Diabetes research and clinical practice最新文献

{"title":"Corrigendum to \"In humans increase in intrapancreatic adipose tissue predicts beta-cell dedifferentiation score before diabetes onset: A pilot study\" [Diabetes Res. Clin. Pr. 221 (2025) MS N. 112029].","authors":"Francesca Cinti, Teresa Mezza, Ilenia Severi, Simona Moffa, Gianfranco Di Giuseppe, Umberto Capece, Gea Ciccarelli, Laura Soldovieri, Michela Brunetti, Cassandra Morciano, Shawn Gugliandolo, Martina Senzacqua, Adriana Avolio, Giuseppe Quero, Vincenzo Tondolo, Enrico Celestino Nista, Rossana Moroni, Saverio Cinti, Sergio Alfieri, Antonio Gasbarrini, Alfredo Pontecorvi, Andrea Giaccari","doi":"10.1016/j.diabres.2025.112097","DOIUrl":"https://doi.org/10.1016/j.diabres.2025.112097","url":null,"abstract":"","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"112097"},"PeriodicalIF":6.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of painful diabetic neuropathy: A systematic review and meta-analysis","authors":"Y. Tao ,&nbsp;H.Y. Zhang ,&nbsp;C. MacGilchrist ,&nbsp;E. Kirwan ,&nbsp;C. McIntosh","doi":"10.1016/j.diabres.2025.112099","DOIUrl":"10.1016/j.diabres.2025.112099","url":null,"abstract":"<div><div>Painful diabetes-related peripheral neuropathy (PDPN) is a common and debilitating complication of diabetes, contributing significantly to morbidity and healthcare costs. This systematic review and <em>meta</em>-analysis aim to determine the global prevalence of PDPN among individuals with diabetic peripheral neuropathy (DPN) and to identify associated risk factors. A comprehensive search of four English and three Chinese databases was conducted for observational studies on PDPN prevalence up to June 22, 2024. Of the 41 studies included, the pooled global prevalence of PDPN was 46.7 % (95 % CI, 41.8–51.7). In subgroup analysis, significant statistical differences were observed in prevalence estimates between different diagnostic methods for neuropathic pain, with neuropathic-specific pain scales indicating higher rates (<em>P =</em> 0.03). Studies with mean diabetes duration of less than 10 years or more than 15 years reported higher prevalence (<em>P</em> &lt; 0.01). Significant risk factors for PDPN included older age (OR = 1.02, 95 % CI, 1.01–1.04), female gender (OR = 1.58, 95 % CI, 1.19–2.11), BMI ≥ 30 kg/m² (OR = 1.62, 95 % CI, 1.43–1.83), longer diabetes duration (OR = 1.05, 95 % CI, 1.01–1.08), and nephropathy (OR = 1.32, 95 % CI, 1.24–1.40). Targeted screening and standardized diagnostic tools are urgently needed to enhance PDPN management and mitigate its burden globally.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112099"},"PeriodicalIF":6.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HOMA-IR and TyG index differ for their relationship with dietary, anthropometric, inflammatory factors and capacity to predict cardiovascular risk","authors":"Domenico Sergi ,&nbsp;Riccardo Spaggiari ,&nbsp;Edoardo Dalla Nora ,&nbsp;Sharon Angelini ,&nbsp;Fabiola Castaldo ,&nbsp;Alice Omenetto ,&nbsp;Gabriella Stifani ,&nbsp;Juana Maria Sanz ,&nbsp;Angelina Passaro ,&nbsp;on behalf of the PANGEA study group","doi":"10.1016/j.diabres.2025.112103","DOIUrl":"10.1016/j.diabres.2025.112103","url":null,"abstract":"<div><h3>Background</h3><div>HOMA-IR and the triglyceride-glucose index (TyG index) are surrogate indexes of insulin resistance. However, it remains to elucidate how HOMA-IR and the TyG index compare for their relationship with cardiometabolic health.</div></div><div><h3>Aim</h3><div>This study aimed at comparing HOMA-IR and the TyG index with regard to their relationship with anthropometric, dietary and inflammatory factors as well as ability to predict cardiovascular risk.</div></div><div><h3>Methods</h3><div>438 subjects aged 55–80 years, underwent anthropometric, metabolic and nutritional characterisation. Spearman’s correlation coefficient was used to evaluate the association between the parameters of interest. Predictors of HOMA-IR, the TyG index and the 10-year risk of cardiovascular events were investigated using stepwise multivariable regression analysis.</div></div><div><h3>Results</h3><div>HOMA-IR and TyG index correlated positively with body mass index, waist circumference, fat mass, systolic and diastolic blood pressure, interleukin-18 and C-reactive protein. However, only HOMA-IR correlated with dietary factors.</div><div>After adjusting for age and sex, waist circumference and interleukin-18 were stronger predictors of HOMA-IR compared to the TyG index. Instead, the TyG index, but not HOMA-IR, emerged as a predictor of cardiovascular risk.</div></div><div><h3>Conclusions</h3><div>The TyG index represents a better predictor of cardiovascular risk compared to HOMA-IR which, instead, exhibits a stronger relationship with anthropometric, inflammatory and nutritional variables.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112103"},"PeriodicalIF":6.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes and pregnancy: A call for terminology standardization in clinical practice","authors":"Edwin Augusto Acho Carranza ,&nbsp;Julio Alberto Leey Casella ,&nbsp;Marcio José Concepción-Zavaleta","doi":"10.1016/j.diabres.2025.112102","DOIUrl":"10.1016/j.diabres.2025.112102","url":null,"abstract":"<div><div>Currently, there is no unified consensus on the terminology used to describe diabetes in the context of pregnancy, leading to confusion among clinicians and challenges in research. This review article proposes a set of terms to classify diabetes during pregnancy based on timing and diagnostic criteria, whether before or during pregnancy. A review of previous documents addressing terminology and classification was conducted, identifying four main terms: (1) pregestational diabetes mellitus, referring to diabetes diagnosed before pregnancy; (2) early gestational diabetes mellitus, diagnosed before 24 weeks of gestation; (3) late gestational diabetes mellitus, diagnosed at or after 24 weeks of gestation; and (4) diabetes in pregnancy, diagnosed at any gestational age. This proposal does not include an analysis of hyperglycemia’s pathophysiological mechanisms or specific diagnostic criteria. The proposed classification could serve as a foundation for a global initiative to establish a consensus on terminology for diabetes in pregnancy. A universally accepted terminology would reduce clinical confusion, provide a framework for defining diagnostic criteria, facilitate research on maternal and fetal complications, and support studies exploring the postpartum progression of diabetes.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112102"},"PeriodicalIF":6.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescription patterns and the cost of antihyperglycemic drugs in patients with diabetes mellitus in Iran from 2014 to 2019","authors":"Mehdi Rezaee ,&nbsp;Mohamad Mehdi Nasehi ,&nbsp;Zahra Aminzade ,&nbsp;Hossein Karami ,&nbsp;Amir Mohammad Vahdani ,&nbsp;Rajabali Daroudi ,&nbsp;Mohammad Effatpanah ,&nbsp;Leila Ghamkhar ,&nbsp;Mahsa Heidari-Foroozan ,&nbsp;Maryam Arab ,&nbsp;Zahra Shahali ,&nbsp;Reza Mehrizi","doi":"10.1016/j.diabres.2025.112078","DOIUrl":"10.1016/j.diabres.2025.112078","url":null,"abstract":"<div><h3>Introduction</h3><div>Diabetes mellitus (DM) is characterized by high blood glucose levels and abnormalities in metabolism. In 2021, 15.14% of adult Iranians had DM. The purpose of this study is to provide policymakers with actionable insights to enhance resource allocation and improve diabetes care by evaluating the prescription patterns and costs of antidiabetic medications in Iran from 2014 to 2019 in 2.5 million patients.</div></div><div><h3>Methods</h3><div>This descriptive-analytical study used data from Iran’s Health Insurance prescriptions database, analyzing approximately 2.5 million diabetic patients from 2014 to 2019. Data included drug types, frequencies, costs, and patient demographics.</div></div><div><h3>Results</h3><div>The analysis covered 20,233,608 prescriptions. Biguanides, sulfonylureas, and Insulin were the most commonly prescribed medications. Moreover, the 40–64 age group had the highest cost. Prescription patterns varied by age, with insulin in younger patients and Metformin in older ones. General practitioners, internal medicine specialists, and endocrinologists were the primary prescribers of anti-diabetic medications. Insulin Aspart incurred the highest costs, followed by Insulin glargine and metformin. The cost of females’ antidiabetic medications was 1.66 times higher than those of males.</div></div><div><h3>Conclusion</h3><div>Insulin was the primary cost driver for antihyperglycemic medications. These cost disparities and variations in prescription patterns underscore the need for targeted interventions to improve diabetes care and manage resources effectively.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"223 ","pages":"Article 112078"},"PeriodicalIF":6.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonlinear association between hemoglobin glycation index and mortality in ischemic stroke Patients: Insights from the MIMIC-IV database.","authors":"Xuhang Huang, Lejun Huang, Haoran Tao, Meng Ren, Li Yan","doi":"10.1016/j.diabres.2025.112105","DOIUrl":"https://doi.org/10.1016/j.diabres.2025.112105","url":null,"abstract":"<p><strong>Aims: </strong>Hemoglobin glycation index (HGI) is closely associated with adverse outcomes in several diseases. However, few studies have investigated the correlation between HGI and prognosis in patients with critical ischemic stroke.</p><p><strong>Methods: </strong>A cohort of patients was established from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Kaplan-Meier analysis, multivariate regression models, and restricted cubic splines (RCS) were used to investigate the associations between HGI and different outcomes. Mediation models were constructed to determine the mediating role of white blood cell (WBC) counts.</p><p><strong>Results: </strong>This study included 2,332 participants. In-hospital mortality differs significantly across HGI groups (24.43 %, 11.82 %, and 10.14 %, P < 0.001). Multivariate regression analyses found that lower HGI was significantly associated with greater mortality risk. Nonlinear analyses revealed an L-shaped association between HGI and short-term mortality (30-day and in-hospital), while a reverse J-shaped relationship emerged for long-term (365-day) mortality. Mediation analysis revealed that WBC counts mediated the association with proportions (%) of 33.73, 19.65, and 30.00, respectively.</p><p><strong>Conclusion: </strong>Lower HGI is consistently related to poorer outcomes in patients with critical ischemic stroke. Higher HGI could be a protective factor in the short term but might increase mortality risk in the long term. WBC counts significantly mediate the association.</p>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":" ","pages":"112105"},"PeriodicalIF":6.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Europe is shaping the future of diabetes care","authors":"","doi":"10.1016/j.diabres.2025.112107","DOIUrl":"10.1016/j.diabres.2025.112107","url":null,"abstract":"","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112107"},"PeriodicalIF":6.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative performance of CKD-EPI equations in people with diabetes: An international pooled analysis of individual participant data","authors":"Rodney Kwok ,&nbsp;Kartik Kishore ,&nbsp;Tina Zafari ,&nbsp;Digsu N Koye ,&nbsp;Mariam Hachem ,&nbsp;Ian H de Boer ,&nbsp;Tae-Dong Jeong ,&nbsp;Won-Ki Min ,&nbsp;Esteban Porrini ,&nbsp;Petter Bjornstad ,&nbsp;Richard J MacIsaac ,&nbsp;Leonid Churilov ,&nbsp;Elif I Ekinci","doi":"10.1016/j.diabres.2025.112104","DOIUrl":"10.1016/j.diabres.2025.112104","url":null,"abstract":"<div><h3>Aim</h3><div>This study assessed the concordance and misclassification of chronic kidney disease (CKD) stages between directly measured glomerular filtration rate (mGFR) and estimates of GFR (eGFR) using the creatinine-based CKD-EPI-2009 and the CKD-EPI-2021 equations in individuals with diabetes.</div></div><div><h3>Methods</h3><div>Data from 5,177 individuals across six international diabetes cohorts included mGFR measurements using exogenous filtration markers. We calculated an intra-class correlation coefficient (ICC), bias, precision and accuracy between mGFR and CKD-EPI estimates using a four-level mixed-effect linear variance component model.</div></div><div><h3>Results</h3><div>The pooled cohort included people with type 1 (n = 1,748, median age: 33 years [IQR: 27, 40], mGFR = 104.2 ml/min per 1.73 m²) and type 2 diabetes (n = 3,429, median age: 66 years [IQR: 58, 73], mGFR = 58.4 ml/min per 1.73 m²). Both CKD-EPI equations showed good agreement (2009 ICC: 0.90; 2021 ICC: 0.87) but substantial bias (2009: 3.7 ml/min/1.73 m²; 2021: 8.6 ml/min/1.73 m²), low precision (2009: 12.4 ml/min/1.73 m²; 2021: 13.91 ml/min/1.73 m²), and limited accuracy (2009 p30: 77 %; 2021 p30: 70 %) compared to mGFR.</div></div><div><h3>Conclusion</h3><div>The use of CKD-EPI equations has the potential for misdiagnosis and suboptimal CKD management in people with diabetes. Alternative methods of estimating kidney function for people with diabetes are needed to optimally manage diabetes-related kidney disease.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"223 ","pages":"Article 112104"},"PeriodicalIF":6.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of resistance exercise training on metabolic health, body composition, and muscle strength in older adults with type 2 diabetes: A systematic review and Meta-Analysis","authors":"Mingxing Feng ,&nbsp;Luyan Gu ,&nbsp;Yan Zeng ,&nbsp;Wenjing Gao ,&nbsp;Chongyu Cai ,&nbsp;Yingqiu Chen ,&nbsp;Xiuying Guo","doi":"10.1016/j.diabres.2025.112079","DOIUrl":"10.1016/j.diabres.2025.112079","url":null,"abstract":"<div><div>This systematic review and <em>meta</em>-analysis evaluated the efficacy of Resistance Exercise Training (RET) on metabolic health, body composition, and muscle strength in older adults with type 2 diabetes (T2DM). Electronic databases were systematically searched and <em>meta</em>-analyses were conducted using random-effects models. Meta-regression analyses were also performed to explore potential sources of heterogeneity. Nineteen randomized controlled trials (RCTs) met the inclusion criteria. RET significantly improved hemoglobin A1c (MD: −0.51, P &lt; 0.0001) and fasting blood glucose (mean differences: MD: −1.43 mg/dl, P = 0.04), though insulin levels remained unchanged. Lipid profile analysis revealed significant reductions in triglycerides (MD: −0.32, P = 0.03), total cholesterol (MD: −7.08, P = 0.005), and low-density lipoprotein (MD: −1.91, P = 0.05), without significant changes in high-density lipoprotein. RET increased lean mass and reduced waist circumference but had no effect on body weight and fat mass. Muscle strength improved significantly, but there was no impact on blood pressure or heart rate. These findings suggest that RET is beneficial for enhancing glycemic control, lipid profiles, lean mass, and muscle strength in older adults with T2DM, while its effects on body weight, fat mass, and cardiovascular health remain inconclusive. Further studies are needed to explore long-term effects.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112079"},"PeriodicalIF":6.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A single blinded randomized controlled trial assessing the effect of photobiomodulation therapy on neuron specific biomarkers in type II diabetes mellitus patients with peripheral neuropathy","authors":"M. Anju ,&nbsp;Saleena Ummer Velladath ,&nbsp;G. Arun Maiya ,&nbsp;Manjunath Hande","doi":"10.1016/j.diabres.2025.112087","DOIUrl":"10.1016/j.diabres.2025.112087","url":null,"abstract":"<div><h3>Background</h3><div>Diabetic peripheral neuropathy is one of the most devastating complications of long-term diabetes mellitus, associated with functional limitations and poor quality of life.</div></div><div><h3>Materials and methods</h3><div>Two hundred subjects were randomized into intervention and control group, with one hundred in each arm. The intervention arm received photobiomodulation therapy for ten days, with Low −Level Helium-Neon Laser at a wavelength of 632.8 nm of dosage 3.1 J/cm² for 9 min on both the dorsal and plantar surfaces of the foot, while the control group received sham laser. Patients were assessed at day 0 of treatment and four weeks after treatment for all the clinical and neuropathy-specific biomarkers. Serum levels of Neuron specific enolase (NSE), Calcitonin gene related peptide (CGRP) Nerve Growth Factor (NGF) for monitoring neuronal changes and monofilament test, Biothesiometer, Numeric Pain Rating Scale (NPRS) to analyze vibration sensation, and pain score. The neuropathic quality of life was assessed using the Norfolk Quality of Life Questionnaire- Diabetic Neuropathy (Norfolk QOL-DN).</div></div><div><h3>Result</h3><div>Trial found significant changes in serum NSE (p &lt; 0.001), CGRP(p &lt; 0.001), MNSI(p &lt; 0.001), VPT(p &lt; 0.001), NPRS(p &lt; 0.001), and NQL(p &lt; 0.001) in the intervention group four weeks after receiving photobiomodulation therapy, whereas no changes in NGF levels(p = 0.937). This was in correlation with improved neuropathic pain and quality of life.</div></div><div><h3>Conclusion</h3><div>Serum levels of NSE and CGRP may be good indicators of effectiveness of photobiomodulation in reducing neuropathic pain and other symptoms in individuals with DPN. Reduced neuropathic symptoms, improved protective sensation of foot and quality of life, and reduced neuropathic pain was observed in intervention group.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112087"},"PeriodicalIF":6.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}