Diabetes research and clinical practice最新文献_第4页

A proposal for breakfast to improve the postprandial glucose response in children with type 1 diabetes - Preliminary results from a camp-based study. 改善 1 型糖尿病患儿餐后血糖反应的早餐建议 - 夏令营研究的初步结果。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-10-03 DOI: 10.1016/j.diabres.2024.111881

Monica Marino, Giada Boccolini, Patrizio Tombolini, Valentina Tiberi, Antonio Iannilli, Sara Santarelli, Francesco Gasparini, Annalisa Carciofi, Antonia Capogna, Valentino Cherubini

引用次数: 0

Role of epicardial adipose tissue in cardiac remodeling 心外膜脂肪组织在心脏重塑中的作用

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-10-02 DOI: 10.1016/j.diabres.2024.111878

引用次数: 0

Reply to ‘Letter to the Editor: Sex differences in the plasma glucagon responses to a high carbohydrate meal and a glucose drink in type 2 diabetes’ 回复 "致编辑的信：2 型糖尿病患者对高碳水化合物膳食和葡萄糖饮料的血浆胰高血糖素反应的性别差异"。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-10-02 DOI: 10.1016/j.diabres.2024.111880

引用次数: 0

Hypoglycemic drugs, circulating inflammatory proteins, and gallbladder diseases: A mediation mendelian randomization study 降糖药、循环炎症蛋白与胆囊疾病：调解泯灭随机化研究。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-10-02 DOI: 10.1016/j.diabres.2024.111882

{"title":"Hypoglycemic drugs, circulating inflammatory proteins, and gallbladder diseases: A mediation mendelian randomization study","authors":"","doi":"10.1016/j.diabres.2024.111882","DOIUrl":"10.1016/j.diabres.2024.111882","url":null,"abstract":"<div><h3>Background</h3><div>The relationship of hypoglycemic drugs, inflammatory proteins and gallbladder diseases remain unknown.</div></div><div><h3>Methods</h3><div>Four hypoglycemic drugs were selected as exposure: glucagon-like peptide-1 receptor agonists (GLP-1RA), dipeptidyl peptidase-4 inhibitors (DPP-4i), sodium-glucose cotransporter 2 inhibitors (SGLT-2i), and metformin. The outcome were two gallbladder diseases: cholecystitis and cholelithiasis. Mendelian Randomization (MR) was employed to determine the association between hypoglycemic drugs and gallbladder diseases.</div></div><div><h3>Results</h3><div>DPP-4i and SGLT-2i had no effect on cholecystitis and cholelithiasis. However, a causal relationship was found between inhibition of ETFDH gene, a target of metformin expressed in cultured fibroblasts, and cholelithiasis (OR: 0.84, 95 %CI: (0.72,0.97), p = 0.021), as well as between GLP1R expression in the brain caudate basal ganglia and cholecystitis (OR: 1.29, 95 %CI: (1.11,1.49), p = 0.001). The effect of ETFDH inhibition on cholelithiasis through Interleukin-10 receptor subunit beta (IL-10RB) levels and Neurotrophin-3 (NT-3) levels, with a mediated proportion of 8 % and 8 %, respectively.</div></div><div><h3>Conclusion</h3><div>Metformin plays a protective role in cholelithiasis, while GLP-1RA have a harmful effect on the risk of cholecystitis. Metformin may reduce the risk of cholelithiasis by modulating the levels of Neurotrophin-3 (NT-3) and Interleukin-10 receptor subunit beta (IL-10RB). Further clinical and mechanistic studies are required to confirm these findings.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethnic differences in the effects of lifestyle interventions on adverse pregnancy outcomes among women with gestational diabetes mellitus: A systematic review and meta-analysis 生活方式干预对妊娠糖尿病妇女不良妊娠结局影响的种族差异：系统回顾和荟萃分析。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-09-29 DOI: 10.1016/j.diabres.2024.111875

{"title":"Ethnic differences in the effects of lifestyle interventions on adverse pregnancy outcomes among women with gestational diabetes mellitus: A systematic review and meta-analysis","authors":"","doi":"10.1016/j.diabres.2024.111875","DOIUrl":"10.1016/j.diabres.2024.111875","url":null,"abstract":"<div><h3>Aims</h3><div>Lifestyle interventions are widely used among women with gestational diabetes mellitus (GDM). This study aimed to assess the ethnic disparities in the effectiveness of lifestyle interventions on reducing adverse pregnancy outcomes, particularly macrosomia and neonatal hypoglycemia among women with GDM.</div></div><div><h3>Methods</h3><div>We systematically searched the PubMed/MEDLINE, Web of Science, and Cochrane Library databases from January 1, 2000, up to March 31, 2024, to identify randomized controlled trials (RCTs) examining the effects of lifestyle interventions in GDM patients. Subgroup analysis was performed to investigate heterogeneity across different ethnic groups (including Asians, Whites/Caucasians, Hispanics/ Latinos, and Unknown ethnicity). The random effects model was used to calculate the relative risk (RR) and 95% confidence interval (CI).</div></div><div><h3>Results</h3><div>After applying inclusion and exclusion criteria, twenty-one studies comprising 4567 participants were included. Lifestyle interventions significantly reduced the incidence of macrosomia ((RR = 0.54; 95 % CI: 0.42–0.70, <em>P</em> < 0.001), with consistent effects observed across racial groups. Conversely, lifestyle interventions were associated with a significant reduction in the risk of neonatal hypoglycemia only among Asians (RR = 0.56; 95 % CI: 0.38–0.84, <em>P</em> = 0.004), while no significant effects were observed in Whites/Caucasians or Hispanics/Latinos (all <em>P</em> > 0.05). Sensitivity analyses confirmed the robustness of the findings.</div></div><div><h3>Conclusions</h3><div>Regardless of ethnic background, this study emphasizes the significant benefits of lifestyle interventions in reducing the risk of macrosomia among women with GDM. However, lifestyle interventions seem to reduce the risk of neonatal hypoglycemia only among Asians, which warrants further studies.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

All-cause and cause-specific mortality risks in individuals with diabetes living alone: A large-scale population-based cohort study 独居糖尿病患者的全因和特定原因死亡风险：大规模人群队列研究。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-09-27 DOI: 10.1016/j.diabres.2024.111876

{"title":"All-cause and cause-specific mortality risks in individuals with diabetes living alone: A large-scale population-based cohort study","authors":"","doi":"10.1016/j.diabres.2024.111876","DOIUrl":"10.1016/j.diabres.2024.111876","url":null,"abstract":"<div><h3>Aims</h3><div>The rise in one-person households is a global trend. We aimed to investigate mortality risk in individuals with diabetes living alone (IDLA) using a large-scale population-based database.</div></div><div><h3>Methods</h3><div>A total of 2,447,557 adults with type 2 diabetes were identified from the Korean National Health Information Database. One-person households were defined based on the number of registered family members. The risks of all-cause and cause-specific mortalities were estimated using a multivariable Cox proportional hazards regression model.</div></div><div><h3>Results</h3><div>During a median follow-up period of 6.0 years, 191,084 deaths (7.8 %) occurred. IDLA had a higher risk of mortality compared to those not living alone after adjusting for potential confounders (HR 1.20, 95 % CI: 1.18–1.22). This association was more prominent in younger individuals, men, and those with low income, and it was dependent on the duration of living alone. The risks of cause-specific mortality were all significantly higher in the IDLA group compared with the non-IDLA group. Adherence to favorable lifestyle behaviors was associated with a significant reduction in all-cause mortality, particularly in IDLA.</div></div><div><h3>Conclusions</h3><div>The elevated risk of mortality in IDLA highlights the need for tailored medical interventions and social assistance, particularly for those with unhealthy lifestyles or low income.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An evaluation of how exercise position statement guidelines are being used in the real world in type 1 diabetes: Findings from the type 1 diabetes exercise initiative (T1DEXI) 评估 1 型糖尿病患者在现实世界中如何使用运动立场声明指南：1 型糖尿病运动倡议 (T1DEXI) 的研究结果。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-09-27 DOI: 10.1016/j.diabres.2024.111874

{"title":"An evaluation of how exercise position statement guidelines are being used in the real world in type 1 diabetes: Findings from the type 1 diabetes exercise initiative (T1DEXI)","authors":"","doi":"10.1016/j.diabres.2024.111874","DOIUrl":"10.1016/j.diabres.2024.111874","url":null,"abstract":"<div><h3>Aims</h3><div>Position statement guidelines should help people with type 1 diabetes (T1D) improve glucose outcomes during exercise.</div></div><div><h3>Methods</h3><div>In a 4-week observational study, continuous glucose, insulin, and nutrient data were collected from 561 adults with T1D. Glucose outcomes were calculated during exercise, post-exercise, and overnight, and were compared for sessions when participants used versus did not use exercise guidelines for open-loop (OL) and automated insulin delivery (AID) therapy.</div></div><div><h3>Results</h3><div>Guidelines requiring behaviour modification were rarely used while guidelines not requiring modification were often used. The guideline recommending reduced meal insulin before exercise was associated with lower time <3.9 mmol/L during exercise (−2.2 %, P=0.02) for OL but not significant for AID (−1.4 %, P=0.27). Compared to exercise with low glucose (<3.9 mmol/L) in prior 24-hours, sessions without recent low glucose had lower time <3.9 mmol/L during exercise (−1.2 %, P<0.001). The AID guideline for no carbohydrates before exercise when CGM is flat, or increasing, was not associated with improved glycaemia.</div></div><div><h3>Conclusions</h3><div>Free-living datasets may be used to evaluate usage and benefit of position statement guidelines. Evidence suggests OL participants who reduced meal insulin prior to exercise and did not have low glucose in the prior 24 h had less time below range.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relevance of gastric emptying to the timing of prandial insulin administration in hospitalised patients with diabetes 胃排空与糖尿病住院患者餐前胰岛素用药时间的相关性。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-09-27 DOI: 10.1016/j.diabres.2024.111877

引用次数: 0

A post-hoc pooled analysis to evaluate efficacy and safety of insulin glargine 300 U/mL in insulin-naïve people with type 2 diabetes with/without prior use of glucagon-like peptide-1 receptor agonist therapy 一项事后汇总分析，旨在评估格列美脲胰岛素 300 U/mL对胰岛素无效的 2 型糖尿病患者的疗效和安全性，这些患者既往接受过胰高血糖素样肽-1 受体激动剂治疗，也未接受过胰高血糖素样肽-1 受体激动剂治疗。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-09-27 DOI: 10.1016/j.diabres.2024.111871

{"title":"A post-hoc pooled analysis to evaluate efficacy and safety of insulin glargine 300 U/mL in insulin-naïve people with type 2 diabetes with/without prior use of glucagon-like peptide-1 receptor agonist therapy","authors":"","doi":"10.1016/j.diabres.2024.111871","DOIUrl":"10.1016/j.diabres.2024.111871","url":null,"abstract":"<div><h3>Aims</h3><div>To evaluate treatment advancement with insulin glargine 300 U/mL (Gla-300), with or without prior glucagon-like peptide-1 receptor agonist (GLP-1 RA) therapy in type 2 diabetes (T2D).</div></div><div><h3>Methods</h3><div>Efficacy and safety outcomes of insulin-naïve patients intensifying with Gla-300, with/without prior GLP-1 RA therapy, were evaluated in three analyses (N = 3562): a pooled analysis of seven interventional studies, a subanalysis comparing participants who stopped GLP-1 RA therapy and initiated Gla-300 with those who received add-on Gla-300, and an expanded analysis including two observational studies.</div></div><div><h3>Results</h3><div>Glycaemic outcomes, including HbA1c improvement and fasting plasma glucose, were similar between groups with/without prior GLP-1 RA use. HbA1c least squares mean change from baseline was − 1.7 % and − 1.6 % with and without prior GLP-1 RA, respectively. Glycaemic outcomes were similar between participants who stopped GLP-1 RA therapy when initiating Gla-300 and those who received add-on Gla-300, although more participants receiving add-on Gla-300 achieved HbA1c targets. The expanded analysis yielded similar results. Incidence of hypoglycaemia was low with no clinically relevant weight changes in all analyses.</div></div><div><h3>Conclusions</h3><div>Treatment advancement with Gla-300 in patients with T2D, with/without prior GLP-1 RA therapy, improved glycaemic outcomes with no relevant impact on weight, while maintaining a low hypoglycaemia risk.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ambulatory blood pressure monitoring and vascular complications in patients with type 1 diabetes mellitus – Systematic review and meta-analysis of observational studies 1 型糖尿病患者的非卧床血压监测与血管并发症--观察性研究的系统回顾和荟萃分析。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-09-27 DOI: 10.1016/j.diabres.2024.111873

{"title":"Ambulatory blood pressure monitoring and vascular complications in patients with type 1 diabetes mellitus – Systematic review and meta-analysis of observational studies","authors":"","doi":"10.1016/j.diabres.2024.111873","DOIUrl":"10.1016/j.diabres.2024.111873","url":null,"abstract":"<div><h3>Aims</h3><div>This study aimed to evaluate the role of the 24-Hour Ambulatory Blood Pressure Monitoring (ABPM) as a possible predictor of vascular outcomes in office normotensive people with type 1 diabetes mellitus (T1DM).</div></div><div><h3>Methods</h3><div>This is a systematic review including cohort studies from the Embase, PubMed/Medline, and Web of Science databases on people with T1DM undergoing ABPM and subsequent evaluation of vascular complications. Measurements of difference (MD) were obtained using random effect model <em>meta</em>-analysis.</div></div><div><h3>Results</h3><div>We found 364 articles and 49 duplicates. Seven studies were included, comprising 635 participants aged 25.8 ± 6.2 years. Most (57.5 %) were men, mean duration of diabetes was 11.8 ± 5.3 years, mean glycated hemoglobin level among participants was 8.5 % ± 1.6 %, and mean follow-up time was 4.2 years. Lower night systolic blood pressure MD − 4.37 mmHg (p = 0.0009) and night diastolic blood pressure MD − 3.97 mmHg (p < 0.0001) were associated with lower incidence of albuminuria. People withT1DM who presented no beginning or progression of retinopathy were those with lower night diastolic blood pressure MD − 3.62 mmHg (p = 0.042), diurnal diastolic blood pressure MD − 2.69 mmHg (p = 0.0138), and 24-hour diastolic blood pressure MD − 3.65 mmHg (p = 0.037).</div></div><div><h3>Conclusion</h3><div>Small mean differences in blood pressure parameters, as measured by ABPM, between people with T1DM are associated with a lower incidence or risk of progression of nephropathy and retinopathy.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0