta-cell development and insulin sensitivity.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"220 ","pages":"Article 111967"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applying 1-hour postload plasma glucose diagnostic criteria reveals high Progressive Risks of potential MASLD 应用负荷后1小时血糖诊断标准显示潜在MASLD的高进展风险。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-01 DOI: 10.1016/j.diabres.2024.111973

Long Teng , Ling Luo , Yanhong Sun , Wei Wang , Zhi Dong , Xiaopei Cao , Junzhao Ye , Bihui Zhong

{"title":"Applying 1-hour postload plasma glucose diagnostic criteria reveals high Progressive Risks of potential MASLD","authors":"Long Teng , Ling Luo , Yanhong Sun , Wei Wang , Zhi Dong , Xiaopei Cao , Junzhao Ye , Bihui Zhong","doi":"10.1016/j.diabres.2024.111973","DOIUrl":"10.1016/j.diabres.2024.111973","url":null,"abstract":"<div><h3>Background</h3><div>Recently, a 1-h PG value of ≥ 8.6 mmol/L, a more sensitive predictor of diabetes mellitus-related long-term cardiovascular complications than routine glucose markers, has been recommended as an additional diagnostic criterion for diabetes in the International Diabetes Federation Position Statement. However, its value in MASLD remains uncertain.</div></div><div><h3>Methods</h3><div>Consecutive participants with imaging assessments of fatty liver and a 75-g oral glucose tolerance test, including 1154 participants with MASLD, 161 fulfilling the nonalcoholic fatty liver disease but not the MASLD diagnostic criteria (NAFLD-non-MASLD) and 1026 subjects with non-fatty liver, were retrospectively enrolled from June 2009 to May 2024.</div></div><div><h3>Results</h3><div>Patients with MASLD or NAFLD-non-MASLD had higher 1-h PG levels than those with non-fatty liver (<em>p</em> < 0.001). In patients with MASLD or NAFLD-non-MASLD, 1-h PG ≥ 8.6 mmol/L was associated with the risk of moderate-to-severe steatosis (<em>p</em> < 0.001), ALT elevation (<em>p</em> < 0.001), advanced fibrosis (<em>p</em> = 0.03), and cardiovascular diseases (<em>p</em> < 0.001). Furthermore, NAFLD-non-MASLD patients with 1-h PG ≥ 8.6 mmol/L showed a higher prevalence of advanced fibrosis than MASLD patients with or without 1-h PG ≥ 8.6 mmol/L (<em>p</em> < 0.05).</div></div><div><h3>Conclusions</h3><div>NAFLD-non-MASLD patients with 1-h PG ≥ 8.6 mmol/L are still at high risk of poor clinical outcomes. These findings support including 1-h PG ≥ 8.6 mmol/L as a component of the metabolic dysfunction definition.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"220 ","pages":"Article 111973"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Duration of physical activity required to Ameliorate hyperglycemia without causing hypoglycemia in type 1 diabetes: A T1DEXI adults and pediatric cohort analyses 改善 1 型糖尿病患者高血糖而不导致低血糖所需的体力活动持续时间：T1DEXI成人和儿童队列分析。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-01 DOI: 10.1016/j.diabres.2024.111981

John Pemberton , Zoey Li , Robin L. Gal , Lauren V. Turner , Simon Bergford , Peter Calhoun , Michael C. Riddell

{"title":"Duration of physical activity required to Ameliorate hyperglycemia without causing hypoglycemia in type 1 diabetes: A T1DEXI adults and pediatric cohort analyses","authors":"John Pemberton , Zoey Li , Robin L. Gal , Lauren V. Turner , Simon Bergford , Peter Calhoun , Michael C. Riddell","doi":"10.1016/j.diabres.2024.111981","DOIUrl":"10.1016/j.diabres.2024.111981","url":null,"abstract":"<div><h3>Aims</h3><div>To estimate physical activity (activity) duration required to lower glucose from above target range (>180 mg/dL) to within target range (TIR: 70–180 mg/dL) in individuals with type 1 diabetes (T1D).</div></div><div><h3>Methods</h3><div>Continuous glucose monitoring and activity data were collected from 404 adults (28-day observation) and 149 adolescents (10-day observation) with T1D. Activities (N = 1902) with a starting glucose between 181-300 mg/dL, duration 10–60 min, and no reported meals during activity were included in the analysis. Kaplan-Meier curves were used to estimate activity duration required to drop starting glucose levels from above to within TIR.</div></div><div><h3>Results</h3><div>An overall starting glucose value of 181–199, 200–224, 225–249, and 250–300 mg/dL required an estimated activity duration of 15, 31, 59, and ≥ 60 min, respectively, to have a 50 % chance of reducing glucose to be within target range, with a 0–11 % incidence of hypoglycemia in the hour after activity. Activity duration requirements increased irrespective of starting glucose levels when glucose was trending upwards before activity and with zero bolus insulin on board at the start of activity. Adult and adolescent results were similar.</div></div><div><h3>Conclusions</h3><div>Time-limited activity is an effective means of restoring TIR when hyperglycemia exists in adolescents and adults with T1D.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"220 ","pages":"Article 111981"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between sex, age, temporal trends, and glycemic control of 221,769 adults with type 2 diabetes in a multi-ethnic middle-income Asian country 亚洲一个多种族中等收入国家221769名2型糖尿病成年人的性别、年龄、时间趋势和血糖控制之间的关系

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-01 DOI: 10.1016/j.diabres.2024.111976

Swee Hung Ang , Lee-Ling Lim , Feisul Idzwan Mustapha , Eliana Ahmad , Sanjay Rampal

{"title":"Association between sex, age, temporal trends, and glycemic control of 221,769 adults with type 2 diabetes in a multi-ethnic middle-income Asian country","authors":"Swee Hung Ang , Lee-Ling Lim , Feisul Idzwan Mustapha , Eliana Ahmad , Sanjay Rampal","doi":"10.1016/j.diabres.2024.111976","DOIUrl":"10.1016/j.diabres.2024.111976","url":null,"abstract":"<div><h3>Aims</h3><div>We examined the association between sex, age, temporal trends, and glycemic control among people with type 2 diabetes (T2D) in a multi-ethnic middle-income Asian country.</div></div><div><h3>Methods</h3><div>Using the National Diabetes Registry (2011–2020), we analyzed data for 221,769 adult Malaysians with T2D.We used quantile regressions to estimate the association of sex, age, and their interaction on HbA<sub>1c <!-->percentile and logistic regression to estimate the odds of good control (HbA<sub>1c</sub> < 7 %).</div></div><div><h3>Results</h3><div>The participants were Malays (61.8 %), females (59.3 %), and aged 50–69 years (63.5 %). The median (interquartile range [IQR]) HbA<sub>1c</sub> was 7.2 % (6.4 %, 8.9 %) for males and 7.3 % (6.4 %, 9.0 %) for females. The prevalence of good control was 42.8 % for males and 41.8 % for females. Glycemic control improved from 2011 to 2020 for both females and males above 40. Control significantly improved with age among both sexes. However, females had increasingly better control than men with increasing age (P<sub>Heterogeneity</sub> < 0.001). The adjusted odds (95 % CI) of good control comparing females to males at 30, 50, and 70 years was 0.90 (0.81, 0.99), 0.93 (0.90, 0.97), and 1.12 (1.08, 1.16) respectively.</div></div><div><h3>Conclusions</h3><div>A more aggressive approach to type 2 diabetes management is needed for both sexes, targeting especially the younger age groups, to improve glycemic control and reduce diabetes burden.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"220 ","pages":"Article 111976"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of diabetes on Sepsis-induced cardiomyopathy 糖尿病对败血症性心肌病的影响。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-01 DOI: 10.1016/j.diabres.2025.112001

Weiwei Lai, Li Liu, Shuhang Wang, Qing Tang, Yancun Liu, Yanfen Chai

{"title":"The impact of diabetes on Sepsis-induced cardiomyopathy","authors":"Weiwei Lai, Li Liu, Shuhang Wang, Qing Tang, Yancun Liu, Yanfen Chai","doi":"10.1016/j.diabres.2025.112001","DOIUrl":"10.1016/j.diabres.2025.112001","url":null,"abstract":"<div><h3>Purpose</h3><div>This study investigated the association between diabetes and Sepsis-induced cardiomyopathy (SIC), focusing on how changes in inflammatory response and cardiac function influence SIC prognosis. The aim is to provide clinicians with more accurate treatment and management strategies, ultimately enhancing patient outcomes and quality of life.</div></div><div><h3>Methods</h3><div>This retrospective cohort study analyzed 258 Sepsis-induced cardiomyopathy (SIC) patients, stratified by diabetes status and HbA1C levels. Data were collected from electronic medical records. Statistical tests included the Kolmogorov-Smirnov, <em>t</em>-test, Mann-Whitney U, Kruskal-Wallis, chi-square, and Spearman correlation. Univariate and multivariate logistic regression assessed diabetes’ impact on SIC severity. Model fit was evaluated with the Hosmer–Lemeshow and negative log-likelihood ratio tests. A nomogram was constructed and validated using ROC curves, calibration curves, and decision curve analysis. Subgroup and interaction analyses were performed (P < 0.05).</div></div><div><h3>Results</h3><div>Diabetes worsened inflammation and immune responses in SIC, significantly affecting markers like LVEF, TnI, CK-MB, BNP, NLR, IL-6, PCT, CRP, APACHE II, and SOFA scores (P < 0.05). Grouping by HbA1C levels revealed no significant differences in LVEF (P = 0.078), Alb (P = 0.105), or L/A (P = 0.211), but differences were found for TnI, CK-MB, BNP, NLR, IL-6, PCT, CRP, APACHE II, and SOFA (P < 0.05). HbA1C strongly correlated with CRP (rs = 0.8664). BNP (OR 1.001) and HbA1C (OR 1.302) were significant risk factors for SIC, with the nomogram showing good predictive performance (AUC 0.693). No significant interaction between HbA1C and BNP on SIC severity was observed (P = 0.791).</div></div><div><h3>Conclusion</h3><div>Diabetes exacerbates inflammatory and immune responses in Sepsis-induced cardiomyopathy patients, leading to worsened cardiac function.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"220 ","pages":"Article 112001"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global, regional and national burdens of chronic kidney disease due to T1DM and T2DM among adolescents and young adults aged 10–35 years from 1990–2021: A trend analysis based on the global burden of disease study 2021 1990-2021年10-35岁 青少年和年轻人中由T1DM和T2DM引起的慢性肾脏疾病的全球、区域和国家负担：基于2021年全球疾病负担研究的趋势分析

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-01 DOI: 10.1016/j.diabres.2024.111985

Bingrong Wu , Yang Zhou , Qing Ni

{"title":"Global, regional and national burdens of chronic kidney disease due to T1DM and T2DM among adolescents and young adults aged 10–35 years from 1990–2021: A trend analysis based on the global burden of disease study 2021","authors":"Bingrong Wu , Yang Zhou , Qing Ni","doi":"10.1016/j.diabres.2024.111985","DOIUrl":"10.1016/j.diabres.2024.111985","url":null,"abstract":"<div><h3>Backgrounds</h3><div>Chronic kidney disease (CKD) is a major complication of diabetes, which is rising among adolescents and young adults worldwide, but data on the trends of these diseases are sparse. This study examined the burden of CKD due to type 1 diabetes (CKD-T1D) and type 2 diabetes (CKD-T2D) among those aged 10–35 from 1990 to 2021 on global, regional, and national levels.</div></div><div><h3>Methods</h3><div>Using Global Burden of Disease 2021 data, joinpoint regression analysis and decomposition analysis were employed to identify significant changes in CKD-T1D and CKD-T2D trends, including incidence, prevalence, mortality, and disability-adjusted life years (DALYs).</div></div><div><h3>Results</h3><div>Globally, CKD-T1D incidence rose until 2019 before declining, while CKD-T2D incidence declined initially, then increased after 2019. Males generally had higher values of all indicators, except for CKD-T1D prevalence, which was higher in females. Central Latin America saw the largest mortality increase, while Oceania had the highest mortality rates. Oceania countries reported the highest DALYs for both CKD types in 2021.</div></div><div><h3>Conclusion</h3><div>The burden of CKD-T1D and CKD-T2D showed a pandemic-related shift. Middle-SDI countries face high incidence and mortality, while high-SDI countries report lower mortality but higher prevalence. Public health interventions are especially needed in low and middle-SDI countries and island nations.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"220 ","pages":"Article 111985"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of continuous glucose monitoring and point-of-care glucose testing in hospitalized patients with diabetes mellitus in non-intensive care unit settings: A systematic review and meta-analysis of randomized controlled trials 在非重症监护病房的糖尿病住院患者中使用连续血糖监测和即时血糖检测：随机对照试验的系统回顾和荟萃分析

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-01 DOI: 10.1016/j.diabres.2024.111986

Gabriel Cavalcante Lima Chagas , Larissa Teixeira , Mariana R.C. Clemente , Rafael Cavalcante Lima Chagas , Diego Vinicius Santinelli Pestana , Lorenna Rodrigues Silva Sombra , Bruno B. Lima , Rodolfo J. Galindo , Marconi Abreu

{"title":"Use of continuous glucose monitoring and point-of-care glucose testing in hospitalized patients with diabetes mellitus in non-intensive care unit settings: A systematic review and meta-analysis of randomized controlled trials","authors":"Gabriel Cavalcante Lima Chagas , Larissa Teixeira , Mariana R.C. Clemente , Rafael Cavalcante Lima Chagas , Diego Vinicius Santinelli Pestana , Lorenna Rodrigues Silva Sombra , Bruno B. Lima , Rodolfo J. Galindo , Marconi Abreu","doi":"10.1016/j.diabres.2024.111986","DOIUrl":"10.1016/j.diabres.2024.111986","url":null,"abstract":"<div><div>The benefits of using continuous glucose monitoring (CGM) in hospitalized patients with diabetes remain uncertain. Point-of-care (POC) glucose testing is the standard of care in this setting. We compared the effect of adding CGM to POC testing versus POC testing alone on glycemic outcomes in this population. We have searched the Cochrane Library, Embase, and MEDLINE databases and relevant conferences up to May 2024. We have included six randomized controlled trials (<em>n</em> = 979 patients) comparing CGM plus POC testing to POC testing alone in non-pregnant, non-critically ill hospitalized adults with diabetes. The addition of CGM improved time in range (mean difference [MD] + 7.24 %; 95 % confidence interval [CI]: +5.06, +9.42; P < 0.00001; I<sup>2</sup> = 35 %), reduced time below range < 70 mg/dL (MD: −1.23 %; 95 %CI: −2.27, −0.18; P = 0.02; I<sup>2</sup> = 64 %) and < 54 mg/dL (MD: −0.95 %; 95 %CI: −1.19, −0.70; P < 0.00001; I<sup>2</sup> = 0 %), and time above range > 250 mg/dL (MD: −3.70 %; 95 %CI: −6.10, −1.29; P = 0.003; I<sup>2</sup> = 39 %) compared to POC testing alone. We observed no statistically significant differences in glycemic variability or insulin doses. In non-critically ill, hospitalized adults with diabetes, the addition of CGM to POC testing for insulin dosing resulted in superior glycemic control and reduction of hypoglycemia compared to POC testing alone.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"220 ","pages":"Article 111986"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes in the Western Pacific: Unravelling complexities, forging solutions

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-01 DOI: 10.1016/j.diabres.2025.112011

引用次数: 0

Incidence trends in ischaemic and non-ischaemic heart failure in people with and without type 2 diabetes, 2000–2019: An observational study in England 2000-2019年2型糖尿病患者和非2型糖尿病患者缺血性和非缺血性心力衰竭发病率趋势：英国的一项观察性研究

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-01 DOI: 10.1016/j.diabres.2024.111980

Kajal Panchal , Claire Lawson , Sharmin Shabnam , Kamlesh Khunti , Francesco Zaccardi

{"title":"Incidence trends in ischaemic and non-ischaemic heart failure in people with and without type 2 diabetes, 2000–2019: An observational study in England","authors":"Kajal Panchal , Claire Lawson , Sharmin Shabnam , Kamlesh Khunti , Francesco Zaccardi","doi":"10.1016/j.diabres.2024.111980","DOIUrl":"10.1016/j.diabres.2024.111980","url":null,"abstract":"<div><h3>Aim</h3><div>To investigate trends in ischaemic and non-ischaemic heart failure (HF) in adults with type 2 diabetes and without diabetes between 1st January 2000 and 31st December 2019 in England.</div></div><div><h3>Methods</h3><div>We used the Clinical Practice Research Datalink datasets, linked to the Hospital Episode Statistics and Office for National Statistics, to estimate sex-specific crude and age-standardised rates of incident ischaemic and non-ischaemic HF up to 10 years per calendar year of diabetes diagnosis and diabetes status.</div></div><div><h3>Results</h3><div>In a cohort of 735,810 individuals, 5,073 ischaemic (2,038 in people with type 2 diabetes and 3,035 in those without) and 16,501 non-ischaemic (6,358 and 10,143, respectively) HF events were recorded during a median follow-up of 10 years. From 2000 to 2004 to 2005–2009, the age-standardised rates of ischaemic HF marginally declined, while rates remained stable for non-ischaemic HF and were consistently higher for non-ischaemic than ischaemic HF, regardless of diabetes status or sex. Adjusted incidence rate ratios demonstrated negligible impact on trends after accounting for differences in demographics, comorbidities and medications.</div></div><div><h3>Conclusions</h3><div>Improving HF prevention and management strategies remains crucial to decrease the risk of HF in the general population and reduce the persistent risk-gap associated with type 2 diabetes in England.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"220 ","pages":"Article 111980"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bidirectional interplay of sleep apnea syndrome and cardio-vascular disorders in diabetes 糖尿病患者睡眠呼吸暂停综合征与心血管疾病的双向相互作用。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-01 DOI: 10.1016/j.diabres.2024.111984

Paul Valensi , Karima Benmohammed , Mohamed Zerguine

{"title":"Bidirectional interplay of sleep apnea syndrome and cardio-vascular disorders in diabetes","authors":"Paul Valensi , Karima Benmohammed , Mohamed Zerguine","doi":"10.1016/j.diabres.2024.111984","DOIUrl":"10.1016/j.diabres.2024.111984","url":null,"abstract":"<div><div>Although often overlooked sleep apnea has emerged as a significant public health concern. Obstructive sleep apnea (OSA) and diabetes commonly co-exist with a vicious cycle worsening the incidence and severity of both conditions. OSA has many implications including cardiometabolic disorders and impaired cardiovascular (CV) prognosis. OSA combined with diabetes generates a cumulative effect on CV outcomes. The association of OSA with several comorbidities including CV disease and heart failure is bi-directional meaning that some of them are likely to contribute to OSA. In patients with diabetes, OSA treatment should be integrated in a holistic strategy of prevention of CV and microvascular complications. This article provides some clues to advance the understanding of the interplay between OSA and CV disorders in diabetes and to consider the role of some CV risk markers like cardiac autonomic neuropathy and artery stiffness and of novel metrics for hypoxic-related events in CV risk stratification, and offers a discussion on the effects of medical approaches including weight loss strategies, GLP1-receptor agonists and sodium–glucose cotransporter 2 inhibitors. It provides a guidance to improve screening and diagnosis of OSA, and adherence to OSA treatment in patients with diabetes.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"220 ","pages":"Article 111984"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0