Diabetes research and clinical practice最新文献

{"title":"Call to action for clinicians in the South-East Asian regions on primary prevention of diabetes in people with prediabetes- A consensus statement","authors":"Ambady Ramachandran ,&nbsp;Arun Nanditha ,&nbsp;Jaakko Tuomilehto ,&nbsp;Rafael Gabriel ,&nbsp;Banshi Saboo ,&nbsp;Viswanathan Mohan ,&nbsp;Manoj Chawla ,&nbsp;Purvi Chawla ,&nbsp;Arun Raghavan ,&nbsp;Amit Gupta ,&nbsp;Shashank Joshi ,&nbsp;Sanjay Agarwal ,&nbsp;Anoop Misra ,&nbsp;Rakesh Sahay ,&nbsp;Mangesh H. Tiwaskar ,&nbsp;A.K. Azad Khan ,&nbsp;S.R. Arvind ,&nbsp;Vijay Viswanathan ,&nbsp;Ashok Kumar Das ,&nbsp;Brij Mohan Makkar ,&nbsp;Antonio Ceriello","doi":"10.1016/j.diabres.2025.111997","DOIUrl":"10.1016/j.diabres.2025.111997","url":null,"abstract":"<div><div>Primary prevention of diabetes still remains as an unmet challenge in a real world setting. While, translational programmes have been successful in the developed nations, the prevailing social and economic inequities in the low and middle income countries, fail to integrate diabetes prevention into their public health systems. The resulting exponential increase in the prevalence of diabetes and the cost of treatment has put primary prevention in the back seat. As a call to action, an expert group was formed to lay down practical guidelines for clinicians in the South East Asian regions to implement primary prevention programmes at an individual or at a community level. The guideline was developed based on the outcomes of the evidence based prevention programmes conducted in India. This decentralised self-guided approach for primary prevention of diabetes follows a three step implementation process of screening, diagnosis of intermediate hyperglycaemia and design and delivery of personalized interventions. Recommendations provided on dietary intake and physical activity can be tailored by the clinician to suit individual needs. Initiation of pharmacological treatment to achieve desired targets has also been addressed. A personalised approach by the clinician may be effective and offer a sustainable solution to curb the rising epidemic.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"221 ","pages":"Article 111997"},"PeriodicalIF":6.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between severe hypoglycemia or impaired awareness of hypoglycemia and diabetes-related health status, global cognition and executive functions in adults with type 1 diabetes without severe anxiety or depression","authors":"Eduardo Sepúlveda ,&nbsp;Rui Poínhos ,&nbsp;Gil Nata ,&nbsp;Nuno Gaspar ,&nbsp;Paula Freitas ,&nbsp;Selene G. Vicente ,&nbsp;Stephanie A. Amiel ,&nbsp;Davide Carvalho","doi":"10.1016/j.diabres.2025.112004","DOIUrl":"10.1016/j.diabres.2025.112004","url":null,"abstract":"<div><h3>Aims</h3><div>To explore the relationship between impaired awareness of hypoglycemia (IAH) or severe hypoglycemia (SH), and health status and cognition in adults with type 1 diabetes (T1D).</div></div><div><h3>Methods</h3><div>T1D adults attending a tertiary diabetes service were recruited into this cross-sectional study. People screening positive for severe anxiety or depression were not included. Hypoglycemia awareness status was assessed using the full-scale and factor 1 of the Minimally Modified Clarke Hypoglycemia Survey (MMCHS; ≥4 and ≥2 = IAH); and data collected on health status (Diabetes Health Profile: barriers to activity, BA; psychological distress, PD; disinhibited eating); global cognition (Montreal Cognitive Assessment); and executive functions (EF; INECO Frontal Screening, IFS). A score of reduced awareness in item 3 and/or 4 of the MMCHS defined experience of ≥1 SH in past 6–12 months.</div></div><div><h3>Results</h3><div>In 165 T1D adults, prevalences of SH, IAH by MMCHS full-scale and factor 1 were 35%, 13% and 28%. Participants with IAH by factor 1 had higher scores for PD (<em>p</em> = 0.008). Participants with SH and IAH (full-scale or factor 1) had higher BA scores (all <em>p</em> &lt; 0.05) but no impairment of global cognition or EF. Participant Z-score IFS was lower than in non-diabetic individuals (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>In our cohort, executive dysfunction in T1D was not associated with SH or IAH. IAH was associated with PD, and both SH and IAH were related to behavioral dysfunction.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"221 ","pages":"Article 112004"},"PeriodicalIF":6.1,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of live microbe intake on cardiovascular disease and mortality in adults with diabetes: A nationwide cohort study","authors":"Jiaqi Li,&nbsp;Jianan Ye,&nbsp;Qin Zhou,&nbsp;Keyu Guo,&nbsp;Zhiguang Zhou","doi":"10.1016/j.diabres.2024.111942","DOIUrl":"10.1016/j.diabres.2024.111942","url":null,"abstract":"<div><h3>Objective</h3><div>This study examines the association between dietary intake of live microbes (LM) and the risk of cardiovascular disease (CVD) and cardiovascular mortality in adults with diabetes.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted using National Health and Nutrition Examination Survey (NHANES) data from 2001 to 2010, with follow-up mortality data through December 31, 2019. A total of 3,955 adults with diabetes were included. Dietary LM intake was categorized as low (LLM), medium (MLM), or high (HLM). Multivariate weighted logistic regression assessed the relationship between LM intake and CVD, and weighted Cox proportional hazards models were used to evaluate cardiovascular mortality.</div></div><div><h3>Results</h3><div>Among the 3,955 participants, 1,064 had CVD. MLM consumers had a significantly lower risk of CVD (OR: 0.55; 95 % CI: 0.33, 0.92) compared to non-consumers, with no significant associations for LLM and HLM. During a median follow-up of 10.5 years, 432 cardiovascular deaths occurred. MLM intake was associated with a lower risk of cardiovascular mortality (HR: 0.65; 95 % CI: 0.49, 0.86).</div></div><div><h3>Conclusion</h3><div>Moderate consumption of dietary live microbes is associated with reduced CVD risk and cardiovascular mortality in adults with diabetes. These findings suggest potential cardiovascular benefits from including LM in the diet of diabetic patients.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"219 ","pages":"Article 111942"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in the association between insulin resistance assessed by estimated glucose disposal rate and the risk of all-cause and cardiovascular deaths in adults without diabetes","authors":"Haixu Wang ,&nbsp;Zeming Zhou ,&nbsp;Xiaoxin Liu ,&nbsp;Ying Chen","doi":"10.1016/j.diabres.2024.111966","DOIUrl":"10.1016/j.diabres.2024.111966","url":null,"abstract":"<div><h3>Aim</h3><div>We intended to examine the relationship between estimated glucose disposal rate (eGDR) and risks of all-cause and cardiovascular deaths in non-diabetic adults.</div></div><div><h3>Methods</h3><div>38,175 participants from the National Health and Nutrition Examination Survey (1999–2018) were included, and deaths were identified through the National Death Index.</div></div><div><h3>Results</h3><div>With a median follow-up of 9.8 years, we found that dose–response relationships between eGDR level and the risk of death differed between genders. In female participants, higher eGDR level was linearly correlated with lower risks of all-cause and cardiovascular deaths. In contrast, among male participants, there were L-shaped relationships between eGDR and risks of all-cause and cardiovascular deaths, with threshold points of 8.50 and 8.49 mg/kg/min, respectively. To the left of threshold points, eGDR was negatively linked with risks of all-cause (HR 0.91, 95 % CI 0.88–0.94, P &lt; 0.001) and cardiovascular deaths (HR 0.87, 95 % CI 0.82–0.93, P &lt; 0.001). After the inflection point, an increase in eGDR was not related to lower risks of all-cause and cardiovascular deaths (P &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Higher eGDR level was associated with lower risks of all-cause and cardiovascular deaths in a linear dose–response manner among non-diabetic females, while L-shaped relationships were observed among non-diabetic males.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"219 ","pages":"Article 111966"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing the acceptability of automated insulin delivery systems in youths with type 1 diabetes and their parents","authors":"Roberto Franceschi ,&nbsp;Riccardo Pertile ,&nbsp;Marco Marigliano ,&nbsp;Enza Mozzillo ,&nbsp;Claudio Maffeis ,&nbsp;Silvana Zaffani ,&nbsp;Carlotta Dusini ,&nbsp;Annalisa Antonelli ,&nbsp;Giulio Maltoni ,&nbsp;Francesca Di Candia ,&nbsp;Erika Cantarelli ,&nbsp;Nicola Minuto ,&nbsp;Marta Bassi ,&nbsp;Ivana Rabbone ,&nbsp;Silvia Savastio ,&nbsp;Stefano Passanisi ,&nbsp;Fortunato Lombardo ,&nbsp;Valentino Cherubini ,&nbsp;Maria Alessandra Saltarelli ,&nbsp;Stefano Tumini","doi":"10.1016/j.diabres.2024.111962","DOIUrl":"10.1016/j.diabres.2024.111962","url":null,"abstract":"<div><h3>Aims</h3><div>New technology has been reported as a factor driving people to choose an automatic insulin delivery system (AIDs) and to sustain its acceptance. We aimed to explore the role of continuous glucose monitoring (CGM) technology (instant scanning vs. real-time) and insulin treatment modality to determine the future acceptance of AIDs among T1D individuals.</div></div><div><h3>Methods</h3><div>239 consecutively enrolled T1D youth and their parents returned the AP questionnaire. All individuals were on CGM, using multiple daily injections (MDI) or sensor-augmented pump (SAP) therapy.</div></div><div><h3>Results</h3><div>The AP-acceptance was more than neutral, with mean overall scores of 3.91 ± 0.47 and 3.99 ± 0.43 (p = 0.07), youths and parents, respectively. Domains’ analysis revealed high scores in intention to use, usefulness, and trust in AIDs, with favorable expected judgments by others. The items with the highest overall mean scores revealed high glucose control and QoL benefits; the main hassle was the size and discomfort of wearing two devices. Multivariate analysis found that male gender and SAP therapy were associated with a higher AP-acceptance overall score (p = 0.045, 0.015, 0.0001, respectively).</div></div><div><h3>Conclusions</h3><div>Participants receiving SAP therapy demonstrated higher expectations and optimistic views about AIDs. This treatment modality can act as a trampoline to AIDs despite individuals’ glucose control and diabetes history.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"219 ","pages":"Article 111962"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balanced diets are associated with a lower risk of type 2 diabetes than plant-based diets","authors":"Bing Kang ,&nbsp;Xiaoqin Yin ,&nbsp;Deqing Chen ,&nbsp;Yandan Wang ,&nbsp;JiangYan Lv ,&nbsp;Jiyong Zhou ,&nbsp;Xiangjun Chen ,&nbsp;Xiaoxia Kou ,&nbsp;Xin Hang ,&nbsp;Qing Yang ,&nbsp;Rui Wu ,&nbsp;Xu Luo ,&nbsp;Changyu Wang ,&nbsp;Shumin Yang ,&nbsp;Qifu Li ,&nbsp;Jinbo Hu","doi":"10.1016/j.diabres.2024.111977","DOIUrl":"10.1016/j.diabres.2024.111977","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Plant-based diets benefit human health, while the deficient in some nutrients limits its application. We aimed to examine whether balanced diets could be better in reducing diabetes risk than plant-based diets.</div></div><div><h3>Methods</h3><div>In cross-sectional analysis of Environment-Inflammation-Metabolic-Diseases Study (EIMDS), we used a questionnaire to investigate the habit of balanced and plant-based diets. In the prospective analysis of UK Biobank, we used the plant-based diet index of health (hPDI) and unhealth (uPDI) to evaluate the plant-based diets, and defined the balanced diet as a daily intake of 5 categories and at least 12 types of food. After analyzing proteomic data in UK Biobank, we explored the causal relationship between signature proteins of balanced diets and incident diabetes based on summary-data-based Mendelian randomization (SMR).</div></div><div><h3>Results</h3><div>Compared to participants who had plant-based diets, those who had balanced diets showed a lower risk of diabetes in EIMDS (Odd Ratio 0.65, 95%CI 0.44–0.95). In UK Biobank, after excluding participants with unhealthy plant-based diets, participants with balanced diets still showed a lower diabetes risk than participants with plant-based diets (Hazard Ratio 0.86, 95%CI 0.77–0.95). Proteomic analysis identified 107 downregulated and 2 upregulated proteins that were associated with higher and lower risk of diabetes, respectively. In SMR analyses, the downregulated signature proteins of balanced diets (AGR2, DBI, IL17RA and SERPINH1) were causally associated with diabetes incidence.</div></div><div><h3>Conclusion</h3><div>Adhered to a balanced diet is associated with a lower risk of diabetes compared to plant-based diet, which might be attributed to signature proteins such as AGR2, DBI, IL17RA and SERPINH1.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"219 ","pages":"Article 111977"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Men with type 1 diabetes had a more than 7-fold odds of elevated depressive symptoms compared to men without diabetes","authors":"Kimberly A. Driscoll ,&nbsp;Cristy R. Geno Rasmussen ,&nbsp;Holly O’Donnell ,&nbsp;Paige Trojanowski ,&nbsp;Amy C. Alman ,&nbsp;Amena Keshawarz ,&nbsp;Janet K. Snell-Bergeon","doi":"10.1016/j.diabres.2024.111947","DOIUrl":"10.1016/j.diabres.2024.111947","url":null,"abstract":"<div><h3>Objective</h3><div>To examine: 1) differences in prevalence of elevated depressive symptoms between individuals with type 1 diabetes (T1D) and without any type of diabetes overall and by sex; and 2) associations between depressive symptoms and HbA1c, self-management behaviors, and cardiovascular health.</div><div>Research Design and Methods: Adults (n = 414) with T1D (mean age = 52 ± 9 years, mean duration = 38 ± 9 years; mean HbA1c = 7.8 ± 1.1 mg/dL or 177 mmol/L; 55 % female) and without any type of diabetes (n = 488; mean age = 51 ± 9 years; 51 % female) from the fourth study visit of CACTI, an observational study, completed questionnaires about depressive symptoms and dietary intake. Only adults with T1D completed a questionnaire about diabetes self-management. Hierarchical logistic regression models were used to examine demographic and clinical characteristics associated with depressive symptoms.</div></div><div><h3>Results</h3><div>Depressive scores were higher in people with T1D overall and in both sexes. Men with T1D had &gt;7-fold increased odds of elevated depressive symptoms compared to men without diabetes (OR 7.4, 95 % CI: 2.1–26.4), whereas there were no increased odds in women (OR 1.4, 95 % CI: 0.6–2.9, significant sex x diabetes interaction [p = 0.03]). Higher levels of depressive symptoms were associated with both lower engagement in self-management behaviors and physical activity.</div></div><div><h3>Conclusions</h3><div>Our results demonstrate that there is an urgent need to screen adults with T1D for depressive symptoms as part of routine medical care and to test interventions to minimize their impact on physical health outcomes.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"219 ","pages":"Article 111947"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing ADA and IDF diagnostic criteria for intermediate hyperglycaemia and diabetes in the SHiDS study","authors":"Yinan Zhang ,&nbsp;Shuang Liu ,&nbsp;Baige Cao ,&nbsp;Jinfang Xu ,&nbsp;Weiping Jia ,&nbsp;Congrong Wang","doi":"10.1016/j.diabres.2024.111963","DOIUrl":"10.1016/j.diabres.2024.111963","url":null,"abstract":"<div><h3>Aims</h3><div>This study aimed to assess the prevalence of IH and diabetes, as well as insulin secretion, insulin sensitivity, and related curve patterns in subjects with different glucose tolerance categories according to the diagnostic criteria established by the American Diabetes Association (ADA) and the more recently published International Diabetes Federation (IDF) guidelines.</div></div><div><h3>Methods</h3><div>We used data of 5,387 adult participants from the Shanghai High-risk Diabetic Screen (SHiDS) study. All participants underwent a five-point 75 g oral glucose tolerance test (OGTT). Glycemic states were then classified according to the ADA/IDF diagnostic criteria, while OGTT-derived indices were employed to evaluate insulin secretion and sensitivity.</div></div><div><h3>Results</h3><div>Overall, 3,729 subjects were diagnosed consistently under ADA/IDF criteria; while 941 and 717 subjects exhibited inconsistencies in the diagnostic classification for diabetes and IH, respectively. Notably, all of these individuals with discrepant diagnoses displayed β-cell dysfunction and/or insulin resistance compared to the NGT/NGT group.</div></div><div><h3>Conclusions</h3><div>The ADA criteria can identify individuals with elevated haemoglobinA1c (HbA1c) levels when the 1-hour plasma glucose (1-h PG) stay within the normal range, while the IDF criteria can identify subjects with impaired insulin sensitivity and secretion when fasting plasma glucose (FPG), 2-hour plasma glucose (2-h PG) and HbA1c values are in the normal range.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"219 ","pages":"Article 111963"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world experience of adjunct weekly semaglutide in Type 1 diabetes. Is it worth it?","authors":"Neale Cohen ,&nbsp;Asher Yeung ,&nbsp;Alicia Jenkins","doi":"10.1016/j.diabres.2024.111979","DOIUrl":"10.1016/j.diabres.2024.111979","url":null,"abstract":"","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"219 ","pages":"Article 111979"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health disparities in diabetes treatment: The challenge of G6PD deficiency","authors":"Ariel Israel ,&nbsp;Itamar Raz ,&nbsp;Ilan Green ,&nbsp;Avivit Golan-Cohen ,&nbsp;Matitiahu Berkovitch ,&nbsp;Eli Magen ,&nbsp;Shlomo Vinker ,&nbsp;Eugene Merzon","doi":"10.1016/j.diabres.2024.111965","DOIUrl":"10.1016/j.diabres.2024.111965","url":null,"abstract":"<div><h3>Aims</h3><div>To assess the impact of Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an enzymatic deficiency prevalent in individuals of African or Asian descent, on Hemoglobin A1c (HbA1c) levels, diabetes medication purchases, and the cumulative incidence of diabetes related complications.</div></div><div><h3>Methods</h3><div>A large cohort study was conducted within a national health organization, comparing 3,913 G6PD-deficient patients to a matched control group without G6PD deficiency over two decades. The main measures and outcomes were the HbA1c levels, patterns of diabetes medication purchases, and the incidence of severe diabetes-related complications.</div></div><div><h3>Results</h3><div>HbA1c levels significantly underestimated blood glucose concentrations in G6PD-deficient individuals. Individuals with diabetes and G6PD deficiency had lower rates of treatment with most diabetes medications, notably GLP-1 receptor agonists and SGLT2 inhibitors. Severe diabetes-related complications were more frequent among G6PD-deficient patients, with adjusted hazards ratios [95% confidence intervals] of 1.44 [1.16–1.81] for severe kidney insufficiency, 1.75 [1.23–2.49] for myocardial infarction, and 1.27 [1.02–1.58] for neuropathy.</div></div><div><h3>Conclusions</h3><div>This research highlights serious gaps in the management of G6PD-deficient patients with diabetes, who suffer from insufficient medication management and higher rates of complications. These findings underscore the need to account for G6PD deficiency in diabetes treatment to ensure equitable and effective healthcare for this vulnerable population.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"219 ","pages":"Article 111965"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}