The potential of 1H NMR spectroscopy for diabetes diagnosis: a review of current applications and future directions

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-07-21 DOI:10.1016/j.diabres.2025.112380

Ariane Schiavenin , Letícia Bergoza , Ru Angelie Edrada-Ebel , Sidnei Moura

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Abstract

By 2045, it is estimated that approximately 783 million, will be living with diabetes. The incidence of diabetes as well other types of is increasing annually and is associated with many adverse outcomes. Early prediction of the risk of hyperglycaemia and intervention are thus important to reduce adverse outcomes. Studies have revealed a correlation between the levels of amino acids, fatty acids, triglycerides, and other metabolites and the occurrence of diabetes. The development of high-throughput technologies used in metabolomics has enabled the detection of changes in the levels of small-molecule metabolites, which can help reflect the overall physiological and pathological status of the body and explore the underlying mechanisms of the development of diabetes. Thus, this review aims to explore the role of metabolomics as promising alternative for hyperglycaemia diagnoses using NMR, as a guide for researchers, as well as for routine method diagnostic users and to provide data for the development of strategies to manage diabetes.

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1H核磁共振波谱在糖尿病诊断中的潜力：目前的应用和未来的发展方向

到2045年，估计约有7.83亿人将患有糖尿病。糖尿病以及其他类型糖尿病的发病率每年都在增加，并与许多不良后果有关。因此，早期预测高血糖风险并进行干预对减少不良后果非常重要。研究表明，氨基酸、脂肪酸、甘油三酯和其他代谢物的水平与糖尿病的发生之间存在相关性。代谢组学高通量技术的发展使得检测小分子代谢物水平的变化成为可能，这有助于反映机体的整体生理病理状态，探索糖尿病发生的潜在机制。因此，本综述旨在探讨代谢组学作为利用核磁共振诊断高血糖的有希望的替代方法的作用，作为研究人员以及常规方法诊断用户的指南，并为糖尿病管理策略的发展提供数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.