Diagnostic Pathology最新文献

Schwannoma of tongue: a clinicopathologic study of 34 cases and review of published literature. 舌神经鞘瘤34例临床病理分析及文献复习。

IF 2.3 3区医学

Diagnostic Pathology Pub Date : 2026-04-30 DOI: 10.1186/s13000-026-01789-5

Nasir Ud Din, Manahil Khan, Jamshid Abdul-Ghafar, Fatima Safdar, Zubair Ahmad

{"title":"Schwannoma of tongue: a clinicopathologic study of 34 cases and review of published literature.","authors":"Nasir Ud Din, Manahil Khan, Jamshid Abdul-Ghafar, Fatima Safdar, Zubair Ahmad","doi":"10.1186/s13000-026-01789-5","DOIUrl":"https://doi.org/10.1186/s13000-026-01789-5","url":null,"abstract":"Background: Schwannomas are exceedingly rare in the tongue. Here, we report clinicopathological features of tongue schwannomas diagnosed at the section of Histopathology, Department of Pathology and Laboratory Medicine, Aga Khan University Hospital (AKUH), Karachi, Pakistan and reviewed the published literature.Methods: Retrospective study of 34 tongue schwannomas diagnosed between 2011 and 2024. Hematoxylin and Eosin (H&E) and immunohistochemical (IHC) slides were reviewed. Demographic and clinical data were obtained.Results: There was a slight female preponderance. Mean age was 30 years. Commonest sites were lateral borders and base of tongue. All tumors were surgically excised. Average tumor size was 2 cm. Histologically, 30 tumors exhibited classical features of schwannoma, while 4 were cellular. On IHC, strong and diffuse positivity of S100 protein and SOX10 was seen. No recurrences were reported in the cases where follow-up was available. None of the 34 cases had clinical features suggestive of Neurofibromatosis.Conclusions: Schwannomas although rare, should be included in the differential diagnosis of tongue masses. Early recognition and surgical excision result in excellent outcomes.","PeriodicalId":11237,"journal":{"name":"Diagnostic Pathology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monocytoid dendritic cells might be a specific marker for lung involvement in dermatomyositis. 单核细胞树突状细胞可能是皮肌炎中肺部受累的特异性标志物。

IF 2.3 3区医学

Diagnostic Pathology Pub Date : 2026-04-29 DOI: 10.1186/s13000-026-01790-y

Johanna Knirsch, Mohammed Al-Effah, Helmut Popper

{"title":"Monocytoid dendritic cells might be a specific marker for lung involvement in dermatomyositis.","authors":"Johanna Knirsch, Mohammed Al-Effah, Helmut Popper","doi":"10.1186/s13000-026-01790-y","DOIUrl":"https://doi.org/10.1186/s13000-026-01790-y","url":null,"abstract":"Dermatomyositis (DM) is a rare autoimmune disease leading to inflammatory and degenerative changes affecting skin and muscles. Interstitial lung disease is a major risk factor for morbidity and mortality in DM. The precise immune mechanism underlying DM, particularly in the context of lung involvement, remains poorly understood. This research focuses on the significance of dendritic cell subsets and Langerhans cells in the immune irregularities observed in DM.The study analyzed 12 cases of DM with lung involvement, and compared the findings to 12 cases with skin involvement. All subjects were untreated at the time of diagnosis, with ages ranging from the 20 to 80 years. Immunohistochemistry was utilized to characterize dendritic cell subsets and to assess cells expressing MDA5. Six cases of rheumatoid arthritis (RA) with fibrosing pneumonia were investigated for comparison.We identified dendritic cells and lymphocytes expressing the melanoma differentiation gene 5 (MDA5) protein. Monocytoid dendritic cells predominated in DM, and were absent in RA, therefore might serve as a diagnostic marker, separating DM from other autoimmune diseases. Our findings suggest that DCs and lymphocytes are constantly attacked by autoantibodies for MDA5, as these cells express the antigen. Furthermore, mature DC in skin and lung and Langerhans in the skin are replaced by immature DC. This might explain prolonged activation of the immune system resulting in fibrosis in both skin and lung tissues. The loss of Langerhans cells might be responsible for an increased penetrance of antigens through the epidermis.","PeriodicalId":11237,"journal":{"name":"Diagnostic Pathology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virtual assistants based on artificial intelligence for oral diagnosis: help for clinicians AI oral diagnosis helper. 基于人工智能的口腔诊断虚拟助手：帮助临床医生的AI口腔诊断助手。

IF 2.3 3区医学

Diagnostic Pathology Pub Date : 2026-04-24 DOI: 10.1186/s13000-026-01751-5

Eduarda Gomes Onofre de Araújo, Livian Isabel de Medeiros Carvalho, Breno Estevam Silva de de Souza, Ilan Hudson Gomes de Santana, Hélder Domiciano Dantas Martins, Hellen Bandeira de Pontes Santos, Cláudia Batista Mélo, Leonardo Amaral Dos Reis, Lívia Máris Ribeiro Paranaíba Dias, Andre Ulisses Dantas Batista, Edson Hilan Gomes de Lucena, Paulo Rogerio Ferreti Bonan

引用次数: 0

Clinical pathological characteristics and prognostic analysis of 140 cases of medullary thyroid carcinoma: validation of the international medullary thyroid carcinoma grading system in a chinese cohort. 140例甲状腺髓样癌的临床病理特征及预后分析：国际甲状腺髓样癌分级系统在中国队列中的验证。

IF 2.3 3区医学

Diagnostic Pathology Pub Date : 2026-04-22 DOI: 10.1186/s13000-026-01787-7

Zhe Zhang, Ye Yang, Yiyuan Dou, Wenchao Liu, Lin Dong, Yuelu Zhu, Haizhen Lu

引用次数: 0

Comparison of immunohistochemistry, PCR, and NGS for the evaluation of mismatch repair deficiency and microsatellite instability in colorectal cancer: a retrospective study. 免疫组织化学、PCR和NGS评估结直肠癌错配修复缺陷和微卫星不稳定性的比较：一项回顾性研究。

IF 2.3 3区医学

Diagnostic Pathology Pub Date : 2026-04-21 DOI: 10.1186/s13000-026-01788-6

Lei Wang, Yuan Hu, Huazun Yuan, Na Yu, Li Xiao, Jingjing Jin

引用次数: 0

Combined assessment of stromal tumor infiltrating lymphocytes and tumor peroxiredoxin 4 expression improved prognostic stratification in postoperative pancreatic cancer patients. 联合评估间质肿瘤浸润淋巴细胞和肿瘤过氧化物还蛋白4的表达可改善胰腺癌术后患者的预后分层。

IF 2.3 3区医学

Diagnostic Pathology Pub Date : 2026-04-16 DOI: 10.1186/s13000-026-01786-8

Yao Liu, Jia Han, Akihiro Shioya, Wenpeng Jiao, Masashi Okuro, Tohru Ito, Sohsuke Yamada

引用次数: 0

Construction of an integrated diagnostic-therapeutic model for prostate cancer using rapid multiplex immunohistochemistry. 应用快速多元免疫组化技术构建前列腺癌综合诊断治疗模型。

IF 2.3 3区医学

Diagnostic Pathology Pub Date : 2026-04-13 DOI: 10.1186/s13000-026-01784-w

Yang Luan, Yin-Shuai Geng, Yong-Quan Gao, Sheng-Ming Lu, Qin Xiao, Xue-Fei Ding

引用次数: 0

Case report: a case of primary cutaneous diffuse large B-cell lymphoma, leg type with TdT positive in an elderly woman. 病例报告：1例老年妇女原发性皮肤弥漫性大b细胞淋巴瘤，腿部型，TdT阳性。

IF 2.3 3区医学

Diagnostic Pathology Pub Date : 2026-04-01 DOI: 10.1186/s13000-026-01768-w

Jingwei Zheng, Xinghui Li, Hao Chen

引用次数: 0

Detection of collagen band-associated regions in H&E-stained colonic biopsies of collagenous colitis patients using superpixel-based feature extraction and neural network classification. 利用超像素特征提取和神经网络分类检测胶原性结肠炎患者h&e染色结肠活检中胶原带相关区域。

IF 2.3 3区医学

Diagnostic Pathology Pub Date : 2026-03-28 DOI: 10.1186/s13000-026-01783-x

Vytautas Kiudelis, Robertas Petrolis, Rima Ramonaitė, Dainius Jančiauskas, Lina Poškienė, Juozas Kupčinskas, Povilas Šabanas, Reda Čerapaitė-Trušinskienė, Diana Meilutytė-Lukauskienė, Algimantas Kriščiukaitis

引用次数: 0

Adenocarcinoma admixed with neuroendocrine carcinoma of the cervix: a clinicopathological diagnostic study and molecular features. 宫颈腺癌合并神经内分泌癌：临床病理诊断研究及分子特征。

IF 2.3 3区医学

Diagnostic Pathology Pub Date : 2026-03-26 DOI: 10.1186/s13000-026-01782-y

Miao Yu, Min Jiang, Xinrong Zhang, Honglei Chen, Xiaoyan Ye

引用次数: 0