Diabetes research and clinical practice最新文献_第6页

Remission of type 2 diabetes depends on time since diagnosis and low-calorie diet composition: Results of a randomized controlled trial in individuals with overweight and obesity 2型糖尿病的缓解取决于诊断后的时间和低热量饮食组成：超重和肥胖个体的随机对照试验结果。

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-02-14 DOI: 10.1016/j.diabres.2026.113159

Bettina Schuppelius , Elena Lalama , Jiudan Zhang , Kilian Ruether , Marta Csanalosi , Stefan Kabisch , Anette Christ , Eicke Latz , Nicolle Kraenkel , Olga Pivovarova-Ramich , Knut Mai , Andreas F.H. Pfeiffer

{"title":"Remission of type 2 diabetes depends on time since diagnosis and low-calorie diet composition: Results of a randomized controlled trial in individuals with overweight and obesity","authors":"Bettina Schuppelius , Elena Lalama , Jiudan Zhang , Kilian Ruether , Marta Csanalosi , Stefan Kabisch , Anette Christ , Eicke Latz , Nicolle Kraenkel , Olga Pivovarova-Ramich , Knut Mai , Andreas F.H. Pfeiffer","doi":"10.1016/j.diabres.2026.113159","DOIUrl":"10.1016/j.diabres.2026.113159","url":null,"abstract":"<div><h3>Aims</h3><div>To investigate the impact of diabetes duration and different nutrient profiles on type 2 diabetes remission (T2DR) in response to very low-calorie diets (VLCDs).</div></div><div><h3>Methods</h3><div>Participants with a BMI > 27 kg/m<sup>2</sup> and diabetes duration of ≤ 4 years or ≥ 8 years were studied before and after a VLCD (600–800 kcal/day) for three months, including discontinuation of antidiabetic medication. Individuals were randomly assigned to one of two VLCDs with slightly different macronutrient composition.</div></div><div><h3>Results</h3><div>T2DR, defined as plasma fasting glucose < 126 mg/dl, was achieved in 34 of 47 participants (72%). Despite similar weight loss of subjects with short and long diabetes duration (−15.2 ± 5.8 kg vs. −13.9 ± 4.8 kg; p = 0.473), subjects with long diabetes duration had a 32% lower remission rate (82% vs. 50%; p = 0.027).T2DR was found to be higher with the high-fiber, high-protein, and low-carb, low-fat formula diet (91% vs. 56%; p = 0.008). Individuals that achieved T2DR had significantly lower fasting plasma glucose and higher C-peptide levels at baseline.</div></div><div><h3>Conclusions</h3><div>Fasting plasma glucose, C-peptide levels, diabetes duration, and used macronutrient profile emerged as important factors for the achievement of T2DR, although a considerable remission is still possible after long duration of type 2 diabetes.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113159"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salivary extracellular vesicles and Raman spectroscopy in precision diagnostics of type 2 diabetes 唾液细胞外囊泡和拉曼光谱在2型糖尿病精确诊断中的应用。

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1016/j.diabres.2026.113139

Ajitesh Dhal , Shao-Jung Lin , Arunima Pandey , Chih-Hsuan Liu , Hung-Yi Liu , Tarakanta Jena , Chitralekha Jena , Dharitri Rath , Pei-Wen Peng , Cheng-Jen Chang , Chang-I Chen , Li-Chern Pan , Tzu-Sen Yang

{"title":"Salivary extracellular vesicles and Raman spectroscopy in precision diagnostics of type 2 diabetes","authors":"Ajitesh Dhal , Shao-Jung Lin , Arunima Pandey , Chih-Hsuan Liu , Hung-Yi Liu , Tarakanta Jena , Chitralekha Jena , Dharitri Rath , Pei-Wen Peng , Cheng-Jen Chang , Chang-I Chen , Li-Chern Pan , Tzu-Sen Yang","doi":"10.1016/j.diabres.2026.113139","DOIUrl":"10.1016/j.diabres.2026.113139","url":null,"abstract":"<div><div>Type 2 Diabetes (T2D) remains a major global health issue, driven by sedentary lifestyles and aging populations, emphasizing the urgent need for precise diagnostics that allow early detection and personalized monitoring. Traditional blood tests, including glucose and HbA1c measurements, offer limited temporal and molecular information. In contrast, saliva provides a non-invasive, easily accessible biofluid that reflects systemic metabolic changes. Its molecular components, especially extracellular vesicles (EVs), such as exosomes and microvesicles, contain proteins, lipids, and microRNAs directly associated with insulin resistance, β-cell dysfunction, and inflammation in T2D. Advances in Raman spectroscopy and surface-enhanced Raman scattering (SERS) now enable high-sensitivity, label-free molecular fingerprinting of salivary EVs, supporting multiplex detection of disease-related biomarkers. Combining Raman-based sensing with EV profiling introduces an innovative approach for non-invasive, precision diabetes diagnostics. This review explores the diagnostic importance of salivary EVs, recent developments in Raman/SERS-based biomolecular detection, and the clinical potential of integrating these technologies for early screening and therapy monitoring. Moreover, incorporating artificial intelligence (AI) for spectral analysis and developing portable Raman devices could facilitate real-time, saliva-based metabolic monitoring, advancing personalized, preventive, and patient-focused diabetes care.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113139"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GLP-1 RA initiation versus metformin and risk of cardiomyopathy in patients with cancer and diabetes treated with chemotherapy, radiation, or immunotherapy: a target trial emulation 在接受化疗、放疗或免疫治疗的癌症和糖尿病患者中，GLP-1 RA起始与二甲双胍和心肌病风险：一项目标试验模拟

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-01-26 DOI: 10.1016/j.diabres.2026.113119

Jesús Gibran Hernández-Pérez , Omer Abdelgadir , Maryam R. Hussain , Jaime P. Almandoz , Carlos H. Barcenas , Amil Shah , Lindsay G. Cowell , Sarah E. Messiah , David S. Lopez

{"title":"GLP-1 RA initiation versus metformin and risk of cardiomyopathy in patients with cancer and diabetes treated with chemotherapy, radiation, or immunotherapy: a target trial emulation","authors":"Jesús Gibran Hernández-Pérez , Omer Abdelgadir , Maryam R. Hussain , Jaime P. Almandoz , Carlos H. Barcenas , Amil Shah , Lindsay G. Cowell , Sarah E. Messiah , David S. Lopez","doi":"10.1016/j.diabres.2026.113119","DOIUrl":"10.1016/j.diabres.2026.113119","url":null,"abstract":"<div><h3>Aims</h3><div>Glucagon-like peptide-1 receptor agonists (GLP-1 RA) have demonstrated cardioprotective effects; however, their association with cardiomyopathy remains unclear among patients with cancer and type 2 diabetes mellitus (T2D) treated with chemotherapy, radiation, or immunotherapy. We evaluated whether GLP-1 RA initiation reduces cardiomyopathy risk compared with metformin.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study using a target trial emulation framework within a large global electronic health record database. Adults aged 18–75 years with cancer and T2D, and prior exposure to chemotherapy, radiation, or immunotherapy were included. Treatment strategies were initiation of GLP-1 RA or metformin between January 2006 and July 2024. The primary outcome was incident cardiomyopathy. A 1:1 propensity score–matched cohort was created, and risk differences (RD) and hazard ratios (HR) were estimated.</div></div><div><h3>Results</h3><div>Among 10,382 matched patients, cardiomyopathy risk at 18.5 years was lower among GLP-1 RA initiators than metformin initiators (0.31% vs 0.94%; RD − 0.64%, 95% CI − 0.90 to − 0.30; HR 0.43, 95% CI 0.24–0.76). Results were consistent across high-risk subgroups.</div></div><div><h3>Conclusions</h3><div>GLP-1 RA initiation was associated with a lower risk of cardiomyopathy compared with metformin among patients with cancer and T2D, supporting a potential role for GLP-1 RA in cardio-oncology prevention strategies.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113119"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RenoTrue: A diabetes-specific machine learning model to estimate glomerular filtration rate for people with diabetes RenoTrue：一个糖尿病特异性机器学习模型，用于估计糖尿病患者的肾小球滤过率。

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-02-02 DOI: 10.1016/j.diabres.2026.113137

Rodney Kwok , Kartik Kishore , Tina Zafari , Digsu N. Koye , Mariam Hachem , Ian H. de Boer , Tae-Dong Jeong , Won-Ki Min , Esteban Porrini , Petter Bjornstad , Yih Chung Tham , Richard J. MacIsaac , Leonid Churilov , Elif I. Ekinci

{"title":"RenoTrue: A diabetes-specific machine learning model to estimate glomerular filtration rate for people with diabetes","authors":"Rodney Kwok , Kartik Kishore , Tina Zafari , Digsu N. Koye , Mariam Hachem , Ian H. de Boer , Tae-Dong Jeong , Won-Ki Min , Esteban Porrini , Petter Bjornstad , Yih Chung Tham , Richard J. MacIsaac , Leonid Churilov , Elif I. Ekinci","doi":"10.1016/j.diabres.2026.113137","DOIUrl":"10.1016/j.diabres.2026.113137","url":null,"abstract":"<div><h3>Background</h3><div>Existing methods for estimating GFR in people with diabetes have shown inaccuracies when compared to mGFR measurements. We developed and validated an artificial neural network – RenoTrue to improve estimating GFR in people with diabetes.</div></div><div><h3>Methods</h3><div>5,619 individuals from five international cohorts with type 1 and type 2 diabetes was split into training (70%), validation (10%) and test (20%) datasets. RenoTrue was developed to estimate GFR using age, sex, and serum creatinine. The performance was evaluated in the test dataset by estimating agreement, bias (mean difference), and accuracy (p30), and compared to CKD-EPI estimates through a multi-level mixed effect regression model.</div></div><div><h3>Findings</h3><div>Median mGFR was 75 ml/ min per 1.73 m<sup>2</sup> [IQR: 49, 100] and median age was 59 years [IQR: 38, 69]. RenoTrue demonstrated high agreement (ICC: 0.87 (95% CI: 0.78, 0.93)), low bias (−0.57 (95% CI: -1.59, 0.46) ml/min per 1.73 m<sup>2</sup>) and p30 of 81% (95% CI: 79%, 83%) compared to mGFR measurements. The 2009 CKD-EPI equation had an ICC of 0.86 (95% CI: 0.77, 0.92), bias of 4.17 (95% CI: 3.14, 5.20) ml/min per 1.73 m<sup>2</sup> and p30 of 74% (95% CI: 72%, 77%).</div></div><div><h3>Conclusion</h3><div>For people with diabetes, RenoTrue demonstrated better performance compared to the 2009 CKD-EPI equation in terms of estimating GFR across the full range of GFR.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113137"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “The effect of preprandial versus postprandial physical activity on glycaemia: Meta-analysis of human intervention studies”. [Diabetes Res. Clin. Pract. 210 (2024) 111638] “餐前和餐后体育活动对血糖的影响：人类干预研究的荟萃分析”的更正。糖尿病研究中心。实践。210(2024)111638]。

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-02-12 DOI: 10.1016/j.diabres.2026.113143

Romy Slebe , Eva Wenker , Linda J. Schoonmade , Emma J. Bouman , Denis P. Blondin , David J.T. Campbell , André C. Carpentier , Joris Hoeks , Parminder Raina , Patrick Schrauwen , Mireille J. Serlie , Dirk Jan Stenvers , Renée de Mutsert , Joline W.J. Beulens , Femke Rutters

引用次数: 0

The impact of GLP-1 and incretin-based therapies on counterregulatory responses to hypoglycemia in diabetes mellitus: mechanisms and clinical implications GLP-1和以肠促胰岛素为基础的治疗对糖尿病低血糖的反调节反应的影响：机制和临床意义

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-02-13 DOI: 10.1016/j.diabres.2026.113155

Pitchai Balakumar , Noohu Abdulla Khan , Vigneshwaran Easwaran , Khalid M. Orayj

{"title":"The impact of GLP-1 and incretin-based therapies on counterregulatory responses to hypoglycemia in diabetes mellitus: mechanisms and clinical implications","authors":"Pitchai Balakumar , Noohu Abdulla Khan , Vigneshwaran Easwaran , Khalid M. Orayj","doi":"10.1016/j.diabres.2026.113155","DOIUrl":"10.1016/j.diabres.2026.113155","url":null,"abstract":"<div><div>Hypoglycemia unawareness is characterized by a reduction in autonomic and neuroglycopenic signals of hypoglycemia; therefore, it is hardly perceivable. Glucagon-like peptide-1 (GLP-1) plays a critical role in glucose metabolism. Experimental model of recurrent hypoglycemia in type 1 diabetes mellitus suggests that increased intestinal GLP-1 expression is associated with impaired counterregulatory responses. However, whether incretin-based drugs or elevated intestinal GLP-1 produce similar impairments, in patients with type 1 and 2 diabetes mellitus and preexisting hypoglycemia-associated autonomic failure, remain incompletely understood. Clinical applications of incretin-based therapies might require caution, especially in sensitive patients, because of GLP-1-mediated disruption of hypoglycemic counterregulation. The impaired counterregulatory response to hypoglycemia could be because of GLP-1’s actions, such as glucagon suppression, reduced sympathoadrenal signaling, modulatory effects on brain signaling during hypoglycemia, delayed gastric emptying, and among others. These factors might collectively contribute to abrogation of counterregulatory mechanisms to hypoglycemia, particularly when GLP-1 is overactive. This impairment should be carefully considered when managing patients with diabetes, especially hypoglycemic-sensitive individuals utilizing incretin-based medications chronically or when these medications are combined with insulin or sulfonylureas. This review brings together the complex role of GLP-1 in disrupting hypoglycemia counterregulation, the related mechanistic insights, and new therapeutic accountabilities pertaining to incretin-based medications.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113155"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distal symmetrical polyneuropathy in prediabetes is associated with abdominal obesity and insulin resistance 糖尿病前期远端对称性多神经病变与腹部肥胖和胰岛素抵抗有关。

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-02-04 DOI: 10.1016/j.diabres.2026.113140

Georgia Anastasiou , Nikolaos Papanas , Fotios Barkas , Nicholas Tentolouris , Georgios Liamis , Lampros K. Michalis , Aris Bechlioulis , Rigas Kalaitzidis , Evangelos Liberopoulos

{"title":"Distal symmetrical polyneuropathy in prediabetes is associated with abdominal obesity and insulin resistance","authors":"Georgia Anastasiou , Nikolaos Papanas , Fotios Barkas , Nicholas Tentolouris , Georgios Liamis , Lampros K. Michalis , Aris Bechlioulis , Rigas Kalaitzidis , Evangelos Liberopoulos","doi":"10.1016/j.diabres.2026.113140","DOIUrl":"10.1016/j.diabres.2026.113140","url":null,"abstract":"<div><h3>Aims</h3><div>To investigate the prevalence and clinical characteristics of distal symmetrical polyneuropathy (DSPN) in prediabetes and associations with cardiometabolic risk factors, insulin resistance and arterial stiffness.</div></div><div><h3>Methods</h3><div>Consecutive adults with prediabetes attending the Outpatient Lipid and Obesity Clinic at the University Hospital of Ioannina, Greece were recruited. This is a cross sectional- analysis of the baseline characteristics of a prospective observational study. DSPN was diagnosed using the neuropathy symptom score (NSS), the neuropathy disability score (NDS) and the vibration perception threshold (VTP). Arterial stiffness was assessed with carotid-femoral pulse wave velocity (PWV).</div></div><div><h3>Results</h3><div>We studied 160 consecutive adults with prediabetes, of whom 27 (16.9%) were diagnosed with DSPN. In multivariate analysis, waist circumference (OR: 1.092, 95% CI: 1.037–1.148, p < 0.001) and HOMA-IR (OR: 1.247, 95% CI: 1.095–1.425, p = 0.004) were independently associated with prevalent DSPN. Additionally, sensitivity analysis showed that current/previous smoking vs never-smoking (OR: 1.347, 95% CI: 1.116–1.891, p = 0.042) and height (OR: 1.083, 95% CI: 1.004–1.168, p = 0.039) were independently linked with prevalent DSPN. Subjects with DSPN had significantly higher median PWV (8.8 vs 8.0 m/s, p = 0.031) and prevalence of abnormal PWV (≥10 m/s) (29.6% vs 11.3%, p = 0.029) compared with no DSPN. PWV was independently associated with VPT (beta: 1.010, 95% CI:0.123–1.897, p = 0.026).</div></div><div><h3>Conclusions</h3><div>The prevalence of DSPN in prediabetes is not negligible in our study. DSPN is independently associated with central obesity and insulin resistance.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113140"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between the C-reactive protein-triglyceride-glucose index and all-cause and cardiovascular mortality in patients with diabetic foot: A retrospective cohort study c反应蛋白-甘油三酯-葡萄糖指数与糖尿病足患者全因死亡率和心血管死亡率之间的关系：一项回顾性队列研究

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-01-28 DOI: 10.1016/j.diabres.2026.113122

Xuecan Cui , Liran Zheng , Min Ding , Bai Chang , Chunmei Zhang , Hairong Ma , Wenyan Xu , Shuai Wang , Meijun Wang

{"title":"The association between the C-reactive protein-triglyceride-glucose index and all-cause and cardiovascular mortality in patients with diabetic foot: A retrospective cohort study","authors":"Xuecan Cui , Liran Zheng , Min Ding , Bai Chang , Chunmei Zhang , Hairong Ma , Wenyan Xu , Shuai Wang , Meijun Wang","doi":"10.1016/j.diabres.2026.113122","DOIUrl":"10.1016/j.diabres.2026.113122","url":null,"abstract":"<div><h3>Aims</h3><div>The C-reactive protein-triglyceride-glucose index (CTI) is a novel biomarker of insulin resistance and inflammation. This study aimed to investigate the association between baseline CTI and all-cause and cardiovascular (CVD) mortality in patients with diabetic foot (DF), providing a scientific basis for clarifying this relationship in clinical practice.</div></div><div><h3>Methods</h3><div>A total of 827 inpatients meeting inclusion criteria were enrolled from a tertiary hospital DF department in Tianjin (2020–2021), with median follow-up of 47 months. Outcomes included all-cause and CVD mortality. Multivariable Cox regression, restricted cubic splines (RCS), Kaplan–Meier analysis, and ROC curves were used to evaluate associations and predictive performance.</div></div><div><h3>Results</h3><div>During follow-up, 325 all-cause deaths occurred, including 158 CVD deaths. Fully adjusted models showed that high CTI was associated with 57% higher all-cause mortality (HR = 1.57, 95% CI:1.24–2.00) and 50% higher CVD mortality (HR = 1.50, 95% CI:1.06–2.11). RCS indicated nonlinear associations (P < 0.05), and ROC supported CTI’s predictive accuracy for mortality.</div></div><div><h3>Conclusions</h3><div>A higher CTI level was independently associated with an increased risk of all-cause and cardiovascular mortality in patients with diabetic foot. The CTI may serve as a promising and easily accessible risk stratification tool, though its clinical utility requires validation in prospective studies.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113122"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel disposition index without insulin is an earlier and sensitive predictor of type 2 diabetes than current diagnostic criteria 一种新的不使用胰岛素的性格指数比目前的诊断标准更早敏感。

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.diabres.2026.113131

Soree Ryang , Jinmi Kim , Minsoo Kim , Myungsoo Im , Doohwa Kim , Yeong Jin Kim , Hyuk Kang , Young Jin Kim , In Joo Kim , Stephane T. Chung , Michael Bergman , Arthur Sherman , Sang Soo Kim , Joon Ha

{"title":"A novel disposition index without insulin is an earlier and sensitive predictor of type 2 diabetes than current diagnostic criteria","authors":"Soree Ryang , Jinmi Kim , Minsoo Kim , Myungsoo Im , Doohwa Kim , Yeong Jin Kim , Hyuk Kang , Young Jin Kim , In Joo Kim , Stephane T. Chung , Michael Bergman , Arthur Sherman , Sang Soo Kim , Joon Ha","doi":"10.1016/j.diabres.2026.113131","DOIUrl":"10.1016/j.diabres.2026.113131","url":null,"abstract":"<div><div>Aims: Early identification of individuals at risk for type 2 diabetes (T2D) is essential for prevention. We evaluated a novel model-derived disposition index without insulin (mDI-woI), which requires only glucose values from a three time-point oral glucose tolerance test (OGTT: 0, 60, 120 min).</div><div>Methods: Among 5,742 healthy Koreans (age 51.2 ± 8.6 years, BMI 24.5 ± 3.1 kg/m<sup>2</sup>) followed biennially for up to 14 years with repeated OGTTs, we compared baseline mDI-woI with current diabetes biomarkers and the oral disposition index (oDI) using AUC-ROC analyses.</div><div>Results: mDI-woI and mean OGTT glucose (mean G) showed the strongest prediction for incident T2D (AUC = 0.79 each), outperforming fasting plasma glucose (0.67), 1 h-PG (0.77), 2 h-PG (0.72), HbA1c (0.71), and oDI (0.68; all P < 0.001). In individuals who progressed to T2D, baseline mDI-woI, mean G, and 1-PG exceeded their thresholds while fasting and 2 h glucose were still below prediabetes cutoffs, indicating earlier risk detection. Moreover, the novel marker mDI-woI is the earliest one, 4 years earlier than mean G and 4.5 years earlier than 1 h-PG, the next two earliest.</div><div>Conclusions: Using only three glucose measurements without measuring insulin, mDI-woI provides a simple, sensitive, and clinically practical early marker that outperforms current diabetes criteria for predicting T2D progression, with strong potential for large-scale studies.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113131"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146096989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal study of arterial stiffness in pediatric patients with Type 1 Diabetes Mellitus (T1DM). Correlations with glycemic metrics derived from Continuous Glucose Monitoring (CGM) devices 1型糖尿病（T1DM）患儿动脉硬化的纵向研究从连续血糖监测（CGM）设备得出的血糖指标的相关性。

IF 7.4 3区医学

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.diabres.2026.113132

Eirini Georeli , Georgia Sotiriou , Athanasia Chainoglou , Assimina Galli-Tsinopoulou , Stella Stabouli , Athanasios Christoforidis

{"title":"Longitudinal study of arterial stiffness in pediatric patients with Type 1 Diabetes Mellitus (T1DM). Correlations with glycemic metrics derived from Continuous Glucose Monitoring (CGM) devices","authors":"Eirini Georeli , Georgia Sotiriou , Athanasia Chainoglou , Assimina Galli-Tsinopoulou , Stella Stabouli , Athanasios Christoforidis","doi":"10.1016/j.diabres.2026.113132","DOIUrl":"10.1016/j.diabres.2026.113132","url":null,"abstract":"<div><h3>Aim</h3><div>To longitudinally investigate early indicators of cardiovascular disease (CVD) in youths with Type 1 Diabetes Mellitus (T1DM) and their associations with novel metrics derived from continuous glucose monitoring (CGM) systems.</div></div><div><h3>Patients and methods</h3><div>Eighty-seven patients (mean age: 10.72 ± 3.35 years), completed 3 visits at six-to-twelve-month intervals. In each visit, Pulse Wave Velocity (PWV) and Augmentation Index @75 (AIx@75) were quantified using a validated, non-invasive method, while glycemic parameters such as HbA1c, time in range (TIR), time above range (TAR) and time below range (TBR) were assessed in the trimester prior to the assessment. Patients were categorized according to TIR into TIR improvers: patients with constantly TIR ≥ 70% or constantly TIR ≥ 60% and improved by +≥10% from baseline versus TIR non-improvers and additionally according to HbA1c into HbA1c improvers: patients with constantly HbA1c ≤ 7% or constantly HbA1c ≤ 8% and improved by −≥0.8% from baseline versus HbA1c non-improvers.</div></div><div><h3>Results</h3><div>TIR improvers showed significant improvement in Δ PWV Z-score according to age and in Δ Systolic Blood Pressure index. No significant difference was observed between HbA1c improvers and non-improvers.</div></div><div><h3>Conclusion</h3><div>New glycemic metrics seem to serve as more sensitive and early predictors of CVD in young patients with T1DM. Further studies are needed to replicate and confirm these preliminary results.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"233 ","pages":"Article 113132"},"PeriodicalIF":7.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0