Diabetes research and clinical practice最新文献_第3页

Insights for personalized choice of a hybrid closed–loop system: an expert opinion 混合闭环系统个性化选择的见解：专家意见

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-01-27 DOI: 10.1016/j.diabres.2026.113120

S. Di Molfetta , F. Boscari , A. Rossi , A. Girelli , G. Lepore , L. Bozzetto , C. Irace , L. Laviola , D. Bruttomesso

{"title":"Insights for personalized choice of a hybrid closed–loop system: an expert opinion","authors":"S. Di Molfetta , F. Boscari , A. Rossi , A. Girelli , G. Lepore , L. Bozzetto , C. Irace , L. Laviola , D. Bruttomesso","doi":"10.1016/j.diabres.2026.113120","DOIUrl":"10.1016/j.diabres.2026.113120","url":null,"abstract":"<div><div>Hybrid closed-loop (HCL) systems have transformed diabetes management by integrating continuous glucose monitoring (CGM) with insulin pumps and algorithm-driven insulin dosing. In type 1 diabetes, randomized controlled trials and meta-analyses consistently demonstrate increased time in range and reduced HbA1c with HCL compared to other insulin treatments, without an increased risk of hypoglycemia. Benefits have also been reported in individuals with type 2 diabetes, in pregnant women, and across other groups of persons with diabetes (PWDs). As multiple HCL systems become available, tailoring the choice to clinical profiles and patient preferences can help optimize system selection. This expert paper discusses pump, CGM device and whole system features, supporting evidence from the literature, and other factors to guide the personalized selection of HCL systems currently available in Italy. Practical examples of sound alignment between device features and patient needs/preferences are also provided. The result is a patient–centered framework that combines device features, clinical needs, lifestyle, and preferences to support shared decision–making and ultimately improve outcomes and quality of life for PWDs.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113120"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leisure-time physical activity and sedentary behavior trajectories during middle and late adulthood in relation to type 2 diabetes mellitus: An 11-year longitudinal study 成年中后期的休闲时间体力活动和久坐行为轨迹与2型糖尿病的关系：一项为期11年的纵向研究

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-01-31 DOI: 10.1016/j.diabres.2026.113135

Mengyao Guo , Shiyi Chen , Huanyu Wang , Jialin Fang , Mingjia Yang

{"title":"Leisure-time physical activity and sedentary behavior trajectories during middle and late adulthood in relation to type 2 diabetes mellitus: An 11-year longitudinal study","authors":"Mengyao Guo , Shiyi Chen , Huanyu Wang , Jialin Fang , Mingjia Yang","doi":"10.1016/j.diabres.2026.113135","DOIUrl":"10.1016/j.diabres.2026.113135","url":null,"abstract":"<div><h3>Background</h3><div>Leisure-time physical activity (LTPA) and sedentary behavior (SB) are considered important modifiable risk factors for Type 2 diabetes mellitus (T2DM). However, the associations of long-term trajectories of LTPA and LTSB with T2DM risk remains uncertain.</div></div><div><h3>Methods</h3><div>Leveraging prospective cohort data from the China Health and Nutrition Survey (CHNS), we identified the long-term trajectories of LTPA and LTSB among 7,188 participants from 2004 (31 to 77 years) to 2015 (42 to 88 years) by group-based trajectory modeling. Cox regression was used to assess the associations of LTPA and LTSB trajectories with T2DM.</div></div><div><h3>Results</h3><div>During a mean follow-up of 9.13 years, 715 new-onset T2DM were identified. Three distinct trajectories were identified for both LTPA and LTSB, respectively. Participants in the high decreasing trajectory, but still remains at a relatively high level of LTPA had a 45% lower risk of T2DM (HR: 0.55; 95% CI: 0.30–0.99), relative to those in the inactive stable trajectory. Conversely, compared with the low stable trajectory, the high increasing trajectory of LTSB had a 130% higher risk of T2DM (HR: 2.30; 95% CI: 1.03–5.10).</div></div><div><h3>Conclusion</h3><div>This prospective study suggests that maintaining higher levels of LTPA and lower levels of LTSB may reduce the risk of T2DM during middle and late adulthood.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113135"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantifying the impact of inequality on traditional and emerging diabetes complications: A registry study of cause-specific hospital admissions and deaths in Australia 量化不平等对传统和新出现的糖尿病并发症的影响：澳大利亚特定原因住院和死亡的登记研究。

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-01-25 DOI: 10.1016/j.diabres.2026.113114

Jedidiah I. Morton , Emily D. Williams , Jonathan E. Shaw , Dianna J. Magliano

{"title":"Quantifying the impact of inequality on traditional and emerging diabetes complications: A registry study of cause-specific hospital admissions and deaths in Australia","authors":"Jedidiah I. Morton , Emily D. Williams , Jonathan E. Shaw , Dianna J. Magliano","doi":"10.1016/j.diabres.2026.113114","DOIUrl":"10.1016/j.diabres.2026.113114","url":null,"abstract":"<div><h3>Background and aims</h3><div>Our aim was to quantify the relationship of a large range of diabetes complications with socioeconomic disadvantage.</div></div><div><h3>Methods</h3><div>This study included 621,114 people with type 2 diabetes from the Australian National Diabetes Services Scheme, with follow-up from July 2010 to June 2022. These data were linked to hospital admission and death datasets. The association of socioeconomic disadvantage with cause-specific outcomes (first occurrence of either admission or death) was assessed using Poisson regression, adjusted for age, sex, and year.</div></div><div><h3>Results</h3><div>Most diabetes-related complications studied were positively associated with increasing socioeconomic disadvantage, with the highest incidence rate ratios per 1-SD increase in socioeconomic disadvantage for admission or death from chronic obstructive pulmonary disease (1.19 (95%CI: 1.18, 1.21)) myocardial infarction (1.12 (1.11, 1.13)), heart failure (1.11 (1.10, 1.12)), cellulitis (1.10 (1.09, 1.12)), and end-stage kidney disease (1.09 (1.07, 1.12)). Foot complications and respiratory diseases showed a positive association with disadvantage, as did cardiovascular and kidney diseases, while most cancers, depression, and dementia did not.</div></div><div><h3>Conclusions</h3><div>Increasing socioeconomic disadvantage was associated with an increased risk of admission or death from most traditional diabetes-related complications and for respiratory disease. However, the associations with emerging complications of diabetes were weaker, null, or the risk decreased with increasing disadvantage.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113114"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights to HDL dysfunctionality: hypothesis of exhausted HDL 对HDL功能障碍的认识：HDL耗竭假说。

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-02-07 DOI: 10.1016/j.diabres.2026.113145

Abdolkarim Mahrooz

{"title":"Insights to HDL dysfunctionality: hypothesis of exhausted HDL","authors":"Abdolkarim Mahrooz","doi":"10.1016/j.diabres.2026.113145","DOIUrl":"10.1016/j.diabres.2026.113145","url":null,"abstract":"<div><div>In recent years, a growing understanding of high-density lipoprotein (HDL) properties has significantly reshaped our comprehension of this crucial lipoprotein. Emerging evidence indicates that HDL can lose its well-documented protective functions, becoming dysfunctional and, paradoxically, even proatherogenic. Dysfunctional HDL (dys-HDL) is recognized as a critical contributor to cardiovascular disease and diabetes mellitus, conditions where cardiovascular complications are the main cause of mortality. The concept of dys-HDL appears broad, necessitating a distinction between HDL with diminished protective functionality and HDL that actively promotes proatherogenic effects. In certain conditions, the transition from protective to proatherogenic HDL appears to be a gradual and progressive process. This transition may be conceptualized through the idea of ‘exhausted’ HDL (ex-HDL), which represents HDL that has experienced reduced functionality but has not yet fully acquired proatherogenic characteristics. It signifies an abnormality leading to a state of ‘partial functional impairment’ in HDL. Hypothetically, dys-HDL could be categorized into two groups: ex-HDL and proatherogenic HDL. Such a classifying offers a path towards more targeted therapies for cardiovascular risk reduction. This review aims to enhance our understanding of HDL dysfunctionality and propose ex-HDL, thereby offering insights into the transition from protective to proatherogenic HDL.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113145"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “A renal biopsy-anchored multi-marker signature involving AOPEP SNP-driven splicing, miR-27b-3p and glycated albumin for stratifying renal damage in type 2 diabetes”. [DIAB 229 (2025) 112460] “肾活检锚定的多标记特征涉及AOPEP snp驱动剪接，miR-27b-3p和糖化白蛋白对2型糖尿病肾损害的分层”的更正。[diab 229(2025) 112460]。

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2025-11-25 DOI: 10.1016/j.diabres.2025.113009

Francesca Conserva , Francesco Pesce , Claudia Cinefra , Tommaso Maria Marvulli , Ighli Di Bari , Alessandra Stasi , Maria Felicia Faienza , Michele Rossini , Adriano Montinaro , Elena Squiccimarro , Giorgia Sclavo , Annalisa Schirinzi , Francesca Di Serio , Viji Nair , Damian Fermin , Rajasree Menon , Edgar Otto , Fabio Sallustio , Anna Gallone , Giovanni Stallone , Paola Pontrelli

引用次数: 0

Utility of continuous glucose monitoring in people with type 2 diabetes on insulin-based regimens in clinical practice: A case series and expert opinion 2型糖尿病患者在胰岛素基础治疗方案中持续血糖监测的临床应用：病例系列和专家意见

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2025-12-13 DOI: 10.1016/j.diabres.2025.113054

Soo Lim , Rimei Nishimura , Jothydev Kesavadev , Alice Pik Shan Kong , Margaret J McGill , Horng-Yih Ou , Chun-Kwan O , Chun-Chuan Lee , Xiaomei Zhang , Linong Ji , Chih-Yuan Wang

{"title":"Utility of continuous glucose monitoring in people with type 2 diabetes on insulin-based regimens in clinical practice: A case series and expert opinion","authors":"Soo Lim , Rimei Nishimura , Jothydev Kesavadev , Alice Pik Shan Kong , Margaret J McGill , Horng-Yih Ou , Chun-Kwan O , Chun-Chuan Lee , Xiaomei Zhang , Linong Ji , Chih-Yuan Wang","doi":"10.1016/j.diabres.2025.113054","DOIUrl":"10.1016/j.diabres.2025.113054","url":null,"abstract":"<div><div>In individuals with type 2 diabetes (T2D) on insulin, continuous glucose monitoring (CGM) provides feedback on intra- and inter-day glycaemic variations that helps tailor the insulin regimen and lifestyle choices, without the pain of multiple finger pricks. However, practical guidance on the use of CGM in this cohort is limited in Asia. In this case series-based review and expert opinion paper, we aim to provide expert guidance, through a case-based approach, on the use of CGM in people with T2D on insulin therapy, primarily in three profiles: (1) individuals with no comorbidities; (2) those with comorbid cardiovascular risk factors; and (3) elderly individuals with T2D on insulin. Five anonymised demonstrative real-world cases, including ambulatory glucose profiles, have been presented. The benefits of CGM in T2D management in each profile as well as supporting literature are discussed and ten key clinical practice points are proposed to aid in optimising the use of CGM for achieving glycaemic targets, adjusting insulin therapy, motivating adherence to lifestyle intervention, reducing the risk of, or minimising the duration of, hypoglycaemia, and improving the overall quality of life and well-being in this population.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113054"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145755538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of glucagon-like peptide-1 receptor agonist use with anxiety disorders, depression, self-harm, and suicidality: a large cohort study 胰高血糖素样肽-1受体激动剂对焦虑、抑郁和自杀风险的影响：一项大型队列研究。

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-01-25 DOI: 10.1016/j.diabres.2026.113104

Filippos Anagnostakis , Michail Kokkorakis , Georgia Anastasiou , Shrihari Nagarajan , Christos S. Mantzoros

{"title":"Association of glucagon-like peptide-1 receptor agonist use with anxiety disorders, depression, self-harm, and suicidality: a large cohort study","authors":"Filippos Anagnostakis , Michail Kokkorakis , Georgia Anastasiou , Shrihari Nagarajan , Christos S. Mantzoros","doi":"10.1016/j.diabres.2026.113104","DOIUrl":"10.1016/j.diabres.2026.113104","url":null,"abstract":"<div><h3>Aims</h3><div>This study examines the incidence of anxiety disorders, depression, self-harm, and suicidality after treatment initiation with antihyperglycemic medications in patients with type 2 diabetes (T2D) who take metformin as first-line treatment.</div></div><div><h3>Methods</h3><div>A large cohort study was conducted using TriNetX electronic health records andincluded adults (≥18 years) with T2D who used metformin and initiated GLP-1 RAs, SGLT2i, DPP4i, or SU between 1 April 2013 and 31 December 2019.</div></div><div><h3>Results</h3><div>The final three propensity-matched cohorts were 1) GLP-1 RA vs DPP4i (n = 28,536), 2) GLP-1 RA vs SU (n = 23,486), and 3) GLP-1 RA vs SGLT2i (n = 24,052). In a median follow-up of 5.5 years, GLP-1 RAs were associated with a higher risk of depression compared to SGLT2i (HR 1.19, 95% CI 1.11–1.28), and DPP4i (HR 1.06, 95% CI 1.00–1.13) but not SU. Anxiety disorder risk was also higher for GLP-1 RAs versus SGLT2i (HR 1.09, 95% CI 1.02– 1.16) and DPP4i (HR 1.07, 95% CI 1.02–1.13) but not SU. On the contrary, GLP-1 RAs were associated with a lower risk for suicidal ideation in comparison with SU (HR 0.62, 95% CI 0.44–0.87).</div></div><div><h3>Conclusions</h3><div>GLP-1 RAs were associated with a higher risk of anxiety disorders and depression, but no difference in suicidality or self-harm in comparison to SGLT2i, DPP4i, and lower suicidality risk compared to SU.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113104"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limitation of existing GFR estimating equations and application of artificial intelligence in improving GFR estimation and chronic kidney disease progression in people with diabetes 现有GFR估算方程的局限性及人工智能在改善GFR估算和糖尿病患者慢性肾脏疾病进展中的应用

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-02-10 DOI: 10.1016/j.diabres.2026.113152

Digsu N. Koye , Rodney Kwok , Yih-Chung Tham , Tina Zafari , Kartik Kishore , Elif I. Ekinci

{"title":"Limitation of existing GFR estimating equations and application of artificial intelligence in improving GFR estimation and chronic kidney disease progression in people with diabetes","authors":"Digsu N. Koye , Rodney Kwok , Yih-Chung Tham , Tina Zafari , Kartik Kishore , Elif I. Ekinci","doi":"10.1016/j.diabres.2026.113152","DOIUrl":"10.1016/j.diabres.2026.113152","url":null,"abstract":"<div><div>The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2009 equation is the most commonly used equation for estimating glomerular filtration rate (GFR) in clinical practice. However, recent studies have questioned the accuracy of this equation in estimating GFR in people with diabetes. We conducted a comprehensive review of existing literature on the role of artificial intelligence and machine learning in estimating GFR and the progression of chronic kidney disease (CKD), specifically in people with diabetes.</div><div>Artificial intelligence, including machine learning and image-based deep learning algorithms have shown promise in improving the accuracy of GFR estimation. Artificial Neural Networks is the commonly used machine learning algorithm in GFR estimation studies. Other artificial intelligence methods include random forests, support vector machines, and ensemble learning models. Many of the studies included in this review reported that artificial intelligence-based GFR estimation equations exhibit lower bias, as well as higher precision and accuracy. However, these findings are not consistent across all the studies. In addition, currently available studies are limited to smaller sample sizes and majority of the studies are from selected countries or populations. Therefore, before implementing these methods in clinical practice, it is essential to validate them on larger sample sizes and diverse patient populations.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113152"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146178406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The psychological impact of time in tight range in adolescents with type 1 diabetes: insights from real-life clinical practice 时间对青少年1型糖尿病患者的心理影响：来自现实生活临床实践的见解

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-02-14 DOI: 10.1016/j.diabres.2026.113160

Stefano Passanisi , Bruno Bombaci , Alessandro Longo , Angela Alibrandi , Giuseppina Salzano , Fortunato Lombardo

{"title":"The psychological impact of time in tight range in adolescents with type 1 diabetes: insights from real-life clinical practice","authors":"Stefano Passanisi , Bruno Bombaci , Alessandro Longo , Angela Alibrandi , Giuseppina Salzano , Fortunato Lombardo","doi":"10.1016/j.diabres.2026.113160","DOIUrl":"10.1016/j.diabres.2026.113160","url":null,"abstract":"<div><h3>Aims</h3><div>Time in Tight Range (TITR) is an emerging continuous glucose monitoring (CGM) metric assessing time spent in the 70–140 mg/dL range. While TITR is increasingly recognized for reflecting optimal glucose control, its psychological impact remains unexplored. This study assessed the relationship between TITR and psychological outcomes in adolescents with type 1 diabetes (T1D).</div></div><div><h3>Methods</h3><div>This cross-sectional study included 123 adolescents with T1D. Participants completed two validated questionnaires: the PAID-Teen, which measures diabetes-related distress, and the PERMA model, which evaluates psychological well-being. CGM data were analyzed to determine participants’ glucose metrics.</div></div><div><h3>Results</h3><div>Achieving TITR ≥ 50% was associated with higher distress scores (<em>OR</em> = 1.023; 95% CI 1.002–1.044; <em>p</em> = 0.029), while no such association was found with PERMA scores. Conversely, time in range (TIR) ≥ 70% showed no significant relationship with psychological outcomes.</div></div><div><h3>Conclusions</h3><div>These findings suggest TITR may impose additional psychological burden beyond conventional glycemic targets. Further longitudinal studies are needed to evaluate its long-term impact on quality of life and optimize diabetes management strategies for youth with T1D.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113160"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNAs modify relationships between hemoglobin A1c and race and ethnicity microrna修饰血红蛋白A1c与种族和民族之间的关系。

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-02-17 DOI: 10.1016/j.diabres.2026.113165

Benjamin M. Stroebel , Bradley E. Aouizerat , Kayla D. Longoria , Meghana Gadgil , Elena Flowers

{"title":"MicroRNAs modify relationships between hemoglobin A1c and race and ethnicity","authors":"Benjamin M. Stroebel , Bradley E. Aouizerat , Kayla D. Longoria , Meghana Gadgil , Elena Flowers","doi":"10.1016/j.diabres.2026.113165","DOIUrl":"10.1016/j.diabres.2026.113165","url":null,"abstract":"<div><h3>Aims</h3><div>To identify microRNAs that modify associations between categories of race and ethnicity and HbA1c, and to identify associated extrinsic factors and biological mechanism through which this modification may occur.</div></div><div><h3>Methods</h3><div>This study was a secondary analysis of the DPP trial, featuring 1000 participants with microRNA data available at baseline, and a subset of 150 with longitudinal microRNA data. Modification of relationships between categories of race and ethnicity and HbA1c by microRNAs were assessed cross-sectionally with linear models, and longitudinally with linear mixed models. In-silico analyses were performed to identify target mRNAs and pathways of identified modifying miRs. Linear models were used to assess for relationships between socioenvironmental variables and modifying miRs in an exploratory analysis.</div></div><div><h3>Results</h3><div>we identified one microRNA that modified associations between categories of race and ethnicity and HbA1c at baseline (miR-29b) and two that showed longitudinal modifications (miR-92a, miR-146a). MiroRNAs that modified relationships between HbA1c and categories of race and ethnicity were also associated with socioenvironmental factors including nutrition, income, education, and exercise in exploratory models.</div></div><div><h3>Conclusions</h3><div>We identified microRNAs that modify associations between self-reported categories of race and ethnicity and HbA1c, potentially reflecting confounding of theses associations by socioenvironmental factors, geographic ancestry, and other individual-level characteristics.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113165"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0