Psoriasis and risk of diabetic retinopathy in patients with type 2 diabetes mellitus

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-09-18 DOI:10.1016/j.diabres.2025.112912

Ming-Pei Yueh , Shih-Kai Kao , Jun-Wei Chen , Jing-Cyuan Huang , Harn-Shen Chen , Tzu-En Wu

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引用次数: 0

Abstract

Aims

To assess the risk of diabetic retinopathy (DR) among patients with type 2 diabetes mellitus (T2DM) who had a prior diagnosis of psoriasis, compared with those without psoriasis.

Methods

This retrospective cohort study utilized the TriNetX database. 85,691 patients with T2DM and comorbid psoriasis and propensity-score matched 85,691 patients with T2DM without psoriasis were analyzed. The primary outcome was the risk of DR. Secondary outcomes included the risks of vision-threatening DR (VTDR), non-proliferative DR (NPDR) and its severity gradations, proliferative DR (PDR), and diabetic macular edema (DME). Cox proportional hazards models were used to estimate hazard ratios (HRs).

Results

Psoriasis group had higher risks of DR (HR [95 % CI] = 2.111 [1.871, 2.383]), VTDR (HR [95 % CI] = 2.424 [1.937, 3.034]), NPDR (HR [95 % CI] = 2.152 [(1.854, 2.497)]), mild NPDR (HR [95 % CI] = 2.082 [1.765, 2.457]), moderate NPDR (HR [95 % CI] = 2.848 [2.000, 4.056]), PDR (HR [95 % CI] = 2.622 [1.753, 3.922]), and DME (HR [95 % CI] = 2.312 [1.794, 2.981]), but not severe NPDR.

Conclusions

Psoriasis is associated with an increased risk of DR in patients with T2DM, highlighting the need for heightened clinical vigilance regarding DR in patients with T2DM and psoriasis.

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银屑病与2型糖尿病视网膜病变的关系

目的：评估既往诊断为牛皮癣的2型糖尿病（T2DM）患者与未诊断为牛皮癣的2型糖尿病（T2DM）患者发生糖尿病视网膜病变（DR）的风险。方法：采用TriNetX数据库进行回顾性队列研究。85,691例T2DM合并银屑病患者与85,691例无银屑病的T2DM患者进行了倾向评分匹配分析。主要终点为DR风险。次要终点包括视力威胁DR （VTDR）、非增殖性DR （NPDR）及其严重程度分级、增殖性DR （PDR）和糖尿病性黄斑水肿（DME）的风险。采用Cox比例风险模型估计风险比（hr）。结果:银屑病组有更高的风险博士(HR(95 % CI) = 2.111 [1.871,2.383]),VTDR (HR(95 % CI) = 2.424 [1.937,3.034]),NPDR (HR(95 % CI) = 2.152[(1.854,2.497)]),轻度NPDR (HR(95 % CI) = 2.082[1.765,2.457]),中度NPDR (HR(95 % CI) = 2.848 [2.000,4.056]),PDR (HR(95 % CI) = 2.622[1.753,3.922]),和测距装置(HR(95 % CI) = 2.312 [1.794,2.981]),NPDR但不严重。结论：银屑病与T2DM患者发生DR的风险增加相关，强调T2DM合并银屑病患者发生DR的临床警惕性需要提高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.