Serum Neurofilament Light Chain and Structural and Functional Nerve Fiber Loss in Painful and Painless Diabetic Polyneuropathy

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-03-19 DOI:10.1016/j.diabres.2025.112098

Laura L. Määttä , Signe T. Andersen , Tina Parkner , Claus V.B. Hviid , Daniel R. Witte , Jishi John , Mathilde M.V. Pascal , Eleanor Ferris , Georgios Baskozos , Juan D. Ramirez , Solomon Tesfaye , Pallai R. Shillo , Andrew S.C Rice , Helen C. Laycock , Troels S. Jensen , David L. Bennett , Andreas C. Themistocleous

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引用次数: 0

Abstract

Aims

To explore associations between the axonal protein neurofilament light chain (NfL) and severity of diabetic polyneuropathy (DPN) and pain.

Methods

We performed cross-sectional analysis of a subset of the PiNS/DOLORisk cohort of people with DPN with and without neuropathic pain. Biobank samples were analyzed for serum NfL (s-NfL) using single molecule array. DPN was defined by Toronto criteria for probable or confirmed DPN. Painful DPN (PDPN) was evaluated according to IASP criteria. Measures of DPN severity included clinical DPN scales, quantitative sensory testing (QST) and intraepidermal nerve fiber density (IENFD).

Results

Participants with confirmed (N = 172) or probable DPN (N = 29) were included. There was no s-NfL difference between participants with DPN (N = 79, 22.8 ng/L [IQR 17.4; 31.3]) and PDPN (N = 122, 22.2 ng/L [16.0; 34.4]). S-NfL was not associated with pain severity or DPN severity evaluated by clinical DPN scales. Higher s-NfL was associated with lower IENFD (13.6 % [95 % CI 3.1; 22.9], unit = 1 fiber/mm, N = 24) and more pronounced loss of nerve fiber function measured by QST (p-trend = 0.02).

Conclusions

Higher s-NfL was associated with nerve fiber dysfunction and loss quantified by QST and IENFD, but not with pain or clinical DPN scales. S-NfL may reflect the severity of nerve fiber damage underlying DPN.

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疼痛性和无痛性糖尿病多发性神经病患者血清神经丝轻链及结构和功能性神经纤维损失。

目的：探讨轴突蛋白Neurofilament Light （NfL）与糖尿病多发性神经病（DPN）及疼痛严重程度的关系。方法：我们对伴有或不伴有神经性疼痛的DPN患者的PiNS/DOLORisk队列进行了横断面分析。采用单分子阵列分析生物样本血清NfL （s-NfL）。根据多伦多标准诊断可能或确诊的DPN。根据IASP标准评估疼痛性DPN （PDPN）。DPN严重程度的测量包括临床DPN量表、定量感觉测试（QST）和表皮内神经纤维密度（IENFD）。结果：纳入确诊（N = 172）或可能DPN （N = 29）的参与者。DPN患者间无s-NfL差异(N = 79,22.8 ng/L [IQR 17.4；31.3])和PDPN (N = 122,22.2 ng/L [16.0；34.4])。S-NfL与疼痛严重程度或临床DPN量表评估的DPN严重程度无关。较高的s-NfL与较低的IENFD相关(13.6 %[95 % CI 3.1；22.9]，单位 = 1纤维/mm， N = 24)，QST测量的神经纤维功能丧失更为明显（p-trend = 0.02）。结论：高s-NfL与QST和IENFD量化的神经纤维功能障碍和损失有关，但与疼痛或临床DPN量表无关。S-NfL可能反映DPN下神经纤维损伤的严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.