加速计测量的周末睡眠补足和睡眠缺失与2型糖尿病风险的关联：一项前瞻性队列研究

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-08-22 DOI:10.1016/j.diabres.2025.112420

Yinan Jiang , Zou Su , Sibo Liu , Hongkun Di , Qi Wu , Wen Hu , Tianzhu Qin , Shili Zhou , Jiawei Yin , Ying Chen , Xiang Cheng , Gang Liu , Liegang Liu , Yanjun Guo , Zhilei Shan

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引用次数: 0

摘要

目的探讨周末睡眠不足与2型糖尿病（T2D）发病风险的关系。方法本研究包括来自英国生物库的80,414名年龄在43-79岁之间的成年人。周末睡眠的增加和减少是通过腕带加速度计数据得出的。Cox风险模型用于检验周末补觉和睡眠不足与T2D风险（从相关的医疗记录、死亡登记和自我报告的诊断中确定）之间的关系。利用代谢生物标志物和代谢组学数据，我们进一步探索了潜在的生物学机制。结果中位（IQR）随访7.3年（6.8 ~ 7.8年），共发生T2D 1465例，累计发病率为1.8%。在工作日睡眠时间较短的个体中，周末补觉1.5小时与较低的T2D风险相关（HR 0.64, 95% CI 0.45-0.92）。相反，在工作日睡眠时间正常的个体中，周末睡眠不足与较高的T2D风险相关（HR 1.33, 95% CI 1.01-1.76）。周末补觉和缺觉表现出明显的代谢生物标志物和代谢组学反应。酪氨酸、亮氨酸、肌酐和一些脂质代谢物可能与周末补觉和缺觉与T2D有关。结论周末补觉可能是工作日睡眠不足的个体对抗T2D的潜在策略。

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Associations of accelerometer-measured weekend sleep catch-up and loss with risk of type 2 diabetes: a prospective cohort study

Aims

To investigate the relationship between weekend sleep catch-up and loss and risk of type 2 diabetes (T2D).

Methods

This study included 80,414 adults aged 43–79 years from the UK Biobank. Weekend sleep catch-up and loss were derived from wrist-worn accelerometer data. Cox hazard models were used to examine the associations of weekend sleep catch-up and loss with T2D risk (identified from linked medical records, death registers and self-reported diagnosis). Leveraging metabolic biomarker and metabolomics data, we further explored the underlying biological mechanisms.

Results

Over a median (IQR) follow-up of 7.3 years (6.8–7.8 years), 1,465 T2D cases occurred, with a cumulative incidence of 1.8 %. Among individuals with short weekday sleep duration, weekend sleep catch-up >1.5 h was associated with lower T2D risk (HR 0.64, 95 % CI 0.45–0.92). Conversely, among individuals with normal weekday sleep duration, weekend sleep loss was associated with higher T2D risk (HR 1.33, 95 % CI 1.01–1.76). Weekend sleep catch-up and loss showed distinct metabolic biomarker and metabolomic responses. Tyrosine, leucine, creatinine, and some lipid metabolites may link weekend sleep catch-up and loss to T2D.

Conclusions

Weekend sleep catch-up could be a potential strategy against T2D among individuals with sleep deprivation during weekdays.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.