1980年至2020年1型糖尿病中超重或肥胖流行的地区、年龄和性别趋势：一项对78项观察性研究的荟萃分析，涉及650,265名参与者。

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-09-14 DOI:10.1016/j.diabres.2025.112899

Yuchen Guo , Chu Lin , Xiaoling Cai , Han Wu, Jingya Yan, Zonglin Li, Ruoyang Jiao, Shuzhen Bai, Wenjia Yang, Fang Lv, Linong Ji

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引用次数: 0

摘要

目的：探讨1型糖尿病（T1D）患者超重或肥胖患病率的时间趋势。方法：PubMed、Embase和Cochrane检索了从研究开始到2024年3月T1D患者超重或肥胖患病率的观察性研究。合并患病率采用随机效应模型计算。结果：这项荟萃分析纳入了78项研究，650,265名参与者。在成年T1D患者中，肥胖症患病率从1985-1990年的3.3% [95%CI:2.1-5.0]上升至2015-2020年的23.7% [95%CI:17.9-30.1]。超重患病率呈持续上升趋势，2015-2020年T1D成人超重患病率达到31.4% [95%CI:25.6-37.5]。在患有T1D的儿童和青少年中，肥胖症患病率在1990-2010年间从6.3% [95%CI:3.8-9.8]上升至12.2% [95%CI:7.2-18.3]，在2010-2020年间小幅下降至9.3% [95%CI:6.7-12.4]。20年来，患有T1D的儿童和青少年的超重患病率保持在20%左右。肥胖患病率在两性中都有所增加，而生活在北美的人可能是各大洲中肥胖患病率最高的。结论：1980-2020年期间，T1D患者超重或肥胖患病率呈上升趋势，这可能导致糖尿病并发症尤其是心血管疾病的风险增加。体重管理可能是未来T1D治疗未满足的临床需求之一。

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Regional, age-specific and sex-specific trends in the prevalence of overweight or obesity in type 1 diabetes from 1980 to 2020: a meta-analysis of 78 observational studies with 650,265 participants

Aims

To investigate the temporal trends in the overweight or obesity prevalence among people with type 1 diabetes (T1D).

Methods

PubMed, Embase, and Cochrane were searched for observational studies reporting the prevalence of overweight or obesity in T1D from the inception to March 2024. The pooled prevalence was calculated in random-effect model.

Results

This meta-analysis incorporated 78 studies with 650,265 participants. Among adults with T1D, the prevalence of obesity increased from 3.3% [95%CI:2.1–5.0] during 1985–1990 to 23.7% [95%CI:17.9–30.1] during 2015–2020. The prevalence of overweight exhibited a sustained upward trajectory, reaching 31.4% [95%CI:25.6–37.5] by 2015–2020 for adults with T1D. In children and adolescents with T1D, the prevalence of obesity rose from 6.3% [95%CI:3.8–9.8] to 12.2% [95%CI:7.2–18.3] during 1990–2010, declining modestly to 9.3% [95%CI:6.7–12.4] during 2010–2020. The prevalence of overweight maintained approximately 20% over two decades for children and adolescence with T1D. Obesity prevalence increased in both sexes, and people living in North America might exhibit the highest obesity prevalence across continents.

Conclusions

The overweight or obesity prevalence has been increasing in T1D during 1980–2020, which may contribute to the increased risk of the diabetic complications, especially cardiovascular diseases. Weight management may be one of unmet clinical needs for future T1D management.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.