2型糖尿病和大血管和微血管并发症发病率的迅速增加对年轻年龄组的影响尤为严重：来自国际联合数据库的十年证据

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-08-24 DOI:10.1016/j.diabres.2025.112431

Matthew Anson , Alex E. Henney , Harry Edwards , Gema H. Ibarburu , Ify Mordi , Shabbar Jaffar , Anupam Garrib , Gregory Y.H. Lip , Duolao Wang , Katarzyna Nabrdalik , Bruce A. Perkins , Daniel J. Cuthbertson , Uazman Alam

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Incidence odds ratios (IOR) were calculated by age group.</div></div><div><h3>Results</h3><div>7,918,666 individuals had T2D. The IOR (95 % CI), comparing individuals aged ≥ 85 years to < 35 years decreased for all complications from 2012 to 2023: <strong>IHD</strong> [IOR 6.82, (6.40, 7.26) to IOR 2.27 (2.17, 2.38)], <strong>heart failure</strong> [IOR 5.38, (5.03, 5.75) to IOR 1.80 (1.72, 1.89)], <strong>cerebral infarction</strong> [IOR 3.06, (2.76, 3.40) to IOR 1.45 (1.34, 1.57)], <strong>neuropathy</strong> [IOR 0.84, (0.74, 0.95) to IOR 0.47 (0.44, 0.49)], <strong>nephropathy</strong> [IOR 1.14, (1.03, 1.27) to IOR 0.90 (0.87, 0.94)] and <strong>retinopathy</strong> [IOR 0.56, (0.50, 0.63) to IOR 0.27 (0.25, 0.29)].</div></div><div><h3>Conclusions</h3><div>Rising rates of T2D associated complications in younger adults signal an emerging epidemic of early-onset comorbidity with substantial lifetime burden. 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引用次数: 0

摘要

目的描述2型糖尿病（T2D）相关并发症的发病率和患病率的最新趋势，以及它们在整个生命周期中的相对影响。方法使用TriNetX全球联邦数据库进行回顾性队列研究。2012年至2023年间，T2D的发病率和患病率及相关并发症：缺血性心脏病（IHD）、心力衰竭、脑梗死、神经病变、肾病和视网膜病变。发生率比值比（IOR）按年龄组计算。结果t2dm患者7918666例。从2012年到2023年，比较≥85岁到≥35岁的所有并发症的IOR (95% CI)：IHD [IOR 6.82,（6.40, 7.26）至IOR 2.27(2.17, 2.38)]，心力衰竭[IOR 5.38,（5.03, 5.75）至IOR 1.80(1.72, 1.89)]，脑梗死[IOR 3.06,（2.76, 3.40）至IOR 1.45(1.34, 1.57)]，神经病变[IOR 0.84,（0.74, 0.95）至IOR 0.47(0.44, 0.49)]，肾病[IOR 1.14,（1.03, 1.27）至IOR 0.90(0.87, 0.94)]，视网膜病变[IOR 0.56,（0.50, 0.63）至IOR 0.27(0.25, 0.29)]。结论：年轻人中T2D相关并发症发生率的上升，标志着早发性合并症的流行，并伴随严重的终生负担。这些发现强调迫切需要早期发现、积极的风险因素管理和针对年轻人群的有针对性的预防策略。

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The rapidly increasing incidence of type 2 diabetes and macrovascular and microvascular complications disproportionately affects younger age groups: A decade of evidence from an international federated database

Aims

To characterise recent trends in incidence and prevalence of type 2 diabetes (T2D) associated complications, and their relative impact across the lifespan.

Methods

We conducted a retrospective cohort study using the TriNetX global federated database. Incidence and prevalence of T2D and associated complications: ischaemic heart disease (IHD), heart failure, cerebral infarction, neuropathy, nephropathy, and retinopathy were assessed between 2012 and 2023. Incidence odds ratios (IOR) were calculated by age group.

Results

7,918,666 individuals had T2D. The IOR (95 % CI), comparing individuals aged ≥ 85 years to < 35 years decreased for all complications from 2012 to 2023: IHD [IOR 6.82, (6.40, 7.26) to IOR 2.27 (2.17, 2.38)], heart failure [IOR 5.38, (5.03, 5.75) to IOR 1.80 (1.72, 1.89)], cerebral infarction [IOR 3.06, (2.76, 3.40) to IOR 1.45 (1.34, 1.57)], neuropathy [IOR 0.84, (0.74, 0.95) to IOR 0.47 (0.44, 0.49)], nephropathy [IOR 1.14, (1.03, 1.27) to IOR 0.90 (0.87, 0.94)] and retinopathy [IOR 0.56, (0.50, 0.63) to IOR 0.27 (0.25, 0.29)].

Conclusions

Rising rates of T2D associated complications in younger adults signal an emerging epidemic of early-onset comorbidity with substantial lifetime burden. These findings emphasise the urgent need for earlier detection, aggressive risk factor management, and targeted prevention strategies in younger populations.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.