Sex hormone binging globulin as an indicator of insulin resistance in type 1 diabetes.

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-10-06 DOI:10.1016/j.diabres.2025.112935

Andrzej S Januszewski, Wayne A Rankin, David N O'Neal, Gary A Wittert, Alicia J Jenkins

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Abstract

Background: Sex hormone-binding globulin (SHBG) regulates sex hormone bioavailability and is a marker of hepatic insulin resistance.

Aim: Determine the relationship of circulating SHBG concentration with components of the metabolic syndrome (MetS) and estimated insulin sensitivity (eIS) in adults with and without T1D.

Methods: Serum SHBG concentrations were determined in 102 adults with T1D and 111 Controls (39% and 41% males, mean(SD): age 39(14) and 38(13) yrs., BMI 26.9(5.4) and 25.8(4.5) kg/m²).

Results: SHBG (median(LQ,UQ) was higher in T1D vs. Controls: 66.1(39.3,98.7) vs. 45.5(30.3,74.8) nmol/L, p = 0.001; and ≈2-fold higher in females than males in both groups, p < 0.0001. SHBG correlated with eIS and was lower with vs. without MetS: T1D (51(32,71) vs. 79(46,106) nmol/L, p = 0.007), Controls (35(30,43) vs. 51(31,84) nmol/L, p = 0.03). In both groups there were significant associations of lower waist-to-hip ratio, waist-to-height ratio, BMI, triglycerides, LDL-C and higher eIS with an increase in sex-specific SHBG concentration tertiles (p < 0.05). In both groups SHBG decreased with number of MetS components, p(trend) = 0.005 and 0.0006, respectively.

Conclusion: In adults with T1D, SHBG decreases with increasing insulin resistance and MetS components. These findings support a potential role for SHBG as a biomarker of metabolic health in T1D, but further studies are needed to determine its clinical utility in identifying individuals who may benefit from interventions targeting insulin sensitivity.

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性激素暴饮暴食球蛋白作为1型糖尿病胰岛素抵抗的指标。

背景：性激素结合球蛋白（SHBG）调节性激素的生物利用度，是肝脏胰岛素抵抗的标志。目的：确定有和没有T1D的成人中循环SHBG浓度与代谢综合征（MetS）成分和估计胰岛素敏感性（eIS）的关系。方法：对102例成人T1D患者和111例对照患者（男性39%和41%，平均（SD）年龄分别为39（14）岁和38（13）岁）进行血清SHBG浓度测定。BMI分别为26.9（5.4）和25.8(4.5)kg/m2。结果：T1D患者SHBG （LQ、UQ中位数）高于对照组：66.1（39.3、98.7）比45.5(30.3、74.8)nmol/L, p = 0.001；结论：成年T1D患者SHBG随胰岛素抵抗和MetS成分的增加而降低。这些发现支持SHBG作为T1D代谢健康的生物标志物的潜在作用，但需要进一步的研究来确定其在识别可能从针对胰岛素敏感性的干预中获益的个体方面的临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.