使用自动胰岛素输送系统的人为因素:使用2 年后对1型糖尿病儿童的实际影响(aids - a研究)。

IF 7.4 3区 医学 Q1 ENDOCRINOLOGY & METABOLISM
J. Schneidewind , S. von Sengbusch , D. Schmidt , K. Lange
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引用次数: 0

摘要

目的:本研究旨在评估在现实环境中使用自动胰岛素输送(AID)系统2 年后儿童的代谢影响、日常生活变化和糖尿病负担。方法:收集111例1型糖尿病儿童在使用AID 12和24 个月时的纵向血糖数据(糖化血红蛋白[HbA1c]、在范围内时间[TiR]、低于范围时间[TbR]、葡萄糖管理指标[GMI])、体重指数(BMI)和AID系统使用情况。1 年后,青少年和家长完成糖尿病相关困扰问卷(P-PAID-C、P-PAID-T和P-PAID-T),并经历变化。结果:不论年龄或先前的疗法,糖化血红蛋白水平下降从8.1 %(65 更易与摩尔)7.7 %(61 更易与摩尔),行动从55 %增加到64 %,为从2.6 %减少到1.8 %,和GMI(7.6 %与7.3 %)改善 1年后。2 年后,HbA1c(7.6 %[60 mmol/mol])、TiR(62 %)、TbR(1.3 %)和GMI(7.4 %)水平稳定下来。青少年和父母报告了日常生活的改善(即睡眠、压力、对低血糖的恐惧)。然而,BMI-SDS得分在第一年有所上升。结论:AID系统的使用与血糖控制的临床相关改善和受影响儿童及其父母每日糖尿病相关负担的减少有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Human factor in the use of automated insulin delivery systems: Real-world effects in children with type 1 diabetes after 2 years of use (AID-A study)

Human factor in the use of automated insulin delivery systems: Real-world effects in children with type 1 diabetes after 2 years of use (AID-A study)

Aims

This study aimed to assess the metabolic effects, changes in daily life, and diabetes burden associated with automated insulin delivery (AID) systems in children in a real-world setting after 2 years of use.

Methods

Longitudinal glycaemic data (glycated haemoglobin [HbA1c], time in range [TiR], time below range [TbR], glucose management indicator [GMI]), body mass index (BMI), and AID system usage were collected from 111 children with type 1 diabetes at 12 and 24 months of AID use. After 1 year, adolescents and parents completed questionnaires on diabetes-related distress (P-PAID-C, P-PAID-T, and PAID-T) and experienced changes.

Results

Regardless of age or previous therapy, the HbA1c level decreased from 8.1 % (65 mmol/mol) to 7.7 % (61 mmol/mol), TiR increased from 55 % to 64 %, TbR decreased from 2.6 % to 1.8 %, and GMI (7.6 % vs. 7.3 %) improved after 1 year. After 2 years, HbA1c (7.6 % [60 mmol/mol]), TiR (62 %), TbR (1.3 %), and GMI (7.4 %) levels stabilised. Adolescents and parents reported improvements in daily life (i.e. sleep, stress, fear of hypoglycaemia). However, the BMI-SDS scores increased in the first year.

Conclusions

AID system use is associated with clinically relevant improvements in glycaemic control and decrease in daily diabetes-related burden on affected children and their parents.
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来源期刊
Diabetes research and clinical practice
Diabetes research and clinical practice 医学-内分泌学与代谢
CiteScore
10.30
自引率
3.90%
发文量
862
审稿时长
32 days
期刊介绍: Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.
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