{"title":"Estimated pulse wave velocity and incident chronic kidney disease: evidence from a prospective cohort and meta-analysis","authors":"Fan Zhang, Yan Bai, Liuyan Huang, Yifei Zhong","doi":"10.1016/j.diabres.2025.112472","DOIUrl":null,"url":null,"abstract":"<div><h3>Aims</h3><div>This study aims to investigate the association between estimated pulse wave velocity (ePWV) and risk of incident chronic kidney disease (CKD).</div></div><div><h3>Methods</h3><div>A total of 3,240 participants aged ≥45 years without baseline CKD were included. Additionally, a meta-analysis of 18 studies involving 209,970 participants was conducted. ePWV was calculated using age and mean arterial pressure, with participants categorized into tertiles: lower (<8.36 m/s), medium (8.36–9.91 m/s), and higher (≥9.92 m/s). Incident CKD was defined as physician-diagnosed CKD or estimated glomerular filtration rate <60 mL/min/1.73 m2 based on cystatin C.</div></div><div><h3>Results</h3><div>During a median follow-up of 9.0 years, 494 participants (15.2 %) developed CKD. After adjusting for potential confounders, compared with the lower-ePWV group, the hazard ratios for CKD were 1.26 (95 % CI, 0.96–1.66) in the medium-ePWV group and 1.53 (95 % CI, 1.07–2.17) in the higher-ePWV group. Each standard deviation increase in ePWV was associated with a 42 % higher risk (HR = 1.42; 95 % CI, 1.23–1.63). Meta-analysis confirmed this association (pooled HR = 1.58; 95 % CI, 1.36–1.83) with evidence of a nonlinear dose–response relationship.</div></div><div><h3>Conclusion</h3><div>Higher ePWV was independently associated with increased risk of incident CKD. These findings suggest that ePWV may serve as a valuable tool for early CKD risk stratification in clinical practice.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"229 ","pages":"Article 112472"},"PeriodicalIF":7.4000,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes research and clinical practice","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0168822725004863","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Aims
This study aims to investigate the association between estimated pulse wave velocity (ePWV) and risk of incident chronic kidney disease (CKD).
Methods
A total of 3,240 participants aged ≥45 years without baseline CKD were included. Additionally, a meta-analysis of 18 studies involving 209,970 participants was conducted. ePWV was calculated using age and mean arterial pressure, with participants categorized into tertiles: lower (<8.36 m/s), medium (8.36–9.91 m/s), and higher (≥9.92 m/s). Incident CKD was defined as physician-diagnosed CKD or estimated glomerular filtration rate <60 mL/min/1.73 m2 based on cystatin C.
Results
During a median follow-up of 9.0 years, 494 participants (15.2 %) developed CKD. After adjusting for potential confounders, compared with the lower-ePWV group, the hazard ratios for CKD were 1.26 (95 % CI, 0.96–1.66) in the medium-ePWV group and 1.53 (95 % CI, 1.07–2.17) in the higher-ePWV group. Each standard deviation increase in ePWV was associated with a 42 % higher risk (HR = 1.42; 95 % CI, 1.23–1.63). Meta-analysis confirmed this association (pooled HR = 1.58; 95 % CI, 1.36–1.83) with evidence of a nonlinear dose–response relationship.
Conclusion
Higher ePWV was independently associated with increased risk of incident CKD. These findings suggest that ePWV may serve as a valuable tool for early CKD risk stratification in clinical practice.
期刊介绍:
Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.