Diabetes research and clinical practice最新文献_第3页

Early diabetes screening shows results in North America and the Caribbean

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-17 DOI: 10.1016/j.diabres.2025.112052

引用次数: 0

Effects of pay-for-performance for primary care physicians on type 2 diabetes outcomes: Evidence from rural China

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-16 DOI: 10.1016/j.diabres.2025.112046

Miaomiao Zhao , Wenjie Qu , Zhixin An , Hui Jin , Yarong Han , Xin Cao , Qunhong Wu , Yuexia Gao

{"title":"Effects of pay-for-performance for primary care physicians on type 2 diabetes outcomes: Evidence from rural China","authors":"Miaomiao Zhao , Wenjie Qu , Zhixin An , Hui Jin , Yarong Han , Xin Cao , Qunhong Wu , Yuexia Gao","doi":"10.1016/j.diabres.2025.112046","DOIUrl":"10.1016/j.diabres.2025.112046","url":null,"abstract":"<div><h3>Aim</h3><div>This study aims to evaluate the impact of a pay-for-performance (P4P) program on health outcomes for patients with type 2 diabetes mellitus in Chinese primary care settings.</div></div><div><h3>Methods</h3><div>Conducted from February to March 2019, this trial involved 1,085 participants from 19 rural villages in China. Family physicians in the intervention group received P4P incentives. We collected clinical health outcomes, including fasting blood glucose, blood pressure, and lipid levels, at baseline and after one year. A differences-in-differences model was employed to assess the P4P program’s effects on these health outcomes. Additionally, a multiple regression analysis was performed to evaluate the influence of P4P on patients’ health behaviors, such as self-management, doctor-patient trust, and self-rated health.</div></div><div><h3>Results</h3><div>Following the intervention, the intervention group showed significant reductions in fasting plasma glucose (0.88 mmol/L), systolic blood pressure (11.10 mmHg), and total cholesterol (0.50 mmol/L) compared to the control group. The P4P program also improved control rates for fasting glucose (OR = 2.34, 95 % CI:1.57–3.48), blood pressure (OR = 7.57, 95 % CI: 4.98–11.50), and total cholesterol (OR = 2.47, 95 % CI:1.61–3.79), while enhancing self-management behaviors (OR = 0.21, 95 % CI: 0.08–0.34) and doctor-patient trust (OR = 0.75, 95 % CI: 0.39–1.11).</div></div><div><h3>Conclusions</h3><div>The P4P incentive effectively improved glycemic control and diabetes management in rural China.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"221 ","pages":"Article 112046"},"PeriodicalIF":6.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time in tight glucose range in adolescents and young adults with diabetes during Ramadan intermittent fasting: Data from real-world users on different treatment strategies

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-16 DOI: 10.1016/j.diabres.2025.112042

Nancy Samir Elbarbary , Eman Abdel Rahman Ismail

{"title":"Time in tight glucose range in adolescents and young adults with diabetes during Ramadan intermittent fasting: Data from real-world users on different treatment strategies","authors":"Nancy Samir Elbarbary , Eman Abdel Rahman Ismail","doi":"10.1016/j.diabres.2025.112042","DOIUrl":"10.1016/j.diabres.2025.112042","url":null,"abstract":"<div><h3>Background</h3><div>Time in tight range (TITR) is a novel glycemic metric assessing normoglycemia in individuals with diabetes.</div></div><div><h3>Aim</h3><div>To assess the attainability of the TITR (70–140 mg/dL) target in youth with diabetes using different treatment strategies during Ramadan fasting.</div></div><div><h3>Methods</h3><div>This prospective study included 276 non-insulin-treated type 2 diabetes mellitus (T2DM) and 426 patients with type 1 diabetes mellitus (T1DM) who were categorized into: multiple daily injections [MDI] + intermittently scanned CGM (isCGM), sensor augmented pump (SAP) and advanced hybrid closed loop (AHCL).</div></div><div><h3>Results</h3><div>At the end of Ramadan, the mean TITR was 42.3 ± 6.6 % for all T1DM patients and 63.5 ± 4.0 % in T2DM (p < 0.001). The highest TITR was in T2DM group together with T1DM on AHCL (62.3 ± 11.6 %), followed by SAP group (37.7 ± 5.7 %) and MDI + isCGM group (23.6 ± 5.9 %, p < 0.001). Hypoglycemic episodes as shown by time below range (TBR) < 70 mg/dL and TBR < 54 mg/dL were minimal during Ramadan in AHCL group in comparison to before Ramadan (2.6 ± 0.7 versus 2.9 ± 0.9 %; p = 0.061 and 0.4 ± 0.1 vs 0.5 ± 0.1 %, p = 0.561, respectively) with a lower coefficient of variation (CoV) (p < 0.001) than other T1DM participants.</div></div><div><h3>Conclusion</h3><div>At the end of Ramadan, TITR was decreased in patients with T1DM except those using AHCL who had similar levels to non-insulin-treated T2DM patients. Advanced technology has the potential for achieving tight glycemic targets, along with a reduction in CoV, without increasing hypoglycemic risk compared with other insulin treatment modalities.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"221 ","pages":"Article 112042"},"PeriodicalIF":6.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A critical review on SGLT2 inhibitors for diabetes mellitus, renal health, and cardiovascular conditions

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-16 DOI: 10.1016/j.diabres.2025.112050

Nitish Kumar , Bimlesh Kumar , Sumel Ashique , Sabina Yasmin , Kumar Venkatesan , Anas Islam , Suman Ghosh , Anwesha Sahu , Utpal Bhui , Mohammad Yousuf Ansari

{"title":"A critical review on SGLT2 inhibitors for diabetes mellitus, renal health, and cardiovascular conditions","authors":"Nitish Kumar , Bimlesh Kumar , Sumel Ashique , Sabina Yasmin , Kumar Venkatesan , Anas Islam , Suman Ghosh , Anwesha Sahu , Utpal Bhui , Mohammad Yousuf Ansari","doi":"10.1016/j.diabres.2025.112050","DOIUrl":"10.1016/j.diabres.2025.112050","url":null,"abstract":"<div><div>Sodium-glucose cotransporter 2 inhibitors (SGLT2i) were originally formulated to reduce blood glucose levels in individuals with diabetes. Recent clinical trials indicate that this compound can be repurposed for other critical conditions. A literature search was performed on PubMed, Scopus, Embase, ProQuest, and Google Scholar, utilizing key terms such as SGLT2i, diabetes, and oxidative stress. SGLT2i has significant beneficial effects not only in cardiovascular disease but also in renal dysfunction. SGLT2i therapy can mitigate critical cardiovascular complications like heart attacks, strokes, mortality rates, and hospitalization duration, as well as delay the necessity for dialysis irrespective of diabetic condition. Evidence supports potential advantages of SGLT2 inhibitors for individuals with renal problems and heart failure, regardless of diabetes status. In addition to diabetic mellitus, this analysis explores the latest updates on SGLT2i and the therapeutic advantages it offers in many renal and cardiovascular diseases (CVDs).</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"221 ","pages":"Article 112050"},"PeriodicalIF":6.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased risk of dementia in Type 1 diabetes: A systematic review with meta-analysis

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-16 DOI: 10.1016/j.diabres.2025.112043

Lily Li , Dana Wong , Caroline A. Fisher , Jennifer J. Conn , Paul R. Wraight , Alexandra Davies , Elizabeth Barson , Kerryn E. Pike

{"title":"Increased risk of dementia in Type 1 diabetes: A systematic review with meta-analysis","authors":"Lily Li , Dana Wong , Caroline A. Fisher , Jennifer J. Conn , Paul R. Wraight , Alexandra Davies , Elizabeth Barson , Kerryn E. Pike","doi":"10.1016/j.diabres.2025.112043","DOIUrl":"10.1016/j.diabres.2025.112043","url":null,"abstract":"<div><div>This systematic review and <em>meta</em>-analysis aimed to synthesize evidence on the association between Type 1 diabetes mellitus (Type 1 diabetes) and dementia risk. A systematic search of CINAHL, EMBASE, MEDLINE, PSYCINFO, and Web of Science databases identified 19 relevant studies for inclusion. Studies, published in English, were assessed for quality using the QUADAS-2 tool, and data were extracted for synthesis. A <em>meta</em>-analysis of six studies reporting hazard ratios (HR) for dementia risk in individuals with Type 1 diabetes versus controls was conducted. The pooled HR for all-cause dementia was 1.50 (95 % CI: 1.25–1.80, <em>p</em> < 0.001), indicating a 50 % increased risk of dementia in people with Type 1 diabetes compared to controls. This review provides robust evidence linking Type 1 diabetes to increased dementia risk and highlights the need for targeted screening and preventive strategies for this population. Further research is necessary to explore the mechanisms underlying the association between Type 1 diabetes and dementia.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112043"},"PeriodicalIF":6.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Switching to insulin lispro U-200 in a pregnant woman using a 780G advanced hybrid closed-loop led to a rapid improvement in glucose metrics

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-15 DOI: 10.1016/j.diabres.2025.112047

Lilian C. Mendoza , Ohad Cohen , Vittorino Smaniotto , Rosa Corcoy

引用次数: 0

Non-pharmacological management strategies for type 2 diabetes in children and young adults: A systematic review

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-15 DOI: 10.1016/j.diabres.2025.112045

Marylin Carino , Ru Hui New , Jonathan Nguyen , Renae Kirkham , Louise Maple-Brown , Angela Titmuss , Diana MacKay

{"title":"Non-pharmacological management strategies for type 2 diabetes in children and young adults: A systematic review","authors":"Marylin Carino , Ru Hui New , Jonathan Nguyen , Renae Kirkham , Louise Maple-Brown , Angela Titmuss , Diana MacKay","doi":"10.1016/j.diabres.2025.112045","DOIUrl":"10.1016/j.diabres.2025.112045","url":null,"abstract":"<div><h3>Purpose</h3><div>The evidence for effective non-pharmacological management of type 2 diabetes in children and young adults is scarce. This systematic review aims to identify the available evidence for non-pharmacological interventions in managing type 2 diabetes in children and young adults.</div></div><div><h3>Methods</h3><div>A systematic search of OVID MEDLINE, Ovid Emcare, EMBASE, CINAHL, Cochrane, APA PsycINFO, Joanna Briggs, ACP Journal Club, Global Health, Scopus databases, INFORMIT, Circumpolar Health, Native Health Database, Indigenous Studies Portal, OpenGrey and <span><span>Clinicaltrials.gov</span><svg><path></path></svg></span> was performed up to March 2024. Information on author, year, study design, setting and population, intervention characteristics, and results were extracted by three reviewers independently.</div></div><div><h3>Results</h3><div>Seven studies met criteria for inclusion. Very low-energy diet (VLED) was associated with reduction in hemoglobin A1c (HbA1c), weight, and body mass index (BMI). No other interventions (intensive group-based lifestyle program, occupational-therapist conducted support program or peer support program) improved HbA1c. Interventions positively impacted well-being, mental health and cardiometabolic outcomes.</div></div><div><h3>Discussion</h3><div>Evidence for non-pharmacological management of youth onset type 2 diabetes is scarce. Available evidence demonstrated that VLED is associated with improved glycemia and weight loss. The role of social support from peers, family, and health professionals shows mixed results<strong>.</strong></div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112045"},"PeriodicalIF":6.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of resistance training on blood pressure and resting heart rate in type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-14 DOI: 10.1016/j.diabres.2025.112016

Ruihao Lin , Kairan Yang , Hengtao Guo, Xiang Zhang

{"title":"The effect of resistance training on blood pressure and resting heart rate in type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials","authors":"Ruihao Lin , Kairan Yang , Hengtao Guo, Xiang Zhang","doi":"10.1016/j.diabres.2025.112016","DOIUrl":"10.1016/j.diabres.2025.112016","url":null,"abstract":"<div><div>This <em>meta</em>-analysis assessed the impacts of resistance training on hemodynamic outcomes, including blood pressure and heart rate, in patients with type 2 diabetes (T2D). Four databases were searched following PRISMA guidelines. Randomized controlled trials (RCTs) comparing resistance training to usual care were included if they evaluated systolic and diastolic blood pressure (SBP and DBP), heart rate, and maximum oxygen uptake (VO<sub>2max</sub>) in adults with T2D. Random-effects models were used to calculate mean differences, with corresponding 95 % confidence intervals (CIs). Twenty-six RCTs were included. Resistance training significantly reduced SBP by −4.13 mmHg (95 % CI: −6.40, −1.85; p = 0.0004) and DBP by −2.03 mmHg (95 % CI: −3.69, −0.38; p = 0.02), with greater reductions in interventions lasting over 12 weeks. Resting heart rate decreased by −3.17 bpm (95 % CI: −6.33, −0.01; p = 0.05) and VO<sub>2max</sub> improved by 0.27 ml/kg/min (95 % CI: 0.02, 0.53; p = 0.04). Meta-regression revealed that intervention duration, session frequency, and study quality did not significantly explain the observed heterogeneity. Resistance training effectively improves hemodynamic outcomes T2D patients, but high heterogeneity in blood pressure outcomes and limited subgroup data on specific subgroups (e.g., women) restrict generalizability. Further research should explore heterogeneity sources and optimize resistance training protocols.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"221 ","pages":"Article 112016"},"PeriodicalIF":6.1,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimated costs of treating two standardised diabetes-related foot ulcers of different severity – A comparison of 7 global regions

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-14 DOI: 10.1016/j.diabres.2025.112036

Ketan Dhatariya , Zulfiqarali G. Abbas , On behalf of the 7 Regions Foot Ulcer Costs Study Group

{"title":"Estimated costs of treating two standardised diabetes-related foot ulcers of different severity – A comparison of 7 global regions","authors":"Ketan Dhatariya , Zulfiqarali G. Abbas , On behalf of the 7 Regions Foot Ulcer Costs Study Group","doi":"10.1016/j.diabres.2025.112036","DOIUrl":"10.1016/j.diabres.2025.112036","url":null,"abstract":"<div><h3>Aims</h3><div>To determine estimated costs to treat two hypothetical diabetes related foot ulcers of differing severity in different World Health Organization regions.</div></div><div><h3>Methods</h3><div>Descriptions of two standardised diabetes related foot ulcers of differing severity were sent to foot teams. Each centre was sent a picture and description of the ulcers, and a series of potential interventions. Respondents were asked to estimate how much each intervention would cost in their centre, and how many times each would be required before the ulcer would heal. These estimated costs were converted to US dollars.</div></div><div><h3>Results</h3><div>Responses were received from 51 centres. Estimated costs for treating each wound were highest in the North America and Caribbean region. The average estimated cost of treating the milder wound was $2,942, (range $79–$17,758). Relative costs compared to those of North America and the Caribbean ranged from 0.36 to 0.75. The average time needed to cover the estimated costs of treating the wound was 8.6 (0.3–62.3) months’ salary. The average estimated cost of treating the more severe wound was $17,403, ($546-$67,178). Relative costs ranged from 0.06 to 0.69. The average time needed to cover the estimated costs of treating the wound was 22.7 (0.2–98.3) months’ salary.</div></div><div><h3>Conclusions</h3><div>The estimated costs of treating ulcers vary widely across the world.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"221 ","pages":"Article 112036"},"PeriodicalIF":6.1,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediabetes and sleep patterns: Linking poor sleep to adverse outcomes through metabolic syndrome

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-02-14 DOI: 10.1016/j.diabres.2025.112044

Zixuan Huang , Jie Deng , Hang Li , Shubin Fang , Yi Wei , Wenbin Lei , Weiping Wen , Lin Chen

{"title":"Prediabetes and sleep patterns: Linking poor sleep to adverse outcomes through metabolic syndrome","authors":"Zixuan Huang , Jie Deng , Hang Li , Shubin Fang , Yi Wei , Wenbin Lei , Weiping Wen , Lin Chen","doi":"10.1016/j.diabres.2025.112044","DOIUrl":"10.1016/j.diabres.2025.112044","url":null,"abstract":"<div><h3>Aims</h3><div>Evaluate how sleep patterns are associated with the risk of adverse health outcomes in individuals with prediabetes, and explore the potential mediating role of metabolic syndrome in these associations.</div></div><div><h3>Methods</h3><div>We assessed 44,938 adults with prediabetes from the UK Biobank. Sleep health was evaluated using sleep pattern, comprised of five sleep factors. Mediation analysis was performed to explore the potential mediating role of metabolic syndrome.</div></div><div><h3>Results</h3><div>Unhealthy sleep patterns were linked to a higher risk of adverse outcomes. Compared to those with a healthy sleep pattern, individuals with an intermediate sleep pattern had a higher propensity to develop adverse outcomes (HRs ranging from 1.07 to 1.31). Respectively, those with a poor sleep pattern also had an increased risk for these outcomes (HRs ranging from 1.21 to 1.92). For each poor sleep factor increase, the risk of these adverse outcomes increased by 4% to 23%. Metabolic syndrome may partially mediate, with mediation proportions ranging from 0.94% to 9.61%.</div></div><div><h3>Conclusions</h3><div>In adults with prediabetes, both poor and intermediate sleep patterns are associated with an increased risk of adverse outcomes. Metabolic syndrome partially mediates the relationship between sleep patterns and adverse outcomes.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"221 ","pages":"Article 112044"},"PeriodicalIF":6.1,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0