Liver disease in people with latent autoimmune diabetes in adults (LADA): A cross-sectional study using magnetic resonance elastography

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-09-08 DOI:10.1016/j.diabres.2025.112465

Ernesto Maddaloni , Marta Zerunian , Vincenzo Cardinale , Annalisa Zurru , Rocco Amendolara , Daniela Luverà , Renata Risi , Luca D’Onofrio , Benedetta Masci , Francesco Covotta , Damiano Caruso , Domenico Alvaro , Andrea Laghi , Raffaella Buzzetti

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Abstract

Aims

To investigate liver disease and its risk factors in LADA compared to type 1 (T1D) and type 2 (T2D) diabetes.

Methods

Liver magnetic resonance (MR) and MR elastography were used to measure proton density fat fraction (PDFF) and stiffness in 31 people with LADA matched for gender, body mass index (BMI) and disease duration with 31 people with T2D, and for gender, BMI and age with 31 people with T1D. Visceral adipose tissue (VAT) was quantified by DXA.

Results

Liver steatosis (PDFF >5.5%) was present in 17 (54.8%), 1 (3.2%) and 0 participants with T2D, LADA and T1D, respectively (p<0.001). Stiffness did not differ among groups. VAT was related to PDFF in the whole population, while BMI was a marker of liver fat content and of liver stiffness only in T2D (interaction p-values: <0.001 and 0.019). HbA1c and VAT associated with liver stiffness differently among diabetes types (interaction p-values: 0.034 and 0.016). Kidney function was inversely associated to liver stiffness in the whole population, without differences by diabetes type.

Conclusions

Liver fat accumulates differently in LADA and in T1D compared to T2D, reflecting a different body fat distribution despite a similar BMI. Factors associated with liver stiffness differ among diabetes types.

Abstract Image

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成人潜伏性自身免疫性糖尿病（LADA）患者的肝脏疾病：磁共振弹性成像横断面研究

目的：探讨LADA与1型（T1D）和2型（T2D）糖尿病的肝脏疾病及其危险因素。方法：采用肝脏磁共振（MR）和磁共振弹性成像（MR elastography）测量31例性别、体重指数（BMI）和病程匹配的LADA患者（31例T2D）和31例T1D患者（性别、BMI和年龄匹配）的质子密度脂肪分数（PDFF）和僵硬度。DXA定量测定内脏脂肪组织（VAT）。结果：T2D、LADA和T1D患者分别有17人（54.8%）、1人（3.2%）和0人存在肝脏脂肪变性（PDFF >5.5%）。结论：与T2D相比，LADA和T1D患者的肝脏脂肪积累不同，尽管BMI相似，但反映了不同的体脂分布。与肝脏僵硬相关的因素因糖尿病类型而异。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.