Diabetes research and clinical practice最新文献_第7页

Association of Novel Clinical and Behavioural Markers with HbA1c Improvement: A Latent Class Analysis of 912 Patients with Type 2 Diabetes Mellitus 新型临床和行为标志物与HbA1c改善的关联：对912例2型糖尿病患者的潜在分类分析

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-01-01 DOI: 10.1016/j.diabres.2024.111971

Yu Gan , Yu Heng Kwan , Jowy Yi Hoong Seah , Lian Leng Low

{"title":"Association of Novel Clinical and Behavioural Markers with HbA1c Improvement: A Latent Class Analysis of 912 Patients with Type 2 Diabetes Mellitus","authors":"Yu Gan , Yu Heng Kwan , Jowy Yi Hoong Seah , Lian Leng Low","doi":"10.1016/j.diabres.2024.111971","DOIUrl":"10.1016/j.diabres.2024.111971","url":null,"abstract":"<div><h3>Objective</h3><div>The escalating prevalence of Type 2 Diabetes Mellitus (T2DM) overwhelms healthcare systems. Lifestyle interventions enhancing patient monitoring and adherence vary in efficacy, emphasizing the need to understand differential response across patient subgroups. This study aimed to segment patients with T2DM into distinct latent classes and identify characteristics associated with optimal 12-month glycated haemoglobin (HbA1c) reduction.</div></div><div><h3>Methods</h3><div>We prospectively recruited 1000 patients with T2DM from government-funded outpatient clinics in Singapore, aged ≥ 40-year-old with HbA1c ≥ 7.0 %. Exclusion criteria included insulin treatment and cognitive impairment. Latent class analysis was applied to 912 patients, using mHealth interventions, age, education, living arrangement, baseline HbA1c, step count, and motivation (Patient Activation Measure) as indicators. 12-Month HbA1c reduction was assessed with one-way ANOVA and pairwise T-test.</div></div><div><h3>Results</h3><div>Within cohort, younger patients with higher education, physical activity, and baseline HbA1c exhibited the greatest HbA1c improvement (1.14 ± 1.79 %). Younger patients with lower education, despite high baseline HbA1c, exhibited a moderately lower HbA1c improvement (0.52 ± 1.41 %).</div></div><div><h3>Conclusion</h3><div>Individuals with higher baseline HbA1c, education, motivation, and activity levels experienced the most significant HbA1c reductions in response to lifestyle interventions. A tailored approach to these modifiable characteristics may help patients achieve substantial 12-month HbA1c reductions.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"219 ","pages":"Article 111971"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between glycemic variability and the incidence of postoperative atrial fibrillation following cardiac Surgery: A retrospective study from MIMIC-IV database 心脏手术后血糖变异性与房颤发生率的关系：来自MIMIC-IV数据库的回顾性研究。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-01-01 DOI: 10.1016/j.diabres.2024.111978

Zeming Zhou , Haorui Zhang , Yuanrui Gu , Ke Zhang , Chenxi Ouyang

{"title":"Relationship between glycemic variability and the incidence of postoperative atrial fibrillation following cardiac Surgery: A retrospective study from MIMIC-IV database","authors":"Zeming Zhou , Haorui Zhang , Yuanrui Gu , Ke Zhang , Chenxi Ouyang","doi":"10.1016/j.diabres.2024.111978","DOIUrl":"10.1016/j.diabres.2024.111978","url":null,"abstract":"<div><h3>Aims</h3><div>This study aimed to explore the association between glycemic variability (GV) and postoperative atrial fibrillation (POAF) incidence.</div></div><div><h3>Methods</h3><div>In this retrospective study, we included patients undergoing cardiac surgeries. GV was calculated as the coefficient of variation of blood glucose and categorized into tertiles based on its distribution. The primary endpoint was the incidence of POAF. Logistic regression and restricted cubic splines were used to assess the relationship between GV and POAF.</div></div><div><h3>Results</h3><div>5365 patients were included, with a median age of 68.3 years, and 25.5 % were female. 1056 (19.7 %) patients developed new-onset POAF. Compared with the low GV group, moderate GV group (odds ratio [OR], 1.82; 95 % confidence interval [CI]: 1.49–2.22) and high GV group (OR, 2.25; 95 % CI, 1.80–2.82) were significantly associated with a higher incidence of POAF. The area under the receiver operating characteristic curve of GV in predicting POAF incidence was 0.77 (95 % CI: 0.76–0.79). There is a threshold-based nonlinear relationship between GV and the incidence of POAF: when GV was < 24 %, the likelihood of POAF increases with higher GV, whereas when GV ≥ 24 %, further increases did not significantly affect the risk of POAF.</div></div><div><h3>Conclusions</h3><div>Increased GV is associated with higher incidence of POAF.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"219 ","pages":"Article 111978"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High one-hour plasma glucose is an intermediate risk state and an early predictor of type 2 diabetes in a longitudinal Korean cohort 在一项纵向韩国队列研究中，高1小时血糖是2型糖尿病的中间危险状态和早期预测因子。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-01-01 DOI: 10.1016/j.diabres.2024.111938

Myungsoo Im , Jinmi Kim , Soree Ryang , Doohwa Kim , Wook Yi , Jeong Mi Kim , Minsoo Kim , Yeong Jin Kim , Young Jin Kim , Hyuk Kang , In Joo Kim , Ram Jagannathan , Stephanie T. Chung , Michael Bergman , Arthur S. Sherman , Sang Soo Kim , Joon Ha

{"title":"High one-hour plasma glucose is an intermediate risk state and an early predictor of type 2 diabetes in a longitudinal Korean cohort","authors":"Myungsoo Im , Jinmi Kim , Soree Ryang , Doohwa Kim , Wook Yi , Jeong Mi Kim , Minsoo Kim , Yeong Jin Kim , Young Jin Kim , Hyuk Kang , In Joo Kim , Ram Jagannathan , Stephanie T. Chung , Michael Bergman , Arthur S. Sherman , Sang Soo Kim , Joon Ha","doi":"10.1016/j.diabres.2024.111938","DOIUrl":"10.1016/j.diabres.2024.111938","url":null,"abstract":"<div><h3>Aims</h3><div>Because one-hour post-load plasma glucose (1h-PG) ≥ 155 mg/dL (8.6 mmol/L) has been proposed as an early marker for future diabetes but lacks sufficient longitudinal confirmation of its risk, we aimed to evaluate the risk of T2D based on 1h-PG and track changes of insulin sensitivity and β-cell function over time by 1h-PG in a longitudinal cohort.</div></div><div><h3>Methods</h3><div>OGTTs were conducted every 2 years in the 10-year longitudinal Korean Genome Epidemiology study (n = 6144) with three groups characterized at baseline: Low 1h-PG (< 155 mg/dL) with Normal Glucose Tolerance (NGT), High 1h-PG (≥155 mg/dL) with NGT, and prediabetes (PreDM).</div></div><div><h3>Results</h3><div>T2D risk was higher in people with High 1h-PG with NGT and PreDM than those with Low 1h-PG with NGT. Baseline insulin sensitivity in Low 1h-PG as measured by the insulin sensitivity and secretion (ISS) model and Matsuda insulin sensitivity index (ISI) was higher than in High 1h-PG, which was comparable to PreDM. β-cell function as assessed by ISS and the insulinogenic index decreased from Low 1h-PG to High 1h-PG to PreDM. Over time, insulin sensitivity decreased in the three groups. Time from High 1h-PG to T2D was 0.9 years shorter than from Low 1h-PG. All participants passed the 1h-PG threshold for T2D (209 mg/dL, 11.6 mmol/L) first, and 74 % passed the 1h-PG threshold for impaired glucose tolerance (IGT; 155 mg/dL) first.</div></div><div><h3>Conclusions</h3><div>High 1h-PG NGT is an intermediate risk category between Low 1h-PG NGT and PreDM and may provide an opportunity for early intervention to prese rve ß-cell function.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"219 ","pages":"Article 111938"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance of a safety protocol for scuba diving in people with type 1 diabetes: 20 years of “Diabete Sommerso®” experience 1型糖尿病患者水肺潜水安全方案的性能：20 年“Diabete Sommerso®”经验。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-01-01 DOI: 10.1016/j.diabres.2024.111945

Elena Gamarra , Pierpaolo Trimboli , Giovanni Careddu , Andrea Fazi , Valentina Turra , Ambra Morelli , Elena Cimino , Paolo Di Bartolo , Umberto Valentini , Matteo Bonomo

{"title":"Performance of a safety protocol for scuba diving in people with type 1 diabetes: 20 years of “Diabete Sommerso®” experience","authors":"Elena Gamarra , Pierpaolo Trimboli , Giovanni Careddu , Andrea Fazi , Valentina Turra , Ambra Morelli , Elena Cimino , Paolo Di Bartolo , Umberto Valentini , Matteo Bonomo","doi":"10.1016/j.diabres.2024.111945","DOIUrl":"10.1016/j.diabres.2024.111945","url":null,"abstract":"<div><h3>Background and aims</h3><div>Scuba diving for people with diabetes was discouraged due to hypoglycemia risks. However, evolving guidelines now enable safe diving for people with diabetes. Among them, the Diabete Sommerso® safety protocol. This study aims to describe data from 20 years of DS activities and evaluate the performance of the protocol in avoiding metabolic complications.</div></div><div><h3>Research design and methods</h3><div>During DS camps, participants are trained to monitor glycemia before and immediately after diving, aiming for stable levels between 150–250 mg/dl. Since 2004, glycemic data from dives conducted with DS/independently by its members have been collected.</div></div><div><h3>Results</h3><div>DS issued diving licenses to 74 type 1 diabetic people. Data are available for 68: median age was 32 years (IQR 22 yrs), diabetes duration 18 years (IQR 16 yrs), HbA1c 7 % (IQR 1 %). 34 used insulin pumps, 43 continuous glucose monitoring. A total of 1179 dives were analyzed, showing a median reduction in glycemia of −38 mg/dl during dives (IQR 92 mg/dl, p < 0.0001). Post-dive hypoglycemia occurred in 23 cases, 45 % of which involved protocol non-adherence. Hypoglycemia prevalence was 1.7 % when the protocol was followed. No severe hypoglycemic episodes occoured during/after diving.</div></div><div><h3>Conclusions</h3><div>Data from 1179 dives indicate that, with adherence to the safety protocol, scuba diving is safe and poses no risk of severe hypoglycemia for people with type 1 diabetes.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"219 ","pages":"Article 111945"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The journey of MASLD: Tracking resolution, relapse, and predictive factors after sleeve gastrectomy and one-anastomosis gastric bypass, a propensity score-matched cohort study 一项倾向评分匹配的队列研究：套筒胃切除术和单口胃旁路术后MASLD的消退、复发和预测因素。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-01-01 DOI: 10.1016/j.diabres.2024.111969

Sara Sadeghi , Farhad Hosseinpanah , Alireza Khalaj , Maryam Mahdavi , Majid Valizadeh , Hamidreza Taheri , Maryam Barzin

{"title":"The journey of MASLD: Tracking resolution, relapse, and predictive factors after sleeve gastrectomy and one-anastomosis gastric bypass, a propensity score-matched cohort study","authors":"Sara Sadeghi , Farhad Hosseinpanah , Alireza Khalaj , Maryam Mahdavi , Majid Valizadeh , Hamidreza Taheri , Maryam Barzin","doi":"10.1016/j.diabres.2024.111969","DOIUrl":"10.1016/j.diabres.2024.111969","url":null,"abstract":"<div><h3>Aims</h3><div>To assess the rates and predictors of resolution and relapse of metabolic-dysfunction associated steatotic liver disease (MASLD) in individuals undergoing sleeve gastrectomy (SG) or one-anastomosis gastric bypass (OAGB).</div></div><div><h3>Methods</h3><div>This observational prospective cohort study involved 1618 propensity score-matched participants (81.5% female) with concurrent MASLD and obesity who underwent SG or OAGB between 2013 and 2023.</div></div><div><h3>Results</h3><div>In the context of a maximum follow-up of four years with a median follow-up of 2.2 years (IQR: 1.0–3.3), the overall rates of MASLD resolution and relapse were 71.1 per 1000 person-month and 8.7 per 1000 person-month, respectively. These rates were comparable between the SG and OAGB groups. Significant resolution predictors were a lower percentage of hepatic steatosis, a higher percentage of 12-month excess weight loss (EWL%), and younger age. In contrast, an increased percentage of liver steatosis, a higher pre-operative (Pre-Op) fat mass percentage (FM%), and older age were significant predictors of relapse.</div></div><div><h3>Conclusion</h3><div>This study found no significant differences in MASLD resolution and relapse rates between SG and OAGB. Key factors influencing MASLD outcomes included the percentage of hepatic steatosis, 12-month EWL%, Pre-Op FM%, and age.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"219 ","pages":"Article 111969"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring insulin resistance and pancreatic function in individuals with overweight and obesity: Insights from OGTTs and IRTs 研究超重和肥胖个体的胰岛素抵抗和胰腺功能：来自ogtt和irt的见解。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-01-01 DOI: 10.1016/j.diabres.2024.111972

Xiaoxuan Liu , Huimin Zhou , Yixian Liu , Jinhong Li, Huijing Luo, Qian He, Yanv Ren, Xiaofang Zhang, Zuoliang Dong

{"title":"Exploring insulin resistance and pancreatic function in individuals with overweight and obesity: Insights from OGTTs and IRTs","authors":"Xiaoxuan Liu , Huimin Zhou , Yixian Liu , Jinhong Li, Huijing Luo, Qian He, Yanv Ren, Xiaofang Zhang, Zuoliang Dong","doi":"10.1016/j.diabres.2024.111972","DOIUrl":"10.1016/j.diabres.2024.111972","url":null,"abstract":"<div><div>To investigate insulin resistance and pancreatic β-cell function in overweight or obese people under the same glucose tolerance conditions.</div><div>The subjects were categorized based on the results of the oral glucose tolerance test (OGTT) and the BMI classification criteria. Basal and postprandial glucose concentrations, insulin concentrations, pancreatic β-cell function (HOMA-β), the insulin resistance index (HOMA-IR), and the insulin early secretion index (ΔI30/ΔG30) were compared between the different weight groups.</div><div>Among individuals with similar glucose tolerances, those in the obese group presented higher HOMA-β, HOMA-IR, and ΔI30/ΔG30 values than did those in the normal weight and overweight groups. Additionally, in individuals with normal glucose tolerance and early diabetes, OGTT 1-h plasma glucose concentrations demonstrated a stronger correlation with early insulin secretion across different body weights.</div><div>When the same glucose-tolerant population was grouped by weight, OGTTs were significantly less different than IRTs. Therefore, integrating both tests is the optimal approach. In individuals with preobesity, there is an increase in pancreatic β-cell function to maintain normal blood glucose levels. As the disease progresses, obesity substantially increases insulin resistance, which acts as a disease-promoting factor. Furthermore, OGTT 1-h plasma glucose concentrations are strongly correlated with insulin secretion in normal or early diabetic populations.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"219 ","pages":"Article 111972"},"PeriodicalIF":6.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the interplay between systolic blood pressure, cardiovascular disease, and diabetes: A call for further research 探索收缩压、心血管疾病和糖尿病之间的相互作用：呼吁进一步研究。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2025-01-01 DOI: 10.1016/j.diabres.2024.111974

Saad Khan, Fatima Naveed, Rizwan Ahmad, Ayesha Khan, Faraz Arshad

引用次数: 0

The road to achieving diabetes education in schools 实现学校糖尿病教育之路。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-12-01 DOI: 10.1016/j.diabres.2024.111944

引用次数: 0

Corrigendum to “Risk factors of first and recurrent genitourinary tract infection in patients with type 2 diabetes treated with SGLT2 inhibitors: a retrospective cohort study” [Diabetes Res. Clin. Pract. 186 (2022) 109816] 对 "接受 SGLT2 抑制剂治疗的 2 型糖尿病患者首次和复发泌尿生殖道感染的风险因素：一项回顾性队列研究 "的更正 [Diabetes Res. Clin. Pract. 186 (2022) 109816]。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-12-01 DOI: 10.1016/j.diabres.2024.111925

Yi-Hsuan Lin , Chia-Hung Lin , Yu-Yao Huang , An-Shun Tai , Shih-Chen Fu , Szu-Tah Chen , Sheng-Hsuan Lin

引用次数: 0

The impact of ethnicity and its definition on diabetes prevalence: A national Australian whole-of-population study 种族及其定义对糖尿病患病率的影响：澳大利亚全国人口研究。

IF 6.1 3区医学

Diabetes research and clinical practice Pub Date : 2024-12-01 DOI: 10.1016/j.diabres.2024.111937

Joanna Y Gong , Agus Salim , Spiros Fourlanos , Dianna J Magliano , Jonathan E Shaw

{"title":"The impact of ethnicity and its definition on diabetes prevalence: A national Australian whole-of-population study","authors":"Joanna Y Gong , Agus Salim , Spiros Fourlanos , Dianna J Magliano , Jonathan E Shaw","doi":"10.1016/j.diabres.2024.111937","DOIUrl":"10.1016/j.diabres.2024.111937","url":null,"abstract":"<div><h3>Aims</h3><div> There were 17.5 million adults included in this study. Within four geographical regions, there wastwo-four-fold intra-regional variation in diabetes risk. Diabetes prevalence among people reporting a single East Asianancestry ranged from less than the Australian prevalence (Japanese 4.2%, Thai 6.1%) to twice the Australian prevalence (Filipino 12.6%). Among peoplereporting a single South/Central Asianancestry, diabetes prevalence ranged from 7.3% (Armenian) to 18.4% (Bangladeshi). Among people reporting a single Middle Eastern/North African ancestry, diabetes prevalence values rangedfrom 5.4% (Jewish) to 12.3% (Iraqi). In Oceania, the diabetes prevalence in people of Australian Aboriginal, Fijian, Maori, Samoan and Tongan ancestry was greater than the Australian prevalence(17.5%, 12.3%, 10.0%, 16.3% and 17.4%, respectively versus 6.3%).</div></div><div><h3>Conclusions</h3><div>  <!-->two-four-fold variation in diabetes prevalence between populations within four geographical regions. Aggregating ethnicity into large geographic regional groups may incorrectly estimate diabetes risk.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"218 ","pages":"Article 111937"},"PeriodicalIF":6.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0