Diabetes research and clinical practice最新文献

{"title":"Comparison of information provided on diabetes distress when using PAID-20, PAID-11 or PAID-5. A registry-based study applying IRT analyses among 10,190 adults with type 1 diabetes in Norway","authors":"Anne Haugstvedt ,&nbsp;Roy M. Nilsen ,&nbsp;Kyrre Breivik ,&nbsp;Marjolein M. Iversen ,&nbsp;Ragnhild B. Strandberg ,&nbsp;Karianne F. Løvaas ,&nbsp;Tone V. Madsen ,&nbsp;Grethe Å. Ueland ,&nbsp;Timothy C. Skinner ,&nbsp;Ingvild Hernar","doi":"10.1016/j.diabres.2025.112267","DOIUrl":"10.1016/j.diabres.2025.112267","url":null,"abstract":"<div><h3>Aims</h3><div>To 1) evaluate information provided on the latent diabetes distress trait when using the Problem Areas In Diabetes, 20 item (PAID-20), PAID-11 or PAID-5, and 2) evaluate the information provided by each scale item.</div></div><div><h3>Methods</h3><div>Using nationwide registry data from 10,190 individuals with type 1 diabetes in Norway, we applied Item Response Theory (IRT) analyses to compare test information curves for PAID-20, PAID-11, PAID-5 and their scale items.</div></div><div><h3>Results</h3><div>The test information curve for PAID-20 captured an overall broader range of the latent distress trait compared to the other versions. At test information level ≥ 10, the ranges (SD under/above mean) were: PAID-20: −1.30 to 3.32; PAID-11; −1.17 to 2.76; and PAID-5: −0.59 to 2.27. Six PAID-20 items had flat information curves with limited contribution to the latent trait, whereas the PAID-11 included 11 of the 12 items most frequently reported as serious problem areas.</div></div><div><h3>Conclusions</h3><div>The PAID-20 captures most information on the latent diabetes distress trait; however, the PAID-11 provides comparable information and captures the most serious problem areas. The PAID-5 provided limited information and covers limited aspects of distress. Overall, the PAID-11 may be a good choice for assessing diabetes distress in both research and clinical practice.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112267"},"PeriodicalIF":6.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Satisfaction of adult patients using continuous subcutaneous insulin infusion or multiple daily injections with type 1 diabetes mellitus","authors":"Lenka Machálková ,&nbsp;Eva Reiterová ,&nbsp;Daniela Bartoníčková ,&nbsp;Monika Durďáková","doi":"10.1016/j.diabres.2025.112265","DOIUrl":"10.1016/j.diabres.2025.112265","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes mellitus (DM) is a chronic disease with prevalence increasing worldwide. The aim of this study was to investigate satisfaction with the current method of insulin delivery (INS) amongst patient with type 1 diabetes mellitus (T1DM) using multiple daily injection (MDI) or continuous subcutaneous insulin infusion (CSII). Furthermore, a sub-aim was to test the effect of selected variables on patient satisfaction with MDI or CSII using regression analysis.</div></div><div><h3>Methods</h3><div>A cross-sectional study carried out in the territory of Moravia in the Czech Republic. A quantitative approach using the Insulin Delivery System Rating Questionnaire (IDSRQ) among 197 respondents with T1DM with INS delivery with MDI or CSII for at least 1 year. Statistical methods used were descriptive statistics, Student’s t-tests and regression analysis.</div></div><div><h3>Results</h3><div>Highly significant differences were found between CSII and MDI patients in satisfaction with the current method of INS delivery (p &lt; 0.001), in how the current method of delivery helps patients maintain stable blood glucose values, prevent high blood glucose (p &lt; 0.001), and in overall satisfaction with the current method of INS delivery (p &lt; 0.001). The average overall satisfaction score was 56.19 points for MDI and 62.08 points for CSII. Regression analysis revealed predictors of overall satisfaction on the mean score on how the current method of INS delivery helps MDI patients (p &lt; 0.01). The effect of other selected variables was not confirmed.</div></div><div><h3>Conclusion</h3><div>The results of the study showed higher overall satisfaction with the method of INS delivery in CSII patients. The current method of INS delivery does not interfere with daily life and activities in most patients.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112265"},"PeriodicalIF":6.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of prevalence, risk factors, and psychosocial factors of gestational diabetes mellitus: A prospective observational study","authors":"Sadhu Nelson Kumar ,&nbsp;Thulamandi Lakshmi Suseela ,&nbsp;Shaik Parveen ,&nbsp;Sathyakkagari Neeraja ,&nbsp;Rayachoty Vaishnavi ,&nbsp;Siddam Jyothi ,&nbsp;Revanuru Sai Ganesh","doi":"10.1016/j.diabres.2025.112256","DOIUrl":"10.1016/j.diabres.2025.112256","url":null,"abstract":"<div><h3>Background</h3><div>Gestational diabetes mellitus <strong>(</strong>GDM) is a significant public health problem due to its negative impacts on maternal and neonatal outcomes. The primary objective of this study was to determine the prevalence of GDM among pregnant women at a single tertiary care hospital and to identify the associated risk factors, including psychosocial stressors. Additionally, we aimed to classify the stressors to understand their relative impact.</div></div><div><h3>Methods</h3><div>We conducted a prospective observational study on 280 antenatal mothers from RIMS, Kadapa, between October 2023 and March 2024. We enrol participants according to standard diagnostic criteria, including and excluding them. GDM was diagnosed using a 75 g oral glucose tolerance test (OGTT) between 24–28 weeks of gestation. Participants were categorized into GDM (n = 60) and non-GDM (n = 220) groups. We evaluated psychosocial stress factors such as emotional burden, social support, and healthcare-related stress using a Gestational Diabetes Stress Scale (GDSS). Statistical analysis was performed using SPSS v20. Chi-square and t-tests were used to assess associations.</div></div><div><h3>Results</h3><div>The prevalence of GDM was 4.7 %. GDM was significantly associated with advanced maternal age (&gt;35 years), pre-pregnancy BMI &gt; 26 kg/m², and a history of hypertension (p &lt; 0.05). Multiparity (third pregnancy) was more common in the GDM group (33.3 %). Emotional burden (23.5 %) was the leading psychosocial stressor, followed by medication, lifestyle, social, and healthcare-related stress.</div></div><div><h3>Conclusion</h3><div>GDM is associated with both clinical and psychosocial factors. Advanced maternal age, obesity, and hypertension were major associated risk factors. The emotional burden significantly contributed to the overall stress in GDM patients. Integrating psychosocial screening into antenatal care could support better clinical outcomes.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112256"},"PeriodicalIF":6.1,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The skeletal muscle mass index is a predictor for all-cause mortality in US adults with type 2 diabetes or pre-diabetes","authors":"Jiao Zhao ,&nbsp;Qi Lu ,&nbsp;Xiao-xia Cong ,&nbsp;Xian-feng Zhang","doi":"10.1016/j.diabres.2025.112254","DOIUrl":"10.1016/j.diabres.2025.112254","url":null,"abstract":"<div><h3>Aims</h3><div>To investigate the relationship between the skeletal muscle mass index (SMI) with all-cause mortality in patients with type 2 diabetes mellitus (T2DM) or pre-diabetes (pre-DM) among American adults.</div></div><div><h3>Methods</h3><div>This study included 3684 patients with T2DM or pre-DM from the National Health and Nutrition Examination Survey 2011–2018.</div></div><div><h3>Results</h3><div>Our study revealed an inverse J-shaped relationship between the SMI with all-cause mortality in US adults with T2DM or pre-DM. We determined the inflection points for all-cause mortality in patients with T2DM or pre-DM were 9.07 kg/m² in males and 7.82 kg/m² in females. In men, the all-cause mortality decreased by approximately 72 % (HR, 0.28; 95 % CI, 0.09–0.93) for each unit increased in the SMI below the inflection point. In women, all-cause mortality was reduced by 60 % (HR, 0.40; 95 % CI, 0.16–0.91) for each unit increased in SMI below the threshold. A reverse J-shaped SMI-mortality association emerged in patients with T2DM, contrasting with a U-shaped pattern in pre-DM individuals.</div></div><div><h3>Conclusions</h3><div>An inverse J-shaped association was observed between the SMI with all-cause mortality in in US adults with T2DM or pre-DM. SMI is a valuable tool for predicting all-cause mortality in patients with T2DM or pre-DM.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112254"},"PeriodicalIF":6.1,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of context-specific sitting time with depressive symptoms in middle-aged and older adults with and without abnormal glucose metabolism","authors":"Rumya Pathmanathan ,&nbsp;Michael Wheeler ,&nbsp;Megan Teychenne ,&nbsp;Mats Hallgren ,&nbsp;Parneet Sethi ,&nbsp;Neville Owen ,&nbsp;David W Dunstan","doi":"10.1016/j.diabres.2025.112240","DOIUrl":"10.1016/j.diabres.2025.112240","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between sitting time and depressive symptoms may be influenced by contextual factors, including the sitting domain, type, and cognitive activity. Research on these dynamics among people with abnormal glucose metabolism (AGM) is limited. We examined associations between contextual sitting time and depressive symptoms in adults with and without AGM (IFG, IGT, T2D).</div></div><div><h3>Methods</h3><div>Data were obtained from the AusDiab (2011–12), involving 4,614 adults. Associations between total and context-specific sitting time (work, transport, leisure-time computer use, and TV viewing) and depressive symptoms measured by the CESD-10 scale were assessed.</div></div><div><h3>Results</h3><div>Among 3,834 participants (59.3 years; 55.8 % women), 926 (24.2 %) had AGM, with 120 (13.0 %) reporting depressive symptoms. Increased sitting time at work (OR 0.65, p &lt; 0.05) and transport (OR 0.76, p &lt; 0.05) were inversely associated with depressive symptoms, while extended TV viewing (OR 1.46, p &lt; 0.01) correlated positively. An interaction showed that those with AGM who engaged in leisure-time computer use for ≥ 0.9 h/day had lower odds of depressive symptoms compared to those sitting for 0–0.4 h/day (OR = 0.51, 95 % CI: 0.29–0.88, p &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Increased mentally passive sitting time is linked to depressive symptoms, particularly in those with AGM. Reducing passive sitting may aid in T2D prevention and management.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112240"},"PeriodicalIF":6.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational inequalities in clinical presentation and pharmacological treatment of early type 2 diabetes: A Danish prevalence study","authors":"Marie T. Sørensen ,&nbsp;Frederik P.B. Kristensen ,&nbsp;Jens S. Nielsen ,&nbsp;Diana H. Christensen ,&nbsp;Sia K. Nicolaisen ,&nbsp;Henning Beck-Nielsen ,&nbsp;Peter Vestergaard ,&nbsp;Niels Jessen ,&nbsp;Michael H. Olsen ,&nbsp;Torben Hansen ,&nbsp;Allan Vaag ,&nbsp;Henrik T. Sørensen ,&nbsp;Reimar W. Thomsen","doi":"10.1016/j.diabres.2025.112231","DOIUrl":"10.1016/j.diabres.2025.112231","url":null,"abstract":"<div><h3>Aims</h3><div>To examine how educational attainment impacts clinical presentation and pharmacological treatment at type 2 diabetes (T2D) diagnosis.</div></div><div><h3>Methods</h3><div>Cross-sectional analysis of 10,020 individuals with recently diagnosed T2D enrolled in the Danish prospective DD2 cohort. Sex- and age-adjusted prevalence ratios (aPRs) for detailed clinical characteristics and pharmacotherapy were computed.</div></div><div><h3>Results</h3><div>In total, 31 % had low, 50 % had moderate, and 19 % had high educational level. Individuals with low rather than high educational level were more often obese (58 % <em>vs</em> 49 %, aPR 1.20 [95 % CI 1.14–1.28]); had less healthy lifestyles (current smokers: 22 % <em>vs</em> 15 %, aPR 1.53 [1.32–1.76]); sedentary activity level: 21 % <em>vs</em> 15 %, aPR 1.36 [1.20–1.55]); and had more often cardiovascular (23 % <em>vs</em>. 17 %, PR 1.30 [1.16–1.46]) and microvascular complications (16 % <em>vs</em> 13 %, aPR 1.18 [1.02–1.35]). Low education associated with higher triglycerides, more insulin resistance, and poorer kidney function, whereas HbA1c, blood pressure, and LDL cholesterol were identical. The use of medications with cardiovascular benefits and newer organ-protective diabetes medications was similar to, or higher than, that in individuals with high education.</div></div><div><h3>Conclusions</h3><div>Awareness of the impact of social and educational determinants on T2D presentation at diagnosis is essential to improve treatment and prognosis.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112231"},"PeriodicalIF":6.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brazilian green propolis effect on biochemical parameters and dietary intake in people living with diabetes","authors":"Gabriela Fonseca Lopes ,&nbsp;Paula Brumana Corrêa ,&nbsp;Fernando Luiz Pereira de Oliveira ,&nbsp;Nathalia Sernizon Guimarães ,&nbsp;Nícia Pedreira Soares ,&nbsp;Andrea Yukie Arikawa ,&nbsp;Aline da Silva Miranda de Menezes e Souza ,&nbsp;Rachel Basques Caligiorne ,&nbsp;Luciana Araújo Marques ,&nbsp;Nancy Scardua Binda ,&nbsp;Sônia Maria de Figueiredo","doi":"10.1016/j.diabres.2025.112236","DOIUrl":"10.1016/j.diabres.2025.112236","url":null,"abstract":"<div><div><strong><em>Objective:</em></strong> To evaluate the effect of dietary supplementation with Brazilian green propolis-BrGrProp on biochemical parameters and dietary intake in People Living with Diabetes − PLWD. <strong><em>Method:</em></strong> Randomized double-blind study performed for thirty days. PLWD (n = 62/Phase-1: PLWD supplemented with BrGrProp (<strong>G1/</strong>n = 31) and another treated with <em>Manihot esculenta</em> starch (Placebo/n = 31). From this group, 22 PLWD (<strong>G2</strong>) participated in the study being treated with BrGrProp, characterized as Phase-2. PLWD received capsules (2× 500 mg/day) of BrGrProp or Placebo. Fasting blood glucose, glycated hemoglobin (HbA1c), total cholesterol and fractions, pyruvic glutamic transaminase, oxalacetic glutamic transaminase, gamma glutamyl transferase, and dietary intake data were determined at the beginning and end of the study. Statistical analysis was performed using the SPSS 21/Minitab-17/Prisma 7.0. <strong><em>Results:</em></strong> Phase-1: no significant changes were observed in the analyzed parameters. Phase 2: Improvement in glycemic parameters (FBG and HbA1c) and most lipid parameters (TC, LDL, HDL and TG), with reduction in the level of Hb1Ac (p = 0.023), increase in the level of HDL (p = 0.048) and in the food intake of the PLWD. The indicators of liver function did not show significant changes. <strong><em>Conclusion:</em></strong> BrGrProp in the diet generates beneficial effects for diabetics, characterized by improvement of HbA1c and HDL parameters, without causing detectable harmful changes.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112236"},"PeriodicalIF":6.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin resistance mediates the association between adiposity markers and incident chronic kidney disease: Findings from the UK Biobank prospective cohort study","authors":"Xiaojun Wang ,&nbsp;Ruilang Lin ,&nbsp;Xueying Ji ,&nbsp;Zhenyi Xu ,&nbsp;Hungchen Chang ,&nbsp;Xuchao Gu ,&nbsp;Maoqing Ye ,&nbsp;Yan Zhang ,&nbsp;Zhijun Bao","doi":"10.1016/j.diabres.2025.112255","DOIUrl":"10.1016/j.diabres.2025.112255","url":null,"abstract":"<div><h3>Background</h3><div>Limited research exists on fat distribution patterns and chronic kidney disease (CKD)/ end-stage kidney disease (ESKD) risks.</div></div><div><h3>Methods</h3><div>This UK Biobank study analyzed 398,307 adults without baseline CKD. Adiposity markers and insulin resistance (IR) indices (TyG index, TG/HDL-C ratio) were assessed. Hazard ratios (HR) and 95% CIs from Cox regression models evaluated adiposity markers and CKD/ESKD risks, with mediation analysis on IR.</div></div><div><h3>Results</h3><div>Over 13.62 years, 17,583 (3.37 per 1000 person-years) CKD and 1,509 (0.29 per 1000 person-years) ESKD cases occurred. After adjusting for BMI, high waist circumference and waist-to-hip ratio (WHR) were associated with a 23.0 % (HR: 1.23, 95 % CI: 1.19–1.27) and 17.0 % (HR: 1.17, 95 % CI: 1.12–1.22) increased risk of CKD and a 37.0 % (HR: 1.37, 95 % CI: 1.22–1.54) and 39.0 % (HR: 1.39, 95 % CI: 1.29–1.49) increased risk of ESKD, respectively. In the mediation analysis, BMI, waist circumference, and WHR accounted for 12 %, 44.4 %, and 23.8 % of the association between the TyG index and CKD, and 7.4 %, 26.7 %, and 13.9 % of the association between the TG/HDL-C ratio and CKD.</div></div><div><h3>Conclusion</h3><div>Elevated WHR was linked to increased risks of CKD and ESKD. The mediating effect of IR indexes between WHR and CKD was more significant than BMI.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112255"},"PeriodicalIF":6.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin adherence is associated with lower risk of osteoporotic fracture among patients with advanced type 2 diabetes","authors":"Chien-Lung Chen ,&nbsp;Shun-Neng Hsu ,&nbsp;Li-Nien Chien","doi":"10.1016/j.diabres.2025.112216","DOIUrl":"10.1016/j.diabres.2025.112216","url":null,"abstract":"<div><h3>Aims</h3><div>To evaluate whether adherence to concurrent metformin (MET) therapy is associated with a reduced risk of fractures among patients with type 2 diabetes mellitus (T2DM).</div></div><div><h3>Methods</h3><div>This retrospective cohort study used Taiwan’s nationwide claims data from 2014 to 2020 to identify patients aged ≥50 years with T2DM who initiated second-line oral antidiabetic therapy while continuing MET. Patients with a prior history of fractures were excluded. MET adherence was defined as a medication possession ratio &gt;40 % and a refill gap ≤90 days. Fractures were identified through inpatient and outpatient claims using specific diagnosis and procedure codes related to fracture treatment and surgical intervention. Propensity score matching (1:1) was used to balance baseline characteristics, and competing risk regression was applied to estimate fracture risk, accounting for the competing risk of death.</div></div><div><h3>Results</h3><div>A total of 76,022 patients were included (38,011 per group). MET adherence was significantly associated with a reduced risk of all-site fractures (adjusted subdistribution hazard ratio[aSHR] = 0.76; 95 % CI: 0.69–0.83; P &lt; 0.001), with consistent effects across fracture sites. No additional benefit was observed with concurrent use of DPP4i or SGLT2i.</div></div><div><h3>Conclusions</h3><div>MET adherence was associated with lower fracture risk in older adults with T2DM, highlighting its potential role in fracture prevention.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112216"},"PeriodicalIF":6.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically proxied glucokinase activation and risk of diabetic complications: Insights from phenome-wide and multi-omics mendelian randomization","authors":"Ziqi Zhang ,&nbsp;Yanxiao Xie ,&nbsp;Zhenlin Bu ,&nbsp;Yingying Xiang ,&nbsp;Wei Sheng ,&nbsp;Ying Cao ,&nbsp;LeShen Lian ,&nbsp;Li Zhang ,&nbsp;Wei Qian ,&nbsp;Guang Ji","doi":"10.1016/j.diabres.2025.112246","DOIUrl":"10.1016/j.diabres.2025.112246","url":null,"abstract":"<div><h3>Aims</h3><div>This study aims to assess the benefits and adverse effects of long-term glucokinase (GK) activation from a genetic perspective.</div></div><div><h3>Methods</h3><div>We identified genetic variants in the GCK gene associated with glycated hemoglobin (HbA1c) levels from a genome-wide association study (GWAS) involving 146,806 individuals, which served as proxies for glucokinase activation. To assess the effects and potential pathways of GK activation on a range of diabetic complications and safety outcomes, we integrated drug-target Mendelian randomization (MR), lipidome-wide and proteome-wide MR, phenome-wide MR, and colocalization analyses.</div></div><div><h3>Results</h3><div>Genetically proxied GK activation was associated with reduced risks of several predefined diabetic complications, including cardiovascular diseases, stroke and diabetic retinopathy. No kidney-related benefits were observed. Safety analysis revealed a relationship between GK activation and elevated AST levels, while impaired interaction between GK and glucokinase regulatory protein (GKRP) was associated with dyslipidemia, increased liver fat content, AST, systolic blood pressure, and uric acid. Phenome-wide MR suggested that GK activation may have potential benefits for lung function and fluid intelligence score.</div></div><div><h3>Conclusions</h3><div>Our genetic evidence supports GK as a promising target for reducing the risk of specific diabetic complications. These findings require further validation through cohort studies and randomized controlled trials in patients with diabetes.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"225 ","pages":"Article 112246"},"PeriodicalIF":6.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}