Diabetes research and clinical practice最新文献_第3页

Reply to “Daytime napping and risk of incident main adverse cardiovascular events and mortality among adults with type 2 diabetes”

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-20 DOI: 10.1016/j.diabres.2025.112106

Xiu Hong Yang , Yao Liu , Xin Xin Jiang , Zhen Xing Zhang , Yi Jun Lu , Chen Sheng Fu , Hui Min Jin , Zhi Bin Ye

引用次数: 0

Time reallocation to moderate-to-vigorous physical activity and its association with chronic kidney disease prevalence in Chinese adults with type 2 diabetes

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-20 DOI: 10.1016/j.diabres.2025.112116

Miao Xu , Tian Xu , Jialin Li , Pingping Zhang , Hui Wang , Youxin Wang , Li Li

{"title":"Time reallocation to moderate-to-vigorous physical activity and its association with chronic kidney disease prevalence in Chinese adults with type 2 diabetes","authors":"Miao Xu , Tian Xu , Jialin Li , Pingping Zhang , Hui Wang , Youxin Wang , Li Li","doi":"10.1016/j.diabres.2025.112116","DOIUrl":"10.1016/j.diabres.2025.112116","url":null,"abstract":"<div><h3>Aims</h3><div>To examine the isotemporal substitution association of replacing moderate-to-vigorous physical activity (MVPA) with other behaviors on the prevalence of chronic kidney disease (CKD) among Chinese adults with type 2 diabetes mellitus (T2DM).</div></div><div><h3>Methods</h3><div>This study included 5421 adults with T2DM from the National Metabolic Management Centre Ningbo Branch. Data on physical activity, sedentary behavior, and sleep were collected using a standardized questionnaire through face-to-face interviews. Isotemporal substitution models were employed to evaluate the associations of reallocating time from other behaviors to MVPA with the risk of CKD.</div></div><div><h3>Results</h3><div>Substitution of 30 min per day of sleeping or sitting with MVPA was associated with a lower CKD prevalence (OR: 0.87 for sleep substitution; 0.90 for sitting substitution). Among individuals with inadequate MVPA levels (less than 150 min per week), the association of replacing 30 min of sleeping, sitting, or low-intensity physical activity with MVPA was particularly strong, cutting the risk of CKD by more than 60%. Stratified analysis among participants with inadequate MVPA revealed that the association of reallocating time to MVPA with lower CKD prevalence were predominantly observed among men, individuals with prolonged sleep duration (sleep duration more than 7.5 h per day), and those with better glycemic control (HbA1c levels below 7%).</div></div><div><h3>Conclusions</h3><div>This study revealed that replacing sleep or sedentary time with MVPA was associated with a lower prevalence of CKD among Chinese adults with T2DM, especially those with low MVPA. Incorporating MVPA into daily routines is potentially beneficial for improving renal health in people with T2DM.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112116"},"PeriodicalIF":6.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncovering actionable cardiovascular risk subgroups in type 2 Diabetes: A latent class analysis

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-19 DOI: 10.1016/j.diabres.2025.112110

Rose J Geurten , Niels Hameleers , Jeroen N Struijs , Henk JG Bilo , Dirk Ruwaard , Arianne MJ Elissen

{"title":"Uncovering actionable cardiovascular risk subgroups in type 2 Diabetes: A latent class analysis","authors":"Rose J Geurten , Niels Hameleers , Jeroen N Struijs , Henk JG Bilo , Dirk Ruwaard , Arianne MJ Elissen","doi":"10.1016/j.diabres.2025.112110","DOIUrl":"10.1016/j.diabres.2025.112110","url":null,"abstract":"<div><h3>Aims</h3><div>The study aimed to identify type 2 diabetes subgroups with varying, actionable cardiovascular disease (CVD) risk factor patterns and explored subgroup differences in characteristics and three-year CVD incidence.</div></div><div><h3>Methods</h3><div>A Latent Class Analyses was performed to determine classes with similar lifestyle and psychosocial CVD risk patterns, predictive value of demographic, socioeconomic and medical factors, and class differences in CVD outcomes.</div></div><div><h3>Results</h3><div>The 3-class model was superior. The ‘low risk’ class was largest (71.2 %). The ‘mobility related risk’ class (19.3 %) showed high probability of limitations in mobility (0.90) and not meeting the exercise norm (0.89). The ‘psychosocial risk’ class (9.5 %) had similar risks, with additional probabilities to be lonely (0.49) and have anxiety and depression (0.56). Strong predictors (OR ≥ 2.00) for membership of risk classes were: female gender, non-western immigrant status, lower education, financial difficulties, being unfit for work and/or prior heart failure. Three years CVD incidence was lower in members of the ‘low risk’ class had cardiology care and/or stroke diagnosis compared to the risk classes.</div></div><div><h3>Conclusions</h3><div>Diverse lifestyle and psychosocial CVD risk factor patterns impact CVD outcomes in individuals with type 2 diabetes, emphasizing the necessity of a whole-person CVD prevention tailored to the person’s needs.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112110"},"PeriodicalIF":6.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of continuous glucose monitoring in people living with obesity, intermediate hyperglycemia or type 2 diabetes.

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-19 DOI: 10.1016/j.diabres.2025.112111

Tadej Battelino, Nebojsa Lalic, Sufyan Hussain, Antonio Ceriello, Sanja Klobucar, Sarah J Davies, Pinar Topsever, Julie Heverly, Francesca Ulivi, Kevin Brady, Tsvetalana Tankova, Júlia Galhardo, Kostas Tagkalos, Erik Werson, Chantal Mathieu, Peter Schwarz

{"title":"The use of continuous glucose monitoring in people living with obesity, intermediate hyperglycemia or type 2 diabetes.","authors":"Tadej Battelino, Nebojsa Lalic, Sufyan Hussain, Antonio Ceriello, Sanja Klobucar, Sarah J Davies, Pinar Topsever, Julie Heverly, Francesca Ulivi, Kevin Brady, Tsvetalana Tankova, Júlia Galhardo, Kostas Tagkalos, Erik Werson, Chantal Mathieu, Peter Schwarz","doi":"10.1016/j.diabres.2025.112111","DOIUrl":"https://doi.org/10.1016/j.diabres.2025.112111","url":null,"abstract":"<p><p>A global trend towards increased obesity, intermediate hyperglycemia (previously termed prediabetes) and type 2 diabetes, has prompted a range of international initiatives to proactively raise awareness and provide action-driven recommendations to prevent and manage these linked disease states. One approach, that has shown success in managing people already diagnosed with type 2 diabetes mellitus, is to use continuous glucose monitoring (CGM) devices to help them manage their chronic condition through understanding and treating their daily glucose fluctuations, in assocation with glucose-lowering medications, including insulin. However, much of the burden of type 2 diabetes mellitus is founded in the delayed detection both of type 2 diabetes mellitus itself, and the intermediate hyperglycaemia that precedes it. In this review, we provide evidence that using CGM technology in people at-risk of intermediate hyperglycaemia or type 2 diabetes mellitus can significantly improve the rate and timing of detection of dysglycaemia. Earlier detection allows intervention, including through continued use of CGM to guide changes to diet and lifestyle, that can delay or prevent harmful progression of early dysglycaemia. Although further research is needed to fully understand the cost-effectiveness of this intervention in people at-risk or with early dysglycemia, the proposition for use of CGM technology is clear.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"112111"},"PeriodicalIF":6.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends and Disparities in Diabetes Mellitus and Atrial fibrillation Related Mortality in the United States: 1999–2020 美国糖尿病和心房颤动相关死亡率的趋势和差异：1999-2020.

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-19 DOI: 10.1016/j.diabres.2025.112112

Muhammad Umer Sohail , Taimor Mohammed Khan , Maryam Sajid , Zahra Imran , Hussain Salim , Saad Ahmed Waqas , Sebastian Mactaggart , Raheel Ahmed

{"title":"Trends and Disparities in Diabetes Mellitus and Atrial fibrillation Related Mortality in the United States: 1999–2020","authors":"Muhammad Umer Sohail , Taimor Mohammed Khan , Maryam Sajid , Zahra Imran , Hussain Salim , Saad Ahmed Waqas , Sebastian Mactaggart , Raheel Ahmed","doi":"10.1016/j.diabres.2025.112112","DOIUrl":"10.1016/j.diabres.2025.112112","url":null,"abstract":"<div><div>The co-occurrence of diabetes mellitus (DM) and atrial fibrillation (AF) poses growing health risks in the United States (U.S.), with diabetes patients having a 34 % higher risk of AF. This study examines trends in DM and AF related mortality among individuals aged ≥ 25 years in the U.S. from 1999 to 2020. Data from the CDC WONDER database were analyzed calculating age-adjusted mortality rates (AAMRs) per 100,000 and annual percent change (APC), stratified by age, sex, race/ethnicity, urbanization, and region. Between 1999 and 2020, 419,036 deaths were recorded among U.S. adults (≥25 years) with comorbid AF and DM. The AAMR rose from 4.83 in 1999 to 15.91 in 2020, with an APC increase of 15.01 from 2018 to 2020. Older adults (≥65) had higher AAMRs than younger adults (25–64). Men (11.23) had higher rates than women (7.16). NH American Indian/Alaskan Natives (9.54) and Whites (9.16) had the highest AAMRs, while NH Asian/Pacific Islanders (6.04) had the lowest. Non-metropolitan areas (10.32) exceeded metropolitan areas (8.53). The Western U.S. (9.87) had the highest regional AAMR. Rising DM and AF-related deaths highlight a growing burden, particularly in men, NH American Indian/Alaskan Natives and Whites, and rural populations, necessitating targeted interventions.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"223 ","pages":"Article 112112"},"PeriodicalIF":6.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Neurofilament Light Chain and Structural and Functional Nerve Fiber Loss in Painful and Painless Diabetic Polyneuropathy

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-19 DOI: 10.1016/j.diabres.2025.112098

Laura L. Määttä , Signe T. Andersen , Tina Parkner , Claus V.B. Hviid , Daniel R. Witte , Jishi John , Mathilde M.V. Pascal , Eleanor Ferris , Georgios Baskozos , Juan D. Ramirez , Solomon Tesfaye , Pallai R. Shillo , Andrew S.C Rice , Helen C. Laycock , Troels S. Jensen , David L. Bennett , Andreas C. Themistocleous

{"title":"Serum Neurofilament Light Chain and Structural and Functional Nerve Fiber Loss in Painful and Painless Diabetic Polyneuropathy","authors":"Laura L. Määttä , Signe T. Andersen , Tina Parkner , Claus V.B. Hviid , Daniel R. Witte , Jishi John , Mathilde M.V. Pascal , Eleanor Ferris , Georgios Baskozos , Juan D. Ramirez , Solomon Tesfaye , Pallai R. Shillo , Andrew S.C Rice , Helen C. Laycock , Troels S. Jensen , David L. Bennett , Andreas C. Themistocleous","doi":"10.1016/j.diabres.2025.112098","DOIUrl":"10.1016/j.diabres.2025.112098","url":null,"abstract":"<div><h3>Aims</h3><div>To explore associations between the axonal protein neurofilament light chain (NfL) and severity of diabetic polyneuropathy (DPN) and pain.</div></div><div><h3>Methods</h3><div>We performed cross-sectional analysis of a subset of the PiNS/DOLORisk cohort of people with DPN with and without neuropathic pain. Biobank samples were analyzed for serum NfL (s-NfL) using single molecule array. DPN was defined by Toronto criteria for probable or confirmed DPN. Painful DPN (PDPN) was evaluated according to IASP criteria. Measures of DPN severity included clinical DPN scales, quantitative sensory testing (QST) and intraepidermal nerve fiber density (IENFD).</div></div><div><h3>Results</h3><div>Participants with confirmed (N = 172) or probable DPN (N = 29) were included. There was no s-NfL difference between participants with DPN (N = 79, 22.8 ng/L [IQR 17.4; 31.3]) and PDPN (N = 122, 22.2 ng/L [16.0; 34.4]). S-NfL was not associated with pain severity or DPN severity evaluated by clinical DPN scales. Higher s-NfL was associated with lower IENFD (13.6 % [95 % CI 3.1; 22.9], unit = 1 fiber/mm, N = 24) and more pronounced loss of nerve fiber function measured by QST (p-trend = 0.02).</div></div><div><h3>Conclusions</h3><div>Higher s-NfL was associated with nerve fiber dysfunction and loss quantified by QST and IENFD, but not with pain or clinical DPN scales. S-NfL may reflect the severity of nerve fiber damage underlying DPN.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"223 ","pages":"Article 112098"},"PeriodicalIF":6.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is the burden of diabetes in Australia underestimated? Comparison of diabetes ascertainment using linked administrative health data and an Australian diabetes registry

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-18 DOI: 10.1016/j.diabres.2025.112113

Emma Cox , Joanne Gale , Michael O. Falster , Juliana de Oliveira Costa , Stephen Colagiuri , Natasha Nassar , Alice A. Gibson

{"title":"Is the burden of diabetes in Australia underestimated? Comparison of diabetes ascertainment using linked administrative health data and an Australian diabetes registry","authors":"Emma Cox , Joanne Gale , Michael O. Falster , Juliana de Oliveira Costa , Stephen Colagiuri , Natasha Nassar , Alice A. Gibson","doi":"10.1016/j.diabres.2025.112113","DOIUrl":"10.1016/j.diabres.2025.112113","url":null,"abstract":"<div><h3>Aims</h3><div>To compare an algorithm for identifying individuals with diabetes using linked administrative health data with an Australian diabetes registry (National Diabetes Services Scheme, NDSS).</div></div><div><h3>Methods</h3><div>This prospective cohort study linked baseline survey data for 266,414 individuals aged ≥ 45 years from the 45 and Up Study, Australia, to administrative health data sets. An algorithm for identifying individuals with diabetes was developed based on a combination of claims for dispensed insulin and glucose lowering medicines, diabetes-related hospital admissions, and diabetes-specific Medicare claims. Using the algorithm, participants were classified as ‘certain’, ‘uncertain’ or ‘no’ diabetes. The algorithm was compared to NDSS registrations as the reference standard.</div></div><div><h3>Results</h3><div>Amongst the 45 and Up Study cohort, there were 53,669 individuals with certain diabetes identified by the algorithm, and 35,900 NDSS registrants. Compared with the NDSS, the sensitivity of the algorithm was 96.9% (95%CI 96.7–97.1) and specificity 91.8% (95%CI 91.7–91.9). Of the 53,699 individuals with diabetes identified by the algorithm, 34,864 were registered to the NDSS (PPV = 64.9%, 95%CI: 64.6–65.2).</div></div><div><h3>Conclusions</h3><div>This study demonstrates the value in using linked administrative data for diabetes monitoring and surveillance. National estimates using the NDSS alone may underestimate the diabetes burden by up to 35%.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112113"},"PeriodicalIF":6.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of sodium-glucose cotransporter-2 inhibitors on ovarian cancer risk in patients with type 2 diabetes mellitus: A multi-institutional TriNetX study 钠-葡萄糖共转运体-2 抑制剂对 2 型糖尿病患者卵巢癌风险的影响：一项多机构 TriNetX 研究。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-18 DOI: 10.1016/j.diabres.2025.112109

Cheng-Hsien Hung , Jheng-Yan Wu , Yueh-Shan Weng , Li-Wei Hsiao , Yu-Chang Liu , I-Tsang Chiang

{"title":"Impact of sodium-glucose cotransporter-2 inhibitors on ovarian cancer risk in patients with type 2 diabetes mellitus: A multi-institutional TriNetX study","authors":"Cheng-Hsien Hung , Jheng-Yan Wu , Yueh-Shan Weng , Li-Wei Hsiao , Yu-Chang Liu , I-Tsang Chiang","doi":"10.1016/j.diabres.2025.112109","DOIUrl":"10.1016/j.diabres.2025.112109","url":null,"abstract":"<div><h3>Introduction</h3><div>Women with type 2 diabetes mellitus (T2DM) have an increased risk of ovarian cancer. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) impact on the risk of ovarian cancer in women with T2DM remains unclear. Therefore, this study aims to assess the association between SGLT2i use and the risk of ovarian cancer in patients with T2DM.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study using the TriNetX network between January 2013 and December 2023. We employed a new-user study design with an active comparator, comparing patients using dipeptidyl peptidase-4 inhibitors (DPP4i). Propensity score matching (PSM) was applied to balance baseline characteristics. The primary outcome was the incidence of ovarian cancer.</div></div><div><h3>Results</h3><div>Following PSM, 92,090 patients were included in each group. The SGLT2i gorup was associated with a significantly lower risk of ovarian cancer compared to the DPP4i group (HR: 0.758, 95 % CI: 0.596–0.965). Subgroup analyses revealed a consistent trend across various populations, with a notably significant risk reduction observed in white patients (HR: 0.667, 95 % CI: 0.485–0.917).</div></div><div><h3>Conclusions</h3><div>Our study suggests that SGLT2i may be associated with lower risk of ovarian cancer in T2DM patients. These findings highlight the need for further investigation into the underlying mechanisms.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112109"},"PeriodicalIF":6.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of diabetes and hyperglycemia on short and long-term mortality after the first-ever known COVID-19 infection

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-18 DOI: 10.1016/j.diabres.2025.112100

Bruno A. Soto , Ana C. Varella , Marcos R.N. Cavalcante , Carla Romagnolli , Ligia M.G. Fedeli , Gerson S.S. de Oliveira , Isabela M. Bensenor , Alessandra C. Goulart

{"title":"The influence of diabetes and hyperglycemia on short and long-term mortality after the first-ever known COVID-19 infection","authors":"Bruno A. Soto , Ana C. Varella , Marcos R.N. Cavalcante , Carla Romagnolli , Ligia M.G. Fedeli , Gerson S.S. de Oliveira , Isabela M. Bensenor , Alessandra C. Goulart","doi":"10.1016/j.diabres.2025.112100","DOIUrl":"10.1016/j.diabres.2025.112100","url":null,"abstract":"<div><h3>Aims</h3><div>To evaluate previous diabetes and hyperglycemia in post-COVID-19 mortality.</div></div><div><h3>Methods</h3><div>We evaluated patients with diabetes (previous diabetes and use of medication and random glucose ≥ 200 mg/dl and HbA1C ≥ 6.5 % or 48 mmol/mol) and patients without diabetes with hyperglycemia 1 year before COVID-19. Hazard ratios (HR) and 95 % confidence intervals, 95 %CI were calculated for all-cause mortality (1-week to 1-year) among those with diabetes (only), diabetes with comorbidities (hypertension, chronic kidney disease-CKD), and patients without diabetes but with hyperglycemia (≥ 100 ≥ 110 and ≥ 126 mg/dl).</div></div><div><h3>Results</h3><div>Of 455 patients, 30.1 % had diabetes. Diabetes only had a high mortality risk in 7 days (HR: 6.24; 95 %CI: 1.03–37.77). Diabetes with hypertension and CKD were associated with increased mortality risks from 1-week (HR: 7.98; 95 %CI, 1.03–61.70) to 1-year (HR: 2.27; 95 %CI: 1.03–4.99) after COVID-19. Among those without diabetes, FBG ≥ 110 and ≥ 126 mg/dl were associated with more than double the risk of dying in 1-year after COVID-19 infection [1-year HR: 2.80 (95 %CI: 1.10 – 7.22) and 1-year HR: 2.54 (95 %CI:1.10–5.88), respectively].</div></div><div><h3>Conclusions</h3><div>Diabetes associated with other comorbidities had the highest risks of all-cause mortality in the short and long-term, hyperglycemia was a long-term marker of poor prognostic after COVID-19 infection.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112100"},"PeriodicalIF":6.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What does nerve ultrasound contribute to the evaluation of diabetic polyneuropathy over time? A prospective follow-up observational study of people with type 2 diabetes

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-03-18 DOI: 10.1016/j.diabres.2025.112115

Bianka Heiling , Thomas Lehmann , Nicolle Müller , Christof Kloos , Alexander Grimm , Gunter Wolf , Hubertus Axer

{"title":"What does nerve ultrasound contribute to the evaluation of diabetic polyneuropathy over time? A prospective follow-up observational study of people with type 2 diabetes","authors":"Bianka Heiling , Thomas Lehmann , Nicolle Müller , Christof Kloos , Alexander Grimm , Gunter Wolf , Hubertus Axer","doi":"10.1016/j.diabres.2025.112115","DOIUrl":"10.1016/j.diabres.2025.112115","url":null,"abstract":"<div><h3>Aims</h3><div>Studies using peripheral nerve ultrasound have shown moderate nerve enlargement in individuals with diabetic polyneuropathy (DPN). Neither extent, course, consistency, nor clinical significance of this finding is clear.</div></div><div><h3>Method</h3><div>We examined 156 people with type 2 diabetes mellitus using nerve ultrasound, nerve conduction studies, and clinical scores. 59 received a follow-up examination after one year and 43 patients after two years.</div></div><div><h3>Results</h3><div>Increase of cross-sectional area (CSA) of the peripheral nerves in DPN was rather negligible compared to normative cut-off values. The CSA of the median nerve at the forearm and wrist and the ulnar nerve at the upper arm, forearm and wrist were significantly larger in individuals with DPN compared to those without DPN. People with DPN had significant changes in most parameters of nerve conduction studies. Ultrasound measurements over time showed a slight increase in CSA in the median nerve at the carpal tunnel and a slight decrease in the fibular nerve at the fibular head. Ultrasound pattern sum score slightly decreased in the DPN group over two years.</div></div><div><h3>Conclusions</h3><div>Ultrasound measurements alone may be insufficient to detect DPN. Follow up with nerve ultrasound over one or two years was short and did not show substantial changes.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112115"},"PeriodicalIF":6.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0