Diabetes research and clinical practice最新文献_第3页

Pancreatic fat infiltration is associated with risk of vertebral fracture in older patients with type 2 diabetes: A longitudinal multicenter study 胰腺脂肪浸润与老年 2 型糖尿病患者椎体骨折的风险有关：一项纵向多中心研究

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-10-22 DOI: 10.1016/j.diabres.2024.111904

Jiangchuan Wang , Zicheng Wei , Yu Wang , Dingzhe Zhang , Miaomiao Wang , Xin Chen , Peng Xia , Jianhua Wang , Chao Xie , Xiao Chen

{"title":"Pancreatic fat infiltration is associated with risk of vertebral fracture in older patients with type 2 diabetes: A longitudinal multicenter study","authors":"Jiangchuan Wang , Zicheng Wei , Yu Wang , Dingzhe Zhang , Miaomiao Wang , Xin Chen , Peng Xia , Jianhua Wang , Chao Xie , Xiao Chen","doi":"10.1016/j.diabres.2024.111904","DOIUrl":"10.1016/j.diabres.2024.111904","url":null,"abstract":"<div><h3>Aims</h3><div>Patients with type 2diabetesmellitus (T2DM) have high fracture risk. This study explored the associations between pancreatic computed tomography (CT) attenuation, a marker of pancreatic fat, and risk of vertebral fracture in T2DM patients.</div></div><div><h3>Methods</h3><div>A total of 1486 T2DM patients who aged 50 years and older and without preexisting vertebral fractures during 2019–2023 at our institutions were followed up untilJanuary 2024. CT attenuation of the pancreas, bone and spleen were measured. Pancreatic attenuation/spleen attenuation ratio (P/S) was calculated. Vertebral fractures were evaluated on spine CT images according to Genant’s semiquantitative scoring system.</div></div><div><h3>Results</h3><div>A total of 135 cases of vertebral fracture were identified during 26 months of follow-up and 270 patients without vertebral fracture were matched. Pancreatic CT attenuation and the P/S ratio were negatively associated with the risk of vertebral fracture (adjusted hazard ratio (aHR) = 0.97, 95 %confidence interval (CI): 0.96–0.99; aHR = 0.26, 95 %CI: 0.12–0.58). Addition of pancreatic attenuation or P/S ratio improved the performance of bone attenuation-based model (area under the curve = 0.72–0.763 vs 0.63–0.728).</div></div><div><h3>Conclusion</h3><div>Pancreatic fat infiltration is an associated factor for vertebral fracture in T2DM patients. Addition of pancreatic fat infiltration improved the predictive performance of the bone-based model.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111904"},"PeriodicalIF":6.1,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salivary glycated albumin could be as reliable a marker of glycemic control as blood glycated albumin in people with diabetes 唾液糖化白蛋白与血液糖化白蛋白一样，可以作为糖尿病患者血糖控制的可靠指标。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-10-22 DOI: 10.1016/j.diabres.2024.111903

Masakazu Aihara , Kouji Yano , Tomoko Irie , Mitsumi Nishi , Kenji Yachiku , Itsushi Minoura , Koshin Sekimizu , Yoshitaka Sakurai , Takashi Kadowaki , Toshimasa Yamauchi , Naoto Kubota

{"title":"Salivary glycated albumin could be as reliable a marker of glycemic control as blood glycated albumin in people with diabetes","authors":"Masakazu Aihara , Kouji Yano , Tomoko Irie , Mitsumi Nishi , Kenji Yachiku , Itsushi Minoura , Koshin Sekimizu , Yoshitaka Sakurai , Takashi Kadowaki , Toshimasa Yamauchi , Naoto Kubota","doi":"10.1016/j.diabres.2024.111903","DOIUrl":"10.1016/j.diabres.2024.111903","url":null,"abstract":"<div><h3>Aims</h3><div>Measurements of diabetes-related biomarkers are necessary to assess glycemic control. The commonly used finger-prick blood glucose and HbA1c measurements are invasive, as is blood glycated albumin (GA) measurement. Therefore, we developed a non-invasive method, namely, measurement of the salivary GA with high accuracy using a high-performance liquid chromatography (HPLC) method.</div></div><div><h3>Methods</h3><div>We recruited participants with diabetes mellitus admitted to The University of Tokyo Hospital. Blood and saliva samples were collected at three time points (fasting and 2-hour postprandial at admission and fasting at discharge). After partial purification using an antibody-based column, the samples were subjected to GA measurement by HPLC method.</div></div><div><h3>Results</h3><div>Among the 56 participants with diabetes mellitus enrolled in the study, there was a correlation between the GA levels measured in blood and saliva at the three time points described above (n = 45, <em>R</em><sup>2</sup> = 0.985, <em>P</em> < 0.001; n = 48, <em>R</em><sup>2</sup> = 0.973, <em>P</em> < 0.001; n = 51, <em>R</em><sup>2</sup> = 0.979, <em>P</em> < 0.001). Multiple regression analysis revealed the associations were maintained even after adjustments for age, BMI, and nephropathy stage.</div></div><div><h3>Conclusions</h3><div>This exploratory research revealed that the salivary GA levels by this method were accurate and might be able to replace blood GA measurement. The home salivary GA measurement is expected to be developed that may reduce the burden and complications in people with diabetes mellitus and improve the quality of life.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"218 ","pages":"Article 111903"},"PeriodicalIF":6.1,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

5-Year effects of a novel continuous remote care model with carbohydrate-restricted nutrition therapy including nutritional ketosis in type 2 diabetes: An extension study 新型持续远程护理模式与碳水化合物限制营养疗法（包括营养酮症）对 2 型糖尿病的 5 年疗效：扩展研究。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-10-20 DOI: 10.1016/j.diabres.2024.111898

Amy L. McKenzie , Shaminie J. Athinarayanan , Michelle R. Van Tieghem , Brittanie M. Volk , Caroline G.P. Roberts , Rebecca N. Adams , Jeff S. Volek , Stephen D. Phinney , Sarah J. Hallberg

{"title":"5-Year effects of a novel continuous remote care model with carbohydrate-restricted nutrition therapy including nutritional ketosis in type 2 diabetes: An extension study","authors":"Amy L. McKenzie , Shaminie J. Athinarayanan , Michelle R. Van Tieghem , Brittanie M. Volk , Caroline G.P. Roberts , Rebecca N. Adams , Jeff S. Volek , Stephen D. Phinney , Sarah J. Hallberg","doi":"10.1016/j.diabres.2024.111898","DOIUrl":"10.1016/j.diabres.2024.111898","url":null,"abstract":"<div><h3>Aims</h3><div>This study assessed the five-year effects of a continuous care intervention (CCI) delivered via telemedicine, counseling people with type 2 diabetes (T2D) on a very low carbohydrate diet with nutritional ketosis.</div></div><div><h3>Methods</h3><div>Participants with T2D were enrolled in a 2-year, open-label, non-randomized study comparing CCI and usual care (UC). After 2 years, 194 of the 262 CCI participants were approached for a three-year extension. Of these, 169 consented, and 122 remained in the study for five years. Primary outcomes were changes in diabetes status assessed using McNemars’ test, including remission and HbA1c < 6.5 % on no glucose lowering medication or only on metformin at 5 years. Changes in body mass, glycemia, and cardiometabolic markers from baseline to 5 years were assessed using linear mixed-effects models.</div></div><div><h3>Results</h3><div>Twenty percent (n = 24) of the five-year completers achieved remission, with sustained remission observed over three years in 15.8 % (n = 19) and four years in 12.5 % (n = 15). Reversal to HbA1c < 6.5 % without medication or only metformin was seen in 32.5 % (n = 39). Sustained improvements were noted in body mass (−7.6 %), HbA1c (−0.3 %), triglycerides (−18.4 %), HDL-C (+17.4 %), and inflammatory markers, with no significant changes in LDL-C and total cholesterol.</div></div><div><h3>Conclusions</h3><div>Over five years, the very low carbohydrate intervention showed excellent retention and significant health benefits, including diabetes remission, weight loss, and improved cardiometabolic markers.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111898"},"PeriodicalIF":6.1,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early screening and diagnosis of gestational diabetes mellitus (GDM) and its impact on perinatal outcomes 妊娠糖尿病（GDM）的早期筛查和诊断及其对围产期结果的影响。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-10-19 DOI: 10.1016/j.diabres.2024.111890

Beenu Bastian , Lisa Gaye Smithers , Alexia Pape , Warren Davis , K. Fu , Monique Francois

{"title":"Early screening and diagnosis of gestational diabetes mellitus (GDM) and its impact on perinatal outcomes","authors":"Beenu Bastian , Lisa Gaye Smithers , Alexia Pape , Warren Davis , K. Fu , Monique Francois","doi":"10.1016/j.diabres.2024.111890","DOIUrl":"10.1016/j.diabres.2024.111890","url":null,"abstract":"<div><h3>Aims</h3><div>To compare the maternal and neonatal outcomes following early diagnosis compared with routine diagnosis of gestational diabetes (GDM).</div></div><div><h3>Methods</h3><div>In this observational study, 3494 women were categorised by weeks of gestation at GDM diagnosis: early GDM (≤20 weeks) and routine GDM (>20 weeks). The early GDM group was further divided by treatment commencement as immediate (<12 weeks) and delayed (12–20 weeks) and by diagnostic fasting blood glucose as higher-FBG (5.3–6.0 mmol/L) and lower-FBG group (FBG 5.1–5.2 mmol/L). Primary outcomes were large for gestational age (LGA) and small for gestational age (SGA). Generalized linear models used to calculate risk ratios and adjusted for confounding.</div></div><div><h3>Results</h3><div>Risk ratios (RR) for LGA and SGA were similar for early versus routine diagnosis, and immediate versus delayed treatment. The higher-FBG immediate treatment group had a lower risk of newborn respiratory distress (RR 0.52, 95 %CI 0.34, 0.81) and emergency caesarean (RR 0.55, 95 %CI 0.34, 0.88) compared to the higher-FBG delayed treatment group. Among the lower-FBG group, no such benefits were seen.</div></div><div><h3>Conclusions</h3><div>Fasting glucose levels modified the effects of early treatment of GDM where a higher-FBG with immediate treatment appears to reduce perinatal complications, but treating women with lower-FBG early has no benefits.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111890"},"PeriodicalIF":6.1,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the insulin pump: Unraveling diabetes tech dependency 超越胰岛素泵：揭开糖尿病技术依赖症的神秘面纱。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-10-19 DOI: 10.1016/j.diabres.2024.111896

Emanuele Feliziani , Maria Caterina Chios , Paolo Pozzilli

{"title":"Beyond the insulin pump: Unraveling diabetes tech dependency","authors":"Emanuele Feliziani , Maria Caterina Chios , Paolo Pozzilli","doi":"10.1016/j.diabres.2024.111896","DOIUrl":"10.1016/j.diabres.2024.111896","url":null,"abstract":"<div><div>The use of technology for Type 1 diabetes (T1D) has significantly developed in the last 20 years leading to several benefits in life-style management but also to potentially overreliance and addiction to such life changing devices. Insulin pumps (CSII) being small, discreet and sophisticated, offer features such as customizable basal rates, bolus calculators and integration with Continuous Glucose Monitoring (CGM) systems becoming a <em>must have</em> for diabetic patients. Indeed CGM, firstly introduced in the late 1990s and now being highly sophisticated provide trends and patterns hence allowing a better management of T1D.</div><div>In this review we inquire the multifactorial aspects of dependency on diabetes technology, focusing not only on the benefits and the advancements these automations offer, but also the challenges, limits and possible risks associated with overreliance on them. Specifically, the impact that early introduction to technology had on patients, the dependency on CSII and CGM, the importance of learning and self-management skills and strategies for addressing unexpected events.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111896"},"PeriodicalIF":6.1,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of glucagon-like peptide-1 receptor agonist on the gastric residue in upper endoscopy 胰高血糖素样肽-1 受体激动剂对上消化道内窥镜检查中胃残留物的影响。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-10-19 DOI: 10.1016/j.diabres.2024.111900

Naim Abu-Freha , Zohar Levi , Anat Nevo-Shor , Revital Guterman , Ruhama Elhayany , Avraham Yitzhak , Dana Zelnik Yovel , Daniel L. Cohen , Haim Shirin

{"title":"The impact of glucagon-like peptide-1 receptor agonist on the gastric residue in upper endoscopy","authors":"Naim Abu-Freha , Zohar Levi , Anat Nevo-Shor , Revital Guterman , Ruhama Elhayany , Avraham Yitzhak , Dana Zelnik Yovel , Daniel L. Cohen , Haim Shirin","doi":"10.1016/j.diabres.2024.111900","DOIUrl":"10.1016/j.diabres.2024.111900","url":null,"abstract":"<div><h3>Aim</h3><div>We aimed to investigate the association between Glucagon-like-peptide-1 receptors agonists (GLP1-RA) use and gastric residue on esophagogastroduodenoscopy (EGD).</div></div><div><h3>Methods</h3><div>A multicenter, retrospective study included all EGDs conducted across seven gastroenterology departments. EGDs with the diagnosis of “poor preparation” or described as a poor preparation in the endoscopist’s report were considered as gastric residue.</div></div><div><h3>Results</h3><div>120,879 EGDs were included in the analysis. Of these, 1671 patients treated with GLP1-RA were compared to 119,208 without GLP1-RA treatment. Of the GLP1-RA group, 93 (5.6 %) had gastric residue compared to 2327 (2.0 %) among the non-GLP1-RA group (p < 0.001). Sup-group analysis: 71 (6.2 %) of the 1141 DM patients treated with GLP1-RA compared to 307 (3.0 %) of the 10,152 DM patients without GLP1-RA treatment (p < 0.001). Additionally, 22 (4.2 %) of 503 non-DM patients treated with GLP1-RA had gastric residue compared to 2065 (2.0 %) of the non-DM non-GLP1-RA group (n = 109,056) (p < 0.001). In multivariate analysis, DM and GLP1-RA were both found to be independent risk factors for excess gastric residue.</div></div><div><h3>Conclusion</h3><div>Our results may have important clinical relevance for EGD preparation among GLP1-RA treated patients, either requiring a longer fasting time prior to EGD or holding the medication prior to EGD according to the half-life of the drug.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111900"},"PeriodicalIF":6.1,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a machine learning model for precision prognosis of rapid kidney function decline in people with diabetes and chronic kidney disease 针对糖尿病和慢性肾脏病患者肾功能快速衰退的精准预后开发机器学习模型。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-10-19 DOI: 10.1016/j.diabres.2024.111897

Woo Vin Lee , Yuri Song , Ji Sun Chun , Minoh Ko , Ha Young Jang , In-Wha Kim , Sehoon Park , Hajeong Lee , Hae-Young Lee , Soo Heon Kwak , Jung Mi Oh

{"title":"Development of a machine learning model for precision prognosis of rapid kidney function decline in people with diabetes and chronic kidney disease","authors":"Woo Vin Lee , Yuri Song , Ji Sun Chun , Minoh Ko , Ha Young Jang , In-Wha Kim , Sehoon Park , Hajeong Lee , Hae-Young Lee , Soo Heon Kwak , Jung Mi Oh","doi":"10.1016/j.diabres.2024.111897","DOIUrl":"10.1016/j.diabres.2024.111897","url":null,"abstract":"<div><h3>Aims</h3><div>To develop a machine learning model for predicting rapid kidney function decline in people with type 2 diabetes (T2D) and chronic kidney disease (CKD) and to pinpoint key modifiable risk factors for targeted interventions.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study on 6,924 individuals with T2D and CKD at Seoul National University Hospital. Kidney function decline was assessed using estimated glomerular filtration rate slopes. The performance of the eXtreme Gradient Boosting (XGBoost) model was evaluated through model diagnosis and time-to-event analyses. Copula simulation was conducted to stratify risk subgroups using modifiable risk factors.</div></div><div><h3>Results</h3><div>A total of 906 (13.1 %) individuals experienced rapid kidney function decline. The XGBoost model demonstrated optimal performance (area under the receiver operating characteristic curve: 0.826). The hazard of end-stage kidney disease within eight years increased across risk quartiles, with statistically significant hazard ratios in Q3 (2.06; 95 % confidence interval [CI]: 1.29–3.29) and Q4 (10.9; 95 % CI: 7.36–16.2). Simulation analysis identified high-risk subgroups by stage A3 albuminuria and at least two of the following: haematocrit < 39.0 %, systolic blood pressure > 120 mmHg, and glycated hemoglobin A1c > 6.5 %.</div></div><div><h3>Conclusions</h3><div>The XGBoost model, augmented by copula simulation, successfully stratified kidney prognosis in individuals with T2D and CKD.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111897"},"PeriodicalIF":6.1,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patients with type 2 diabetes and surgical foot wounds: Overtrust in primary care physicians, isolation, and difficulties contemplating the future 2 型糖尿病患者和脚部手术伤口：对初级保健医生的过度信任、孤独感以及对未来的担忧。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-10-18 DOI: 10.1016/j.diabres.2024.111861

Judith Charbit , Marie-Laure Gbessoua , Juliette Jacquot , Nathalie Garnier , Veronique Labbe Gentils , Meriem Sal , Narimane Berkane , Sopio Tatulashvili , Emmanuel Cosson , Hélène Bihan

{"title":"Patients with type 2 diabetes and surgical foot wounds: Overtrust in primary care physicians, isolation, and difficulties contemplating the future","authors":"Judith Charbit , Marie-Laure Gbessoua , Juliette Jacquot , Nathalie Garnier , Veronique Labbe Gentils , Meriem Sal , Narimane Berkane , Sopio Tatulashvili , Emmanuel Cosson , Hélène Bihan","doi":"10.1016/j.diabres.2024.111861","DOIUrl":"10.1016/j.diabres.2024.111861","url":null,"abstract":"<div><h3>Aims</h3><div>In Europe, 27 % of patients with a podiatric complication of diabetes are referred to a specialized structure for surgery after more than 3 months’ disease progression. Our study aimed to analyze access to healthcare and future self-projection in patients with severe diabetic foot conditions.</div></div><div><h3>Methods</h3><div>We performed a qualitative study with semi-structured interviews in patients hospitalized with diabetic foot conditions requiring surgical treatment. We collected quantitative data on the diabetes characteristics, levels of social precariousness, anxiety and depression.</div></div><div><h3>Results</h3><div>We conducted 13 interviews with 2 females and 11 males; mean age 62.7 years. Five had undergone surgical debridement, six toe amputation, and two mid-tarsal amputation. Most were socioeconomically deprived and/or isolated. Three discourse themes emerged: 1) heterogeneity in the care pathway, with systemic barriers, negligence or overtrust 2) relationship between social support and the ability to project oneself into the future, 3) poverty of speech.</div></div><div><h3>Conclusions</h3><div>Education should emphasize the importance of prompt referral to a specialized structure after the onset of a wound. The lack of support from loved ones and social support appeared to be associated with patients’ failure to plan for their future. We advocate for a psychological evaluation and support for all these patients.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111861"},"PeriodicalIF":6.1,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to “Relevance of gastric emptying to the timing of prandial insulin administration in hospitalised patients with diabetes” 对 "胃排空与住院糖尿病患者餐前胰岛素用药时间的相关性 "的答复

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-10-18 DOI: 10.1016/j.diabres.2024.111901

Andrew P. Demidowich , Camille Stanback , Mihail Zilbermint

引用次数: 0

Sleep disorders in younger and middle-older age adults with newly diagnosed type 2 diabetes mellitus: A retrospective cohort study in >1million individuals 新诊断为 2 型糖尿病的年轻和中老年人的睡眠障碍：一项对超过 100 万人进行的回顾性队列研究。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-10-16 DOI: 10.1016/j.diabres.2024.111887

Joseph Henson , Gema Hernández Ibarburu , Zuzanna Drebert , Tommy Slater , Andrew P. Hall , Kamlesh Khunti , Jack A. Sargeant , Francesco Zaccardi , Melanie J. Davies , Thomas Yates

{"title":"Sleep disorders in younger and middle-older age adults with newly diagnosed type 2 diabetes mellitus: A retrospective cohort study in >1million individuals","authors":"Joseph Henson , Gema Hernández Ibarburu , Zuzanna Drebert , Tommy Slater , Andrew P. Hall , Kamlesh Khunti , Jack A. Sargeant , Francesco Zaccardi , Melanie J. Davies , Thomas Yates","doi":"10.1016/j.diabres.2024.111887","DOIUrl":"10.1016/j.diabres.2024.111887","url":null,"abstract":"<div><h3>Aims</h3><div>To explore the 5-year incidence and relative rates of sleep disorders in younger (16-≤40 years) and middle-older (=>40 years) age adults with and without newly diagnosed type 2 diabetes.</div></div><div><h3>Methods</h3><div>This retrospective, observational cohort study utilised data from the US Collaborative Network within the TriNetX database. We compared 5-year cumulative incidence of sleep disorders in younger (n = 110,088) and middle-older populations (n = 1,185,961).</div></div><div><h3>Results</h3><div>The absolute risk of developing any type of sleep disorder was greater in individuals with type 2 diabetes vs. those without. Over the 5-year follow-up period, 14.2 % of younger adults and 18.5 % of middle-older age adults with newly diagnosed type 2 diabetes developed any form of sleep disorder, compared to 4.5 % and 7.9 % propensity matched individuals without diabetes. We observed a more pronounced relative rate across the observed sleep disorders in younger adults.</div></div><div><h3>Conclusions</h3><div>The 5-year risk of sleep disorders is higher in those with newly diagnosed type 2 diabetes vs. those without. A higher absolute risk was seen in middle-older adults, but relative rates were consistently higher in younger adults with type 2 diabetes. Sleep should be regularly discussed as part of a holistic approach to diabetes care, particularly in those aged ≤40.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111887"},"PeriodicalIF":6.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0