Diabetes research and clinical practice最新文献_第3页

Distinct microRNA signatures in Platelet-Rich Plasma-Derived extracellular vesicles predict healing outcomes in chronic diabetic foot ulcers 富血小板血浆来源的细胞外囊泡中不同的microRNA特征预测慢性糖尿病足溃疡的愈合结果。

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-02-04 DOI: 10.1016/j.diabres.2026.113142

Yu-Chi Tsai , Shu-Yu Wu , Chien-Ju Wu , Hao-Yu Chiao , Hsu-Ping Tseng , Yu-Min He , Tim-Mo Chen , Min-Yu Tu , Yuan-sheng Tzeng

{"title":"Distinct microRNA signatures in Platelet-Rich Plasma-Derived extracellular vesicles predict healing outcomes in chronic diabetic foot ulcers","authors":"Yu-Chi Tsai , Shu-Yu Wu , Chien-Ju Wu , Hao-Yu Chiao , Hsu-Ping Tseng , Yu-Min He , Tim-Mo Chen , Min-Yu Tu , Yuan-sheng Tzeng","doi":"10.1016/j.diabres.2026.113142","DOIUrl":"10.1016/j.diabres.2026.113142","url":null,"abstract":"<div><h3>Background</h3><div>Diabetic foot ulcers (DFUs) present a major challenge due to impaired angiogenesis and chronic inflammation. Autologous platelet-rich plasma (PRP) is a widely used therapy, but clinical outcomes remain inconsistent. We hypothesized that the microRNA (miRNA) cargo of platelet-derived extracellular vesicles (PRP-EVs) drives this therapeutic variability.</div></div><div><h3>Methods</h3><div>Ten patients with refractory DFUs were enrolled. Autologous PRP-EVs were isolated, and wound healing-associated miRNAs were quantified via qRT-PCR. Clinical wound closure was monitored weekly, with the primary efficacy endpoint assessed at 6 weeks. The biological effects of patient-specific PRP-EVs on keratinocyte migration were evaluated in vitro.</div></div><div><h3>Results</h3><div>PRP treatment resulted in significant wound area reduction, achieving an average closure rate of approximately 90% by week 6. However, miRNA expression exhibited substantial heterogeneity. High levels of miR-20a-5p and miR-21-5p in PRP-EVs were significantly associated with delayed clinical healing and impaired keratinocyte migration. Conversely, elevated miR-223-3p correlated with accelerated wound closure.</div></div><div><h3>Conclusion</h3><div>The intrinsic miRNA composition of PRP-EVs is a critical determinant of PRP therapeutic efficacy. miR-20a-5p and miR-21-5p serve as negative predictive biomarkers, whereas miR-223-3p indicates a favorable prognosis. Profiling these miRNAs offers a novel approach for PRP quality control and personalized regenerative strategies.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113142"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of metformin use during pregnancy on fetal congenital malformations across 11 organ systems: a meta-analysis and drug-target Mendelian randomization study 妊娠期间使用二甲双胍对胎儿11个器官系统先天性畸形的影响：一项荟萃分析和药物靶孟德尔随机化研究。

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-01-31 DOI: 10.1016/j.diabres.2026.113118

Hanbing Ji , Yutong Wu , Sijia Wu , Xiaoru Sun , Yuanyuan Yu , Lei Hou , Rusong Zhao , Chuan Wang , Yifan Yu , Yilei Ge , Yun Wei , Qingxin Luo , Le Wang , Tiemei Liu , Ziyan Zhang , Jiawei Xiu , Yang Song , Hongkai Li , Shanshan Gao , Fuzhong Xue , Hao Chen

{"title":"Impact of metformin use during pregnancy on fetal congenital malformations across 11 organ systems: a meta-analysis and drug-target Mendelian randomization study","authors":"Hanbing Ji , Yutong Wu , Sijia Wu , Xiaoru Sun , Yuanyuan Yu , Lei Hou , Rusong Zhao , Chuan Wang , Yifan Yu , Yilei Ge , Yun Wei , Qingxin Luo , Le Wang , Tiemei Liu , Ziyan Zhang , Jiawei Xiu , Yang Song , Hongkai Li , Shanshan Gao , Fuzhong Xue , Hao Chen","doi":"10.1016/j.diabres.2026.113118","DOIUrl":"10.1016/j.diabres.2026.113118","url":null,"abstract":"<div><h3>Aims</h3><div>Metformin is a cost-effective alternative to insulin for gestational diabetes mellitus (GDM), yet concerns regarding potential teratogenicity persist. This study aimed to evaluate the association between prenatal metformin exposure and multisystem congenital malformations (CMs), and to explore biologically relevant pathways.</div></div><div><h3>Methods</h3><div>This study first conducted a meta-analysis of RCTs and cohort studies assessing maternal metformin use and fetal CMs. Subsequently, drug-target Mendelian randomization (DTMR) examined genetically proxied associations between metformin pharmacodynamic targets (eQTLs) and 64 CMs (FinnGen), reflecting lifelong target perturbation, adjusting for maternal confounders and validating with placental eQTL data.</div></div><div><h3>Results</h3><div>Meta-analysis showed a protective effect of metformin versus insulin on overall CMs (<em>RR</em> = 0.83, 95% CI 0.71–0.99). In DTMR, following Bonferroni correction and covariate adjustment, seven of 92 target genes (e.g., <em>NDUFS5</em>, <em>NDUFA2</em>) showed significant associations, primarily exhibiting protective effects against circulatory and musculoskeletal system. Validation in placental eQTLs corroborated the direction of effects for 17 gene-outcome pairs, reinforcing the robustness of key safety signals.</div></div><div><h3>Conclusion</h3><div>By integrating clinical and genetic evidence, this study is consistent with the overall clinical safety of metformin use during pregnancy with respect to congenital malformations and provides hypothesis-generating insights into relevant biological pathways.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113118"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Dietary glycocalyx mimetic reduces vascular risk in Type 2 diabetes: evidence from urinary peptidomic classifiers in a South–Asian Surinamese Cohort”. [DIAB 229 (2025) 112931] “饮食糖萼模拟物降低2型糖尿病血管风险：来自南亚苏里南队列尿肽组学分类的证据”的勘误表。[diab 229 (2025) 112931]

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2025-10-25 DOI: 10.1016/j.diabres.2025.112953

Sajjad Biglari , Lushun Yuan , Harald Mischak , Justyna Siwy , Agnieszka Latosinska , Miroslaw Banasik , Bernard M. van den Berg

引用次数: 0

Risk of type 2 diabetes mellitus after respiratory syncytial viral infection: A retrospective cohort study using US database 呼吸道合胞病毒感染后2型糖尿病的风险：一项使用美国数据库的回顾性队列研究

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.diabres.2026.113123

Sunny Ssu-Yu Chen , Tina Ting-An Lin , Yi-Lin Chiang , Chien-Yun Chen , Hui-Yuan Chen , Yao-Min Hung , Renin Chang

{"title":"Risk of type 2 diabetes mellitus after respiratory syncytial viral infection: A retrospective cohort study using US database","authors":"Sunny Ssu-Yu Chen , Tina Ting-An Lin , Yi-Lin Chiang , Chien-Yun Chen , Hui-Yuan Chen , Yao-Min Hung , Renin Chang","doi":"10.1016/j.diabres.2026.113123","DOIUrl":"10.1016/j.diabres.2026.113123","url":null,"abstract":"<div><h3>Objective</h3><div>Whether respiratory syncytial virus (RSV) infection contributes to the development of type 2 diabetes (T2DM) or serves as an early warning indicator of T2DM risk remains unclear.</div></div><div><h3>Methods</h3><div>The study utilized TriNetX US Collaborative Database between January 1, 2022, and March 31, 2024. Patients with a history of T2DM diagnosis, antidiabetic medication use, or HbA1c ≥ 6.5 were excluded. RSV infection was designated as the index event with propensity score matching. The risk of T2DM was assessed using Cox proportional hazards regression models. Sensitivity analyses were conducted for two periods: 2010–2015 and 2016–2019, and across different databases.</div></div><div><h3>Results</h3><div>A total of 3,052,016 patients, including 15,205 with RSV (mean age, 51.1 years; 59.9% female) and 3,036,811 without RSV (mean age, 46.9 years; 53.4% female). T2DM incidence was 5.69% in the RSV group vs 2.48% in controls, HR 2.684 [95% CI: 2.378–3.030], E-value 4.81. Risk was significantly increased from infection to 3 and 6 months (HR 3 months: 2.697 [95% CI: 2.332–3.119]; HR 6 months: 2.271 [95% CI: 1.911–2.699]). All sensitivity analyses consistently showed a positive trend.</div></div><div><h3>Conclusions</h3><div>Our findings suggest an association between RSV infection and subsequent T2DM. Prospective studies and mechanistic investigations are warranted to validate these observations and elucidate the underlying pathways.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113123"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of liraglutide treatment for 35-days on total and regional fat free, lean, and bone mass, and on the Myostatin–Activin–Follistatin–IGF-1 axes: a secondary analysis of a randomized placebo-controlled crossover study 利拉鲁肽治疗35天对总和局部脂肪、瘦肉和骨量的影响，以及对肌生成抑制素-激活素-卵泡素- igf -1轴的影响：一项随机安慰剂对照交叉研究的二次分析。

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-01-20 DOI: 10.1016/j.diabres.2026.113113

Valeria Gutierrez de Piñeres , Arantxa Ramirez-Cisneros , Claudia S. Tamayo-Torres , Angeliki M. Angelidi , Marianthi Kavelidou , Konstantinos Stefanakis , Christos S. Mantzoros

{"title":"Effects of liraglutide treatment for 35-days on total and regional fat free, lean, and bone mass, and on the Myostatin–Activin–Follistatin–IGF-1 axes: a secondary analysis of a randomized placebo-controlled crossover study","authors":"Valeria Gutierrez de Piñeres , Arantxa Ramirez-Cisneros , Claudia S. Tamayo-Torres , Angeliki M. Angelidi , Marianthi Kavelidou , Konstantinos Stefanakis , Christos S. Mantzoros","doi":"10.1016/j.diabres.2026.113113","DOIUrl":"10.1016/j.diabres.2026.113113","url":null,"abstract":"<div><div><strong>Background</strong>: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are used to treat obesity and metabolic diseases, yet their early impact on body composition and circulating regulators of muscle and bone remain unclear. This study aimed to assess early effects of liraglutide on total and regional body composition and associated changes in circulating markers of muscle and bone metabolism.</div><div><strong>Methods</strong>: Twenty adults with obesity received liraglutide 3.0 mg/day or placebo for 35 days in this crossover randomized controlled trial. In this secondary analysis, body composition was assessed by dual-energy X-ray absorptiometry at the end of each phase, while hormones were measured by ELISA at baseline and at each of 6 weekly visits over 5 weeks.</div><div><strong>Results</strong>: Liraglutide reduced body weight, BMI, and total and regional mass (trunk, hip, and extremities). Absolute fat-free mass was slightly but significantly lower. Absolute lean mass in the trunk and extremities decreased, whereas relative lean mass and fat-free mass percentages remained stable at treatment completion.</div><div><strong>Conclusions:</strong> Short-term liraglutide treatment reduces total and regional mass without altering relative body composition. Further research is warranted to confirm and clarify the clinical significance of these changes, to further study hormonal changes and identify strategies to preserve muscle mass during weight loss.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113113"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes technology use in the Middle East and Southeast Asia: penetrance, challenges, and unmet needs 中东和东南亚的糖尿病技术使用：外显率、挑战和未满足的需求。

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-01-24 DOI: 10.1016/j.diabres.2026.113117

Asma Deeb , Hussain Al Saffar , Nadha Yaqoob , Andrea E. Scaramuzza

{"title":"Diabetes technology use in the Middle East and Southeast Asia: penetrance, challenges, and unmet needs","authors":"Asma Deeb , Hussain Al Saffar , Nadha Yaqoob , Andrea E. Scaramuzza","doi":"10.1016/j.diabres.2026.113117","DOIUrl":"10.1016/j.diabres.2026.113117","url":null,"abstract":"<div><h3>Aims</h3><div>Little data exist on the extent of diabetes technology use in the treatment of diabetes in young people outside high-income, Western countries. Here we explored uptake of diabetes technology in the Middle East, Southeast Asia, and beyond.</div></div><div><h3>Methods</h3><div>A multinational, cross-sectional survey was distributed via major pediatric endocrine societies to healthcare professionals (HCPs) managing children and adolescents with diabetes. The survey assessed CGM and insulin pump penetrance, challenges to adoption, and perceived solutions.</div></div><div><h3>Results</h3><div>Based on 196 responses from 27 countries, a profound technology gap was confirmed. Nearly half of HCPs (49.2%) reported CGM use in fewer than 5% of their patients, while insulin pump use was even lower, with 74.1% reporting use in under 5% of their pediatric population. While lack of financial resources was the principal barrier (>95%), HCPs also highlighted critical non-financial needs, including simpler technology (53.3%), maintaining patient motivation (52.3%), and deficits in provider training (47.2%) and structured patient education (46.7%).</div></div><div><h3>Conclusion</h3><div>The adoption of modern diabetes technology is critically low in these regions, reinforcing the existence of an interregional “technology gap”. Improving outcomes for children and adolescents with type 1 diabetes not only relies on funding to promote equitable access but also support through culturally-adapted education for providers, patients, and their families.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113117"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights for personalized choice of a hybrid closed–loop system: an expert opinion 混合闭环系统个性化选择的见解：专家意见

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-01-27 DOI: 10.1016/j.diabres.2026.113120

S. Di Molfetta , F. Boscari , A. Rossi , A. Girelli , G. Lepore , L. Bozzetto , C. Irace , L. Laviola , D. Bruttomesso

{"title":"Insights for personalized choice of a hybrid closed–loop system: an expert opinion","authors":"S. Di Molfetta , F. Boscari , A. Rossi , A. Girelli , G. Lepore , L. Bozzetto , C. Irace , L. Laviola , D. Bruttomesso","doi":"10.1016/j.diabres.2026.113120","DOIUrl":"10.1016/j.diabres.2026.113120","url":null,"abstract":"<div><div>Hybrid closed-loop (HCL) systems have transformed diabetes management by integrating continuous glucose monitoring (CGM) with insulin pumps and algorithm-driven insulin dosing. In type 1 diabetes, randomized controlled trials and meta-analyses consistently demonstrate increased time in range and reduced HbA1c with HCL compared to other insulin treatments, without an increased risk of hypoglycemia. Benefits have also been reported in individuals with type 2 diabetes, in pregnant women, and across other groups of persons with diabetes (PWDs). As multiple HCL systems become available, tailoring the choice to clinical profiles and patient preferences can help optimize system selection. This expert paper discusses pump, CGM device and whole system features, supporting evidence from the literature, and other factors to guide the personalized selection of HCL systems currently available in Italy. Practical examples of sound alignment between device features and patient needs/preferences are also provided. The result is a patient–centered framework that combines device features, clinical needs, lifestyle, and preferences to support shared decision–making and ultimately improve outcomes and quality of life for PWDs.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113120"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gestational diabetes mellitus phenotypes defined by 75-g oral glucose tolerance test response patterns: associations with perinatal outcomes and persistent postpartum diabetes 75克口服葡萄糖耐量试验反应模式定义的妊娠糖尿病表型：与围产期结局和产后持续性糖尿病的关系

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-02-08 DOI: 10.1016/j.diabres.2026.113148

Hanne Bulat Cim , Canan Satır Özel , Melis Altuğ İnan , Nisan Helin Dönmez , Esmehan Ayşit , Ergül Demirçivi , Bilge Kapudere , Neslişah Ar , Abdulkadir Turgut

{"title":"Gestational diabetes mellitus phenotypes defined by 75-g oral glucose tolerance test response patterns: associations with perinatal outcomes and persistent postpartum diabetes","authors":"Hanne Bulat Cim , Canan Satır Özel , Melis Altuğ İnan , Nisan Helin Dönmez , Esmehan Ayşit , Ergül Demirçivi , Bilge Kapudere , Neslişah Ar , Abdulkadir Turgut","doi":"10.1016/j.diabres.2026.113148","DOIUrl":"10.1016/j.diabres.2026.113148","url":null,"abstract":"<div><h3>Aims</h3><div>To assess whether 75-g oral glucose tolerance test (OGTT) response patterns define clinically meaningful phenotypes among women with gestational diabetes mellitus (GDM) and whether these phenotypes are associated with perinatal outcomes and persistent postpartum diabetes.</div></div><div><h3>Methods</h3><div>This single-center ambispective cohort included women diagnosed with GDM by a 75-g OGTT at 24–28 weeks’ gestation (IADPSG) between January 2020 and May 2025. Women were classified as isolated fasting hyperglycemia (Group 1), isolated post-load hyperglycemia (Group 2), or combined hyperglycemia (Group 3). From ≥ 12 weeks postpartum onward, participants were recontacted for assessment of glycemic status, and outcomes were verified using available clinical records, laboratory results when available, and medication data.</div></div><div><h3>Results</h3><div>Among 251 women (mean age 31.4 years; mean BMI 32.5 kg/m<sup>2</sup>), insulin therapy was most frequent in Group 3 (27.4%; p < 0.001), which also had higher HbA1c (p = 0.011) and earlier delivery (p = 0.008). Persistent postpartum diabetes occurred in 12%. In multivariable analyses, higher BMI and phenotypes incorporating fasting hyperglycemia (Groups 1/3) were independently associated with persistent postpartum diabetes.</div></div><div><h3>Conclusion</h3><div>OGTT pattern–based phenotyping differentiates GDM subgroups in routine care, with differences in metabolic severity, treatment need, selected perinatal indicators, and postpartum diabetes risk, supporting targeted antenatal management and postpartum follow-up.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113148"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leisure-time physical activity and sedentary behavior trajectories during middle and late adulthood in relation to type 2 diabetes mellitus: An 11-year longitudinal study 成年中后期的休闲时间体力活动和久坐行为轨迹与2型糖尿病的关系：一项为期11年的纵向研究

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-01-31 DOI: 10.1016/j.diabres.2026.113135

Mengyao Guo , Shiyi Chen , Huanyu Wang , Jialin Fang , Mingjia Yang

{"title":"Leisure-time physical activity and sedentary behavior trajectories during middle and late adulthood in relation to type 2 diabetes mellitus: An 11-year longitudinal study","authors":"Mengyao Guo , Shiyi Chen , Huanyu Wang , Jialin Fang , Mingjia Yang","doi":"10.1016/j.diabres.2026.113135","DOIUrl":"10.1016/j.diabres.2026.113135","url":null,"abstract":"<div><h3>Background</h3><div>Leisure-time physical activity (LTPA) and sedentary behavior (SB) are considered important modifiable risk factors for Type 2 diabetes mellitus (T2DM). However, the associations of long-term trajectories of LTPA and LTSB with T2DM risk remains uncertain.</div></div><div><h3>Methods</h3><div>Leveraging prospective cohort data from the China Health and Nutrition Survey (CHNS), we identified the long-term trajectories of LTPA and LTSB among 7,188 participants from 2004 (31 to 77 years) to 2015 (42 to 88 years) by group-based trajectory modeling. Cox regression was used to assess the associations of LTPA and LTSB trajectories with T2DM.</div></div><div><h3>Results</h3><div>During a mean follow-up of 9.13 years, 715 new-onset T2DM were identified. Three distinct trajectories were identified for both LTPA and LTSB, respectively. Participants in the high decreasing trajectory, but still remains at a relatively high level of LTPA had a 45% lower risk of T2DM (HR: 0.55; 95% CI: 0.30–0.99), relative to those in the inactive stable trajectory. Conversely, compared with the low stable trajectory, the high increasing trajectory of LTSB had a 130% higher risk of T2DM (HR: 2.30; 95% CI: 1.03–5.10).</div></div><div><h3>Conclusion</h3><div>This prospective study suggests that maintaining higher levels of LTPA and lower levels of LTSB may reduce the risk of T2DM during middle and late adulthood.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113135"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantifying the impact of inequality on traditional and emerging diabetes complications: A registry study of cause-specific hospital admissions and deaths in Australia 量化不平等对传统和新出现的糖尿病并发症的影响：澳大利亚特定原因住院和死亡的登记研究。

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-01-25 DOI: 10.1016/j.diabres.2026.113114

Jedidiah I. Morton , Emily D. Williams , Jonathan E. Shaw , Dianna J. Magliano

{"title":"Quantifying the impact of inequality on traditional and emerging diabetes complications: A registry study of cause-specific hospital admissions and deaths in Australia","authors":"Jedidiah I. Morton , Emily D. Williams , Jonathan E. Shaw , Dianna J. Magliano","doi":"10.1016/j.diabres.2026.113114","DOIUrl":"10.1016/j.diabres.2026.113114","url":null,"abstract":"<div><h3>Background and aims</h3><div>Our aim was to quantify the relationship of a large range of diabetes complications with socioeconomic disadvantage.</div></div><div><h3>Methods</h3><div>This study included 621,114 people with type 2 diabetes from the Australian National Diabetes Services Scheme, with follow-up from July 2010 to June 2022. These data were linked to hospital admission and death datasets. The association of socioeconomic disadvantage with cause-specific outcomes (first occurrence of either admission or death) was assessed using Poisson regression, adjusted for age, sex, and year.</div></div><div><h3>Results</h3><div>Most diabetes-related complications studied were positively associated with increasing socioeconomic disadvantage, with the highest incidence rate ratios per 1-SD increase in socioeconomic disadvantage for admission or death from chronic obstructive pulmonary disease (1.19 (95%CI: 1.18, 1.21)) myocardial infarction (1.12 (1.11, 1.13)), heart failure (1.11 (1.10, 1.12)), cellulitis (1.10 (1.09, 1.12)), and end-stage kidney disease (1.09 (1.07, 1.12)). Foot complications and respiratory diseases showed a positive association with disadvantage, as did cardiovascular and kidney diseases, while most cancers, depression, and dementia did not.</div></div><div><h3>Conclusions</h3><div>Increasing socioeconomic disadvantage was associated with an increased risk of admission or death from most traditional diabetes-related complications and for respiratory disease. However, the associations with emerging complications of diabetes were weaker, null, or the risk decreased with increasing disadvantage.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113114"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0