Diabetes research and clinical practice最新文献

{"title":"A single blinded randomized controlled trial assessing the effect of photobiomodulation therapy on neuron specific biomarkers in type II diabetes mellitus patients with peripheral neuropathy","authors":"M. Anju ,&nbsp;Saleena Ummer Velladath ,&nbsp;G. Arun Maiya ,&nbsp;Manjunath Hande","doi":"10.1016/j.diabres.2025.112087","DOIUrl":"10.1016/j.diabres.2025.112087","url":null,"abstract":"<div><h3>Background</h3><div>Diabetic peripheral neuropathy is one of the most devastating complications of long-term diabetes mellitus, associated with functional limitations and poor quality of life.</div></div><div><h3>Materials and methods</h3><div>Two hundred subjects were randomized into intervention and control group, with one hundred in each arm. The intervention arm received photobiomodulation therapy for ten days, with Low −Level Helium-Neon Laser at a wavelength of 632.8 nm of dosage 3.1 J/cm² for 9 min on both the dorsal and plantar surfaces of the foot, while the control group received sham laser. Patients were assessed at day 0 of treatment and four weeks after treatment for all the clinical and neuropathy-specific biomarkers. Serum levels of Neuron specific enolase (NSE), Calcitonin gene related peptide (CGRP) Nerve Growth Factor (NGF) for monitoring neuronal changes and monofilament test, Biothesiometer, Numeric Pain Rating Scale (NPRS) to analyze vibration sensation, and pain score. The neuropathic quality of life was assessed using the Norfolk Quality of Life Questionnaire- Diabetic Neuropathy (Norfolk QOL-DN).</div></div><div><h3>Result</h3><div>Trial found significant changes in serum NSE (p &lt; 0.001), CGRP(p &lt; 0.001), MNSI(p &lt; 0.001), VPT(p &lt; 0.001), NPRS(p &lt; 0.001), and NQL(p &lt; 0.001) in the intervention group four weeks after receiving photobiomodulation therapy, whereas no changes in NGF levels(p = 0.937). This was in correlation with improved neuropathic pain and quality of life.</div></div><div><h3>Conclusion</h3><div>Serum levels of NSE and CGRP may be good indicators of effectiveness of photobiomodulation in reducing neuropathic pain and other symptoms in individuals with DPN. Reduced neuropathic symptoms, improved protective sensation of foot and quality of life, and reduced neuropathic pain was observed in intervention group.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112087"},"PeriodicalIF":6.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Based on the multi-theory model perspective, what are the influencing factors of health behavior change among community-dwelling elderly patients with type 2 diabetes in China? A qualitative study","authors":"Panpan Huai ,&nbsp;Bo Zhang ,&nbsp;Linghui Zhang ,&nbsp;Yan Hou ,&nbsp;Longhua Zhang ,&nbsp;Hui Yang ,&nbsp;Jinli Guo","doi":"10.1016/j.diabres.2025.112096","DOIUrl":"10.1016/j.diabres.2025.112096","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;The high prevalence of chronic diseases in the elderly, especially type 2 diabetes, poses a major challenge to the global health system. In China, elderly patients with type 2 diabetes mainly rely on family and community for long-term management. In view of the importance of health behavior change in improving the health of patients with chronic diseases, the multi-theory model (MTM), as the fourth generation of theoretical model in the field of health behavior change, provides a new perspective for promoting patients’ behavior change in chronic disease management and has been widely used in many health fields. However, from the perspective of research methods, the application of multi-theory model in qualitative research is less, accounting for only 6 % of the total research. In terms of research objects, there is no research applied to diabetes patients. Therefore, this study adopts qualitative research methods and takes MTM theory as the guiding framework to deeply analyze the factors of health behavior change in elderly patients with type 2 diabetes in the community. This paper aims to provide a basis for the development of targeted intervention strategies, explore and optimize MTM constructs, provide a reference for future empirical research, and promote a better understanding and application of MTM.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This study used semi-structured interviews and MTM theory as the guiding framework to deeply analyze the factors of health behavior change in elderly patients with type 2 diabetes in the community. Thematic analysis and topic modeling (python machine learning) were used to analyze the interview data simultaneously. By comparing the results of thematic analysis and topic modeling, the key factors for health behavior change with community elderly patients with type 2 diabetes were identified.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;This study combined thematic analysis with machine learning and provided a comprehensive and nuanced picture of the key factors for health behavior change among older people with type 2 diabetes in the community. Thematic analysis yielded eight key factors and 19 influencing factors, and python topic modeling yielded eight key factors and eight influencing factors. By comparing the similarities and differences between the results of thematic analysis and python topic modeling, this study finally determined 9 key factors and 20 influencing factors of health behavior change in elderly patients with type 2 diabetes in the community, including The Science of Dietary Rationing and Exercise, Internal self-confidence, Convenience and accessibility of fitness facilities, etc.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;In this study, two analytical methods (thematic analysis and topic modeling) were used to analyze the interview results. Nine different key factors and 20 influencing factors were finally identified. In the future, targeted interventions can be carried o","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112096"},"PeriodicalIF":6.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of haptoglobin phenotype and levels with sight-threatening diabetic retinopathy in type 2 diabetes: A Fenofibrate Intervention and Event Lowering in diabetes (FIELD) substudy","authors":"Kwok Leung Ong ,&nbsp;Andrzej S. Januszewski ,&nbsp;Habib Francis ,&nbsp;Rachel L. O’Connell ,&nbsp;Abubakar Mangani ,&nbsp;Liping Li ,&nbsp;Peter G. Colman ,&nbsp;David R. Sullivan ,&nbsp;Russell S. Scott ,&nbsp;Alicia J. Jenkins ,&nbsp;Anthony C. Keech ,&nbsp;on behalf of the FIELD Study Investigators","doi":"10.1016/j.diabres.2025.112080","DOIUrl":"10.1016/j.diabres.2025.112080","url":null,"abstract":"<div><h3>Aims</h3><div>Haptoglobin (HP) phenotype has been reported to modulate fenofibrate benefit on coronary artery disease in type 2 diabetes. It is unknown whether HP phenotype and levels modulate fenofibrate benefit on sight-threatening diabetic retinopathy (STDR).</div></div><div><h3>Methods</h3><div>In plasma from 8,047 Australasian adults with type 2 diabetes in the FIELD trial, HP phenotype was determined, and HP levels were measured at baseline and after six-week fenofibrate run-in.</div></div><div><h3>Results</h3><div>There were 307 new first on-trial STDR events over five years. Baseline HP levels and phenotype were not related to STDR risk. Fenofibrate benefit on STDR vs. placebo (–32 % overall), was greatest in participants with the lowest baseline HP level tertile (hazard ratio [95 % CI] 0.41 [0.26–0.65], vs. 0.82 [0.56–1.21] and 0.84 [0.56–1.27] for tertiles 2 and 3 respectively, <em>P</em> for heterogeneity = 0.019). During run-in, fenofibrate reduced HP levels by 20.7 %. However, fenofibrate benefit on STDR did not differ significantly by HP phenotype or change in HP levels during run-in after adjustment for confounding factors.</div></div><div><h3>Conclusions</h3><div>Regarding STDR, fenofibrate benefit is greatest in type 2 diabetes patients with the lowest baseline HP levels, which may reflect patients more susceptible to oxidative retinal injury. All HP phenotypes benefit from fenofibrate.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112080"},"PeriodicalIF":6.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting diabetic retinopathy based on biomarkers: Classification and regression tree models","authors":"Tao Tao ,&nbsp;Kangkang Liu ,&nbsp;Liuxue Yang ,&nbsp;Ruxi Liu ,&nbsp;Yingqi Xu ,&nbsp;Yicai Xu ,&nbsp;Ying Zhang ,&nbsp;Dan Liang ,&nbsp;Yi Sun ,&nbsp;Wenbiao Hu","doi":"10.1016/j.diabres.2025.112091","DOIUrl":"10.1016/j.diabres.2025.112091","url":null,"abstract":"<div><h3>Objective</h3><div>We choose the classification and regression tree (CART) model as the analysis tool to identify clinical indicators that assess the risk factors for diabetic retinopathy (DR) and to determine the key risk factors associated with DR.</div></div><div><h3>Methods</h3><div>In this study, a total of 781 patients with diabetic mellitus(DM) were enrolled, including 395 patients with diabetic retinopathy(DR) and 386 patients without diabetic retinopathy. Univariate and multivariate logistic regression analysis were used to assess the risk factors of DR. Moreover, a machine learning approach, CART models were used to identify the high-order interactive effect of biomarkers and predict the DR.</div></div><div><h3>Results</h3><div>Out of 96 clinical test indicators, 11 were ultimately identified as the most critical. It was revealed in CART model analysis based on these 11 indicators that when urine creatinine(Ucr）≥ 127.75 mg/dl and cortisol ≥ 318.8 µg/l happened in DM patients, the prevalence of DR was 100 %, Even when UCr &lt; 127.75 mg/dl, if cortisol ≥ 226.75 µg/l, 79.6 % of DM patients still have DR. Furthermore, even if neither of these two indicators exceeded the normal range, it increased the likelihood of DR when C-reactive protein (CRP) ≥ 10.11 mg/l. It was confirmed in the subgroup analysis with the CART model that there was an increase in CRP, a decrease in The 30-minute C-peptide level (C-P1), along with elevated cortisol, urinary protein (PRO), and UCr levels in identifying risk factors for DR. It was suggested the presence of kidney function impairment and insulin resistance, which triggered an inflammatory response, and ultimately exacerbated DR development increasing DR prevalence.</div></div><div><h3>Conclusion</h3><div>Based on the CART model analysis, routine serum biochemistry markers such as UCr, cortisol, and CRP, along with their respective thresholds, have been identified as potentially useful for identifying risk factors associated with DR at different the prevalence of DR rates. These findings might provided clinicians with a useful reference for the preliminary assessment of DR severity.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112091"},"PeriodicalIF":6.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The antitumor effects of metformin are potentially mediated through LPA receptor inhibition","authors":"Koichi Sato ,&nbsp;Hideaki Ogasawara ,&nbsp;Yuichi Ikeda ,&nbsp;Hidetoshi Kumagai ,&nbsp;Ryota Inoue ,&nbsp;Takahiro Tsuno ,&nbsp;Koichi Matsunaga ,&nbsp;Emi Ishida ,&nbsp;Jun Shirakawa","doi":"10.1016/j.diabres.2025.112094","DOIUrl":"10.1016/j.diabres.2025.112094","url":null,"abstract":"<div><h3>Aims</h3><div>Although metformin has antitumor effects, the detailed mechanism of action, particularly with respect to the cellular responses mediated through G protein-coupled receptors (GPCRs), remains unclear.</div></div><div><h3>Methods and results</h3><div>Here, we assayed a panel of 200 GPCRs in cells treated with metformin and reported that signaling through several receptors, including lysophosphatidic acid (LPA) receptors, was suppressed. Metformin significantly attenuated LPA-induced intracellular Ca²⁺ mobilization in LPA receptor 1 (LPAR1)-, 2 (LPAR2)-, and 3 (LPAR3)-transfected rat hepatoma RH7777 cells. LPA treatment increased LPAR3-transfected RH7777 cell adhesion and migration. This response to LPA was attenuated by treatment with the G_q/11 inhibitor YM-254890 and metformin. In contrast, these inhibitors had minimal effects on the cell migration induced by epidermal growth factor.</div></div><div><h3>Conclusions</h3><div>These results indicate that the inhibition of LPA receptor signaling by metformin, especially the consequent suppression of LPAR3-mediated cell migration, may contribute to the antitumor effects of metformin.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112094"},"PeriodicalIF":6.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visit-to-visit lipid variability and adverse kidney events in real-world type 2 diabetes patients","authors":"Hsuan-Yu Su ,&nbsp;Yi-Hsin Chang ,&nbsp;Chen-Yi Yang ,&nbsp;Wei-Hung Lin ,&nbsp;Huang-Tz Ou","doi":"10.1016/j.diabres.2025.112093","DOIUrl":"10.1016/j.diabres.2025.112093","url":null,"abstract":"<div><h3>Aim</h3><div>To examine the association between long-term variability in low-density lipoprotein cholesterol (LDL-C) and the development of adverse kidney events among type 2 diabetes patients.</div></div><div><h3>Methods</h3><div>Kidney events of interest included sustained estimated glomerular filtration rate (eGFR) &lt; 15 mL/min/1.73 m², 30 % eGFR decline, and composite kidney events. The Cox proportional hazard model was used to assess the association between LDL-C variability and kidney events.</div></div><div><h3>Results</h3><div>A total of 15,444 patents were included (54 % male, mean age of 62.3 years, baseline HbA1c of 7.6 %, and eGFR of 84.2 mL/min/1.73 m²). The risk of kidney events increased with greater LDL-C variability across variability indices, except for that measured by coefficient of variation. Specifically, average real variability had the best predictive performance, with an optimal cut-off value of 19.26 for discriminating patients’ risk of a sustained eGFR &lt; 15 mL/min/1.73 m². A greater effect of lipid variability on kidney event risk was observed among a subset of patients aged &lt; 75 years, with eGFR ≥ 90 mL/min/1.73 m², or having fewer diabetes-related complications.</div></div><div><h3>Conclusions</h3><div>An increased risk of adverse kidney events with greater visit-to-visit variability in LDL-C highlights the clinical importance of monitoring both the single-point LDL-C and its stability over time.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112093"},"PeriodicalIF":6.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Raster Scan Optoacoustic Mesoscopy for detecting microvascular complications in diabetes mellitus: A narrative brief review","authors":"Dimitrios Pantazopoulos ,&nbsp;Evanthia Gouveri ,&nbsp;Vasilis Ntziachristos ,&nbsp;Nikolaos Papanas","doi":"10.1016/j.diabres.2025.112095","DOIUrl":"10.1016/j.diabres.2025.112095","url":null,"abstract":"<div><div>Diabetes mellitus (DM) may lead to microvascular and macrovascular complications. Screening for these complications is crucial, and so non-invasive methods with high-dissemination potential are needed. Diabetic peripheral neuropathy (DPN) is particularly challenging to screen due to the lack of reliable clinical markers and endpoints. In this context, Raster Scan Optoacoustic Mesoscopy (RSOM) emerges as a highly promising technique that offers hybrid, non-invasive imaging of optical absorption using light-induced ultrasound waves within tissue without the use of contrast agents. RSOM provides high-resolution visualisation of micro-vasculature and other tissue structures along with functional information. The technique has already assessed microvasculature loss as a function of diabetes progression and used it to characterise DPN severity. RSOM has also shown that cutaneous vessels in the mesoscopic range (mean diameters of 30–40 µm) are most prominently affected by DM and that the mean number of cutaneous vessels was lower in subjects with DM than in healthy participants (p &lt; 0.001 and p &lt; 0.05, respectively). Although experience is still limited, we present an overview of the novel technique in relation to its potential for detecting early DM onset and development of microvascular complications.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112095"},"PeriodicalIF":6.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effect of aspirin versus clopidogrel monotherapy on incident type 2 diabetes in patients with atherosclerotic cardiovascular diseases: A target trial emulation study","authors":"Chengsheng Ju ,&nbsp;Xi Xiong ,&nbsp;David T.W. Lui ,&nbsp;Vincent K.C. Yan ,&nbsp;Matthew Adesuyan ,&nbsp;Ming Xu ,&nbsp;Frederick K. Ho ,&nbsp;Carlos K.H. Wong ,&nbsp;Ian C.K. Wong ,&nbsp;Esther W.Y. Chan ,&nbsp;Li Wei","doi":"10.1016/j.diabres.2025.112082","DOIUrl":"10.1016/j.diabres.2025.112082","url":null,"abstract":"<div><h3>Aims</h3><div>To compare the effects of low-dose aspirin and clopidogrel on the risk of incident type 2 diabetes among patients with ASCVD.</div></div><div><h3>Methods</h3><div>This target trial emulation study was performed using<!--> <!-->the IQVIA Medical Research Data UK primary care database, including adults with an incident first ASCVD event who initiated low-dose aspirin or clopidogrel between 2004 and 2021. We applied an overlap weighting approach to balance treatment groups. The observational analogues of intention-to-treat and per-protocol effects were estimated using pooled logistic regression.</div></div><div><h3>Results</h3><div>A total of 111,292 ASCVD patients who initiated aspirin (n = 78,012) or clopidogrel (n = 33,280) were included. In intention-to-treat analyses, aspirin and clopidogrel had similar risks of diabetes (Hazard ratio [HR] 1.02, 95 % Confidence interval [CI] 0.96 to 1.07), cardiovascular events (1.00, 0.95 to 1.05), and bleeding events (1.02, 0.97 to 1.08). In per-protocol analyses, risks remained comparable for diabetes (1.06, 0.97 to 1.15), cardiovascular events (0.96, 0.89 to 1.03), and bleeding events (1.01, 0.92 to 1.10).</div></div><div><h3>Conclusions</h3><div>Aspirin and clopidogrel have similar risks of incident diabetes, cardiovascular events, and bleeding events among patients with ASCVD. The choice between these agents may thus be influenced more by factors like cost, patient preference, or tolerance than by clinical outcomes alone.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112082"},"PeriodicalIF":6.1,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of quality of care and long-term mortality risk for individuals presenting with ST-segment myocardial infarction (STEMI) by diabetes mellitus status: A nationwide cohort study","authors":"Andrew Cole ,&nbsp;Nicholas Weight ,&nbsp;Harindra C. Wijeysundera ,&nbsp;Muhammad Rashid ,&nbsp;Dahai Yu ,&nbsp;Emma L Healey ,&nbsp;Nicholas WS Chew ,&nbsp;Zbigniew Siudak ,&nbsp;Kamlesh Khunti ,&nbsp;Evangelos Kontopantelis ,&nbsp;Mamas A Mamas","doi":"10.1016/j.diabres.2025.112092","DOIUrl":"10.1016/j.diabres.2025.112092","url":null,"abstract":"<div><h3>Aims</h3><div>This study aimed to assess how diabetes influences the quality of care and longer-term outcomes in contemporary STEMI cohorts.</div></div><div><h3>Methods</h3><div>We analysed 283,658 adults hospitalised with STEMI from the United Kingdom Myocardial Ischaemia National Audit Project (MINAP) registry between 2005 and 2019. This was linked with Office of National Statistics data to provide out of hospital mortality outcomes. We compared longer-term outcomes depending on diabetes status and assessed the effect of quality of care using the opportunity-based quality-indicator score (OBQI).</div></div><div><h3>Results</h3><div>Individuals with diabetes were older (median age 68.7 vs. 65.5), underwent percutaneous coronary intervention less frequently (60 % vs. 63 %) and were less likely to achieve a door-to-balloon time of &lt; 60 min (69 % vs. 75 %) or &lt; 120 min (89 % vs. 92 %). Their adjusted all-cause mortality risk was higher during follow-up, from 30 days (HR: 1.49, CI: 1.44–1.54), to up to 10 years of follow up (HR: 1.54, CI: 1.52–1.57), compared to individuals without diabetes. Excellent inpatient care was associated with lower mortality rates within individuals with diabetes (Diabetes: HR 0.56, CI: 0.50–0.64, No diabetes: HR 0.62, CI: 0.58–0.67).</div></div><div><h3>Conclusions</h3><div>Individuals with diabetes have a higher risk of long-term mortality after STEMI. They experience delays in angiography and receive lower quality inpatient care.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112092"},"PeriodicalIF":6.1,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistance exercise training and its impact on metabolic syndrome in type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials","authors":"Chaoran Han ,&nbsp;Hongyu Xue ,&nbsp;Shengtao Yang ,&nbsp;Binghong Gao","doi":"10.1016/j.diabres.2025.112077","DOIUrl":"10.1016/j.diabres.2025.112077","url":null,"abstract":"<div><div>This <em>meta</em>-analysis investigated the impact of resistance exercise training (RET) on metabolic syndrome (MetS) markers in patients with type 2 diabetes mellitus (T2DM) by synthesizing evidence from randomized controlled trials (RCTs). A systematic search was conducted in four databases up to September 2024. Data were analyzed using random-effects models to calculate mean differences (MD) and 95 % confidence intervals (CI). Fifty RCTs involving 2271 participants (1186 in the intervention group, 1085 in the control group) were included. RET significantly improved key MetS markers, including reductions in fasting blood glucose (MD = −7.09 mg/dl; p &lt; 0.00001), triglyceride (MD = −14.05 mg/dl; p &lt; 0.0001), systolic (MD: −4.13 mmHg; p = 0.0004) and diastolic (MD: −2.03 mmHg; p = 0.02) blood pressure, and waist circumference (MD = −2.18 cm; p &lt; 0.00001). Additionally, RET was associated with increased high-density lipoprotein levels (MD: 1.86 mg/dl; p = 0.002). Subgroup analyses indicated consistent benefits across varing intervention durations and participant genders, underscoring the broad applicability of RET for diverse T2DM populations. These findings suggest that RET is an effective intervention for improving MetS markers in individuals with T2DM. However, limitations such as high heterogeneity and small sample sizes may affect generalizability.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112077"},"PeriodicalIF":6.1,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}